{"id":"https://openalex.org/W3006132480","doi":null,"title":"Drug-naive patients with schizophrenia have metabolic disorders that are not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes.","display_name":"Drug-naive patients with schizophrenia have metabolic disorders that are not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3006132480","mag":"3006132480","pmid":"https://pubmed.ncbi.nlm.nih.gov/31949685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963064"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5916406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963064","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042070020","display_name":"Jinhong Chen","orcid":"https://orcid.org/0000-0003-0952-9990","observed_orcids":["https://orcid.org/0000-0003-0952-9990"]},"institutions":[{"id":"https://openalex.org/I4210159426","display_name":"Hunan Institute of Mental Health","ror":"https://ror.org/05psxec48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159426"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhong Chen","raw_affiliation_strings":["Department of Sleeping Disorders and Neurosis, Brain Hospital of Hunan Province Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sleeping Disorders and Neurosis, Brain Hospital of Hunan Province Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210159426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102860680","display_name":"Liwen Tan","orcid":"https://orcid.org/0000-0002-7611-4034","observed_orcids":["https://orcid.org/0000-0002-7611-4034"]},"institutions":[{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwen Tan","raw_affiliation_strings":["Department of Clinical Psychology, The Second Xiangya Hospital of Central-south University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Psychology, The Second Xiangya Hospital of Central-south University Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065772657","display_name":"Long Zhou","orcid":"https://orcid.org/0000-0003-4474-8232","observed_orcids":["https://orcid.org/0000-0003-4474-8232"]},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Long","raw_affiliation_strings":["Department of Clinical psychology, The Third Xiangya Hospital of Central-South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical psychology, The Third Xiangya Hospital of Central-South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103137340","display_name":"Lifeng Wang","orcid":"https://orcid.org/0000-0003-3934-3708","observed_orcids":["https://orcid.org/0000-0003-3934-3708"]},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lifeng Wang","raw_affiliation_strings":["Department of Clinical psychology, The Third Xiangya Hospital of Central-South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical psychology, The Third Xiangya Hospital of Central-South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159426","display_name":"Hunan Institute of Mental Health","ror":"https://ror.org/05psxec48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159426"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Hu","raw_affiliation_strings":["Department of Sleeping Disorders and Neurosis, Brain Hospital of Hunan Province Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sleeping Disorders and Neurosis, Brain Hospital of Hunan Province Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210159426"]}]},{"author_position":"last","author":{"id":null,"display_name":"Dong Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159426","display_name":"Hunan Institute of Mental Health","ror":"https://ror.org/05psxec48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159426"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Yang","raw_affiliation_strings":["Department of Sleeping Disorders and Neurosis, Brain Hospital of Hunan Province Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sleeping Disorders and Neurosis, Brain Hospital of Hunan Province Changsha, Hunan, China","institution_ids":["https://openalex.org/I4210159426"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1788,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51460414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"12","first_page":"5969","last_page":"5980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7900000214576721},{"id":"https://openalex.org/keywords/drug-naive-patients","display_name":"drug-naive patients","score":0.8159999847412109},{"id":"https://openalex.org/keywords/first-episode-schizophrenia","display_name":"first-episode schizophrenia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/leptin-gene","display_name":"leptin gene","score":0.8709999918937683},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6769999861717224},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.746999979019165},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.8830000162124634},{"id":"https://openalex.org/keywords/postprandial-blood-glucose","display_name":"postprandial blood glucose","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6840004324913025},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.590714156627655},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5831001996994019},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5828129053115845},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5724307894706726},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.553951621055603},{"id":"https://openalex.org/C2777090001","wikidata":"https://www.wikidata.org/wiki/Q5308827","display_name":"Drug-na\u00efve","level":3,"score":0.4979255199432373},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4863463044166565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4366839826107025},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.43214482069015503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.422323614358902},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4185722768306732},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3364134430885315},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2800418734550476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24932104349136353},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21112525463104248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15070420503616333},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.10921436548233032}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5916406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31949685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6963064","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6963064/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3006132480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5916406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1830515907","https://openalex.org/W1963499612","https://openalex.org/W1967102579","https://openalex.org/W1968864854","https://openalex.org/W1971184880","https://openalex.org/W1972904691","https://openalex.org/W1980391156","https://openalex.org/W1987790744","https://openalex.org/W2006085148","https://openalex.org/W2010957995","https://openalex.org/W2014235406","https://openalex.org/W2015127210","https://openalex.org/W2025940044","https://openalex.org/W2043774233","https://openalex.org/W2043993231","https://openalex.org/W2044364656","https://openalex.org/W2046889389","https://openalex.org/W2047231312","https://openalex.org/W2047627511","https://openalex.org/W2052837781","https://openalex.org/W2054277944","https://openalex.org/W2054405411","https://openalex.org/W2059764720","https://openalex.org/W2072700176","https://openalex.org/W2074397445","https://openalex.org/W2075675327","https://openalex.org/W2085208568","https://openalex.org/W2095667216","https://openalex.org/W2111304940","https://openalex.org/W2116680356","https://openalex.org/W2128357550","https://openalex.org/W2129600815","https://openalex.org/W2132964759","https://openalex.org/W2140154855","https://openalex.org/W2144334285","https://openalex.org/W2147425510","https://openalex.org/W2149173020","https://openalex.org/W2163362890","https://openalex.org/W2190733500","https://openalex.org/W2230556265","https://openalex.org/W2378532668","https://openalex.org/W2392377600","https://openalex.org/W2797138237"],"related_works":["https://openalex.org/W2058823571","https://openalex.org/W4229334864","https://openalex.org/W4213238204","https://openalex.org/W2335600565","https://openalex.org/W4213337090","https://openalex.org/W3135702022","https://openalex.org/W2142652386","https://openalex.org/W2731944841","https://openalex.org/W2360083853","https://openalex.org/W1980282695"],"abstract_inverted_index":{"Schizophrenia":[0],"is":[1,6,24],"a":[2],"mental":[3],"disorder":[4],"that":[5],"primarily":[7],"caused":[8],"by":[9,27],"polygenic":[10],"mutations.":[11],"Schizophrenic":[12,162],"patients":[13,68,217],"are":[14],"more":[15],"likely":[16],"to":[17,92,141,207],"suffer":[18],"from":[19],"metabolic":[20,85,222,240],"syndrome":[21],"(MS),":[22],"which":[23],"usually":[25],"accompanied":[26],"polymorphisms":[28,58,225],"in":[29,75,158,170,176,189,196,203,226],"the":[30,35,40,47,76,119,144,153,171,177,190,197,204,208,227],"leptin":[31,178,191],"(LEP)":[32],"gene":[33,45,192,199],"at":[34,46,99],"-2548":[36,100,187],"(G/A)":[37,101,188],"locus":[38],"and":[39,59,69,83,97,102,118,160,163,173,179,193,210,230],"5-hydroxytryptamine":[41],"receptor":[42],"2C":[43],"(5-HTR2C)":[44],"-759":[48,103,194],"(C/T)":[49,104,195],"locus.":[50],"Hence,":[51],"we":[52],"hypothesized":[53],"an":[54],"association":[55],"between":[56],"these":[57],"schizophrenia":[60,110,216,238],"incidence.":[61],"A":[62],"total":[63],"of":[64,95,114,143,186,221],"148":[65],"drug-naive":[66,215],"schizophrenic":[67],"165":[70],"normal":[71],"controls":[72],"were":[73,87,149,234],"enrolled":[74],"study.":[77],"Blood":[78],"glucose":[79,117,122,209],"levels,":[80,82],"lipid":[81,211],"other":[84],"markers":[86],"measured.":[88],"MALDI-TOFMS":[89],"was":[90,155],"performed":[91,156],"analyse":[93],"genotypes":[94,172,185],"LEP":[96,228],"5-HTR2C":[98,180,198,231],"loci,":[105],"respectively.":[106],"Patients":[107,182],"with":[108,183,237],"first-episode":[109],"showed":[111,133,166,200,218],"higher":[112,128],"levels":[113,139],"fasting":[115],"blood":[116],"2-h":[120],"postprandial":[121],"(2":[123],"hPG),":[124],"as":[125,127],"well":[126],"insulin":[129],"resistance":[130],"indices,":[131],"but":[132,224],"lower":[134],"high-density":[135],"lipoprotein":[136],"cholesterol":[137],"(HDL-C)":[138],"compared":[140],"those":[142],"controls.":[145],"The":[146],"above":[147],"results":[148],"partly":[150],"observed":[151],"when":[152],"analysis":[154],"separately":[157],"males":[159],"females.":[161],"healthy":[164],"participants":[165],"no":[167,201],"significant":[168],"differences":[169,202],"allele":[174],"frequencies":[175],"genes.":[181],"varying":[184],"indices":[205],"related":[206],"metabolism.":[212],"Taken":[213],"together,":[214],"some":[219],"incidence":[220],"disorders,":[223],"(-2548G/A)":[229],"(-759C/T)":[232],"genes":[233],"not":[235],"associated":[236],"or":[239],"disorders.":[241]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-02-24T00:00:00"}
