{"id":"https://openalex.org/W3008089983","doi":null,"title":"Arginine metabolism and creatine biosynthesis in Yucatan miniature piglets","display_name":"Arginine metabolism and creatine biosynthesis in Yucatan miniature piglets","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3008089983","mag":"3008089983"},"language":"en","primary_location":{"id":"pmh:oai:research.library.mun.ca:13752","doi":null,"is_oa":true,"landing_page_url":"https://research.library.mun.ca/13752/1/thesis.pdf","pdf_url":"https://research.library.mun.ca/13752/1/thesis.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.library.mun.ca/13752/1/thesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031187853","display_name":"O. Chandani Dinesh","orcid":"https://orcid.org/0000-0002-8765-4407","observed_orcids":["https://orcid.org/0000-0002-8765-4407"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"O. Chandani Dinesh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8765-4407","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031187853"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.06440000236034393,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-biosynthesis","display_name":"creatine synthesis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/arginine-metabolism","display_name":"arginine metabolism","score":0.984000027179718},{"id":"https://openalex.org/keywords/guanidinoacetic-acid","display_name":"guanidinoacetic acid","score":0.8970000147819519},{"id":"https://openalex.org/keywords/l-arginine-glycine-amidinotransferase","display_name":"L-arginine:glycine amidinotransferase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.6669999957084656},{"id":"https://openalex.org/keywords/total-parenteral-nutrition","display_name":"total parenteral nutrition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neonatal-piglets","display_name":"newborn piglets","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dietary-arginine","display_name":"dietary arginine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dietary-methionine","display_name":"dietary methionine","score":0.953000009059906},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.984000027179718},{"id":"https://openalex.org/keywords/isotopic-tracers","display_name":"isotope tracers","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.9819152355194092},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.7621114253997803},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5723299384117126},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5137951970100403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5106750130653381},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45381468534469604},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4117836058139801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4019814729690552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38980239629745483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37627121806144714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3638799786567688}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.library.mun.ca:13752","doi":null,"is_oa":true,"landing_page_url":"https://research.library.mun.ca/13752/1/thesis.pdf","pdf_url":"https://research.library.mun.ca/13752/1/thesis.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/7481","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14783/7481","pdf_url":"https://memorial.scholaris.ca/bitstreams/14d0f164-d9a9-4c8a-9bdd-fe69f6a4482c/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"},{"id":"mag:3008089983","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/13752/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.library.mun.ca:13752","doi":null,"is_oa":true,"landing_page_url":"https://research.library.mun.ca/13752/1/thesis.pdf","pdf_url":"https://research.library.mun.ca/13752/1/thesis.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.5666999816894531,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329650","display_name":"Evonik Industries","ror":null},{"id":"https://openalex.org/F4320331236","display_name":"Janeway Children's Hospital Foundation","ror":"https://ror.org/05j96kg65"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3008089983.pdf","grobid_xml":"https://content.openalex.org/works/W3008089983.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1967647423","https://openalex.org/W1973932773","https://openalex.org/W1998028654","https://openalex.org/W2043030073","https://openalex.org/W2073024608","https://openalex.org/W2168526937"],"related_works":["https://openalex.org/W2905860919","https://openalex.org/W2891762431","https://openalex.org/W3120876784","https://openalex.org/W7163410051","https://openalex.org/W2514908337","https://openalex.org/W2748995254","https://openalex.org/W1980584108","https://openalex.org/W2115214449","https://openalex.org/W2286753248","https://openalex.org/W2807940007"],"abstract_inverted_index":{"Creatine":[0,16,50],"and":[1,74,137,183,241,248,260,273,280,295,308,334],"creatine":[2,33,44,71,95,108,142,155,161,175,179,197,212,249,274,281,340],"phosphate":[3],"are":[4,9,336],"amino":[5,125,270],"acid-derived":[6],"compounds":[7],"that":[8,22,171,186,237,329],"necessary":[10],"to":[11,39,57,70,153,177,194,207,221,314],"meet":[12],"short-term":[13],"energy":[14],"requirements.":[15],"is":[17,24,85,96,131],"a":[18,89,98,230,317],"potent":[19],"neuromodulator":[20],"such":[21,347],"it":[23],"critical":[25],"for":[26,123,300,319],"neurological":[27],"development":[28],"in":[29,34,133,181,214,258,305],"neonates.":[30,362],"Neonates":[31],"receive":[32],"mother's":[35],"milk.":[36],"However,":[37,94,304],"up":[38],"77%":[40],"of":[41,55,68,91,100,149,203,268,278,324,332,339,344,361],"the":[42,53,106,124,147,150,210,265,276,289,306,322,342],"daily":[43],"requirement":[45,109],"must":[46,110,119,352],"be":[47,111,192,353],"synthesized":[48],"endogenously.":[49],"synthesis":[51,116],"involves":[52],"conversion":[54,67],"arginine":[56,129,240,294,313,333],"guanidinoacetic":[58],"acid":[59,126],"(GAA)":[60],"via":[61],"L-arginine:glycine":[62],"amidinotransferase":[63],"(AGAT).":[64],"The":[65,165,199],"subsequent":[66],"GAA":[69,247,279,302],"requires":[72],"methionine":[73,335],"guanidinoacetate":[75],"N-methyltransferase":[76],"(GAMT).":[77],"Following":[78],"preterm":[79],"birth,":[80],"total":[81],"parenteral":[82],"nutrition":[83],"(PN)":[84],"often":[86],"required":[87],"as":[88,285,287,316,348],"means":[90],"nutritional":[92],"support.":[93],"not":[97,163,191,243],"component":[99],"pediatric":[101],"PN.":[102],"In":[103,144],"this":[104,138,145,204,325],"situation,":[105],"entire":[107],"met":[112],"by":[113],"de":[114],"novo":[115],"which":[117],"consequently":[118],"create":[120],"considerable":[121],"demand":[122],"precursors.":[127],"Poor":[128],"status":[130],"common":[132],"neonates":[134,187],"during":[135,349],"PN,":[136],"may":[139,190],"compromise":[140],"optimal":[141,196],"accretion.":[143,198],"thesis,":[146],"capacity":[148,224],"neonatal":[151],"piglet":[152],"synthesize":[154],"was":[156,162,206,219],"addressed,":[157],"particularly":[158],"when":[159,357],"dietary":[160,239,330,345,359],"supplied.":[164],"data":[166],"from":[167,282,288],"first":[168],"experiment":[169],"demonstrated":[170],"PN":[172,189,350],"support":[173],"with":[174],"led":[176],"greater":[178],"concentrations":[180,267,331],"plasma":[182,266],"tissues,":[184],"suggesting":[185],"receiving":[188],"able":[193],"sustain":[195],"second":[200],"major":[201],"objective":[202],"thesis":[205,326],"investigate":[208],"whether":[209],"low":[211],"accretion":[213],"piglets":[215],"fed":[216],"creatine-free":[217],"diets":[218],"due":[220],"limited":[222,226],"enzyme":[223,244],"or":[225],"substrate":[227],"availability.":[228],"Using":[229],"multiple":[231],"isotope":[232],"tracer":[233],"method,":[234],"we":[235,253,262],"determined":[236,292],"inadequate":[238],"methionine,":[242],"capacity,":[245],"limits":[246],"biosynthesis.":[250],"Lastly,":[251],"because":[252],"measured":[254],"high":[255],"AGAT":[256],"activity":[257],"kidney":[259],"pancreas,":[261],"investigated":[263],"how":[264],"precursor":[269,318],"acids":[271],"(arginine/citrulline)":[272],"affected":[275],"release":[277],"these":[283],"organs":[284],"well":[286],"intestine.":[290],"We":[291],"both":[293],"citrulline":[296,310],"can":[297],"provide":[298,312],"precursors":[299],"renal":[301],"synthesis.":[303],"pancreas":[307],"intestine,":[309],"cannot":[311],"serve":[315],"GAA.":[320],"Overall,":[321],"results":[323],"clearly":[327],"demonstrate":[328],"important":[337],"mediators":[338],"synthesis;":[341],"absence":[343],"creatine,":[346],"feeding,":[351],"taken":[354],"into":[355],"consideration":[356],"determining":[358],"requirements":[360]},"counts_by_year":[],"updated_date":"2026-09-12T09:15:50.089291","created_date":"2020-03-06T00:00:00"}