{"id":"https://openalex.org/W3007918331","doi":"https://doi.org/10.1002/cpsc.106","title":"Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three\u2010Dimensional Esophageal Organoids","display_name":"Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three\u2010Dimensional Esophageal Organoids","publication_year":2020,"publication_date":"2020-02-27","ids":{"openalex":"https://openalex.org/W3007918331","doi":"https://doi.org/10.1002/cpsc.106","mag":"3007918331","pmid":"https://pubmed.ncbi.nlm.nih.gov/32105412","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7288850"},"language":"en","primary_location":{"id":"doi:10.1002/cpsc.106","doi":"https://doi.org/10.1002/cpsc.106","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpsc.106","pdf_url":null,"source":{"id":"https://openalex.org/S2764651103","display_name":"Current Protocols in Stem Cell Biology","issn_l":"1938-8969","issn":["1938-8969","1941-7322"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Stem Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7288850","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052023689","display_name":"Hiroshi Nakagawa","orcid":"https://orcid.org/0000-0001-7330-4863","observed_orcids":["https://orcid.org/0000-0001-7330-4863"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hiroshi Nakagawa","raw_affiliation_strings":["Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090388223","display_name":"Yuta Kasagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuta Kasagi","raw_affiliation_strings":["Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070643615","display_name":"Tatiana A. Karakasheva","orcid":"https://orcid.org/0000-0001-9070-2804","observed_orcids":["https://orcid.org/0000-0001-9070-2804"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana A. Karakasheva","raw_affiliation_strings":["Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047742804","display_name":"Takeo Hara","orcid":"https://orcid.org/0000-0001-6591-0759","observed_orcids":["https://orcid.org/0000-0001-6591-0759"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takeo Hara","raw_affiliation_strings":["Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016090753","display_name":"Bailey Aaron","orcid":"https://orcid.org/0000-0003-4492-8866","observed_orcids":["https://orcid.org/0000-0003-4492-8866"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bailey Aaron","raw_affiliation_strings":["Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030182456","display_name":"Masataka Shimonosono","orcid":"https://orcid.org/0000-0002-9857-3338","observed_orcids":["https://orcid.org/0000-0002-9857-3338"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masataka Shimonosono","raw_affiliation_strings":["Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063991205","display_name":"Takashi Kijima","orcid":"https://orcid.org/0000-0003-1681-7069","observed_orcids":["https://orcid.org/0000-0003-1681-7069"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Kijima","raw_affiliation_strings":["Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010792621","display_name":"V\u00e9ronique Giroux","orcid":"https://orcid.org/0000-0002-3722-6447","observed_orcids":["https://orcid.org/0000-0002-3722-6447"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Veronique Giroux","raw_affiliation_strings":["Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113122109","display_name":"Dominique D. Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominique Bailey","raw_affiliation_strings":["Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066272868","display_name":"Benjamin J. Wilkins","orcid":"https://orcid.org/0000-0002-1797-7323","observed_orcids":["https://orcid.org/0000-0002-1797-7323"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Wilkins","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075581309","display_name":"Julian A. Abrams","orcid":"https://orcid.org/0000-0002-6021-9376","observed_orcids":["https://orcid.org/0000-0002-6021-9376"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian A. Abrams","raw_affiliation_strings":["Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056998508","display_name":"Gary W. Falk","orcid":"https://orcid.org/0000-0002-7143-1436","observed_orcids":["https://orcid.org/0000-0002-7143-1436"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary W. Falk","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089210937","display_name":"Seema Sharma Aceves","orcid":"https://orcid.org/0000-0002-2622-7081","observed_orcids":["https://orcid.org/0000-0002-2622-7081"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema S. Aceves","raw_affiliation_strings":["Division of Allergy & Immunology Rady Children's Hospital; University of California San Diego San Diego California","University of California San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy & Immunology Rady Children's Hospital; University of California San Diego San Diego California","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210087384"]},{"raw_affiliation_string":"University of California San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047011247","display_name":"Jonathan M. Spergel","orcid":"https://orcid.org/0000-0002-4658-5353","observed_orcids":["https://orcid.org/0000-0002-4658-5353"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Spergel","raw_affiliation_strings":["Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012899782","display_name":"Kathryn E. Hamilton","orcid":"https://orcid.org/0000-0001-9575-2499","observed_orcids":["https://orcid.org/0000-0001-9575-2499"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn E. Hamilton","raw_affiliation_strings":["Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054395736","display_name":"Kelly A. Whelan","orcid":"https://orcid.org/0000-0001-7402-4935","observed_orcids":["https://orcid.org/0000-0001-7402-4935"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Whelan","raw_affiliation_strings":["Department of Pathology & Laboratory Medicine, Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine, Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077168668","display_name":"Amanda B. Muir","orcid":"https://orcid.org/0000-0003-2616-7063","observed_orcids":["https://orcid.org/0000-0003-2616-7063"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda B. Muir","raw_affiliation_strings":["Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Epithelial Biology Center, Department of Pediatrics, Perlman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5052023689","https://openalex.org/A5077168668"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I2799503643","https://openalex.org/I4390039230","https://openalex.org/I79576946"],"apc_list":{"value":4750,"currency":"USD","value_usd":4750},"apc_paid":null,"fwci":2.6789,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89783689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"52","issue":"1","first_page":"e106","last_page":"e106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.18209999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-epithelium","display_name":"esophageal epithelium","score":0.8309999704360962},{"id":"https://openalex.org/keywords/epithelial-homeostasis","display_name":"epithelial homeostasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/eosinophilic-esophagitis","display_name":"eosinophilic esophagitis","score":1.0},{"id":"https://openalex.org/keywords/esophagitis","display_name":"esophagitis","score":0.906000018119812},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5379999876022339},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.7549999952316284},{"id":"https://openalex.org/keywords/esophageal-mucosa","display_name":"esophageal mucosa","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8506072759628296},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6584136486053467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6054038405418396},{"id":"https://openalex.org/C2781065132","wikidata":"https://www.wikidata.org/wiki/Q2057356","display_name":"Eosinophilic esophagitis","level":3,"score":0.5658894777297974},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.5210446715354919},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4140235483646393},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4015940725803375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3918669819831848},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3646697402000427},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.24685999751091003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2160676121711731},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11614620685577393},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015925","descriptor_name":"Cryopreservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057765","descriptor_name":"Eosinophilic Esophagitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cpsc.106","doi":"https://doi.org/10.1002/cpsc.106","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpsc.106","pdf_url":null,"source":{"id":"https://openalex.org/S2764651103","display_name":"Current Protocols in Stem Cell Biology","issn_l":"1938-8969","issn":["1938-8969","1941-7322"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-70"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protocols in Stem Cell Biology","raw_type":"journal-article"},{"id":"pmid:32105412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32105412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current protocols in stem cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7288850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7288850","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Protoc Stem Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7288850","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7288850","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Protoc Stem Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1360126120","display_name":"Contribution of rigid matrix to allergic eosinophilic esophagitis pathogenesis","funder_award_id":"R01AI092135","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G142750078","display_name":"The Role of the Microenvironment in Barrett's Esophagus","funder_award_id":"U54CA163004","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1449376054","display_name":"Consortium of Eosinophilic Gastrointestinal Disease Researchers","funder_award_id":"U54AI117804","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1619152892","display_name":"Mechanisms of Esophageal Carcinogenesis","funder_award_id":"P01CA098101","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1966300088","display_name":"The functional role of mitophagy in esophageal cell biology","funder_award_id":"K01DK103953","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2083689853","display_name":"Lysyl oxidase mediated fibrosis in eosinophilic esophagitis","funder_award_id":"K08DK106444","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2312078907","display_name":null,"funder_award_id":"K08DK106444","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2626970174","display_name":null,"funder_award_id":"U54CA163004","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2969096386","display_name":null,"funder_award_id":"K01DK103953","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3031784058","display_name":"Mentoring Patient Oriented Research in Allergic Eosinophilic Gastrointestinal Disorders","funder_award_id":"K24AI135034","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3144313669","display_name":"Autophagy regulation of esophageal basal cell dynamics","funder_award_id":"R03DK118304","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3148304603","display_name":null,"funder_award_id":"HL132996\u201002S1","funder_id":"https://openalex.org/F4320309099","funder_display_name":"Children's Hospital of Philadelphia"},{"id":"https://openalex.org/G3504430253","display_name":"Autophagy and esophageal tissue remodeling in EoE","funder_award_id":"R01DK114436","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G397555987","display_name":null,"funder_award_id":"R01AA026297","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4021028342","display_name":null,"funder_award_id":"R01DK114436","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4041853508","display_name":null,"funder_award_id":"T32 DK083256","funder_id":"https://openalex.org/F4320309099","funder_display_name":"Children's Hospital of Philadelphia"},{"id":"https://openalex.org/G6943149810","display_name":"Esophageal tissue aging under homeostatic and inflammatory conditions","funder_award_id":"R01DK121159","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G705321869","display_name":"The Role of Lysyl Oxidase in Epithelial Differentiation in Eosinophilic Esophagitis","funder_award_id":"R03DK118310","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7668806916","display_name":null,"funder_award_id":"R03DK118310 01A1","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7681912068","display_name":"The role of IMP1 mRNA binding protein in intestinal epithelial biology","funder_award_id":"K01DK100485","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G776886754","display_name":null,"funder_award_id":"P01CA098101","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8307107140","display_name":"Mechanism of Respiratory System-Esophageal Separation","funder_award_id":"R01HL132996","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8963766838","display_name":null,"funder_award_id":"R01 DK114457","funder_id":"https://openalex.org/F4320309099","funder_display_name":"Children's Hospital of Philadelphia"},{"id":"https://openalex.org/G9000872793","display_name":"Center of Excellence in Environmental Toxicology","funder_award_id":"P30ES013508","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000896881","display_name":"Data Management and Coordinating Center: Rare Diseases Clinical Research Network","funder_award_id":"U2CTR002818","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898571","display_name":"Aldh2 and epithelial homeostasis and pathobiology","funder_award_id":"R01AA026297","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000906123","display_name":"Multidisciplinary Training in Translational Gastrointestinal and Liver Research","funder_award_id":"T32DK083256","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000909123","display_name":"Center for Molecular Studies in Digestive and Liver Diseases","funder_award_id":"P30DK050306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000916142","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA013696","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G988612351","display_name":"IMP1 REGULATION OF AUTOPHAGY IN THE INTESTINAL EPITHELIUM","funder_award_id":"R03DK114463","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309099","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48"},{"id":"https://openalex.org/F4320311352","display_name":"American Partnership for Eosinophilic Disorders","ror":"https://ror.org/023943s16"},{"id":"https://openalex.org/F4320313725","display_name":"North American Society for Pediatric Gastroenterology, Hepatology and Nutrition","ror":"https://ror.org/005vg3k81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2011298735","https://openalex.org/W2024876545","https://openalex.org/W2050186814","https://openalex.org/W2058808589","https://openalex.org/W2129302035","https://openalex.org/W2142379908","https://openalex.org/W2147224721","https://openalex.org/W2148172811","https://openalex.org/W2746233794","https://openalex.org/W2782431872","https://openalex.org/W2794100731","https://openalex.org/W2905134409","https://openalex.org/W2954489011"],"related_works":["https://openalex.org/W4402274301","https://openalex.org/W2782431872","https://openalex.org/W2794100731","https://openalex.org/W4396828990","https://openalex.org/W7138835587","https://openalex.org/W2626477410","https://openalex.org/W3149484435","https://openalex.org/W4382363834","https://openalex.org/W3024619924","https://openalex.org/W3211428057"],"abstract_inverted_index":{"The":[0],"homeostatic":[1],"proliferation-differentiation":[2],"gradient":[3],"in":[4,73,128,138,195],"the":[5,25,74,77,123],"esophageal":[6,38,47,154,160,170,177,196],"epithelium":[7,194],"is":[8],"perturbed":[9],"under":[10,68],"inflammatory":[11,50,69,78],"disease":[12,18,51],"conditions":[13,70],"such":[14],"as":[15],"gastroesophageal":[16],"reflux":[17],"and":[19,32,43,61,102,112,134,167,183],"eosinophilic":[20],"esophagitis.":[21],"Herein":[22],"we":[23],"describe":[24],"protocols":[26],"for":[27,122,179],"rapid":[28],"generation":[29],"(<14":[30],"days)":[31],"characterization":[33],"of":[34,76,125,130,153,169,176,185,192],"single-cell-derived,":[35],"three-dimensional":[36],"(3D)":[37],"organoids":[39,55,118,155,171,178],"from":[40,156],"human":[41],"subjects":[42],"mice":[44],"with":[45],"normal":[46,57],"mucosa":[48],"or":[49,96,158],"conditions.":[52],"While":[53],"3D":[54,117,186],"recapitulate":[56],"epithelial":[58,66,81,161],"renewal,":[59],"proliferation,":[60],"differentiation,":[62],"non-cell":[63],"autonomous":[64],"reactive":[65,193],"changes":[67,82,92,104],"are":[71,83,93,105],"evaluated":[72],"absence":[75],"milieu.":[79],"Reactive":[80],"reconstituted":[84],"upon":[85],"exposure":[86],"to":[87],"exogenous":[88],"recombinant":[89],"cytokines.":[90],"These":[91],"modulated":[94],"pharmacologically":[95],"genetically":[97],"ex":[98],"vivo.":[99],"Molecular,":[100],"structural,":[101],"functional":[103],"characterized":[106],"by":[107,143],"morphology,":[108],"flow":[109],"cytometry,":[110],"biochemistry,":[111],"gene":[113],"expression":[114],"analyses.":[115],"Esophageal":[116],"can":[119],"be":[120],"translated":[121],"development":[124],"personalized":[126],"medicine":[127],"assessment":[129],"individual":[131],"cytokine":[132],"sensitivity":[133],"molecularly":[135],"targeted":[136],"therapeutics":[137],"esophagitis":[139],"patients":[140],"\u00a9":[141],"2020":[142],"John":[144],"Wiley":[145],"&":[146],"Sons,":[147],"Inc.":[148],"Basic":[149,163,172,188],"Protocol":[150,164,173,189],"1:":[151],"Generation":[152],"biopsy":[157],"murine":[159],"sheets":[162],"2:":[165],"Propagation":[166],"cryopreservation":[168],"3:":[174],"Harvesting":[175],"RNA":[180],"isolation,":[181],"immunohistochemistry,":[182],"evaluation":[184],"architecture":[187],"4:":[190],"Modeling":[191],"organoids.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-03-06T00:00:00"}
