{"id":"https://openalex.org/W3008317004","doi":"https://doi.org/10.3390/ijms21041509","title":"GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease\u2013A Systematic Review","display_name":"GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease\u2013A Systematic Review","publication_year":2020,"publication_date":"2020-02-22","ids":{"openalex":"https://openalex.org/W3008317004","doi":"https://doi.org/10.3390/ijms21041509","mag":"3008317004","pmid":"https://pubmed.ncbi.nlm.nih.gov/32098413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7073149"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21041509","doi":"https://doi.org/10.3390/ijms21041509","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21041509","pdf_url":"https://www.mdpi.com/1422-0067/21/4/1509/pdf?version=1582803680","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/4/1509/pdf?version=1582803680","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069254447","display_name":"Yusaku Mori","orcid":"https://orcid.org/0000-0002-1734-0605","observed_orcids":["https://orcid.org/0000-0002-1734-0605"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yusaku Mori","raw_affiliation_strings":["Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, 142-8555 Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1734-0605","affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, 142-8555 Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106073103","display_name":"Takanori Matsui","orcid":"https://orcid.org/0000-0001-9506-7571","observed_orcids":["https://orcid.org/0000-0001-9506-7571"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Matsui","raw_affiliation_strings":["Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, 830-0011 Fukuoka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9506-7571","affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, 830-0011 Fukuoka, Japan","institution_ids":["https://openalex.org/I105296287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073711245","display_name":"Tsutomu Hirano","orcid":"https://orcid.org/0000-0003-1859-0005","observed_orcids":["https://orcid.org/0000-0003-1859-0005"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]},{"id":"https://openalex.org/I4210146782","display_name":"Ebina General Hospital","ror":"https://ror.org/04j3mpm77","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210146782"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsutomu Hirano","raw_affiliation_strings":["Diabetes Center, Ebina General Hospital, Ebina, 243-0433 Kanagawa, Japan","Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, 142-8555 Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1859-0005","affiliations":[{"raw_affiliation_string":"Diabetes Center, Ebina General Hospital, Ebina, 243-0433 Kanagawa, Japan","institution_ids":["https://openalex.org/I4210146782"]},{"raw_affiliation_string":"Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, 142-8555 Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030113532","display_name":"Sho\u2010ichi Yamagishi","orcid":"https://orcid.org/0000-0003-0102-0823","observed_orcids":["https://orcid.org/0000-0003-0102-0823"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho-ichi Yamagishi","raw_affiliation_strings":["Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, 142-8555 Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0102-0823","affiliations":[{"raw_affiliation_string":"Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine, Shinagawa, 142-8555 Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069254447"],"corresponding_institution_ids":["https://openalex.org/I119182057"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":0.9807,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.7332543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"1509","last_page":"1509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-dependent-insulinotropic-polypeptide","display_name":"glucose-dependent insulinotropic polypeptide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gip-receptor-agonist","display_name":"GIP receptor agonist","score":0.9639999866485596},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.9399999976158142},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9210000038146973},{"id":"https://openalex.org/keywords/incretin-based-therapy","display_name":"incretin-based therapy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/anti-obesity-effect","display_name":"anti-obesity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.640999972820282},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.9460023641586304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7339625358581543},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6670674085617065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5793320536613464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5583954453468323},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.545444130897522},{"id":"https://openalex.org/C2780533449","wikidata":"https://www.wikidata.org/wiki/Q417762","display_name":"Exenatide","level":4,"score":0.5332548022270203},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.49070966243743896},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.4798573851585388},{"id":"https://openalex.org/C2776129832","wikidata":"https://www.wikidata.org/wiki/Q22677256","display_name":"Gastric inhibitory polypeptide","level":4,"score":0.45113712549209595},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.41690677404403687},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.4160710275173187},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3746579885482788},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35825812816619873},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.16124114394187927}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D005749","descriptor_name":"Gastric Inhibitory Polypeptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019858","descriptor_name":"Enteroendocrine Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019858","descriptor_name":"Enteroendocrine Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019858","descriptor_name":"Enteroendocrine Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21041509","doi":"https://doi.org/10.3390/ijms21041509","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21041509","pdf_url":"https://www.mdpi.com/1422-0067/21/4/1509/pdf?version=1582803680","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7073149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7073149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:32098413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32098413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8fff012aa0334f8b8bb5a01ce1aeaff6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8fff012aa0334f8b8bb5a01ce1aeaff6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 4, p 1509 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21041509","doi":"https://doi.org/10.3390/ijms21041509","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21041509","pdf_url":"https://www.mdpi.com/1422-0067/21/4/1509/pdf?version=1582803680","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G782783172","display_name":"Vasoprotective effects of nesfatin-1","funder_award_id":"16K21370","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309791","display_name":"Suzuken Memorial Foundation","ror":"https://ror.org/03yvcwz92"},{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"},{"id":"https://openalex.org/F4320317302","display_name":"Boehringer Ingelheim Japan","ror":"https://ror.org/02r1d7x68"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320327566","display_name":"Mitsubishi Tanabe Pharma Corporation","ror":"https://ror.org/038ehsm73"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"},{"id":"https://openalex.org/F4320333376","display_name":"MSD K.K.","ror":"https://ror.org/01kaqxm37"},{"id":"https://openalex.org/F4320333624","display_name":"Eli Lilly Japan","ror":"https://ror.org/01sv7f575"},{"id":"https://openalex.org/F4320333871","display_name":"Bayer Yakuhin","ror":"https://ror.org/05arv2073"},{"id":"https://openalex.org/F4320333876","display_name":"Novo Nordisk Pharma","ror":"https://ror.org/05gzvb546"},{"id":"https://openalex.org/F4320333907","display_name":"Sanofi K.K.","ror":"https://ror.org/040h02z76"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334790","display_name":"Daiichi Sankyo Company","ror":"https://ror.org/027y26122"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3008317004.pdf","grobid_xml":"https://content.openalex.org/works/W3008317004.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W172609984","https://openalex.org/W244067736","https://openalex.org/W1043894300","https://openalex.org/W1526927233","https://openalex.org/W1535671016","https://openalex.org/W1552829599","https://openalex.org/W1582261481","https://openalex.org/W1749239599","https://openalex.org/W1752045965","https://openalex.org/W1921371649","https://openalex.org/W1923719155","https://openalex.org/W1942626993","https://openalex.org/W1966817549","https://openalex.org/W1967256054","https://openalex.org/W1967295307","https://openalex.org/W1967442749","https://openalex.org/W1969932276","https://openalex.org/W1972706930","https://openalex.org/W1976676978","https://openalex.org/W1978076661","https://openalex.org/W1979023228","https://openalex.org/W1982294133","https://openalex.org/W1983641973","https://openalex.org/W1984384276","https://openalex.org/W1986711635","https://openalex.org/W1987012320","https://openalex.org/W1989947557","https://openalex.org/W1990021330","https://openalex.org/W1992535385","https://openalex.org/W1998540497","https://openalex.org/W1999982031","https://openalex.org/W2008082500","https://openalex.org/W2008190845","https://openalex.org/W2011543174","https://openalex.org/W2018294401","https://openalex.org/W2025406583","https://openalex.org/W2025811936","https://openalex.org/W2026544876","https://openalex.org/W2030684076","https://openalex.org/W2047255460","https://openalex.org/W2047798798","https://openalex.org/W2049619797","https://openalex.org/W2049965331","https://openalex.org/W2062265409","https://openalex.org/W2062304895","https://openalex.org/W2064130493","https://openalex.org/W2066219800","https://openalex.org/W2067710447","https://openalex.org/W2068907080","https://openalex.org/W2071090755","https://openalex.org/W2072686461","https://openalex.org/W2075567076","https://openalex.org/W2080103614","https://openalex.org/W2082213840","https://openalex.org/W2082503109","https://openalex.org/W2082873393","https://openalex.org/W2086610472","https://openalex.org/W2089548847","https://openalex.org/W2090313537","https://openalex.org/W2094411506","https://openalex.org/W2096344196","https://openalex.org/W2098486305","https://openalex.org/W2102392334","https://openalex.org/W2103318165","https://openalex.org/W2108992306","https://openalex.org/W2112748428","https://openalex.org/W2115030211","https://openalex.org/W2115398645","https://openalex.org/W2115778460","https://openalex.org/W2116589351","https://openalex.org/W2119198856","https://openalex.org/W2123187967","https://openalex.org/W2126919962","https://openalex.org/W2127488841","https://openalex.org/W2127650366","https://openalex.org/W2128136193","https://openalex.org/W2131592975","https://openalex.org/W2132198562","https://openalex.org/W2132586447","https://openalex.org/W2132774188","https://openalex.org/W2135854640","https://openalex.org/W2136076830","https://openalex.org/W2136968036","https://openalex.org/W2138561622","https://openalex.org/W2142830692","https://openalex.org/W2144027461","https://openalex.org/W2144877857","https://openalex.org/W2157068658","https://openalex.org/W2158666727","https://openalex.org/W2159250215","https://openalex.org/W2159566085","https://openalex.org/W2161231838","https://openalex.org/W2162422341","https://openalex.org/W2171294019","https://openalex.org/W2171732130","https://openalex.org/W2182241779","https://openalex.org/W2274724098","https://openalex.org/W2280540792","https://openalex.org/W2301526740","https://openalex.org/W2305885852","https://openalex.org/W2317991825","https://openalex.org/W2321571427","https://openalex.org/W2411384485","https://openalex.org/W2416842703","https://openalex.org/W2417331731","https://openalex.org/W2425644022","https://openalex.org/W2444268874","https://openalex.org/W2471084456","https://openalex.org/W2503484702","https://openalex.org/W2519510391","https://openalex.org/W2548983381","https://openalex.org/W2577368877","https://openalex.org/W2599557486","https://openalex.org/W2599730432","https://openalex.org/W2623630298","https://openalex.org/W2741958922","https://openalex.org/W2760658785","https://openalex.org/W2766290330","https://openalex.org/W2768190175","https://openalex.org/W2777592053","https://openalex.org/W2785925223","https://openalex.org/W2792805849","https://openalex.org/W2795411596","https://openalex.org/W2800427972","https://openalex.org/W2801740840","https://openalex.org/W2804558913","https://openalex.org/W2805959091","https://openalex.org/W2809069439","https://openalex.org/W2894746763","https://openalex.org/W2895666357","https://openalex.org/W2895924902","https://openalex.org/W2900149048","https://openalex.org/W2900730935","https://openalex.org/W2902410297","https://openalex.org/W2909601957","https://openalex.org/W2917743074","https://openalex.org/W2921476363","https://openalex.org/W2921514534","https://openalex.org/W2923407010","https://openalex.org/W2946180605","https://openalex.org/W2948612418","https://openalex.org/W2969925328","https://openalex.org/W2971096582","https://openalex.org/W2974098728","https://openalex.org/W2981447858","https://openalex.org/W2991494694","https://openalex.org/W2999824588","https://openalex.org/W4206445899"],"related_works":["https://openalex.org/W4417502109","https://openalex.org/W4400760615","https://openalex.org/W4205521731","https://openalex.org/W7203712344","https://openalex.org/W7098426288","https://openalex.org/W2033746319","https://openalex.org/W1968925787","https://openalex.org/W2985692253","https://openalex.org/W2134250131","https://openalex.org/W2029071587"],"abstract_inverted_index":{"Glucose-dependent":[0],"insulinotropic":[1],"polypeptide":[2],"(GIP)":[3],"and":[4,18,76,112,153,200,206,236,244],"glucagon-like":[5],"peptide-1":[6],"(GLP-1)":[7],"are":[8,12,28,79,133,220],"gut":[9],"hormones":[10],"that":[11,195],"secreted":[13],"from":[14,40],"enteroendocrine":[15],"L":[16],"cells":[17,20,43],"K":[19],"in":[21,44,56,156,167,189,222,226,238],"response":[22],"to":[23,31,36,97,147,171,185],"digested":[24],"nutrients,":[25],"respectively.":[26],"They":[27],"also":[29],"referred":[30],"incretin":[32,63],"for":[33,82,110],"their":[34,107],"ability":[35],"stimulate":[37],"insulin":[38],"secretion":[39],"pancreatic":[41],"beta":[42],"a":[45,118],"glucose-dependent":[46],"manner.":[47],"Furthermore,":[48],"GLP-1":[49,72],"exerts":[50],"anorexic":[51],"effects":[52,188,208,233],"via":[53],"its":[54],"actions":[55],"the":[57,83,125,149,163,231],"central":[58],"nervous":[59],"system.":[60],"Since":[61],"native":[62],"is":[64],"rapidly":[65],"inactivated":[66],"by":[67,136],"dipeptidyl":[68],"peptidase-4":[69],"(DPP-4),":[70],"DPP-resistant":[71],"receptor":[73,179],"agonists":[74,180,219],"(GLP-1RAs),":[75],"DPP-4":[77],"inhibitors":[78],"currently":[80],"used":[81],"treatment":[84],"of":[85,106,120,128,151,165,177,198,234],"type":[86,159],"2":[87,160],"diabetes":[88],"as":[89,103],"incretin-based":[90,129],"therapy.":[91],"These":[92,192],"new-class":[93],"agents":[94,101],"have":[95,123,182],"superiority":[96],"classical":[98],"oral":[99],"hypoglycemic":[100],"such":[102],"sulfonylureas":[104],"because":[105],"low":[108],"risks":[109],"hypoglycemia":[111],"body":[113],"weight":[114],"gain.":[115],"In":[116],"addition,":[117],"number":[119],"preclinical":[121],"studies":[122],"shown":[124,146],"cardioprotective":[126],"properties":[127],"therapy,":[130],"whose":[131],"findings":[132],"further":[134],"supported":[135],"several":[137],"randomized":[138],"clinical":[139],"trials.":[140],"Indeed,":[141],"GLP-1RA":[142],"has":[143],"been":[144,183],"significantly":[145],"reduce":[148],"risk":[150],"cardiovascular":[152,168,232],"renal":[154],"events":[155],"patients":[157],"with":[158,210,216],"diabetes.":[161],"However,":[162],"role":[164],"GIP":[166,178,235],"disease":[169],"remains":[170],"be":[172],"elucidated.":[173],"Recently,":[174],"pharmacological":[175],"doses":[176],"(GIPRAs)":[181],"found":[184],"exert":[186],"anti-obesity":[187],"animal":[190,242],"models.":[191],"observations":[193],"suggest":[194],"combination":[196],"therapy":[197],"GLP-1R":[199],"GIPR":[201],"may":[202],"induce":[203],"superior":[204],"metabolic":[205],"anti-diabetic":[207],"compared":[209],"each":[211],"agonist":[212],"individually.":[213],"Clinical":[214],"trials":[215],"GLP-1R/GIPR":[217],"dual":[218],"ongoing":[221],"diabetic":[223],"patients.":[224],"Therefore,":[225],"this":[227],"review,":[228],"we":[229],"summarize":[230],"GIPRAs":[237],"cell":[239],"culture":[240],"systems,":[241],"models,":[243],"humans.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-06T00:00:00"}