{"id":"https://openalex.org/W3006985196","doi":"https://doi.org/10.1016/j.blre.2020.100672","title":"Targeting MCL-1 in hematologic malignancies: Rationale and progress","display_name":"Targeting MCL-1 in hematologic malignancies: Rationale and progress","publication_year":2020,"publication_date":"2020-02-21","ids":{"openalex":"https://openalex.org/W3006985196","doi":"https://doi.org/10.1016/j.blre.2020.100672","mag":"3006985196","pmid":"https://pubmed.ncbi.nlm.nih.gov/32204955"},"language":"en","primary_location":{"id":"doi:10.1016/j.blre.2020.100672","doi":"https://doi.org/10.1016/j.blre.2020.100672","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.blre.2020.100672","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0268960X20300229/pdf","source":{"id":"https://openalex.org/S169446993","display_name":"Blood Reviews","issn_l":"0268-960X","issn":["0268-960X","1532-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0268960X20300229/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005591514","display_name":"Andrew H. Wei","orcid":"https://orcid.org/0000-0002-7514-3298","observed_orcids":["https://orcid.org/0000-0002-7514-3298"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Andrew H. Wei","raw_affiliation_strings":["Alfred Hospital and Monash University, Melbourne, VIC, Australia. Electronic address: Andrew.wei@monash.edu","Alfred Hospital and Monash University, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alfred Hospital and Monash University, Melbourne, VIC, Australia. Electronic address: Andrew.wei@monash.edu","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"]},{"raw_affiliation_string":"Alfred Hospital and Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033407869","display_name":"Andrew Warwick Roberts","orcid":"https://orcid.org/0000-0002-7341-5720","observed_orcids":["https://orcid.org/0000-0002-7341-5720"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew W. Roberts","raw_affiliation_strings":["University of Melbourne, Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Melbourne, Royal Melbourne Hospital, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002073335","display_name":"Andrew G Spencer","orcid":"https://orcid.org/0000-0002-0531-7424","observed_orcids":["https://orcid.org/0000-0002-0531-7424"]},"institutions":[{"id":"https://openalex.org/I2801993434","display_name":"The Alfred Hospital","ror":"https://ror.org/01wddqe20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801993434","https://openalex.org/I4210163178"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew Spencer","raw_affiliation_strings":["Alfred Hospital, Monash University, Australian Centre for Blood Diseases, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alfred Hospital, Monash University, Australian Centre for Blood Diseases, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047442341","display_name":"Aaron Seth Rosenberg","orcid":"https://orcid.org/0000-0003-0714-734X","observed_orcids":["https://orcid.org/0000-0003-0714-734X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Seth Rosenberg","raw_affiliation_strings":["University of California Davis School of Medicine, Sacramento, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Davis School of Medicine, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023752321","display_name":"David Samuel DiCapua Siegel","orcid":"https://orcid.org/0000-0002-3604-2574","observed_orcids":["https://orcid.org/0000-0002-3604-2574"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Siegel","raw_affiliation_strings":["John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013626352","display_name":"Roland B. Walter","orcid":"https://orcid.org/0000-0002-9268-3341","observed_orcids":["https://orcid.org/0000-0002-9268-3341"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roland B. Walter","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833346","display_name":"Sean R. Caenepeel","orcid":"https://orcid.org/0000-0002-9446-4927","observed_orcids":["https://orcid.org/0000-0002-9446-4927"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Caenepeel","raw_affiliation_strings":["Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102816712","display_name":"Paul E. Hughes","orcid":"https://orcid.org/0000-0003-1095-9883","observed_orcids":["https://orcid.org/0000-0003-1095-9883"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Hughes","raw_affiliation_strings":["Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019736369","display_name":"Zach McIver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zach McIver","raw_affiliation_strings":["Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012989885","display_name":"Khalid Mezzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalid Mezzi","raw_affiliation_strings":["Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045840242","display_name":"Phuong Khanh H Morrow","orcid":"https://orcid.org/0009-0007-5349-6344","observed_orcids":["https://orcid.org/0009-0007-5349-6344"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phuong Khanh Morrow","raw_affiliation_strings":["Amgen Inc., Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Inc., Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061495135","display_name":"AS Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Stein","raw_affiliation_strings":["Gehr Family Center for Leukemia, City of Hope Medical Center, Duarte, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gehr Family Center for Leukemia, City of Hope Medical Center, Duarte, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5005591514"],"corresponding_institution_ids":["https://openalex.org/I2801993434","https://openalex.org/I56590836"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":9.6885,"has_fulltext":true,"cited_by_count":210,"citation_normalized_percentile":{"value":0.99109294,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"44","issue":null,"first_page":"100672","last_page":"100672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mcl-1-inhibitors","display_name":"Mcl-1 inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9419999718666077},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.968999981880188},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":1.0},{"id":"https://openalex.org/keywords/anti-apoptotic-proteins","display_name":"anti-apoptotic proteins","score":0.8999999761581421},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9750000238418579},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/azd5991","display_name":"AZD5991","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.8075258731842041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6853833794593811},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6043022274971008},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5927962064743042},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5925413370132446},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.513172447681427},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5000553131103516},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.45967844128608704},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43768784403800964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.270022988319397},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.254684716463089}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064549","descriptor_name":"Myeloid Cell Leukemia Sequence 1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.blre.2020.100672","doi":"https://doi.org/10.1016/j.blre.2020.100672","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.blre.2020.100672","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0268960X20300229/pdf","source":{"id":"https://openalex.org/S169446993","display_name":"Blood Reviews","issn_l":"0268-960X","issn":["0268-960X","1532-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Reviews","raw_type":"journal-article"},{"id":"pmid:32204955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32204955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood reviews","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7444791","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7442684","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7442684","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7442684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Rev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.blre.2020.100672","doi":"https://doi.org/10.1016/j.blre.2020.100672","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.blre.2020.100672","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0268960X20300229/pdf","source":{"id":"https://openalex.org/S169446993","display_name":"Blood Reviews","issn_l":"0268-960X","issn":["0268-960X","1532-1681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6471908409","display_name":null,"funder_award_id":"CA138464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6953427905","display_name":null,"funder_award_id":"CA138464","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G776903742","display_name":null,"funder_award_id":"P30-CA093373","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000011451","display_name":null,"funder_award_id":"CA138464","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000859530","display_name":"UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development Program","funder_award_id":"K12CA138464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3006985196.pdf","grobid_xml":"https://content.openalex.org/works/W3006985196.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W1211118294","https://openalex.org/W1499746632","https://openalex.org/W1500940860","https://openalex.org/W1535142282","https://openalex.org/W1625022788","https://openalex.org/W1851949377","https://openalex.org/W1933867057","https://openalex.org/W1964569316","https://openalex.org/W1969232124","https://openalex.org/W1970209296","https://openalex.org/W1973433643","https://openalex.org/W1977079962","https://openalex.org/W1978244665","https://openalex.org/W1980425699","https://openalex.org/W1980727670","https://openalex.org/W1982254984","https://openalex.org/W1990983360","https://openalex.org/W1991249033","https://openalex.org/W1992710197","https://openalex.org/W2009486785","https://openalex.org/W2014767087","https://openalex.org/W2017457433","https://openalex.org/W2019279061","https://openalex.org/W2024216850","https://openalex.org/W2025952260","https://openalex.org/W2027020478","https://openalex.org/W2027395744","https://openalex.org/W2030029504","https://openalex.org/W2032753042","https://openalex.org/W2034466441","https://openalex.org/W2037289115","https://openalex.org/W2040155913","https://openalex.org/W2043133177","https://openalex.org/W2046116275","https://openalex.org/W2047590682","https://openalex.org/W2048217074","https://openalex.org/W2057068774","https://openalex.org/W2057942504","https://openalex.org/W2059416155","https://openalex.org/W2060385539","https://openalex.org/W2060435066","https://openalex.org/W2060766263","https://openalex.org/W2061670954","https://openalex.org/W2064759291","https://openalex.org/W2066107979","https://openalex.org/W2066404900","https://openalex.org/W2068603782","https://openalex.org/W2068720118","https://openalex.org/W2068962767","https://openalex.org/W2069432530","https://openalex.org/W2071535939","https://openalex.org/W2077398861","https://openalex.org/W2080221630","https://openalex.org/W2087369364","https://openalex.org/W2088802752","https://openalex.org/W2088883749","https://openalex.org/W2091562724","https://openalex.org/W2098910097","https://openalex.org/W2103580937","https://openalex.org/W2106461522","https://openalex.org/W2113278680","https://openalex.org/W2117677381","https://openalex.org/W2120308617","https://openalex.org/W2123122199","https://openalex.org/W2123621979","https://openalex.org/W2134363605","https://openalex.org/W2135491950","https://openalex.org/W2136910701","https://openalex.org/W2137240394","https://openalex.org/W2147318282","https://openalex.org/W2147590336","https://openalex.org/W2151676539","https://openalex.org/W2163375473","https://openalex.org/W2166478202","https://openalex.org/W2166864956","https://openalex.org/W2171224722","https://openalex.org/W2176436801","https://openalex.org/W2176912713","https://openalex.org/W2239142370","https://openalex.org/W2274893797","https://openalex.org/W2289539591","https://openalex.org/W2318638659","https://openalex.org/W2319210200","https://openalex.org/W2326290971","https://openalex.org/W2432564198","https://openalex.org/W2480801180","https://openalex.org/W2485824342","https://openalex.org/W2503782024","https://openalex.org/W2515842163","https://openalex.org/W2517675534","https://openalex.org/W2534349779","https://openalex.org/W2560039438","https://openalex.org/W2563975158","https://openalex.org/W2584413057","https://openalex.org/W2598696175","https://openalex.org/W2602232709","https://openalex.org/W2605114805","https://openalex.org/W2620804057","https://openalex.org/W2622796688","https://openalex.org/W2624307079","https://openalex.org/W2739544745","https://openalex.org/W2741462465","https://openalex.org/W2743418290","https://openalex.org/W2744673575","https://openalex.org/W2762450632","https://openalex.org/W2774533007","https://openalex.org/W2786195554","https://openalex.org/W2791366448","https://openalex.org/W2800133359","https://openalex.org/W2803775493","https://openalex.org/W2804360523","https://openalex.org/W2885967791","https://openalex.org/W2889850618","https://openalex.org/W2890422678","https://openalex.org/W2891173371","https://openalex.org/W2891248360","https://openalex.org/W2891630328","https://openalex.org/W2892395616","https://openalex.org/W2892573863","https://openalex.org/W2895964723","https://openalex.org/W2897811394","https://openalex.org/W2898284215","https://openalex.org/W2901321510","https://openalex.org/W2901716885","https://openalex.org/W2901783207","https://openalex.org/W2904096648","https://openalex.org/W2905070646","https://openalex.org/W2909486746","https://openalex.org/W2912814154","https://openalex.org/W2915161729","https://openalex.org/W2922692686","https://openalex.org/W2926677816","https://openalex.org/W2940005218","https://openalex.org/W2942538710","https://openalex.org/W2951296099","https://openalex.org/W2964007752","https://openalex.org/W2974182987","https://openalex.org/W2981626104","https://openalex.org/W2994122682","https://openalex.org/W6730879717","https://openalex.org/W6742185969","https://openalex.org/W6756861685","https://openalex.org/W6769335146"],"related_works":["https://openalex.org/W2791038413","https://openalex.org/W4234339317","https://openalex.org/W3080900421","https://openalex.org/W4225091882","https://openalex.org/W3179857300","https://openalex.org/W2584413057","https://openalex.org/W3214672817","https://openalex.org/W4384199484","https://openalex.org/W4389467983","https://openalex.org/W2012639655"],"abstract_inverted_index":{"Myeloid":[0],"cell":[1,17],"leukemia":[2,25],"sequence":[3],"1":[4],"(MCL-1)":[5],"is":[6,34,74,104,138],"an":[7],"antiapoptotic":[8],"protein":[9],"that":[10],"plays":[11],"a":[12,106,127],"key":[13,70],"role":[14],"in":[15,19,95],"promoting":[16],"survival":[18],"multiple":[20],"myeloma":[21],"(MM),":[22],"acute":[23],"myeloid":[24],"(AML),":[26],"and":[27,39,66,88,132],"non-Hodgkin":[28],"lymphoma":[29],"(NHL).":[30],"Overexpression":[31],"of":[32,72,82,117,122,135],"MCL-1":[33,43,55,76,123,136],"associated":[35],"with":[36,97],"treatment":[37,128],"resistance":[38],"poor":[40],"prognosis;":[41],"thus,":[42],"inhibitors":[44,56,77,137],"are":[45],"rational":[46],"therapeutic":[47,108],"options":[48],"for":[49,113,129],"malignancies":[50,131],"depending":[51],"on":[52],"MCL-1.":[53],"Several":[54],"have":[57],"entered":[58],"clinical":[59,133],"trials,":[60],"including":[61],"AZD5991,":[62],"S64315,":[63],"AMG":[64,67],"176,":[65],"397.":[68],"A":[69],"area":[71],"investigation":[73],"whether":[75,105],"will":[78],"complement":[79],"the":[80],"activity":[81],"BCL-2":[83],"inhibitors,":[84],"such":[85],"as":[86,126],"venetoclax,":[87],"synergistically":[89],"enhance":[90],"anti-tumor":[91],"efficacy":[92],"when":[93],"given":[94],"combination":[96],"other":[98],"anti-cancer":[99],"drugs.":[100],"Another":[101],"important":[102],"question":[103],"safe":[107],"window":[109],"can":[110],"be":[111],"found":[112],"this":[114],"new":[115],"class":[116],"inhibitors.":[118],"In":[119],"summary,":[120],"inhibition":[121],"shows":[124],"potential":[125],"hematologic":[130],"evaluation":[134],"currently":[139],"underway.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":47},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":11}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}