{"id":"https://openalex.org/W3007745985","doi":"https://doi.org/10.1017/s0007114520000768","title":"Natural variants of \u03b1-gliadin peptides within wheat proteins with reduced toxicity in coeliac disease","display_name":"Natural variants of \u03b1-gliadin peptides within wheat proteins with reduced toxicity in coeliac disease","publication_year":2020,"publication_date":"2020-02-26","ids":{"openalex":"https://openalex.org/W3007745985","doi":"https://doi.org/10.1017/s0007114520000768","mag":"3007745985","pmid":"https://pubmed.ncbi.nlm.nih.gov/32100654"},"language":"en","primary_location":{"id":"doi:10.1017/s0007114520000768","doi":"https://doi.org/10.1017/s0007114520000768","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114520000768","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B3BB452849474109799ADAEDBA5288AD/S0007114520000768a.pdf/div-class-title-natural-variants-of-gliadin-peptides-within-wheat-proteins-with-reduced-toxicity-in-coeliac-disease-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B3BB452849474109799ADAEDBA5288AD/S0007114520000768a.pdf/div-class-title-natural-variants-of-gliadin-peptides-within-wheat-proteins-with-reduced-toxicity-in-coeliac-disease-div.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035323865","display_name":"Nika Japelj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nika Japelj","raw_affiliation_strings":["St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054053563","display_name":"Tanja \u0160uligoj","orcid":"https://orcid.org/0000-0001-9916-2891","observed_orcids":["https://orcid.org/0000-0001-9916-2891"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tanja Suligoj","raw_affiliation_strings":["St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034519468","display_name":"Beatriz C\u00f4rte\u2010Real","orcid":"https://orcid.org/0000-0002-9702-4185","observed_orcids":["https://orcid.org/0000-0002-9702-4185"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Beatriz C\u00f4rte-Real","raw_affiliation_strings":["St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048572596","display_name":"Joachim W. Messing","orcid":"https://orcid.org/0000-0001-8260-2643","observed_orcids":["https://orcid.org/0000-0001-8260-2643"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joachim Messing","raw_affiliation_strings":["Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043351468","display_name":"Paul J. Ciclitira","orcid":"https://orcid.org/0000-0002-9230-0646","observed_orcids":["https://orcid.org/0000-0002-9230-0646"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Paul J. Ciclitira","raw_affiliation_strings":["St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-9230-0646","affiliations":[{"raw_affiliation_string":"St Thomas' Hospital, Guy's & St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043351468"],"corresponding_institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I200166805"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":0.1786,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.46628666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"123","issue":"12","first_page":"1382","last_page":"1389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11348","display_name":"Celiac Disease Research and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10733","display_name":"Wheat and Barley Genetics and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celiac-disease","display_name":"celiac disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alpha-gliadin","display_name":"alpha-gliadin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gluten-peptides","display_name":"gluten peptides","score":0.6019999980926514},{"id":"https://openalex.org/keywords/gluten-free-diet","display_name":"gluten-free diet","score":0.5519999861717224},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hla-dq2-5","display_name":"HLA-DQ2.5","score":0.8399999737739563},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.8420000076293945},{"id":"https://openalex.org/keywords/wheat-cultivars","display_name":"wheat cultivars","score":0.6629999876022339},{"id":"https://openalex.org/keywords/duodenal-toxicity","display_name":"duodenal toxicity","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2780092158","wikidata":"https://www.wikidata.org/wiki/Q279074","display_name":"Gliadin","level":3,"score":0.8248924016952515},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.6889020800590515},{"id":"https://openalex.org/C2780349322","wikidata":"https://www.wikidata.org/wiki/Q11088","display_name":"Coeliac disease","level":3,"score":0.6719449758529663},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5802558660507202},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5655993819236755},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5552453994750977},{"id":"https://openalex.org/C2776336767","wikidata":"https://www.wikidata.org/wiki/Q188251","display_name":"Gluten","level":2,"score":0.5431645512580872},{"id":"https://openalex.org/C2778740566","wikidata":"https://www.wikidata.org/wiki/Q181136","display_name":"Glutamic acid","level":3,"score":0.5303923487663269},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.521987795829773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5182631015777588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4802718162536621},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.47094595432281494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3867184519767761},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34339162707328796},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2865266799926758},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19766893982887268},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11349579691886902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09041538834571838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08401939272880554},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002446","descriptor_name":"Celiac Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004386","descriptor_name":"Duodenum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005903","descriptor_name":"Gliadin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005983","descriptor_name":"Glutens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014908","descriptor_name":"Triticum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055261","descriptor_name":"Immunogenetic Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0007114520000768","doi":"https://doi.org/10.1017/s0007114520000768","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114520000768","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B3BB452849474109799ADAEDBA5288AD/S0007114520000768a.pdf/div-class-title-natural-variants-of-gliadin-peptides-within-wheat-proteins-with-reduced-toxicity-in-coeliac-disease-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},{"id":"pmid:32100654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32100654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1017/s0007114520000768","doi":"https://doi.org/10.1017/s0007114520000768","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114520000768","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/B3BB452849474109799ADAEDBA5288AD/S0007114520000768a.pdf/div-class-title-natural-variants-of-gliadin-peptides-within-wheat-proteins-with-reduced-toxicity-in-coeliac-disease-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3007745985.pdf","grobid_xml":"https://content.openalex.org/works/W3007745985.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W323336631","https://openalex.org/W1786321957","https://openalex.org/W1971658716","https://openalex.org/W1975094828","https://openalex.org/W1975126199","https://openalex.org/W1981871095","https://openalex.org/W2001119767","https://openalex.org/W2005034078","https://openalex.org/W2042313682","https://openalex.org/W2059935861","https://openalex.org/W2082180505","https://openalex.org/W2083562009","https://openalex.org/W2085927277","https://openalex.org/W2089602960","https://openalex.org/W2102306181","https://openalex.org/W2104899206","https://openalex.org/W2124562936","https://openalex.org/W2131017558","https://openalex.org/W2141820146","https://openalex.org/W2290387922","https://openalex.org/W2768290209","https://openalex.org/W2805397568"],"related_works":["https://openalex.org/W2913925280","https://openalex.org/W2085927277","https://openalex.org/W2020204131","https://openalex.org/W2409739966","https://openalex.org/W4406850114","https://openalex.org/W2062492658","https://openalex.org/W4206117384","https://openalex.org/W2151392742","https://openalex.org/W2124562936","https://openalex.org/W2154128794"],"abstract_inverted_index":{"The":[0,80,101],"only":[1],"generally":[2],"accepted":[3],"treatment":[4],"of":[5,54,106,157,168],"coeliac":[6],"disease":[7],"(CD)":[8],"is":[9],"a":[10],"lifelong":[11],"gluten-free":[12],"diet.":[13],"Wheat":[14],"gluten":[15],"proteins":[16],"include":[17],"gliadins,":[18],"low":[19],"and":[20,90,127,162],"high":[21],"molecular":[22],"weight":[23],"glutenins.":[24],"However,":[25],"we":[26,50],"have":[27],"found":[28],"significant":[29],"structural":[30,42],"variations":[31],"within":[32],"these":[33],"protein":[34],"families":[35],"among":[36],"different":[37],"cultivars.":[38],"To":[39],"determine":[40],"which":[41],"motifs":[43],"might":[44],"be":[45],"less":[46],"toxic":[47],"than":[48],"others,":[49],"assessed":[51],"five":[52],"variants":[53,93],"\u03b1-gliadin":[55,112],"immunodominant":[56],"CD-toxic":[57],"peptides":[58,81,113,153],"synthesised":[59],"as":[60],"16mers":[61],"in":[62,96,111,137],"CD":[63,142,148,169],"T":[64,70,85],"cell":[65,71,86],"stimulation":[66],"assays":[67],"with":[68,118,154],"gluten-sensitive":[69],"lines":[72],"generated":[73],"from":[74,77],"duodenal":[75],"biopsies":[76],"CD-affected":[78],"individuals.":[79],"harboured":[82],"the":[83,133],"overlapping":[84],"epitopes":[87],"DQ":[88],"2.5-glia-\u03b1-2":[89],"naturally":[91],"occurring":[92],"that":[94,104,150],"differed":[95],"certain":[97],"amino":[98],"acids":[99,125],"(AA).":[100],"results":[102],"revealed":[103,132,151],"introduction":[105],"two":[107,123,152],"selected":[108,155],"AA":[109,120],"substitutions":[110,121],"reduced":[114],"immunogenicity.":[115],"A":[116],"peptide":[117,134],"three":[119],"involving":[122],"glutamic":[124,159],"(E)":[126,161],"one":[128],"glutamine":[129],"residue":[130],"(G)":[131],"was":[135],"negative":[136],"5:5":[138],"samples.":[139],"We":[140],"used":[141],"small-intestinal":[143],"organ":[144],"culture":[145],"to":[146],"assess":[147],"toxicity":[149],"substitution":[156],"both":[158],"acid":[160],"proline":[163],"(P)":[164],"residues":[165],"abrogated":[166],"evidence":[167],"toxicity.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-06T00:00:00"}