{"id":"https://openalex.org/W3006239261","doi":"https://doi.org/10.3390/biom10020293","title":"Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway","display_name":"Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway","publication_year":2020,"publication_date":"2020-02-13","ids":{"openalex":"https://openalex.org/W3006239261","doi":"https://doi.org/10.3390/biom10020293","mag":"3006239261","pmid":"https://pubmed.ncbi.nlm.nih.gov/32069948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7072149"},"language":"en","primary_location":{"id":"doi:10.3390/biom10020293","doi":"https://doi.org/10.3390/biom10020293","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/biom10020293","pdf_url":"https://www.mdpi.com/2218-273X/10/2/293/pdf?version=1583050538","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/10/2/293/pdf?version=1583050538","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030694848","display_name":"Ari Meerson","orcid":"https://orcid.org/0000-0002-5811-7952","observed_orcids":["https://orcid.org/0000-0002-5811-7952"]},"institutions":[{"id":"https://openalex.org/I4210145032","display_name":"Migal - Galilee Technology Center","ror":"https://ror.org/04kaqnt29","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210145032"]},{"id":"https://openalex.org/I68147069","display_name":"Tel Hai Academic College","ror":"https://ror.org/009st3569","country_code":"IL","type":"education","lineage":["https://openalex.org/I68147069"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ari Meerson","raw_affiliation_strings":["Faculty of Sciences, Tel-Hai Academic College, Upper Galilee 1220800, Israel","MIGAL\u2014Galilee Research Institute, POB 831, Kiryat Shmona 1101602, Israel"],"raw_orcid":"https://orcid.org/0000-0002-5811-7952","affiliations":[{"raw_affiliation_string":"Faculty of Sciences, Tel-Hai Academic College, Upper Galilee 1220800, Israel","institution_ids":["https://openalex.org/I68147069"]},{"raw_affiliation_string":"MIGAL\u2014Galilee Research Institute, POB 831, Kiryat Shmona 1101602, Israel","institution_ids":["https://openalex.org/I4210145032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030694848"],"corresponding_institution_ids":["https://openalex.org/I4210145032","https://openalex.org/I68147069"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1901},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1901},"fwci":0.5539,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.52673065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"2","first_page":"293","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-4443","display_name":"miR-4443","score":1.0},{"id":"https://openalex.org/keywords/leptin-signaling","display_name":"leptin signaling","score":0.7649999856948853},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/drosha","display_name":"Drosha","score":0.7820000052452087},{"id":"https://openalex.org/keywords/exportin-5","display_name":"XPO5","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rna-induced-silencing-complex","display_name":"RNA-induced silencing complex","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mirna-seed-region","display_name":"miRNA seed region","score":0.44999998807907104},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.7960000038146973},{"id":"https://openalex.org/keywords/let-7f-5p","display_name":"let-7f-5p","score":0.9760000109672546},{"id":"https://openalex.org/keywords/primate-conservation","display_name":"primate conservation","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2776802755","wikidata":"https://www.wikidata.org/wiki/Q261483","display_name":"Drosha","level":5,"score":0.9565670490264893},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.8903738260269165},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7171755433082581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.694830060005188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5089075565338135},{"id":"https://openalex.org/C201853390","wikidata":"https://www.wikidata.org/wiki/Q413236","display_name":"Argonaute","level":5,"score":0.4664340317249298},{"id":"https://openalex.org/C155330019","wikidata":"https://www.wikidata.org/wiki/Q21106117","display_name":"RNA-induced silencing complex","level":5,"score":0.44831234216690063},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4094926714897156},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4078773260116577},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3894263505935669},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3889520764350891},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20668897032737732},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.20076128840446472}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043244","descriptor_name":"Ribonuclease III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060565","descriptor_name":"Argonaute Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060565","descriptor_name":"Argonaute Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom10020293","doi":"https://doi.org/10.3390/biom10020293","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/biom10020293","pdf_url":"https://www.mdpi.com/2218-273X/10/2/293/pdf?version=1583050538","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmid:32069948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32069948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7072149","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7072149/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:dba702d33fdd436693e46e3881233159","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/dba702d33fdd436693e46e3881233159","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 10, Iss 2, p 293 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom10020293","doi":"https://doi.org/10.3390/biom10020293","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/biom10020293","pdf_url":"https://www.mdpi.com/2218-273X/10/2/293/pdf?version=1583050538","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321292","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542"},{"id":"https://openalex.org/F4320323051","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982"},{"id":"https://openalex.org/F4320325669","display_name":"Stockholms Universitet","ror":"https://ror.org/05f0yaq80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3006239261.pdf","grobid_xml":"https://content.openalex.org/works/W3006239261.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1968525732","https://openalex.org/W1978472192","https://openalex.org/W1989015932","https://openalex.org/W2020458511","https://openalex.org/W2027541642","https://openalex.org/W2049836150","https://openalex.org/W2055043387","https://openalex.org/W2060465190","https://openalex.org/W2097836344","https://openalex.org/W2109923675","https://openalex.org/W2112543725","https://openalex.org/W2136969669","https://openalex.org/W2155785723","https://openalex.org/W2171393946","https://openalex.org/W2237846683","https://openalex.org/W2299595562","https://openalex.org/W2316713425","https://openalex.org/W2513021971","https://openalex.org/W2550114267","https://openalex.org/W2746091890","https://openalex.org/W2766881582","https://openalex.org/W2790611328","https://openalex.org/W2793436007","https://openalex.org/W2800615247","https://openalex.org/W2898252178","https://openalex.org/W2898440040","https://openalex.org/W2919539004","https://openalex.org/W2949499332","https://openalex.org/W3025335157","https://openalex.org/W6756187474","https://openalex.org/W6777324685"],"related_works":["https://openalex.org/W2136969669","https://openalex.org/W1968525732","https://openalex.org/W2299595562","https://openalex.org/W2061664626","https://openalex.org/W2018045673","https://openalex.org/W3150203197","https://openalex.org/W2305872675","https://openalex.org/W2384104163","https://openalex.org/W2078398296","https://openalex.org/W2148718639"],"abstract_inverted_index":{"The":[0,118],"human":[1],"small":[2,151],"RNA":[3,152],"miR-4443":[4,36,58,86,109,119,142],"is":[5,37,143],"functionally":[6],"involved":[7],"in":[8,14,63,76,112,123,127,135],"several":[9],"types":[10],"of":[11,17,22,46,82,91,108],"cancer":[12],"and":[13,24,31,59,70,95,148],"the":[15,18,41,77,83,89,115],"biology":[16],"immune":[19],"system,":[20],"downstream":[21],"insulin":[23],"leptin":[25],"signaling.":[26],"Next":[27],"generation":[28],"sequencing":[29],"evidence":[30],"structural":[32],"prediction":[33],"suggest":[34,104,140],"that":[35,141],"not":[38,126],"produced":[39,153],"via":[40],"canonical":[42,92],"Drosha-Exportin":[43],"5-Dicer":[44],"pathway":[45],"microRNA":[47,61],"biogenesis.":[48],"We":[49],"tested":[50],"this":[51],"hypothesis":[52],"by":[53,154],"using":[54],"qRT-PCR":[55],"to":[56],"measure":[57],"other":[60,128],"levels":[62,90],"HCT-116":[64],"cells":[65],"with":[66,114],"Drosha,":[67,145],"Exportin":[68,146],"5,":[69,147],"Dicer":[71],"knockouts,":[72],"as":[73,75],"well":[74],"parental":[78],"cell":[79],"line.":[80],"Neither":[81],"knockouts":[84],"decreased":[85],"levels,":[87],"while":[88,130],"microRNAs":[93],"(miR-21":[94],"let-7f-5p)":[96],"were":[97],"dramatically":[98],"reduced.":[99],"Previously":[100],"published":[101],"Ago2-RIP-Seq":[102],"data":[103],"a":[105,144,155],"limited":[106],"incorporation":[107],"into":[110],"RISC,":[111],"agreement":[113],"functional":[116],"studies.":[117],"locus":[120],"shows":[121],"conservation":[122],"primates":[124],"but":[125],"mammals,":[129],"its":[131],"seed":[132],"region":[133],"appears":[134],"additional":[136],"microRNAs.":[137],"Our":[138],"results":[139],"Dicer-independent,":[149],"non-canonical":[150],"yet":[156],"unknown":[157],"biogenesis":[158],"pathway.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-02-24T00:00:00"}