{"id":"https://openalex.org/W3008965124","doi":"https://doi.org/10.1016/j.jaci.2019.12.631","title":"Hereditary angioedema (HAE) prophylaxis with plasma kallikrein inhibitors: Role of target binding kinetics, pharmacokinetics and treatment adherence","display_name":"Hereditary angioedema (HAE) prophylaxis with plasma kallikrein inhibitors: Role of target binding kinetics, pharmacokinetics and treatment adherence","publication_year":2020,"publication_date":"2020-02-01","ids":{"openalex":"https://openalex.org/W3008965124","doi":"https://doi.org/10.1016/j.jaci.2019.12.631","mag":"3008965124"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2019.12.631","doi":"https://doi.org/10.1016/j.jaci.2019.12.631","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2019.12.631","pdf_url":"http://www.jacionline.org/article/S0091674919323334/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jacionline.org/article/S0091674919323334/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103824380","display_name":"Rangaraj Narayanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rangaraj Narayanan","raw_affiliation_strings":["Shire (a Takeda company)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire (a Takeda company)","institution_ids":["https://openalex.org/I4210140176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076437039","display_name":"Haobin Luo","orcid":"https://orcid.org/0000-0002-6497-0159","observed_orcids":["https://orcid.org/0000-0002-6497-0159"]},"institutions":[{"id":"https://openalex.org/I4210090535","display_name":"Renewable Energy Systems (United Kingdom)","ror":"https://ror.org/00gsbmb44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210090535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haobin Luo","raw_affiliation_strings":["RES Group Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RES Group Inc","institution_ids":["https://openalex.org/I4210090535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347603","display_name":"Zhiwei Zhang","orcid":"https://orcid.org/0000-0002-6131-3233","observed_orcids":["https://orcid.org/0000-0002-6131-3233"]},"institutions":[{"id":"https://openalex.org/I4210090535","display_name":"Renewable Energy Systems (United Kingdom)","ror":"https://ror.org/00gsbmb44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210090535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zhiwei Zhang","raw_affiliation_strings":["RES Group Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RES Group Inc","institution_ids":["https://openalex.org/I4210090535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059392154","display_name":"Paul Jasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090535","display_name":"Renewable Energy Systems (United Kingdom)","ror":"https://ror.org/00gsbmb44","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210090535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Jasper","raw_affiliation_strings":["RES Group Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RES Group Inc","institution_ids":["https://openalex.org/I4210090535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016222613","display_name":"Peng L\u00fc","orcid":"https://orcid.org/0009-0005-8401-4067","observed_orcids":["https://orcid.org/0009-0005-8401-4067"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Lu","raw_affiliation_strings":["Shire, a Takeda company, Cambridge, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire, a Takeda company, Cambridge, PA","institution_ids":["https://openalex.org/I4210140176"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089364449","display_name":"Salom\u00e9 Juethner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salome Juethner","raw_affiliation_strings":["Shire (a Takeda company)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire (a Takeda company)","institution_ids":["https://openalex.org/I4210140176"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103012653","display_name":"Dan Sexton","orcid":"https://orcid.org/0000-0001-8224-1753","observed_orcids":["https://orcid.org/0000-0001-8224-1753"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Sexton","raw_affiliation_strings":["Shire (a Takeda company)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire (a Takeda company)","institution_ids":["https://openalex.org/I4210140176"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"145","issue":"2","first_page":"AB105","last_page":"AB105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":1.0},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/plasma-kallikrein-inhibitor","display_name":"plasma kallikrein inhibitor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lanadelumab","display_name":"lanadelumab","score":0.9769999980926514},{"id":"https://openalex.org/keywords/contact-system","display_name":"contact system","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8820000290870667},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.9409999847412109},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.9679999947547913},{"id":"https://openalex.org/keywords/missed-doses","display_name":"missed doses","score":0.8379999995231628},{"id":"https://openalex.org/keywords/quantitative-systems-pharmacology","display_name":"quantitative systems pharmacology","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.9103230834007263},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.685967743396759},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6217707991600037},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6089751720428467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5989219546318054},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5742748975753784},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5145856738090515},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.4308452904224396},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42163020372390747},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3078197240829468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21688300371170044},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11212044954299927},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07904136180877686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07713523507118225},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2019.12.631","doi":"https://doi.org/10.1016/j.jaci.2019.12.631","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2019.12.631","pdf_url":"http://www.jacionline.org/article/S0091674919323334/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2019.12.631","doi":"https://doi.org/10.1016/j.jaci.2019.12.631","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2019.12.631","pdf_url":"http://www.jacionline.org/article/S0091674919323334/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3008965124.pdf","grobid_xml":"https://content.openalex.org/works/W3008965124.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396835356","https://openalex.org/W4308904602","https://openalex.org/W3007451997","https://openalex.org/W2911730861","https://openalex.org/W4247169018","https://openalex.org/W3024136063","https://openalex.org/W2963411376","https://openalex.org/W4210391005","https://openalex.org/W4410248555","https://openalex.org/W4214560256"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-06T00:00:00"}
