{"id":"https://openalex.org/W3009409673","doi":"https://doi.org/10.1371/journal.pgen.1008605","title":"The influence of rare variants in circulating metabolic biomarkers","display_name":"The influence of rare variants in circulating metabolic biomarkers","publication_year":2020,"publication_date":"2020-03-09","ids":{"openalex":"https://openalex.org/W3009409673","doi":"https://doi.org/10.1371/journal.pgen.1008605","mag":"3009409673","pmid":"https://pubmed.ncbi.nlm.nih.gov/32150548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7108731"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1008605","doi":"https://doi.org/10.1371/journal.pgen.1008605","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1008605","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008605&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008605&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072098567","display_name":"Fernando Riveros-Mckay","orcid":"https://orcid.org/0000-0002-6671-1177","observed_orcids":["https://orcid.org/0000-0002-6671-1177"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fernando Riveros-Mckay","raw_affiliation_strings":["Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6671-1177","affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002190135","display_name":"Clare Oliver\u2010Williams","orcid":"https://orcid.org/0000-0002-3573-2426","observed_orcids":["https://orcid.org/0000-0002-3573-2426"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Oliver-Williams","raw_affiliation_strings":["Homerton College, Cambridge, United Kingdom","MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3573-2426","affiliations":[{"raw_affiliation_string":"Homerton College, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004138949","display_name":"Savita Karthikeyan","orcid":"https://orcid.org/0000-0002-4798-5746","observed_orcids":["https://orcid.org/0000-0002-4798-5746"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Savita Karthikeyan","raw_affiliation_strings":["MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4798-5746","affiliations":[{"raw_affiliation_string":"MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009265821","display_name":"Klaudia Walter","orcid":"https://orcid.org/0000-0003-4448-0301","observed_orcids":["https://orcid.org/0000-0003-4448-0301"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Klaudia Walter","raw_affiliation_strings":["Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4448-0301","affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040373478","display_name":"Kousik Kundu","orcid":"https://orcid.org/0000-0002-1019-8351","observed_orcids":["https://orcid.org/0000-0002-1019-8351","https://orcid.org/0000-0001-7496-2075"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kousik Kundu","raw_affiliation_strings":["Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-1019-8351","affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014699562","display_name":"Willem Hendrik Ouwehand","orcid":"https://orcid.org/0000-0002-7744-1790","observed_orcids":["https://orcid.org/0000-0002-7744-1790","https://orcid.org/0000-0001-5250-0160","https://orcid.org/0000-0002-6915-9015"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Willem H. Ouwehand","raw_affiliation_strings":["Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom","NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7744-1790","affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002450989","display_name":"David J. Roberts","orcid":"https://orcid.org/0000-0003-0648-6585","observed_orcids":["https://orcid.org/0000-0003-0648-6585"]},"institutions":[{"id":"https://openalex.org/I1307946715","display_name":"NHS Blood and Transplant","ror":"https://ror.org/0227qpa16","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307946715"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Roberts","raw_affiliation_strings":["NHS Blood and Transplant-Oxford Centre, Level 2, John Radcliffe Hospital, Oxford, United Kingdom","Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom","The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHS Blood and Transplant-Oxford Centre, Level 2, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I1307946715","https://openalex.org/I2802742124"]},{"raw_affiliation_string":"Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]},{"raw_affiliation_string":"The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012263812","display_name":"Emanuele Di Angelantonio","orcid":"https://orcid.org/0000-0001-8776-6719","observed_orcids":["https://orcid.org/0000-0001-8776-6719","https://orcid.org/0000-0003-1158-6791"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emanuele Di Angelantonio","raw_affiliation_strings":["British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210142469"]},{"raw_affiliation_string":"MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I34931013"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040292172","display_name":"Nicole Soranzo","orcid":"https://orcid.org/0000-0003-1095-3852","observed_orcids":["https://orcid.org/0000-0003-1095-3852","https://orcid.org/0000-0003-0044-443X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicole Soranzo","raw_affiliation_strings":["Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033502820","display_name":"John Danesh","orcid":"https://orcid.org/0000-0003-1158-6791","observed_orcids":["https://orcid.org/0000-0003-1158-6791"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Danesh","raw_affiliation_strings":["British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210142469"]},{"raw_affiliation_string":"MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I34931013"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":null,"display_name":"INTERVAL Study","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"INTERVAL Study","raw_affiliation_strings":["MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047081077","display_name":"Eleanor Wheeler","orcid":"https://orcid.org/0000-0002-8616-6444","observed_orcids":["https://orcid.org/0000-0002-8616-6444"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Eleanor Wheeler","raw_affiliation_strings":["MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom","Institute of Translational Genomics, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"Institute of Translational Genomics, Helmholtz Zentrum M\u00fcnchen\u2014German Research Center for Environmental Health, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031210932","display_name":"Eleftheria Zeggini","orcid":"https://orcid.org/0000-0003-4238-659X","observed_orcids":["https://orcid.org/0000-0003-4238-659X","https://orcid.org/0000-0002-6550-9794","https://orcid.org/0000-0001-9611-9281","https://orcid.org/0000-0001-7312-7078"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Eleftheria Zeggini","raw_affiliation_strings":["Institute of Translational Genomics, Helmholtz Zentrum M\u00fcnchen-German Research Center for Environmental Health, Neuherberg, Germany","Wellcome Sanger Institute, Cambridge, United Kingdom","British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Translational Genomics, Helmholtz Zentrum M\u00fcnchen-German Research Center for Environmental Health, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210142469"]},{"raw_affiliation_string":"MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091904917","display_name":"Adam S. Butterworth","orcid":"https://orcid.org/0000-0002-6915-9015","observed_orcids":["https://orcid.org/0000-0002-6915-9015"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4389425352","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I34931013","https://openalex.org/I4389425352"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam S. Butterworth","raw_affiliation_strings":["British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom","MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210142469"]},{"raw_affiliation_string":"MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4389425352"]},{"raw_affiliation_string":"The National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749","https://openalex.org/I34931013"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]},{"raw_affiliation_string":"MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I87048295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054870758","display_name":"In\u00eas Barroso","orcid":"https://orcid.org/0000-0001-5800-4520","observed_orcids":["https://orcid.org/0000-0001-5800-4520"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I4210158597","display_name":"MRC Epidemiology Unit","ror":"https://ror.org/052578691","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210158597","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"In\u00eas Barroso","raw_affiliation_strings":["MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","Wellcome Sanger Institute, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5800-4520","affiliations":[{"raw_affiliation_string":"MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Wellcome Sanger Institute, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2802476451"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5054870758"],"corresponding_institution_ids":["https://openalex.org/I2802476451","https://openalex.org/I4210116691","https://openalex.org/I4210156194","https://openalex.org/I4210158597","https://openalex.org/I87048295"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.2517,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.22296476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"e1008605","last_page":"e1008605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.9399999976158142},{"id":"https://openalex.org/keywords/circulating-metabolites","display_name":"circulating metabolites","score":0.9470000267028809},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.718999981880188},{"id":"https://openalex.org/keywords/plasma-lipoproteins","display_name":"serum lipoproteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lipids","display_name":"lipids","score":0.7480000257492065},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-based-association","display_name":"gene-based association","score":0.6309999823570251},{"id":"https://openalex.org/keywords/gene-set-analysis","display_name":"gene set analysis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-complex","display_name":"pyruvate dehydrogenase complex","score":0.9369999766349792},{"id":"https://openalex.org/keywords/idl","display_name":"IDL","score":0.6039999723434448},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8730000257492065},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.8679999709129333},{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.9860000014305115},{"id":"https://openalex.org/keywords/acsl1","display_name":"ACSL1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pahs","display_name":"PAHs","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hal","display_name":"HAL","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7414175271987915},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6322353482246399},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.5543837547302246},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5541226863861084},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5533959269523621},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5380868911743164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4709262251853943},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.4570145905017853},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.4479788541793823},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42931675910949707},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3154793381690979},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1740238070487976}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":18,"locations":[{"id":"doi:10.1371/journal.pgen.1008605","doi":"https://doi.org/10.1371/journal.pgen.1008605","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1008605","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008605&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/480699","doi":"https://doi.org/10.1101/480699","is_oa":true,"landing_page_url":"https://doi.org/10.1101/480699","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/11/29/480699.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7108731","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7108731","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:32150548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32150548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pgen00:1008605","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008605","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f81347d66d174b55a9280f39db55ed9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f81347d66d174b55a9280f39db55ed9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 16, Iss 3, p e1008605 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/11958258","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/The_influence_of_rare_variants_in_circulating_metabolic_biomarkers/11958258","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:58544","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=58544","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genet. 16:e1008605 (2020)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:push-zb.helmholtz-munich.de:58544","doi":null,"is_oa":true,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=58544","pdf_url":null,"source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genet. 16:e1008605 (2020)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/291294","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/291294","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Webpages"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/301570","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/301570","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/303945","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/303945","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/304259","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/304259","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"nlmid: 101239074","raw_type":"Article"},{"id":"doi:10.17863/cam.38473","doi":"https://doi.org/10.17863/cam.38473","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.38473","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.17863/cam.48639","doi":"https://doi.org/10.17863/cam.48639","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.48639","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.17863/cam.51029","doi":"https://doi.org/10.17863/cam.51029","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.51029","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17863/cam.51339","doi":"https://doi.org/10.17863/cam.51339","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.51339","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:3015839240","doi":null,"is_oa":false,"landing_page_url":"https://aspace.repository.cam.ac.uk/handle/1810/304259","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1008605","doi":"https://doi.org/10.1371/journal.pgen.1008605","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1008605","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008605&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1087839611","display_name":"Aetiology of type 2 diabetes and related metabolic disorders","funder_award_id":"MC_UU_12015/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1727433039","display_name":null,"funder_award_id":"RE/13/6/30180)","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G1953244154","display_name":null,"funder_award_id":"MR/L003120/1","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2424152919","display_name":"Large-scale integrative genomic studies of high-dimensional traits in cardiovascular diseases (renewal)","funder_award_id":"RG/18/13/33946","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G2797452859","display_name":null,"funder_award_id":"RG/18/13/33946","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2804450655","display_name":null,"funder_award_id":"BTRU-2014-10024","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G3217060148","display_name":null,"funder_award_id":"SP/09/002","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3425072377","display_name":null,"funder_award_id":"WT206194, 206194","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3783408021","display_name":null,"funder_award_id":"HEALTH-F2-2012-279233","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G3986547339","display_name":null,"funder_award_id":"MR/L003120/1","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G4194769985","display_name":null,"funder_award_id":"NIHR BTRU\u20102014\u201010024","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4584873075","display_name":null,"funder_award_id":"SP/09/002","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G4642712072","display_name":null,"funder_award_id":"WT206194","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5003223212","display_name":null,"funder_award_id":"RE/13/6/30180, RG/18/13/33946, RG/13/13/30194","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G5117680084","display_name":null,"funder_award_id":"RG/18/13/33946","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G587296758","display_name":null,"funder_award_id":"BTRU-2014\u201310024","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6467398148","display_name":null,"funder_award_id":"BTRU-2014-10024","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6546307666","display_name":"EPIC-CVD: Individualised CVD risk assessment: tailoring targeted and cost-effective approaches to Europe's diverse populations","funder_award_id":"279233","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6550979745","display_name":null,"funder_award_id":"206194","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6787924332","display_name":null,"funder_award_id":"RG/18/13/33946","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G7549917023","display_name":"Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers.","funder_award_id":"206194","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7595091512","display_name":"Large-scale integrative studies of risk factors in coronary heart disease: from discovery to application (renewal). (Joint funding with MRC)","funder_award_id":"RG/13/13/30194","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G7939076303","display_name":null,"funder_award_id":"MR/L003120","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7992221752","display_name":null,"funder_award_id":"RE/13/6/30180","funder_id":"https://openalex.org/F4320336709","funder_display_name":"NIHR Cambridge Biomedical Research Centre"},{"id":"https://openalex.org/G8004734101","display_name":"Research Excellence","funder_award_id":"RE/13/6/30180","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G8346449347","display_name":null,"funder_award_id":"NIHR BTRU-2014-10024","funder_id":"https://openalex.org/F4320310960","funder_display_name":"NHS Blood and Transplant"},{"id":"https://openalex.org/G908762537","display_name":"Large-scale integrative studies of risk factors in coronary heart disease: from discovery to application","funder_award_id":"MR/L003120/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320310960","display_name":"NHS Blood and Transplant","ror":"https://ror.org/0227qpa16"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313269","display_name":"Scottish Government","ror":"https://ror.org/04v2xmd71"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320853","display_name":"Public Health Agency","ror":"https://ror.org/03ek62e72"},{"id":"https://openalex.org/F4320321578","display_name":"Cambridge University Hospitals","ror":"https://ror.org/04v54gj93"},{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320333685","display_name":"Chief Scientist Office, Scottish Government Health and Social Care Directorate","ror":"https://ror.org/01613vh25"},{"id":"https://openalex.org/F4320334175","display_name":"NIHR BioResource","ror":"https://ror.org/04dmgak75"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334630","display_name":"Economic and Social Research Council","ror":"https://ror.org/03n0ht308"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335314","display_name":"Homerton College, University of Cambridge","ror":null},{"id":"https://openalex.org/F4320335543","display_name":"Health and Social Care Research and Development Division","ror":null},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":"https://ror.org/05m8dr349"},{"id":"https://openalex.org/F7757660664","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3009409673.pdf","grobid_xml":"https://content.openalex.org/works/W3009409673.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1547212375","https://openalex.org/W1907868928","https://openalex.org/W1925850247","https://openalex.org/W1969195427","https://openalex.org/W1984068087","https://openalex.org/W1989277387","https://openalex.org/W1991523990","https://openalex.org/W1996682563","https://openalex.org/W2006861751","https://openalex.org/W2013317474","https://openalex.org/W2020915011","https://openalex.org/W2024280594","https://openalex.org/W2030007406","https://openalex.org/W2030701454","https://openalex.org/W2032611127","https://openalex.org/W2037013058","https://openalex.org/W2040612932","https://openalex.org/W2047783882","https://openalex.org/W2057394745","https://openalex.org/W2073432882","https://openalex.org/W2079386976","https://openalex.org/W2099328768","https://openalex.org/W2100909778","https://openalex.org/W2102732029","https://openalex.org/W2103441770","https://openalex.org/W2103504539","https://openalex.org/W2109468984","https://openalex.org/W2110227562","https://openalex.org/W2110256992","https://openalex.org/W2110415949","https://openalex.org/W2115141971","https://openalex.org/W2115801316","https://openalex.org/W2119021831","https://openalex.org/W2119180969","https://openalex.org/W2121549471","https://openalex.org/W2122060560","https://openalex.org/W2124794869","https://openalex.org/W2125392951","https://openalex.org/W2133730856","https://openalex.org/W2135185355","https://openalex.org/W2139852278","https://openalex.org/W2144086069","https://openalex.org/W2151675684","https://openalex.org/W2153118028","https://openalex.org/W2159482845","https://openalex.org/W2166124982","https://openalex.org/W2168372732","https://openalex.org/W2169718193","https://openalex.org/W2170096200","https://openalex.org/W2261356418","https://openalex.org/W2277462866","https://openalex.org/W2310542696","https://openalex.org/W2323589075","https://openalex.org/W2338551889","https://openalex.org/W2342541891","https://openalex.org/W2417483443","https://openalex.org/W2461793432","https://openalex.org/W2505992742","https://openalex.org/W2535426958","https://openalex.org/W2537679995","https://openalex.org/W2550031966","https://openalex.org/W2559028527","https://openalex.org/W2559588208","https://openalex.org/W2562408240","https://openalex.org/W2582743722","https://openalex.org/W2617316722","https://openalex.org/W2752200415","https://openalex.org/W2753659515","https://openalex.org/W2765748387","https://openalex.org/W2767038995","https://openalex.org/W2767053787","https://openalex.org/W2771599286","https://openalex.org/W2780667489","https://openalex.org/W2787647639","https://openalex.org/W2790635296","https://openalex.org/W2795506919","https://openalex.org/W4233698560","https://openalex.org/W4294216483","https://openalex.org/W4399638371","https://openalex.org/W6868500248"],"related_works":["https://openalex.org/W7014917973","https://openalex.org/W4321370552","https://openalex.org/W4200434241","https://openalex.org/W4378781655","https://openalex.org/W4386600614","https://openalex.org/W1496855348","https://openalex.org/W6962479208","https://openalex.org/W4225164066","https://openalex.org/W2594275078","https://openalex.org/W4307414449"],"abstract_inverted_index":{"Circulating":[0],"metabolite":[1,37,145],"levels":[2],"are":[3],"biomarkers":[4],"for":[5,51,69,113,122],"cardiovascular":[6],"disease":[7],"(CVD).":[8],"Here":[9],"we":[10,152],"studied,":[11],"association":[12,49],"of":[13,73,105,125,162,191],"rare":[14,47],"variants":[15],"and":[16,21,53,84,87,101,129,156,174],"226":[17],"serum":[18],"lipoproteins,":[19],"lipids":[20],"amino":[22],"acids":[23],"in":[24,46,62,117,148,159,195],"7,142":[25],"(discovery":[26],"plus":[27],"follow-up)":[28],"healthy":[29],"participants.":[30],"We":[31],"leveraged":[32],"the":[33,40,63,70,106,114,149,160,188],"information":[34],"from":[35],"multiple":[36],"measurements":[38,146],"on":[39],"same":[41,150],"participants":[42],"to":[43,171,185],"improve":[44],"discovery":[45],"variant":[48],"analyses":[50,119],"gene-based":[52],"gene-set":[54,118],"tests":[55,74],"by":[56],"incorporating":[57],"correlated":[58],"metabolites":[59],"as":[60,132,134,180],"covariates":[61],"validation":[64],"stage.":[65],"Gene-based":[66],"analysis":[67],"corrected":[68,121],"effective":[71,123],"number":[72,124],"performed,":[75],"confirmed":[76],"established":[77],"associations":[78,91],"at":[79,92],"APOB,":[80],"APOC3,":[81],"PAH,":[82],"HAL":[83],"PCSK":[85],"(p<1.32x10-7)":[86],"identified":[88,153],"novel":[89,154],"gene-trait":[90],"a":[93],"lower":[94],"stringency":[95],"threshold":[96],"with":[97,127],"ACSL1,":[98],"MYCN,":[99],"FBXO36":[100],"B4GALNT3":[102],"(p<2.5x10-6).":[103],"Regulation":[104],"pyruvate":[107],"dehydrogenase":[108],"(PDH)":[109],"complex":[110],"was":[111],"associated":[112],"first":[115],"time,":[116],"also":[120],"tests,":[126],"IDL":[128],"LDL":[130],"parameters,":[131],"well":[133],"circulating":[135],"cholesterol":[136],"(pMETASKAT<2.41x10-6).":[137],"In":[138],"conclusion,":[139],"using":[140],"an":[141],"approach":[142],"that":[143],"leverages":[144],"obtained":[147],"participants,":[151],"loci":[155],"pathways":[157],"involved":[158],"regulation":[161],"these":[163,196],"important":[164],"metabolic":[165],"biomarkers.":[166],"As":[167],"large-scale":[168],"biobanks":[169],"continue":[170],"amass":[172],"sequencing":[173],"phenotypic":[175],"information,":[176],"analytical":[177],"approaches":[178],"such":[179],"ours":[181],"will":[182],"be":[183],"useful":[184],"fully":[186],"exploit":[187],"copious":[189],"amounts":[190],"biological":[192],"data":[193],"generated":[194],"efforts.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-03-13T00:00:00"}