{"id":"https://openalex.org/W3006288718","doi":null,"title":"Expression of HIF-1\u03b1 and Robo4 in the retinas of streptozotocin-induced diabetic mice.","display_name":"Expression of HIF-1\u03b1 and Robo4 in the retinas of streptozotocin-induced diabetic mice.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3006288718","mag":"3006288718","pmid":"https://pubmed.ncbi.nlm.nih.gov/31933855","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945086"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5909268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945086","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100621273","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0003-4094-1211","observed_orcids":["https://orcid.org/0000-0003-4094-1211"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076139369","display_name":"Haitao Xu","orcid":"https://orcid.org/0000-0003-1791-547X","observed_orcids":["https://orcid.org/0000-0003-1791-547X","https://orcid.org/0000-0003-4642-7942","https://orcid.org/0009-0002-0977-6430","https://orcid.org/0009-0002-4607-4219"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Xu","raw_affiliation_strings":["Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036993709","display_name":"Mei Han","orcid":"https://orcid.org/0000-0001-6175-0022","observed_orcids":["https://orcid.org/0000-0001-6175-0022"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Han","raw_affiliation_strings":["Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764594","display_name":"Jialu Zhang","orcid":"https://orcid.org/0000-0001-7237-5942","observed_orcids":["https://orcid.org/0000-0001-7237-5942"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialu Zhang","raw_affiliation_strings":["Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032486219","display_name":"Jianan Xie","orcid":"https://orcid.org/0000-0001-9084-8272","observed_orcids":["https://orcid.org/0000-0001-9084-8272"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia'nan Xie","raw_affiliation_strings":["Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100771412","display_name":"Rui Tian","orcid":"https://orcid.org/0000-0003-0911-6766","observed_orcids":["https://orcid.org/0000-0003-0911-6766"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Tian","raw_affiliation_strings":["Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Center, The Second Hospital of Jilin University Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7249,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71570312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"12","issue":"2","first_page":"507","last_page":"515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/robo4","display_name":"Robo4","score":0.996999979019165},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/retinal-nerve-fiber-layer","display_name":"retinal nerve fiber layer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ganglion-cell-layer","display_name":"ganglion cell layer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/outer-plexiform-layer","display_name":"outer plexiform layer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/retinal-edema","display_name":"retinal edema","score":0.5720000267028809},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780188069","wikidata":"https://www.wikidata.org/wiki/Q4133186","display_name":"Ganglion cell layer","level":3,"score":0.719286322593689},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.6722100377082825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.642672061920166},{"id":"https://openalex.org/C2777506830","wikidata":"https://www.wikidata.org/wiki/Q4113799","display_name":"Inner nuclear layer","level":3,"score":0.6337921619415283},{"id":"https://openalex.org/C2781099447","wikidata":"https://www.wikidata.org/wiki/Q4113797","display_name":"Inner plexiform layer","level":3,"score":0.6231945753097534},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5985484719276428},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5973941087722778},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.5940548181533813},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5825791954994202},{"id":"https://openalex.org/C2780592520","wikidata":"https://www.wikidata.org/wiki/Q4423908","display_name":"Nerve fiber layer","level":3,"score":0.4829844534397125},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.46604931354522705},{"id":"https://openalex.org/C2781334511","wikidata":"https://www.wikidata.org/wiki/Q108158","display_name":"Ganglion","level":2,"score":0.4533284902572632},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.45199114084243774},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4325031638145447},{"id":"https://openalex.org/C2777585161","wikidata":"https://www.wikidata.org/wiki/Q2357246","display_name":"Outer plexiform layer","level":3,"score":0.4289079010486603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42179393768310547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4110531508922577},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3800632655620575},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1909554898738861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18122994899749756},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.151664137840271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06567370891571045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5909268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6945086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:31933855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31933855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:3006288718","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31933855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5909268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W43171","https://openalex.org/W1829945471","https://openalex.org/W1905242869","https://openalex.org/W1971582876","https://openalex.org/W1977949685","https://openalex.org/W1984469651","https://openalex.org/W1986622894","https://openalex.org/W1988166118","https://openalex.org/W1994385899","https://openalex.org/W1997757103","https://openalex.org/W2010486643","https://openalex.org/W2017350775","https://openalex.org/W2018516857","https://openalex.org/W2050279712","https://openalex.org/W2081880462","https://openalex.org/W2088059932","https://openalex.org/W2089553333","https://openalex.org/W2097621592","https://openalex.org/W2112337731","https://openalex.org/W2145426294","https://openalex.org/W2163557331","https://openalex.org/W2590026484","https://openalex.org/W2767850684"],"related_works":["https://openalex.org/W1994385899","https://openalex.org/W2392777780","https://openalex.org/W3029464577","https://openalex.org/W2389308579","https://openalex.org/W2004090173","https://openalex.org/W2374155583","https://openalex.org/W2945465667","https://openalex.org/W1984469651","https://openalex.org/W2419538046","https://openalex.org/W4416202373"],"abstract_inverted_index":{"PURPOSE:":[0],".":[1,180],"METHODS:":[2],"A":[3],"high-fat":[4],"diet":[5],"together":[6],"with":[7],"STZ":[8],"stimulated":[9],"type":[10],"2":[11],"diabetes":[12],"mellitus":[13],"(DM).":[14],"HE":[15],"staining":[16],"was":[17,35,113,137],"used":[18],"to":[19,38],"observe":[20],"the":[21,25,40,47,72,79,88,103,108,130,143,168],"morphologic":[22],"features":[23],"of":[24,32,42,71],"retinas":[26,48,171],"following":[27],"4,":[28],"or":[29],"8":[30,177],"weeks":[31],"hyperglycemia.":[33],"Immunofluorescence":[34],"carried":[36],"out":[37],"analyze":[39],"expression":[41,123,136,149],"HIF-1\u03b1":[43,53,112,135,156],"and":[44,54,57,65,78,99,119,121,127,142,154,157,160,172,176],"Robo4":[45,55,122,148,158],"in":[46,87,102,117,125,139,152,167],"at":[49],"different":[50],"time":[51],"points.":[52],"mRNA":[56,159],"protein":[58,161],"expressions":[59,162],"were":[60,84,163],"quantified":[61],"by":[62,96],"real-time":[63],"PCR":[64],"western":[66],"blot.":[67],"RESULTS:":[68],"The":[69],"arrangements":[70],"retinal":[73],"nerve":[74],"fiber":[75],"layer":[76,82,146],"(NFL)":[77],"ganglion":[80],"cell":[81],"(GCL)":[83],"slightly":[85,115,166],"turbulent":[86],"4-week":[89,109],"old":[90,105,110,132,170],"diabetic":[91,133],"mice,":[92],"which":[93],"became":[94],"aggravated":[95],"NFL":[97,118,126,153],"edema":[98],"cytoplasmic":[100],"vacuoles":[101],"8-week":[104,131],"group.":[106],"In":[107,129],"group,":[111],"expressed":[114],"higher":[116],"GCL,":[120,141],"increased":[124,150,165],"GCL.":[128,155],"retinas,":[134],"enhanced":[138],"NFL,":[140],"outer":[144],"plexiform":[145],"(OPL);":[147],"apparently":[151],"also":[164],"1-week":[169],"significantly":[173],"after":[174],"4":[175],"weeks.":[178],"CONCLUSIONS:":[179]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-02-24T00:00:00"}