{"id":"https://openalex.org/W3005358366","doi":"https://doi.org/10.4018/978-1-5225-0751-2.ch012","title":"Rational Design of Polymeric Micelle for Cancer Therapy","display_name":"Rational Design of Polymeric Micelle for Cancer Therapy","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W3005358366","doi":"https://doi.org/10.4018/978-1-5225-0751-2.ch012","mag":"3005358366"},"language":"en","primary_location":{"id":"doi:10.4018/978-1-5225-0751-2.ch012","doi":"https://doi.org/10.4018/978-1-5225-0751-2.ch012","is_oa":false,"landing_page_url":"https://doi.org/10.4018/978-1-5225-0751-2.ch012","pdf_url":null,"source":{"id":"https://openalex.org/S4210233881","display_name":"Advances in medical technologies and clinical practice book series","issn_l":"2327-9354","issn":["2327-9354","2327-9370"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Technologies and Clinical Practice","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2185869303","display_name":"Novel Approaches for Drug Delivery"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052405188","display_name":"Yixian Huang","orcid":"https://orcid.org/0009-0004-2601-2875","observed_orcids":["https://orcid.org/0009-0004-2601-2875"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixian Huang","raw_affiliation_strings":["University of Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759529","display_name":"Jingjing Sun","orcid":"https://orcid.org/0000-0002-6230-1015","observed_orcids":["https://orcid.org/0000-0002-6230-1015"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingjing Sun","raw_affiliation_strings":["University of Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100448223","display_name":"Song Li","orcid":"https://orcid.org/0000-0003-1658-949X","observed_orcids":["https://orcid.org/0000-0003-1658-949X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Song Li","raw_affiliation_strings":["University of Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.29343066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"311","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":1.0},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.5920000076293945},{"id":"https://openalex.org/keywords/enhanced-permeability-and-retention-effect","display_name":"enhanced permeability and retention effect","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.5410000085830688},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.7936028242111206},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6235308647155762},{"id":"https://openalex.org/C4863142","wikidata":"https://www.wikidata.org/wiki/Q907920","display_name":"Solubilization","level":2,"score":0.6224358081817627},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.6137509942054749},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5293496251106262},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5084935426712036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47013574838638306},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4681912660598755},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4198516607284546},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3834230303764343},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3717963695526123},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3631213903427124},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3626585602760315},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.3463974893093109},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23310056328773499},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2027173936367035},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16299840807914734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15054824948310852},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13263913989067078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1303463876247406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4018/978-1-5225-0751-2.ch012","doi":"https://doi.org/10.4018/978-1-5225-0751-2.ch012","is_oa":false,"landing_page_url":"https://doi.org/10.4018/978-1-5225-0751-2.ch012","pdf_url":null,"source":{"id":"https://openalex.org/S4210233881","display_name":"Advances in medical technologies and clinical practice book series","issn_l":"2327-9354","issn":["2327-9354","2327-9370"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Medical Technologies and Clinical Practice","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W165178680","https://openalex.org/W1871308790","https://openalex.org/W1968183176","https://openalex.org/W1968804178","https://openalex.org/W1975825141","https://openalex.org/W1979632677","https://openalex.org/W1980667131","https://openalex.org/W1985882425","https://openalex.org/W1986986096","https://openalex.org/W1989124419","https://openalex.org/W1989220118","https://openalex.org/W1990869510","https://openalex.org/W1993888660","https://openalex.org/W1994115700","https://openalex.org/W1994340285","https://openalex.org/W1995690527","https://openalex.org/W1996292197","https://openalex.org/W1997175432","https://openalex.org/W1998985467","https://openalex.org/W2001982737","https://openalex.org/W2005185145","https://openalex.org/W2010219154","https://openalex.org/W2012655347","https://openalex.org/W2012688580","https://openalex.org/W2013004764","https://openalex.org/W2013300088","https://openalex.org/W2013784950","https://openalex.org/W2017747686","https://openalex.org/W2019081161","https://openalex.org/W2019404476","https://openalex.org/W2019633596","https://openalex.org/W2024587306","https://openalex.org/W2024873626","https://openalex.org/W2025785292","https://openalex.org/W2027478810","https://openalex.org/W2029364244","https://openalex.org/W2029829580","https://openalex.org/W2030729645","https://openalex.org/W2033330903","https://openalex.org/W2033760359","https://openalex.org/W2033793518","https://openalex.org/W2034835929","https://openalex.org/W2036828387","https://openalex.org/W2037951704","https://openalex.org/W2046785634","https://openalex.org/W2047732005","https://openalex.org/W2052979358","https://openalex.org/W2055566115","https://openalex.org/W2055991021","https://openalex.org/W2056347214","https://openalex.org/W2059700588","https://openalex.org/W2060265857","https://openalex.org/W2060571466","https://openalex.org/W2061719532","https://openalex.org/W2064444932","https://openalex.org/W2067557497","https://openalex.org/W2070840273","https://openalex.org/W2072247408","https://openalex.org/W2072883571","https://openalex.org/W2075634481","https://openalex.org/W2078394930","https://openalex.org/W2082511916","https://openalex.org/W2083349615","https://openalex.org/W2084909525","https://openalex.org/W2087224485","https://openalex.org/W2088209210","https://openalex.org/W2088728874","https://openalex.org/W2089374836","https://openalex.org/W2091796668","https://openalex.org/W2105021536","https://openalex.org/W2118374257","https://openalex.org/W2120377744","https://openalex.org/W2127009195","https://openalex.org/W2128736925","https://openalex.org/W2132878122","https://openalex.org/W2139107535","https://openalex.org/W2141395077","https://openalex.org/W2144133117","https://openalex.org/W2149907341","https://openalex.org/W2150647921","https://openalex.org/W2153662691","https://openalex.org/W2154321074","https://openalex.org/W2165463761","https://openalex.org/W2165535625","https://openalex.org/W2168024298","https://openalex.org/W2174160083","https://openalex.org/W2319556652","https://openalex.org/W2320383080","https://openalex.org/W2327242595","https://openalex.org/W2333809012","https://openalex.org/W2335526829","https://openalex.org/W4229610749"],"related_works":["https://openalex.org/W2127967445","https://openalex.org/W2081833688","https://openalex.org/W1516577260","https://openalex.org/W3086986601","https://openalex.org/W2052372616","https://openalex.org/W2481294268","https://openalex.org/W2158483050","https://openalex.org/W2122400711","https://openalex.org/W2321756509","https://openalex.org/W2479143417"],"abstract_inverted_index":{"Clinical":[0],"application":[1],"of":[2,15,60,78,90,103,122,128],"anticancer":[3],"drugs":[4],"is":[5,98],"limited":[6],"by":[7],"problems":[8],"such":[9],"as":[10,116,118],"low":[11],"water":[12],"solubility,":[13],"lack":[14],"tissue-specificity":[16],"and":[17,51,63],"toxicity.":[18],"Formulation":[19],"development":[20],"represents":[21],"an":[22,37,129],"important":[23],"approach":[24],"to":[25,43,47,66,93],"these":[26],"problems.":[27],"Among":[28],"the":[29,101],"many":[30],"delivery":[31,40,89],"systems":[32,86,108],"studied,":[33],"polymeric":[34],"micelles":[35],"are":[36],"attractive":[38],"nano-scaled":[39],"system":[41],"due":[42],"their":[44],"simplicity,":[45],"ability":[46],"solubilize":[48],"water-insoluble":[49],"drugs,":[50],"small":[52],"size":[53],"(10-100":[54],"nm)":[55],"that":[56,109],"can":[57],"take":[58],"advantage":[59],"enhanced":[61],"permeability":[62],"retention":[64],"effect":[65],"specifically":[67],"accumulate":[68],"in":[69,81,113],"tumors.":[70],"This":[71],"book":[72],"chapter":[73],"provides":[74],"a":[75,119],"brief":[76],"review":[77],"recent":[79],"advancements":[80],"developing":[82],"environmentally":[83],"responsive":[84],"micellar":[85,124],"for":[87],"controlled":[88],"chemotherapeutic":[91],"agents":[92],"tumor":[94],"tissues.":[95],"The":[96],"emphasis":[97],"placed":[99],"on":[100],"discussion":[102],"several":[104],"dual":[105],"functional":[106],"nanomicellar":[107],"were":[110],"recently":[111],"developed":[112],"our":[114],"laboratory":[115],"well":[117],"new":[120],"strategy":[121],"improving":[123],"formulations":[125],"via":[126],"incorporation":[127],"interfacial":[130],"drug-interactive":[131],"motif(s).":[132]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2020-02-14T00:00:00"}
