{"id":"https://openalex.org/W3006910022","doi":"https://doi.org/10.3390/pharmaceutics12030198","title":"Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues","display_name":"Niosome-Based Approach for In Situ Gene Delivery to Retina and Brain Cortex as Immune-Privileged Tissues","publication_year":2020,"publication_date":"2020-02-25","ids":{"openalex":"https://openalex.org/W3006910022","doi":"https://doi.org/10.3390/pharmaceutics12030198","mag":"3006910022","pmid":"https://pubmed.ncbi.nlm.nih.gov/32106545","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7150807"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics12030198","doi":"https://doi.org/10.3390/pharmaceutics12030198","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics12030198","pdf_url":"https://www.mdpi.com/1999-4923/12/3/198/pdf?version=1584416916","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/12/3/198/pdf?version=1584416916","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031039823","display_name":"Nuseibah Al Qtaish","orcid":"https://orcid.org/0000-0001-5966-6155","observed_orcids":["https://orcid.org/0000-0001-5966-6155"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuseibah AL Qtaish","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5966-6155","affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061975371","display_name":"Idoia Gallego","orcid":"https://orcid.org/0000-0002-9312-8147","observed_orcids":["https://orcid.org/0000-0002-9312-8147"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Idoia Gallego","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9312-8147","affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052386999","display_name":"Ilia Villate-Beitia","orcid":"https://orcid.org/0000-0002-3738-7611","observed_orcids":["https://orcid.org/0000-0002-3738-7611"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ilia Villate-Beitia","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3738-7611","affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061525853","display_name":"Myriam Sainz-Ramos","orcid":"https://orcid.org/0000-0001-7266-5771","observed_orcids":["https://orcid.org/0000-0001-7266-5771"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Myriam Sainz-Ramos","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7266-5771","affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061438043","display_name":"Tania Bel\u00e9n L\u00f3pez-M\u00e9ndez","orcid":"https://orcid.org/0000-0001-5029-6549","observed_orcids":["https://orcid.org/0000-0001-5029-6549"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tania Bel\u00e9n L\u00f3pez-M\u00e9ndez","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5029-6549","affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041567089","display_name":"Santiago Grijalvo","orcid":"https://orcid.org/0000-0002-8405-4844","observed_orcids":["https://orcid.org/0000-0002-8405-4844"]},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210122902","display_name":"Institute of Advanced Chemistry of Catalonia","ror":"https://ror.org/03srn9y98","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210122902"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Santiago Grijalvo","raw_affiliation_strings":["Institute for Advanced Chemistry of Catalonia, (IQAC-CSIC), E-08034 Barcelona, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Chemistry of Catalonia, (IQAC-CSIC), E-08034 Barcelona, Spain","institution_ids":["https://openalex.org/I4210122902"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025885734","display_name":"Ram\u00f3n Eritja","orcid":"https://orcid.org/0000-0001-5383-9334","observed_orcids":["https://orcid.org/0000-0001-5383-9334"]},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210122902","display_name":"Institute of Advanced Chemistry of Catalonia","ror":"https://ror.org/03srn9y98","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210122902"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n Eritja","raw_affiliation_strings":["Institute for Advanced Chemistry of Catalonia, (IQAC-CSIC), E-08034 Barcelona, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5383-9334","affiliations":[{"raw_affiliation_string":"Institute for Advanced Chemistry of Catalonia, (IQAC-CSIC), E-08034 Barcelona, Spain","institution_ids":["https://openalex.org/I4210122902"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-08034 Barcelona, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019433569","display_name":"Cristina Soto\u2010S\u00e1nchez","orcid":"https://orcid.org/0000-0003-4447-5967","observed_orcids":["https://orcid.org/0000-0003-4447-5967","https://orcid.org/0000-0001-5002-5976"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Soto-S\u00e1nchez","raw_affiliation_strings":["Neuroprothesis and Neuroengineering Research Group, Miguel Hern\u00e1ndez University, E-03202 Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroprothesis and Neuroengineering Research Group, Miguel Hern\u00e1ndez University, E-03202 Elche, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063483625","display_name":"Gema Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0002-9795-2846","observed_orcids":["https://orcid.org/0000-0002-9795-2846"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gema Mart\u00ednez-Navarrete","raw_affiliation_strings":["Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-03202 Elche, Spain","Neuroprothesis and Neuroengineering Research Group, Miguel Hern\u00e1ndez University, E-03202 Elche, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9795-2846","affiliations":[{"raw_affiliation_string":"Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-03202 Elche, Spain","institution_ids":["https://openalex.org/I4210105141"]},{"raw_affiliation_string":"Neuroprothesis and Neuroengineering Research Group, Miguel Hern\u00e1ndez University, E-03202 Elche, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037134228","display_name":"Eduardo Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-7052-6011","observed_orcids":["https://orcid.org/0000-0002-7052-6011"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Fern\u00e1ndez","raw_affiliation_strings":["Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-03202 Elche, Spain","Neuroprothesis and Neuroengineering Research Group, Miguel Hern\u00e1ndez University, E-03202 Elche, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7052-6011","affiliations":[{"raw_affiliation_string":"Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-03202 Elche, Spain","institution_ids":["https://openalex.org/I4210105141"]},{"raw_affiliation_string":"Neuroprothesis and Neuroengineering Research Group, Miguel Hern\u00e1ndez University, E-03202 Elche, Spain","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054254948","display_name":"Gustavo Puras","orcid":"https://orcid.org/0000-0002-1536-7601","observed_orcids":["https://orcid.org/0000-0002-1536-7601","https://orcid.org/0000-0003-3739-670X"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Gustavo Puras","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1536-7601","affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070577695","display_name":"Jos\u00e9 Lu\u00eds Pedraz","orcid":"https://orcid.org/0000-0002-3938-2267","observed_orcids":["https://orcid.org/0000-0002-3938-2267","https://orcid.org/0000-0002-9566-8403"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Luis Pedraz","raw_affiliation_strings":["NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NanoBioCel group, University of the Basque Country (UPV/EHU), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), E-01006 Vitoria-Gasteiz, Spain","institution_ids":["https://openalex.org/I4210105141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054254948","https://openalex.org/A5070577695"],"corresponding_institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210105141"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1901},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1901},"fwci":0.8369,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.66306028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"3","first_page":"198","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niosomes","display_name":"niosomes","score":1.0},{"id":"https://openalex.org/keywords/nonviral-gene-delivery","display_name":"non-viral gene delivery","score":0.871999979019165},{"id":"https://openalex.org/keywords/cationic-lipids","display_name":"cationic lipids","score":0.8500000238418579},{"id":"https://openalex.org/keywords/nonionic-surfactants","display_name":"nonionic surfactants","score":0.9269999861717224},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9860000014305115},{"id":"https://openalex.org/keywords/targeted-gene-delivery","display_name":"targeted gene delivery","score":0.5540000200271606},{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C72918618","wikidata":"https://www.wikidata.org/wiki/Q1993211","display_name":"Niosome","level":4,"score":0.9416582584381104},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.7360790967941284},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4861714243888855},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.45685794949531555},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4434441328048706},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4280356466770172},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4173501133918762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3540770411491394},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.34834590554237366},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3381721079349518},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3031363785266876},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13307145237922668},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.13244229555130005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13237732648849487},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.11188623309135437}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.3390/pharmaceutics12030198","doi":"https://doi.org/10.3390/pharmaceutics12030198","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics12030198","pdf_url":"https://www.mdpi.com/1999-4923/12/3/198/pdf?version=1584416916","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7150807","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7150807","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:32106545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32106545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:addi.ehu.eus:10810/42769","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10810/42769","pdf_url":"https://addi.ehu.eus/bitstream/10810/42769/1/pharmaceutics-12-00198-v2.pdf","source":{"id":"https://openalex.org/S4306401964","display_name":"Communities in ADDI (University of the Basque Country)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169108374","host_organization_name":"University of the Basque Country","host_organization_lineage":["https://openalex.org/I169108374"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/201969","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/201969","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:digital.csic.es:10261/205618","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/205618","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:dnet:addi________::79f7a48ae11dc3cb6efa8c029c94dc73","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10810/42769","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3ada87a8d05b42ca9f0e021450550814","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3ada87a8d05b42ca9f0e021450550814","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 12, Iss 3, p 198 (2020)","raw_type":"article"},{"id":"pmh:oai:hispana.mcu.es:60854958","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10810/42769","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics12030198","doi":"https://doi.org/10.3390/pharmaceutics12030198","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics12030198","pdf_url":"https://www.mdpi.com/1999-4923/12/3/198/pdf?version=1584416916","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1008360734","display_name":null,"funder_award_id":"IT907\u201016","funder_id":"https://openalex.org/F4320321919","funder_display_name":"Euskal Herriko Unibertsitatea"}],"funders":[{"id":"https://openalex.org/F4320321919","display_name":"Euskal Herriko Unibertsitatea","ror":"https://ror.org/000xsnr85"},{"id":"https://openalex.org/F4320323089","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina","ror":"https://ror.org/01gm5f004"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3006910022.pdf","grobid_xml":"https://content.openalex.org/works/W3006910022.grobid-xml"},"referenced_works_count":175,"referenced_works":["https://openalex.org/W115958638","https://openalex.org/W1210825731","https://openalex.org/W1504222414","https://openalex.org/W1526743142","https://openalex.org/W1929439741","https://openalex.org/W1964002661","https://openalex.org/W1966236756","https://openalex.org/W1972116828","https://openalex.org/W1974616755","https://openalex.org/W1975724790","https://openalex.org/W1978438548","https://openalex.org/W1980289234","https://openalex.org/W1981856730","https://openalex.org/W1981877907","https://openalex.org/W1981960353","https://openalex.org/W1986218064","https://openalex.org/W1987280378","https://openalex.org/W1987547969","https://openalex.org/W1987659508","https://openalex.org/W1989779591","https://openalex.org/W1997204008","https://openalex.org/W2000136129","https://openalex.org/W2000164810","https://openalex.org/W2001060576","https://openalex.org/W2002122821","https://openalex.org/W2009588273","https://openalex.org/W2009936215","https://openalex.org/W2013129457","https://openalex.org/W2013530347","https://openalex.org/W2015904405","https://openalex.org/W2017839195","https://openalex.org/W2022358190","https://openalex.org/W2024353096","https://openalex.org/W2027573138","https://openalex.org/W2027761325","https://openalex.org/W2028514393","https://openalex.org/W2030828211","https://openalex.org/W2033547005","https://openalex.org/W2033776334","https://openalex.org/W2038565727","https://openalex.org/W2041607789","https://openalex.org/W2049512332","https://openalex.org/W2050270937","https://openalex.org/W2054914288","https://openalex.org/W2055117699","https://openalex.org/W2056219450","https://openalex.org/W2056736337","https://openalex.org/W2056901048","https://openalex.org/W2063747172","https://openalex.org/W2064209115","https://openalex.org/W2066432116","https://openalex.org/W2066606615","https://openalex.org/W2067669828","https://openalex.org/W2068589006","https://openalex.org/W2075072955","https://openalex.org/W2075662063","https://openalex.org/W2075890776","https://openalex.org/W2076340813","https://openalex.org/W2078392705","https://openalex.org/W2078555248","https://openalex.org/W2079664490","https://openalex.org/W2080592529","https://openalex.org/W2081644109","https://openalex.org/W2085762303","https://openalex.org/W2086805229","https://openalex.org/W2087497808","https://openalex.org/W2088040141","https://openalex.org/W2089912700","https://openalex.org/W2094822863","https://openalex.org/W2094990985","https://openalex.org/W2097675279","https://openalex.org/W2099842373","https://openalex.org/W2103323421","https://openalex.org/W2114564223","https://openalex.org/W2120742252","https://openalex.org/W2123988283","https://openalex.org/W2127621191","https://openalex.org/W2128593286","https://openalex.org/W2129049178","https://openalex.org/W2129637849","https://openalex.org/W2131677861","https://openalex.org/W2135566609","https://openalex.org/W2139257010","https://openalex.org/W2144254115","https://openalex.org/W2166550261","https://openalex.org/W2167949866","https://openalex.org/W2169821578","https://openalex.org/W2170913716","https://openalex.org/W2171327090","https://openalex.org/W2188352683","https://openalex.org/W2189602750","https://openalex.org/W2199356015","https://openalex.org/W2207168550","https://openalex.org/W2210923860","https://openalex.org/W2219182836","https://openalex.org/W2236375555","https://openalex.org/W2285665497","https://openalex.org/W2289195768","https://openalex.org/W2314642321","https://openalex.org/W2345503771","https://openalex.org/W2385719444","https://openalex.org/W2395099523","https://openalex.org/W2406954244","https://openalex.org/W2482516180","https://openalex.org/W2501824672","https://openalex.org/W2545689480","https://openalex.org/W2559966155","https://openalex.org/W2565278824","https://openalex.org/W2571955572","https://openalex.org/W2576361957","https://openalex.org/W2578855353","https://openalex.org/W2600121439","https://openalex.org/W2607137613","https://openalex.org/W2736065260","https://openalex.org/W2739438137","https://openalex.org/W2751621730","https://openalex.org/W2755653587","https://openalex.org/W2765377832","https://openalex.org/W2769549860","https://openalex.org/W2769745398","https://openalex.org/W2770906767","https://openalex.org/W2782690276","https://openalex.org/W2782917400","https://openalex.org/W2784041397","https://openalex.org/W2794372602","https://openalex.org/W2794702512","https://openalex.org/W2799957635","https://openalex.org/W2802042729","https://openalex.org/W2802060782","https://openalex.org/W2802585007","https://openalex.org/W2803581075","https://openalex.org/W2884131579","https://openalex.org/W2887204204","https://openalex.org/W2889739943","https://openalex.org/W2891412130","https://openalex.org/W2891653767","https://openalex.org/W2897278865","https://openalex.org/W2901706505","https://openalex.org/W2903812021","https://openalex.org/W2905420437","https://openalex.org/W2911559459","https://openalex.org/W2913486029","https://openalex.org/W2914016174","https://openalex.org/W2914096421","https://openalex.org/W2914425913","https://openalex.org/W2917045955","https://openalex.org/W2922482486","https://openalex.org/W2936058854","https://openalex.org/W2936059353","https://openalex.org/W2942446910","https://openalex.org/W2944341817","https://openalex.org/W2944707498","https://openalex.org/W2948569822","https://openalex.org/W2953512703","https://openalex.org/W2954923515","https://openalex.org/W2955054239","https://openalex.org/W2955720713","https://openalex.org/W2963890011","https://openalex.org/W2968460843","https://openalex.org/W2969296462","https://openalex.org/W2969783143","https://openalex.org/W2971675351","https://openalex.org/W2972380832","https://openalex.org/W2972473003","https://openalex.org/W2975845651","https://openalex.org/W2977252884","https://openalex.org/W2979614510","https://openalex.org/W2980405523","https://openalex.org/W2981137429","https://openalex.org/W2981991770","https://openalex.org/W2982358904","https://openalex.org/W2982680362","https://openalex.org/W2990475843","https://openalex.org/W2998515012","https://openalex.org/W6766884729"],"related_works":["https://openalex.org/W2557449063","https://openalex.org/W2803581075","https://openalex.org/W2207168550","https://openalex.org/W7046180264","https://openalex.org/W2891412130","https://openalex.org/W2054914288","https://openalex.org/W2600121439","https://openalex.org/W3202836887","https://openalex.org/W1915921132","https://openalex.org/W4382982326"],"abstract_inverted_index":{"Non-viral":[0],"vectors":[1,100],"have":[2,23],"emerged":[3],"as":[4,157,165],"a":[5,46,62,74],"promising":[6],"alternative":[7],"to":[8,14,81,148],"viral":[9],"gene":[10,28,102],"delivery":[11,103],"systems":[12],"due":[13],"their":[15,133],"safer":[16],"profile.":[17],"Among":[18],"non-viral":[19,99],"vectors,":[20],"recently,":[21],"niosomes":[22,119,147],"shown":[24],"favorable":[25],"properties":[26,85],"for":[27,52,101],"delivery,":[29],"including":[30],"low":[31],"toxicity,":[32],"high":[33],"stability,":[34],"and":[35,73,86,115,120,161,171],"easy":[36],"production.":[37],"The":[38],"three":[39],"main":[40],"components":[41],"of":[42,70,118,128,145],"niosome":[43],"formulations":[44],"include":[45],"cationic":[47,134],"lipid":[48],"that":[49,65,77,123],"is":[50,91],"responsible":[51],"the":[53,57,67,71,109,126,129,141,150,158,162],"electrostatic":[54],"interactions":[55],"with":[56],"negatively":[58],"charged":[59],"genetic":[60,130,151],"material,":[61],"non-ionic":[63],"surfactant":[64],"enhances":[66],"long-term":[68],"stability":[69],"niosome,":[72],"helper":[75],"component":[76],"can":[78],"be":[79,176],"added":[80],"improve":[82],"its":[83],"physicochemical":[84,113],"biological":[87,116],"performance.":[88],"This":[89],"review":[90],"aimed":[92],"at":[93],"providing":[94],"recent":[95],"information":[96],"about":[97],"niosome-based":[98],"purposes.":[104],"Specially,":[105],"we":[106,137],"will":[107,138,175],"discuss":[108],"composition,":[110],"preparation":[111],"methods,":[112],"properties,":[114],"evaluation":[117],"corresponding":[121],"nioplexes":[122],"result":[124],"from":[125],"addition":[127],"material":[131,152],"onto":[132],"surface.":[135],"Next,":[136],"focus":[139],"on":[140],"in":[142],"situ":[143],"application":[144],"such":[146,156],"deliver":[149],"into":[153],"immune-privileged":[154],"tissues":[155],"brain":[159],"cortex":[160],"retina.":[163],"Finally,":[164],"future":[166],"perspectives,":[167],"non-invasive":[168],"administration":[169],"routes":[170],"different":[172],"targeting":[173],"strategies":[174],"discussed.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-03-06T00:00:00"}
