{"id":"https://openalex.org/W3006874508","doi":null,"title":"Development of a myocardial infarction model by the design of a miniaturized 3D culture platform","display_name":"Development of a myocardial infarction model by the design of a miniaturized 3D culture platform","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3006874508","mag":"3006874508"},"language":"en","primary_location":{"id":"mag:3006874508","doi":null,"is_oa":false,"landing_page_url":"https://essay.utwente.nl/79975/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001770301","display_name":"Tom Boonen","orcid":"https://orcid.org/0009-0006-7461-8032","observed_orcids":["https://orcid.org/0009-0006-7461-8032"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tom Boonen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-7461-8032","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001770301"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction-model","display_name":"myocardial infarction model","score":0.9179999828338623},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cardiomyocyte-maturation","display_name":"cardiomyocyte maturation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/engineered-heart-tissue","display_name":"engineered heart tissue","score":0.8529999852180481},{"id":"https://openalex.org/keywords/microfluidic-platform","display_name":"microfluidic platform","score":0.7820000052452087},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7929999828338623},{"id":"https://openalex.org/keywords/carbon-source","display_name":"carbon source","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8085174560546875},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4767485558986664},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46528783440589905},{"id":"https://openalex.org/C2910924664","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Human Induced Pluripotent Stem Cells","level":5,"score":0.46301954984664917},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.43545860052108765},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41301167011260986},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33375489711761475},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3260612189769745},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3222728371620178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31958118081092834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.296481192111969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2806079387664795},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2699754238128662},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1933598518371582},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.184350848197937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1232718825340271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09895157814025879},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0859571099281311}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3006874508","doi":null,"is_oa":false,"landing_page_url":"https://essay.utwente.nl/79975/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1593594825","https://openalex.org/W1747672433","https://openalex.org/W1821166167","https://openalex.org/W1934476967","https://openalex.org/W1965500282","https://openalex.org/W1966140207","https://openalex.org/W1970526294","https://openalex.org/W1973791641","https://openalex.org/W1978593765","https://openalex.org/W1989507960","https://openalex.org/W1992159608","https://openalex.org/W1996376161","https://openalex.org/W2004145886","https://openalex.org/W2005465930","https://openalex.org/W2010020475","https://openalex.org/W2011844821","https://openalex.org/W2018463503","https://openalex.org/W2018474760","https://openalex.org/W2024971068","https://openalex.org/W2048015545","https://openalex.org/W2051070943","https://openalex.org/W2052319461","https://openalex.org/W2063749889","https://openalex.org/W2071518542","https://openalex.org/W2071571360","https://openalex.org/W2077129929","https://openalex.org/W2083599207","https://openalex.org/W2100674093","https://openalex.org/W2101228997","https://openalex.org/W2102322990","https://openalex.org/W2104717900","https://openalex.org/W2116393753","https://openalex.org/W2120473106","https://openalex.org/W2120949673","https://openalex.org/W2125987139","https://openalex.org/W2136122531","https://openalex.org/W2138203975","https://openalex.org/W2145411235","https://openalex.org/W2157329190","https://openalex.org/W2163068618","https://openalex.org/W2163307683","https://openalex.org/W2170806689","https://openalex.org/W2171313781","https://openalex.org/W2172517621","https://openalex.org/W2183793823","https://openalex.org/W2252419928","https://openalex.org/W2503257611","https://openalex.org/W2509523536","https://openalex.org/W2538427375","https://openalex.org/W2551814827","https://openalex.org/W2587079466","https://openalex.org/W2612983729","https://openalex.org/W2743978568","https://openalex.org/W2771796009","https://openalex.org/W2777623363","https://openalex.org/W2921549315","https://openalex.org/W2934515379"],"related_works":["https://openalex.org/W207992492","https://openalex.org/W7037719852","https://openalex.org/W3029730275","https://openalex.org/W4302340090","https://openalex.org/W2911855595","https://openalex.org/W2126890416","https://openalex.org/W4387105746","https://openalex.org/W2507227639","https://openalex.org/W7018832773","https://openalex.org/W3011609945"],"abstract_inverted_index":{"Currently":[0],"the":[1,7,17,35,38,52,115,119,167],"leading":[2],"cause":[3],"of":[4,19,37,48,54,85,114,146,174],"death":[5],"in":[6,15,51,80,93,106,118],"western":[8],"world":[9],"is":[10,24,68,129],"cardiovascular":[11],"disease":[12,58],"(CVD)":[13],"and":[14,57,127],"the\r\nfuture":[16],"amount":[18],"people":[20],"suffering":[21],"from":[22,65],"CVD":[23],"only":[25],"projected":[26],"to":[27],"rise.":[28],"However":[29],"high-throughput\r\ndisease":[30],"models":[31],"are":[32],"lacking.":[33],"Since":[34],"generation":[36],"first":[39],"induced":[40],"pluripotent":[41],"stem":[42],"cells":[43,148],"(iPSCs),\r\nthese":[44],"iPSCs":[45,66],"have":[46],"become":[47],"great":[49],"interest":[50],"field":[53],"drug":[55],"testing":[56],"modelling.":[59],"The":[60],"big\r\nproblem":[61],"with":[62],"cardiomyocytes":[63],"derived":[64],"(iPSC-CM)":[67],"that":[69,128],"after":[70],"differentiation":[71],"these":[72],"cells\r\nshow":[73],"an":[74,81,99,154],"immature":[75,82],"phenotype":[76],"which":[77],"manifests":[78],"itself":[79],"metabolism.":[83],"Because":[84],"this\r\nimmature":[86],"metabolism":[87,124],"they":[88],"cannot":[89],"yet":[90],"be":[91],"used":[92],"modeling":[94],"CVD.":[95],"During":[96],"this":[97],"project":[98],"attempt":[100],"has\r\nbeen":[101],"taken":[102],"at":[103],"maturing":[104],"iPSC-CMs":[105],"two":[107,150,179],"dimensional":[108,135],"(2D)":[109],"cell":[110],"culture,":[111],"by":[112],"alteration":[113],"carbon\r\nsource":[116],"available":[117],"medium.":[120],"Unfortunately":[121],"no":[122],"mature":[123],"was":[125],"achieved":[126],"why\r\nthe":[130],"focus":[131],"shifted":[132],"towards":[133],"three":[134],"(3D)":[136],"culture":[137,141,173],"possibilities.":[138],"A":[139],"3D":[140],"method":[142],"of\r\nsuspending":[143],"a":[144,162],"strip":[145],"cardiac":[147],"between":[149],"flexible":[151],"pillars":[152],"called":[153],"engineered":[155],"heart":[156],"tissue":[157],"(EHT)\r\nhas":[158],"been":[159],"incorporated":[160],"into":[161],"microfluidic":[163],"platform.":[164],"This":[165],"platform,":[166],"microEHT":[168],"array,":[169],"allows":[170],"for":[171,177],"easy\r\nparallel":[172],"miniaturized":[175],"EHTs":[176],"over":[178],"months.":[180]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-06T00:00:00"}
