{"id":"https://openalex.org/W3006586433","doi":null,"title":"Metalloprotease Regulation Shapes The Bmp Gradient In Space And Time","display_name":"Metalloprotease Regulation Shapes The Bmp Gradient In Space And Time","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3006586433","mag":"3006586433"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:20.500.14332/30656","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/30656","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086288677","display_name":"Francesca B. Tuazon","orcid":"https://orcid.org/0000-0002-3868-2217","observed_orcids":["https://orcid.org/0000-0002-3868-2217"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Francesca B. Tuazon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3868-2217","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086288677"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphogen-gradient-formation","display_name":"morphogen gradient formation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tolloid","display_name":"Tolloid","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chordin","display_name":"chordin","score":0.734000027179718},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.9160000085830688},{"id":"https://openalex.org/keywords/zebrafish-gastrulation","display_name":"zebrafish gastrulation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dorsoventral-patterning","display_name":"dorsoventral patterning","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.5006320476531982},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3669049143791199},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.19259187579154968},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1903371512889862},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12965157628059387}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:20.500.14332/30656","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/30656","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-16052","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI27663187","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:edissertations-5399","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/bitstreams/606b3168-c29c-4f54-aa55-ddd8a96b51ed/download","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"mag:3006586433","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=16052&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3064293923","https://openalex.org/W2754516781","https://openalex.org/W2033017711","https://openalex.org/W1985018025","https://openalex.org/W2063646605","https://openalex.org/W1964480763","https://openalex.org/W4245871153","https://openalex.org/W6943482668","https://openalex.org/W2026267009","https://openalex.org/W3212891945"],"abstract_inverted_index":{"A":[0],"fundamental":[1],"question":[2],"in":[3,43,65,113,129,143,220,282],"developmental":[4],"biology":[5],"is":[6,38,136,156],"how":[7],"morphogens,":[8],"such":[9],"as":[10,183],"Bone":[11],"Morphogenetic":[12],"Protein":[13],"(BMP),":[14],"form":[15],"precise":[16],"signaling":[17,52,82,203,259,291],"gradients":[18],"to":[19,25,39,54,102,195],"impart":[20],"positional":[21],"and":[22,47,67,76,90,108,126,142,162,172,181,198,215,234,267,280,285],"functional":[23],"identity":[24],"the":[26,29,44,50,56,60,72,85,105,114,131,184,201,207,222,237,243,247,289],"cells":[27],"of":[28,35,49,74,170,209,246],"early":[30,115],"embryo.":[31],"The":[32],"primary":[33,185],"goal":[34],"this":[36],"research":[37],"employ":[40],"recent":[41],"advances":[42],"quantitative":[45,100,193],"measurement":[46],"visualization":[48],"BMP":[51,62,81,87,132,159,189,202,223,238,249,290],"gradient":[53,64,160,190,204,224,239,292],"elucidate":[55],"mechanisms":[57],"that":[58,79,104,120,153,187,200,213,254,261],"shape":[59],"zebrafish":[61,116,294],"morphogen":[63],"space":[66],"time.":[68],"Specifically,":[69],"I":[70,118,151,211,271],"investigated":[71],"roles":[73,219,276],"Bmp1a":[75,107,122,180],"Tolloid,":[77,182,279],"metalloproteases":[78],"promote":[80],"by":[83,179,206,265],"cleaving":[84],"critical":[86],"antagonist":[88],"Chordin,":[89],"their":[91],"competitive":[92],"inhibitor":[93],"Sizzled.\\nI":[94],"combined":[95],"rigorous":[96],"mutant":[97],"analyses":[98,145],"with":[99,146],"immunofluorescence":[101,194],"determine":[103],"proteases":[106],"Tolloid":[109,214,235,266],"spatially":[110],"restrict":[111],"Chordin":[112,149,154,171,176],"gastrula.":[117],"discovered":[119,212],"maternally-deposited":[121],"plays":[123],"an":[124,147],"unexpected":[125],"non-redundant":[127],"role":[128],"establishing":[130,284],"gradient,":[133],"while":[134,240],"Sizzled":[135,216,241,281],"surprisingly":[137],"dispensable.":[138],"Combining":[139],"mathematical":[140],"models":[141],"vivo":[144],"immobile":[148],"construct,":[150],"demonstrate":[152],"diffusion":[155],"dispensable":[157],"for":[158,277],"formation":[161],"DV":[163,295],"patterning.":[164,296],"These":[165,251],"data":[166],"exclude":[167],"a":[168,175,257],"counter-gradient":[169],"instead":[173],"favor":[174],"sink,":[177],"established":[178],"mechanism":[186],"drives":[188],"formation.\\nI":[191],"applied":[192],"wild-type":[196],"embryos":[197],"determined":[199],"steepens":[205,236],"end":[208],"gastrulation.":[210],"play":[217],"separate":[218],"shaping":[221,288],"during":[225,293],"gastrulation:":[226],"they":[227],"are":[228],"first":[229],"required":[230],"at":[231],"different":[232],"stages":[233],"limits":[242],"lateral":[244],"extent":[245],"highest":[248],"levels.":[250],"results":[252],"suggest":[253],"gastrulation":[255],"represents":[256],"new":[258],"environment":[260],"requires":[262],"additional":[263],"regulation":[264],"Sizzled.":[268],"Taken":[269],"together,":[270],"have":[272],"defined":[273],"distinct":[274],"spatiotemporal":[275],"Bmp1a,":[278],"both":[283],"then":[286],"later":[287]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2020-02-24T00:00:00"}