{"id":"https://openalex.org/W3009106416","doi":"https://doi.org/10.1111/imm.13185","title":"T\u2010cells producing multiple combinations of IFN\u03b3, TNF and IL10 are associated with mild forms of dengue infection","display_name":"T\u2010cells producing multiple combinations of IFN\u03b3, TNF and IL10 are associated with mild forms of dengue infection","publication_year":2020,"publication_date":"2020-03-04","ids":{"openalex":"https://openalex.org/W3009106416","doi":"https://doi.org/10.1111/imm.13185","mag":"3009106416","pmid":"https://pubmed.ncbi.nlm.nih.gov/32128816","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7160666"},"language":"en","primary_location":{"id":"doi:10.1111/imm.13185","doi":"https://doi.org/10.1111/imm.13185","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imm.13185","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imm.13185","source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imm.13185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031676296","display_name":"Marcela Helena Gon\u00e7alves-Pereira","orcid":"https://orcid.org/0000-0002-7821-6392","observed_orcids":["https://orcid.org/0000-0002-7821-6392"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcela Helena Gon\u00e7alves Pereira","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063142500","display_name":"Maria Marta Figueiredo","orcid":"https://orcid.org/0000-0003-2538-5878","observed_orcids":["https://orcid.org/0000-0003-2538-5878"]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Marta Figueiredo","raw_affiliation_strings":["Instituto Rene Rachou Funda\u00e7\u00e3o Oswaldo Cruz Belo Horizonte Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Rene Rachou Funda\u00e7\u00e3o Oswaldo Cruz Belo Horizonte Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089371837","display_name":"Camila Pereira Queiroz","orcid":"https://orcid.org/0000-0002-5753-624X","observed_orcids":["https://orcid.org/0000-0002-5753-624X"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Pereira Queiroz","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022612001","display_name":"T\u00e9lcia Vasconcelos Barros Magalh\u00e3es","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123796","display_name":"Grupo Santa Casa de Belo Horizonte","ror":"https://ror.org/024w2fr05","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210123796"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T\u00e9lcia Vasconcelos Barros Magalh\u00e3es","raw_affiliation_strings":["Hospital Santa Casa BH, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Santa Casa BH, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210123796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056537348","display_name":"Adriana Mafra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161537","display_name":"Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais","ror":"https://ror.org/056r88m65","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210161537"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Mafra","raw_affiliation_strings":["Hospital Metropolitano Odilon Behrens Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais Belo Horizonte Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Metropolitano Odilon Behrens Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais Belo Horizonte Brazil","institution_ids":["https://openalex.org/I4210161537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022293117","display_name":"L\u00edlian Martins Oliveira Diniz","orcid":"https://orcid.org/0000-0001-7802-4377","observed_orcids":["https://orcid.org/0000-0001-7802-4377"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lilian Martins Oliveira Diniz","raw_affiliation_strings":["Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001043884","display_name":"\u00daltimo Lib\u00e2nio da Costa","orcid":"https://orcid.org/0000-0003-3666-5314","observed_orcids":["https://orcid.org/0000-0003-3666-5314"]},"institutions":[{"id":"https://openalex.org/I4210161650","display_name":"Secretaria Municipal de Sa\u00fade","ror":"https://ror.org/05355vt65","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210161650"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00daltimo Lib\u00e2nio da Costa","raw_affiliation_strings":["Secretaria Municipal de Sa\u00fade Belo Horizonte Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Secretaria Municipal de Sa\u00fade Belo Horizonte Brazil","institution_ids":["https://openalex.org/I4210161650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017399345","display_name":"Kenneth J. Gollob","orcid":"https://orcid.org/0000-0003-4184-3867","observed_orcids":["https://orcid.org/0000-0003-4184-3867"]},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kenneth J. Gollob","raw_affiliation_strings":["International Research Center A. C. Camargo C\u00e2ncer Center S\u00e3o Paulo Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Research Center A. C. Camargo C\u00e2ncer Center S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I3019035496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054733762","display_name":"Lis Ribeiro do Valle Antonelli","orcid":"https://orcid.org/0000-0002-4969-8812","observed_orcids":["https://orcid.org/0000-0002-4969-8812"]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lis Ribeiro do Valle Antonelli","raw_affiliation_strings":["Instituto Rene Rachou Funda\u00e7\u00e3o Oswaldo Cruz Belo Horizonte Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Rene Rachou Funda\u00e7\u00e3o Oswaldo Cruz Belo Horizonte Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072210483","display_name":"Helton C. Santiago","orcid":"https://orcid.org/0000-0002-5695-8256","observed_orcids":["https://orcid.org/0000-0002-5695-8256"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"Helton da Costa Santiago","raw_affiliation_strings":["Center for Immunization Research, Johns Hopkins University, Baltimore, MD, USA","Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5695-8256","affiliations":[{"raw_affiliation_string":"Center for Immunization Research, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5072210483"],"corresponding_institution_ids":["https://openalex.org/I110200422","https://openalex.org/I145311948"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":4.1184,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94722434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"160","issue":"1","first_page":"90","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue","display_name":"dengue","score":0.8830000162124634},{"id":"https://openalex.org/keywords/polyfunctional-t-cells","display_name":"polyfunctional T cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/severe-dengue","display_name":"severe dengue","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dengue-with-warning-signs","display_name":"dengue with warning signs","score":0.8970000147819519},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.597000002861023},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.8396194577217102},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.7456596493721008},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6029144525527954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5806804299354553},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.5137151479721069},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4925904870033264},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4796714782714844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4290947914123535},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4213007092475891}],"mesh":[{"descriptor_ui":"D000085242","descriptor_name":"Viral Proteases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003715","descriptor_name":"Dengue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020365","descriptor_name":"RNA Helicases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D043583","descriptor_name":"Nucleoside-Triphosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/imm.13185","doi":"https://doi.org/10.1111/imm.13185","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imm.13185","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imm.13185","source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7160666","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7160666","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:32128816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32128816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:arca.fiocruz.br:icict/41008","doi":null,"is_oa":false,"landing_page_url":"https://arca.fiocruz.br/handle/icict/41008","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1111/imm.13185","doi":"https://doi.org/10.1111/imm.13185","is_oa":true,"landing_page_url":"https://doi.org/10.1111/imm.13185","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/imm.13185","source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G307732494","display_name":null,"funder_award_id":"404138/2012\u20108","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G669186507","display_name":"ESTUDO DE BIOMARCADORES DE RESIST\u00caNCIA E SUSCEPTIBILIDADE A DIFERENTES FORMAS CL\u00cdNICAS DE INFEC\u00c7\u00d5ES POR DENGUE E ZIKA","funder_award_id":"APQ-03452-13","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"}],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"},{"id":"https://openalex.org/F4320323917","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08"},{"id":"https://openalex.org/F4320324369","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3009106416.pdf","grobid_xml":"https://content.openalex.org/works/W3009106416.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1497030000","https://openalex.org/W1518659327","https://openalex.org/W1599438649","https://openalex.org/W1850437202","https://openalex.org/W1942194807","https://openalex.org/W1966646357","https://openalex.org/W1972509912","https://openalex.org/W1973587186","https://openalex.org/W1974781378","https://openalex.org/W1991668266","https://openalex.org/W1995606259","https://openalex.org/W2037345926","https://openalex.org/W2046808741","https://openalex.org/W2049946738","https://openalex.org/W2051335877","https://openalex.org/W2053490656","https://openalex.org/W2062347251","https://openalex.org/W2066738380","https://openalex.org/W2071288084","https://openalex.org/W2080395015","https://openalex.org/W2081020320","https://openalex.org/W2087668602","https://openalex.org/W2094527424","https://openalex.org/W2095377201","https://openalex.org/W2100359781","https://openalex.org/W2104344689","https://openalex.org/W2115005895","https://openalex.org/W2115832440","https://openalex.org/W2121585949","https://openalex.org/W2125924084","https://openalex.org/W2136097155","https://openalex.org/W2137488647","https://openalex.org/W2139197205","https://openalex.org/W2140608155","https://openalex.org/W2141783094","https://openalex.org/W2143483107","https://openalex.org/W2146980643","https://openalex.org/W2147632178","https://openalex.org/W2149918862","https://openalex.org/W2151742317","https://openalex.org/W2160908140","https://openalex.org/W2161268300","https://openalex.org/W2161986026","https://openalex.org/W2162218978","https://openalex.org/W2162790097","https://openalex.org/W2167778863","https://openalex.org/W2169893334","https://openalex.org/W2199803373","https://openalex.org/W2285684471","https://openalex.org/W2313004328","https://openalex.org/W2346674882","https://openalex.org/W2509430738","https://openalex.org/W2531376405","https://openalex.org/W2560755407","https://openalex.org/W2586907961","https://openalex.org/W2589232255","https://openalex.org/W2622444804","https://openalex.org/W2740763668","https://openalex.org/W2761617108","https://openalex.org/W2779483906","https://openalex.org/W2794617008","https://openalex.org/W2795023978","https://openalex.org/W2895261413","https://openalex.org/W2997201024"],"related_works":["https://openalex.org/W7160547236","https://openalex.org/W4313381113","https://openalex.org/W2997201024","https://openalex.org/W6992634317","https://openalex.org/W2979015788","https://openalex.org/W2261015717","https://openalex.org/W3165866992","https://openalex.org/W2604153505","https://openalex.org/W4213244031","https://openalex.org/W1980302281"],"abstract_inverted_index":{"Summary":[0],"Multifunctional":[1],"interleukin":[2],"10":[3],"(IL10)+Th1":[4],"cells":[5,55,230,240],"have":[6],"been":[7],"implicated":[8],"in":[9,79,146,172,244],"favorable":[10],"evolution":[11,246],"of":[12,29,82,89,100,138,165,185,220,225,247],"many":[13],"infectious":[14],"diseases,":[15],"promoting":[16],"an":[17],"efficacious":[18],"immune":[19],"response":[20],"while":[21],"limiting":[22],"immunopathology.":[23],"Here,":[24],"we":[25],"investigated":[26],"the":[27,80,173],"presence":[28,81,224],"multifunctional":[30,139,180,199,229],"CD4+":[31,106,144,200],"and":[32,41,64,74,95,103,107,132,149,151,167,201,207,227],"CD8+":[33,108,153,160,202],"T\u2010cells":[34,109,140,145,154,161,181,203],"that":[35,118,179,238],"expressed":[36],"interferon":[37],"gamma":[38],"(IFN\u03b3),":[39],"IL10":[40,102,208],"tumor":[42],"necrosis":[43],"factor":[44],"(TNF),":[45],"or":[46,85],"its":[47],"combinations":[48],"during":[49,91],"dengue":[50,60,62,70,128,175,235,248],"infection.":[51,249],"Peripheral":[52],"blood":[53],"mononuclear":[54],"(PBMCs)":[56],"from":[57],"outpatients":[58],"with":[59,69,71,120,125,127,129,194,213,233],"(mild":[61],"forms)":[63],"hospitalized":[65],"patients":[66,68,119,126],"(or":[67],"warning":[72,130],"signs":[73,131],"severe":[75,133],"dengue)":[76],"were":[77,169],"cultured":[78],"envelope":[83],"(ENV)":[84],"NS3":[86],"peptide":[87],"libraries":[88],"DENV":[90],"critical":[92,147],"(hospitalization":[93],"period)":[94],"convalescence":[96],"phases.":[97],"The":[98,223],"production":[99],"IFN\u03b3,":[101,205],"TNF":[104,206],"by":[105,112,189],"was":[110,231],"assessed":[111],"flow":[113],"cytometry.":[114],"Our":[115],"data":[116],"show":[117],"mild":[121,174,234],"dengue,":[122,134],"when":[123,192],"compared":[124,193],"presented":[135],"higher":[136,183],"frequencies":[137],"like":[141],"NS3\u2010specific":[142,159],"IFN\u03b3/IL10\u2010producing":[143],"phase":[148],"NS3\u2010":[150],"ENV\u2010specific":[152],"producing":[155,162,204],"IFN\u03b3/IL10.":[156],"In":[157],"addition,":[158],"high":[163],"levels":[164,184],"IFN\u03b3/TNF":[166],"IFN\u03b3/TNF/IL10":[168],"also":[170],"observed":[171,178],"group.":[176],"We":[177],"produced":[182],"cytokines":[186],"as":[187],"measured":[188],"intracellular":[190],"content":[191],"single":[195],"producer":[196],"T\u2010cells.":[197],"Importantly,":[198],"simultaneously":[209],"displayed":[210],"positive":[211],"correlation":[212],"platelet":[214],"levels,":[215],"suggesting":[216,237],"a":[217,242],"protective":[218],"role":[219,243],"this":[221],"population.":[222],"IL10+Th1":[226],"IL10+Tc1":[228],"associated":[232],"presentation,":[236],"these":[239],"play":[241],"clinical":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-13T00:00:00"}