{"id":"https://openalex.org/W3007926432","doi":"https://doi.org/10.1021/acs.joc.9b03416","title":"Reworking Organic Synthesis for the Modern Age: Synthetic Strategies Based on Continuous-Flow Addition and Condensation Reactions with Heterogeneous Catalysts","display_name":"Reworking Organic Synthesis for the Modern Age: Synthetic Strategies Based on Continuous-Flow Addition and Condensation Reactions with Heterogeneous Catalysts","publication_year":2020,"publication_date":"2020-02-18","ids":{"openalex":"https://openalex.org/W3007926432","doi":"https://doi.org/10.1021/acs.joc.9b03416","mag":"3007926432","pmid":"https://pubmed.ncbi.nlm.nih.gov/32069417"},"language":"en","primary_location":{"id":"doi:10.1021/acs.joc.9b03416","doi":"https://doi.org/10.1021/acs.joc.9b03416","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.joc.9b03416","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001948322","display_name":"Woo\u2010Jin Yoo","orcid":"https://orcid.org/0000-0002-1207-9399","observed_orcids":["https://orcid.org/0000-0002-1207-9399"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Woo-Jin Yoo","raw_affiliation_strings":["Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110469472","display_name":"Haruro Ishitani","orcid":"https://orcid.org/0009-0004-7155-0947","observed_orcids":["https://orcid.org/0009-0004-7155-0947"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruro Ishitani","raw_affiliation_strings":["Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042731264","display_name":"Yuki Saito","orcid":"https://orcid.org/0000-0002-4825-7783","observed_orcids":["https://orcid.org/0000-0002-4825-7783"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Saito","raw_affiliation_strings":["Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071159479","display_name":"Benjamin Laroche","orcid":"https://orcid.org/0000-0002-7397-3343","observed_orcids":["https://orcid.org/0000-0002-7397-3343"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Benjamin Laroche","raw_affiliation_strings":["Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049553063","display_name":"Sh\u016b Kobayashi","orcid":"https://orcid.org/0000-0002-8235-4368","observed_orcids":["https://orcid.org/0000-0002-8235-4368"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shu\u0305 Kobayashi","raw_affiliation_strings":["Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan","Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8235-4368","affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049553063"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":4.5554,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.96315537,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"85","issue":"8","first_page":"5132","last_page":"5145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flow-chemistry","display_name":"flow chemistry","score":0.9470000267028809},{"id":"https://openalex.org/keywords/heterogeneous-catalysis","display_name":"heterogeneous catalysis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/atom-economy","display_name":"atom economy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/addition-reactions","display_name":"addition reactions","score":0.9490000009536743},{"id":"https://openalex.org/keywords/condensation-reactions","display_name":"condensation reactions","score":1.0},{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.7300000190734863},{"id":"https://openalex.org/keywords/natural-product-synthesis","display_name":"natural product synthesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/catalyst-poisoning","display_name":"catalyst poisoning","score":0.5320000052452087},{"id":"https://openalex.org/keywords/byproduct-formation","display_name":"by-product formation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/column-clogging","display_name":"column clogging","score":0.640999972820282},{"id":"https://openalex.org/keywords/green-chemistry","display_name":"green chemistry","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C535685238","wikidata":"https://www.wikidata.org/wiki/Q1153832","display_name":"Organic synthesis","level":3,"score":0.5985280871391296},{"id":"https://openalex.org/C2985264121","wikidata":"https://www.wikidata.org/wiki/Q216320","display_name":"Continuous flow","level":2,"score":0.5875000953674316},{"id":"https://openalex.org/C132482357","wikidata":"https://www.wikidata.org/wiki/Q5462089","display_name":"Flow chemistry","level":3,"score":0.5663122534751892},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.519730806350708},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.5080611705780029},{"id":"https://openalex.org/C139872579","wikidata":"https://www.wikidata.org/wiki/Q903758","display_name":"Atom economy","level":3,"score":0.4634957015514374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45348355174064636},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4243859052658081},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.38978105783462524},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.37844160199165344},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3629290759563446},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2915008068084717},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2636290192604065},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2455163300037384},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07764774560928345},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.joc.9b03416","doi":"https://doi.org/10.1021/acs.joc.9b03416","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.joc.9b03416","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"pmid:32069417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32069417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of organic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W1523818626","https://openalex.org/W1540112508","https://openalex.org/W1748815478","https://openalex.org/W1779547969","https://openalex.org/W1835416322","https://openalex.org/W1852482303","https://openalex.org/W1865411423","https://openalex.org/W1937018166","https://openalex.org/W1942298470","https://openalex.org/W1952053475","https://openalex.org/W1954905398","https://openalex.org/W1967973073","https://openalex.org/W1974311061","https://openalex.org/W1976881666","https://openalex.org/W1979094582","https://openalex.org/W1985140287","https://openalex.org/W1989502014","https://openalex.org/W1991060795","https://openalex.org/W2001249953","https://openalex.org/W2005858315","https://openalex.org/W2009515989","https://openalex.org/W2012757735","https://openalex.org/W2024652664","https://openalex.org/W2025551065","https://openalex.org/W2026519604","https://openalex.org/W2028040372","https://openalex.org/W2035451228","https://openalex.org/W2036832988","https://openalex.org/W2037745055","https://openalex.org/W2041239020","https://openalex.org/W2042868401","https://openalex.org/W2046505262","https://openalex.org/W2047856561","https://openalex.org/W2049436659","https://openalex.org/W2050370389","https://openalex.org/W2051542700","https://openalex.org/W2052186324","https://openalex.org/W2053617085","https://openalex.org/W2054060682","https://openalex.org/W2060516595","https://openalex.org/W2062199824","https://openalex.org/W2062467969","https://openalex.org/W2069016748","https://openalex.org/W2070853854","https://openalex.org/W2081150689","https://openalex.org/W2082788361","https://openalex.org/W2083415062","https://openalex.org/W2084672441","https://openalex.org/W2085836399","https://openalex.org/W2085967937","https://openalex.org/W2089984193","https://openalex.org/W2091838088","https://openalex.org/W2094886308","https://openalex.org/W2095867727","https://openalex.org/W2098657151","https://openalex.org/W2099520977","https://openalex.org/W2101457406","https://openalex.org/W2106056177","https://openalex.org/W2108504105","https://openalex.org/W2108986259","https://openalex.org/W2110125894","https://openalex.org/W2115932239","https://openalex.org/W2117724954","https://openalex.org/W2121360682","https://openalex.org/W2123126411","https://openalex.org/W2123945278","https://openalex.org/W2139209781","https://openalex.org/W2145550978","https://openalex.org/W2148221234","https://openalex.org/W2148413758","https://openalex.org/W2149135858","https://openalex.org/W2158783483","https://openalex.org/W2159311337","https://openalex.org/W2159491858","https://openalex.org/W2161985777","https://openalex.org/W2162105003","https://openalex.org/W2163213688","https://openalex.org/W2165348656","https://openalex.org/W2267694889","https://openalex.org/W2290751673","https://openalex.org/W2291845424","https://openalex.org/W2309033470","https://openalex.org/W2310127065","https://openalex.org/W2313725137","https://openalex.org/W2322841093","https://openalex.org/W2323962122","https://openalex.org/W2328311188","https://openalex.org/W2329323209","https://openalex.org/W2331825725","https://openalex.org/W2334219370","https://openalex.org/W2410196108","https://openalex.org/W2471120898","https://openalex.org/W2507205646","https://openalex.org/W2514072766","https://openalex.org/W2530554277","https://openalex.org/W2560998373","https://openalex.org/W2574290081","https://openalex.org/W2581729611","https://openalex.org/W2585237876","https://openalex.org/W2621108245","https://openalex.org/W2717963049","https://openalex.org/W2732192647","https://openalex.org/W2737442629","https://openalex.org/W2746884522","https://openalex.org/W2753023124","https://openalex.org/W2756217145","https://openalex.org/W2768269700","https://openalex.org/W2793801613","https://openalex.org/W2794431416","https://openalex.org/W2803294788","https://openalex.org/W2887810974","https://openalex.org/W2889122759","https://openalex.org/W2898956742"],"related_works":["https://openalex.org/W2793801613","https://openalex.org/W4387260975","https://openalex.org/W7223048175","https://openalex.org/W7093310325","https://openalex.org/W2987771359","https://openalex.org/W3091771767","https://openalex.org/W2574290081","https://openalex.org/W2291845424","https://openalex.org/W2241973846","https://openalex.org/W4362506750"],"abstract_inverted_index":{"While":[0],"organic":[1,100,118,146],"synthesis":[2,19,50,97,143],"carried":[3],"out":[4],"in":[5,15,35,167],"most":[6],"laboratories":[7],"uses":[8],"batch":[9,33],"methods,":[10],"there":[11],"is":[12,180],"growing":[13],"interest":[14],"modernizing":[16],"fine":[17],"chemical":[18],"through":[20],"continuous-flow":[21,96,117,136,159],"processes.":[22],"As":[23],"a":[24],"synthetic":[25],"method,":[26],"flow":[27,75],"processes":[28],"have":[29,46],"several":[30,52,63],"advantages":[31],"over":[32],"systems":[34],"terms":[36],"of":[37,51,84,95,98,113,126,144,169,174],"environmental":[38],"compatibility,":[39],"efficiency,":[40],"and":[41,43,115,129,138,152,164,177],"safety,":[42],"recent":[44],"advances":[45],"allowed":[47],"for":[48,141],"the":[49,67,74,111,142,172],"complex":[53,99,145],"molecules,":[54],"including":[55],"active":[56],"pharmaceutical":[57],"ingredients":[58],"(APIs).":[59],"Nevertheless,":[60],"due":[61,86],"to":[62,66,87,107,156],"reasons":[64],"related":[65],"difficulties":[68],"arising":[69],"from":[70],"byproduct":[71],"formation":[72],"during":[73],"process,":[76],"such":[77,148],"as":[78,149],"lower":[79],"yields,":[80],"poor":[81,88],"selectivities,":[82],"clogging":[83],"columns":[85],"solubility,":[89],"catalyst":[90],"poisoning,":[91],"etc.,":[92],"successful":[93],"examples":[94,125],"molecules":[101,147],"are":[102,120],"still":[103],"limited.":[104],"In":[105,154],"order":[106,155],"solve":[108],"this":[109],"bottleneck,":[110],"development":[112,173],"selective":[114],"atom-economical":[116,127],"transformations":[119],"needed.":[121],"This":[122],"perspective":[123],"highlights":[124],"addition":[128,163],"condensation":[130,165],"reactions":[131,176],"with":[132],"heterogeneous":[133,178],"catalysts":[134,179],"under":[135],"conditions":[137],"their":[139],"applications":[140],"natural":[150],"products":[151],"APIs.":[153],"realize":[157],"new":[158],"methodologies,":[160],"based":[161],"on":[162],"reactions,":[166,171],"place":[168],"substitution":[170],"novel":[175],"required.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":10}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2020-03-06T00:00:00"}