{"id":"https://openalex.org/W3005605896","doi":"https://doi.org/10.1136/gutjnl-2019-319811","title":"Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study","display_name":"Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study","publication_year":2020,"publication_date":"2020-02-14","ids":{"openalex":"https://openalex.org/W3005605896","doi":"https://doi.org/10.1136/gutjnl-2019-319811","mag":"3005605896","pmid":"https://pubmed.ncbi.nlm.nih.gov/32060129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980697"},"language":"en","primary_location":{"id":"doi:10.1136/gutjnl-2019-319811","doi":"https://doi.org/10.1136/gutjnl-2019-319811","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gutjnl-2019-319811","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980697","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074616706","display_name":"Rachael Z. Stolzenberg\u2010Solomon","orcid":"https://orcid.org/0000-0003-3698-7006","observed_orcids":["https://orcid.org/0000-0003-3698-7006"]},"institutions":[{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachael Stolzenberg-Solomon","raw_affiliation_strings":["Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","Metabolic Nutrition Branch, National Cancer Institute Division of Cancer Epidemiology and Genetics, Rockville, MD 20850, USA"],"raw_orcid":"https://orcid.org/0000-0003-3698-7006","affiliations":[{"raw_affiliation_string":"Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","institution_ids":["https://openalex.org/I4391012607"]},{"raw_affiliation_string":"Metabolic Nutrition Branch, National Cancer Institute Division of Cancer Epidemiology and Genetics, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081153667","display_name":"Andriy Derkach","orcid":"https://orcid.org/0000-0003-2178-8493","observed_orcids":["https://orcid.org/0000-0003-2178-8493","https://orcid.org/0000-0002-0395-362X"]},"institutions":[{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andriy Derkach","raw_affiliation_strings":["Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","institution_ids":["https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091281907","display_name":"Steven C. Moore","orcid":"https://orcid.org/0000-0002-8169-1661","observed_orcids":["https://orcid.org/0000-0002-8169-1661"]},"institutions":[{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Moore","raw_affiliation_strings":["Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","institution_ids":["https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039379417","display_name":"Stephanie J. Weinstein","orcid":"https://orcid.org/0000-0002-3834-1535","observed_orcids":["https://orcid.org/0000-0002-3834-1535"]},"institutions":[{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J Weinstein","raw_affiliation_strings":["Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","institution_ids":["https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027838123","display_name":"Demetrius Albanes","orcid":"https://orcid.org/0000-0001-8330-4293","observed_orcids":["https://orcid.org/0000-0001-8330-4293"]},"institutions":[{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demetrius Albanes","raw_affiliation_strings":["Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Nutrition Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","institution_ids":["https://openalex.org/I4391012607"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050414089","display_name":"Joshua Neil Sampson","orcid":"https://orcid.org/0000-0003-2875-3365","observed_orcids":["https://orcid.org/0000-0003-2875-3365"]},"institutions":[{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Sampson","raw_affiliation_strings":["Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA","institution_ids":["https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074616706"],"corresponding_institution_ids":["https://openalex.org/I4391012607"],"apc_list":null,"apc_paid":null,"fwci":2.6501,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.92226488,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"69","issue":"11","first_page":"2008","last_page":"2015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.13279999792575836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-risk-biomarkers","display_name":"cancer risk biomarkers","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dipeptides","display_name":"dipeptides","score":0.8659999966621399},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.7670000195503235},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.5740000009536743},{"id":"https://openalex.org/keywords/gamma-glutamyl-cycle","display_name":"gamma-glutamyl cycle","score":0.8339999914169312},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/subclinical-disease","display_name":"subclinical disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.40400001406669617},{"id":"https://openalex.org/keywords/time-varying-association","display_name":"time-varying association","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7525299787521362},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.7489429116249084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6004512906074524},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5756509304046631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44468557834625244},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.39779311418533325},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3832557797431946},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3313193917274475}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/gutjnl-2019-319811","doi":"https://doi.org/10.1136/gutjnl-2019-319811","is_oa":false,"landing_page_url":"https://doi.org/10.1136/gutjnl-2019-319811","pdf_url":null,"source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmid:32060129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32060129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7980697","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980697","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:gutjnl:69/11/2008","doi":null,"is_oa":false,"landing_page_url":"http://gut.bmj.com/cgi/content/short/69/11/2008","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7980697","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980697","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Gut","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1646535665","display_name":"Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study","funder_award_id":"Z01CP010195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1590421136","https://openalex.org/W1974990354","https://openalex.org/W1980270094","https://openalex.org/W1985322186","https://openalex.org/W1989568128","https://openalex.org/W2010408200","https://openalex.org/W2017771330","https://openalex.org/W2018507034","https://openalex.org/W2034124109","https://openalex.org/W2044573413","https://openalex.org/W2045319985","https://openalex.org/W2052387402","https://openalex.org/W2056538184","https://openalex.org/W2069376956","https://openalex.org/W2105524540","https://openalex.org/W2140965288","https://openalex.org/W2141651438","https://openalex.org/W2144636739","https://openalex.org/W2158392564","https://openalex.org/W2159482845","https://openalex.org/W2169277652","https://openalex.org/W2180377648","https://openalex.org/W2187607014","https://openalex.org/W2275798837","https://openalex.org/W2292191963","https://openalex.org/W2315731425","https://openalex.org/W2329566104","https://openalex.org/W2334426418","https://openalex.org/W2359903822","https://openalex.org/W2465888413","https://openalex.org/W2466752335","https://openalex.org/W2564262333","https://openalex.org/W2575694335","https://openalex.org/W2581068128","https://openalex.org/W2604473882","https://openalex.org/W2741311062","https://openalex.org/W2765167996","https://openalex.org/W2784328305","https://openalex.org/W2787856596","https://openalex.org/W2800004611","https://openalex.org/W2803406529","https://openalex.org/W2808976292","https://openalex.org/W2809388839","https://openalex.org/W2912363239","https://openalex.org/W2917416499","https://openalex.org/W2944864006","https://openalex.org/W2951735444","https://openalex.org/W2964941009","https://openalex.org/W4237426518","https://openalex.org/W6685629620"],"related_works":["https://openalex.org/W4410600520","https://openalex.org/W4319655613","https://openalex.org/W4393094875","https://openalex.org/W2789492138","https://openalex.org/W4387798768","https://openalex.org/W4408347984","https://openalex.org/W2800004611","https://openalex.org/W7134803153","https://openalex.org/W3214829650","https://openalex.org/W3214714144"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"whether":[3],"prediagnostic":[4,31,209],"metabolites":[5,28,184,210],"were":[6,71,82,136,156,174],"associated":[7,176,222],"with":[8,41,177,190,223],"incident":[9,42],"pancreatic":[10],"ductal":[11],"adenocarcinoma":[12],"(PDAC)":[13],"in":[14,30,44,116,120,138],"a":[15,45,112,129],"prospective":[16],"cohort":[17,122],"study.":[18],"DESIGN:":[19],"We":[20,97],"conducted":[21],"an":[22,57],"untargeted":[23],"analysis":[24],"of":[25,49,91],"554":[26],"known":[27],"measured":[29,72],"serum":[32],"(up":[33],"to":[34,37,84,105,212],"24":[35],"years)":[36],"determine":[38],"their":[39],"association":[40],"PDAC":[43,178],"nested":[46,59],"case-control":[47,54,60],"study":[48,61],"male":[50],"smokers":[51],"(372":[52],"matched":[53,68,83],"sets)":[55],"and":[56,65,94,108,123,148,150,154,162,168,201,218],"independent":[58],"that":[62,208],"included":[63],"women":[64],"non-smokers":[66],"(107":[67],"sets).":[69],"Metabolites":[70],"using":[73,128],"Orbitrap":[74],"Elite":[75],"or":[76],"Q-Exactive":[77],"high-resolution/accurate":[78],"mass":[79],"spectrometers.":[80],"Controls":[81],"cases":[85],"by":[86],"age,":[87],"sex,":[88],"race,":[89],"date":[90],"blood":[92,199],"draw,":[93],"follow-up":[95],"time.":[96],"used":[98],"conditional":[99],"logistic":[100],"regression":[101],"adjusted":[102],"for":[103,111],"age":[104],"calculate":[106],"ORs":[107,127],"95%":[109],"CIs":[110],"1":[113],"SD":[114],"increase":[115],"log-metabolite":[117],"level":[118],"separately":[119],"each":[121],"combined":[124],"the":[125,159,191],"two":[126],"fixed-effects":[130],"meta-analysis.":[131],"RESULTS:":[132],").":[133],"Similar":[134],"associations":[135,188,193],"observed":[137,194],"both":[139],"cohorts.":[140],"The":[141],"dipeptides":[142,160],"glycylvaline,":[143],"aspartylphenylalanine,":[144],"pyroglutamylglycine,":[145],"phenylalanylphenylalanine,":[146],"phenylalanylleucine":[147],"tryptophylglutamate":[149],"amino":[151,170],"acids":[152],"aspartate":[153],"glutamate":[155],"positively":[157],"while":[158],"tyrosylglutamine":[161],"\u03b1-glutamyltyrosine,":[163],"fibrinogen":[164],"cleavage":[165],"peptide":[166],"DSGEGDFXAEGGGVR":[167],"glutathione-related":[169],"acid":[171],"cysteine-glutathione":[172],"disulfide":[173],"inversely":[175],"after":[179,197],"Bonferroni":[180],"correction.":[181],"Five":[182],"top":[183],"demonstrated":[185],"significant":[186],"time-varying":[187],"(p<0.023)":[189],"strongest":[192],"10-15":[195],"years":[196],"participants'":[198],"collection":[200],"attenuated":[202],"thereafter.":[203],"CONCLUSION:":[204],"Our":[205],"results":[206],"suggest":[207],"related":[211],"subclinical":[213],"disease,":[214],"\u03b3-glutamyl":[215],"cycle":[216],"metabolism":[217],"adiposity/insulin":[219],"resistance":[220],"are":[221],"PDAC.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-02-24T00:00:00"}