{"id":"https://openalex.org/W3005259402","doi":"https://doi.org/10.1038/s41598-020-59154-5","title":"The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency","display_name":"The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency","publication_year":2020,"publication_date":"2020-02-10","ids":{"openalex":"https://openalex.org/W3005259402","doi":"https://doi.org/10.1038/s41598-020-59154-5","mag":"3005259402","pmid":"https://pubmed.ncbi.nlm.nih.gov/32042022"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-59154-5","doi":"https://doi.org/10.1038/s41598-020-59154-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-59154-5","pdf_url":"https://www.nature.com/articles/s41598-020-59154-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-59154-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047216868","display_name":"Chie\u2010Hong Wang","orcid":"https://orcid.org/0000-0003-0774-5323","observed_orcids":["https://orcid.org/0000-0003-0774-5323"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chie-Hong Wang","raw_affiliation_strings":["Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602372","display_name":"Cheng\u2010Hsuan Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Hsuan Chang","raw_affiliation_strings":["Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028957185","display_name":"Tsung-Li Lin","orcid":"https://orcid.org/0000-0002-9480-8224","observed_orcids":["https://orcid.org/0000-0002-9480-8224"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Li Lin","raw_affiliation_strings":["Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-9480-8224","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079171500","display_name":"Ru\u2010Huei Fu","orcid":"https://orcid.org/0000-0001-9367-1759","observed_orcids":["https://orcid.org/0000-0001-9367-1759"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ru-Huei Fu","raw_affiliation_strings":["Center for Translational Medicine, China Medical University Hospital, Taichung, Taiwan","Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452718","display_name":"Yu\u2010Chuen Huang","orcid":"https://orcid.org/0000-0001-7757-2283","observed_orcids":["https://orcid.org/0000-0001-7757-2283"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chuen Huang","raw_affiliation_strings":["Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan","School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074493882","display_name":"Shih\u2010Yin Chen","orcid":"https://orcid.org/0000-0002-6925-7627","observed_orcids":["https://orcid.org/0000-0002-6925-7627"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Yin Chen","raw_affiliation_strings":["Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan","School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083079715","display_name":"Woei\u2010Cherng Shyu","orcid":"https://orcid.org/0000-0002-3335-8450","observed_orcids":["https://orcid.org/0000-0002-3335-8450"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Woei-Cherng Shyu","raw_affiliation_strings":["Center for Translational Medicine, China Medical University Hospital, Taichung, Taiwan","Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101818503","display_name":"Shih\u2010Ping Liu","orcid":"https://orcid.org/0000-0002-5803-4460","observed_orcids":["https://orcid.org/0000-0002-5803-4460"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Ping Liu","raw_affiliation_strings":["Center for Translational Medicine, China Medical University Hospital, Taichung, Taiwan. spliu@mail.cmu.edu.tw","Department of Social Work, Asia University, Taichung, Taiwan. spliu@mail.cmu.edu.tw","Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan. spliu@mail.cmu.edu.tw","Department of Social Work, Asia University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, China Medical University Hospital, Taichung, Taiwan. spliu@mail.cmu.edu.tw","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Department of Social Work, Asia University, Taichung, Taiwan. spliu@mail.cmu.edu.tw","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan. spliu@mail.cmu.edu.tw","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Department of Social Work, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101818503"],"corresponding_institution_ids":["https://openalex.org/I143578492","https://openalex.org/I184693016","https://openalex.org/I4210126829"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.4222,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52484722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"2187","last_page":"2187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cordycepin","display_name":"cordycepin","score":1.0},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pluripotency-maintenance","display_name":"pluripotency maintenance","score":0.9120000004768372},{"id":"https://openalex.org/keywords/jak2-stat3-signaling-pathway","display_name":"JAK2/STAT3 signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/integrin-alphavbeta5","display_name":"integrin \u03b1v\u03b25","score":0.7580000162124634},{"id":"https://openalex.org/keywords/il-6-family-cytokines","display_name":"IL-6 family cytokines","score":0.902999997138977},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7549999952316284},{"id":"https://openalex.org/keywords/yamanaka-factors","display_name":"Yamanaka factors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/embryoid-body-formation","display_name":"embryoid body formation","score":0.625},{"id":"https://openalex.org/keywords/power-generation-efficiency","display_name":"power generation efficiency","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2780066241","wikidata":"https://www.wikidata.org/wiki/Q2256677","display_name":"Cordycepin","level":2,"score":0.8228736519813538},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.695449709892273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6898706555366516},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5951502323150635},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5674359798431396},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.5331171154975891},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.5281011462211609},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.46024057269096375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4525635838508606},{"id":"https://openalex.org/C68710172","wikidata":"https://www.wikidata.org/wiki/Q14906191","display_name":"Ciliary neurotrophic factor","level":4,"score":0.43026214838027954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38148170709609985},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.3324124217033386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08464580774307251},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003839","descriptor_name":"Deoxyadenosines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41598-020-59154-5","doi":"https://doi.org/10.1038/s41598-020-59154-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-59154-5","pdf_url":"https://www.nature.com/articles/s41598-020-59154-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:32042022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32042022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7010772","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7010772","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-59154-5","doi":"https://doi.org/10.1038/s41598-020-59154-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-59154-5","pdf_url":"https://www.nature.com/articles/s41598-020-59154-5.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1990154044","display_name":null,"funder_award_id":"2314-B-039","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G3901385523","display_name":null,"funder_award_id":"DMR-107","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5316937097","display_name":"Using Segawa Disease-Specific Human Ips Cells for Drug Screening and Cell Therapy","funder_award_id":"MOST106-2314-B039-014-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G798678081","display_name":null,"funder_award_id":"DMR-107-071 and DMR- CELL-1814","funder_id":"https://openalex.org/F4320322609","funder_display_name":"China Medical University Hospital"},{"id":"https://openalex.org/G939887807","display_name":null,"funder_award_id":"MOST 106","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322609","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3005259402.pdf","grobid_xml":"https://content.openalex.org/works/W3005259402.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W139824189","https://openalex.org/W1430768662","https://openalex.org/W1554341622","https://openalex.org/W1779691448","https://openalex.org/W1859966362","https://openalex.org/W1968855063","https://openalex.org/W1977463819","https://openalex.org/W1984831356","https://openalex.org/W1997936048","https://openalex.org/W2014085049","https://openalex.org/W2025175358","https://openalex.org/W2031022464","https://openalex.org/W2043457504","https://openalex.org/W2047015004","https://openalex.org/W2061046795","https://openalex.org/W2065786458","https://openalex.org/W2066099366","https://openalex.org/W2066647113","https://openalex.org/W2080914918","https://openalex.org/W2081620485","https://openalex.org/W2086840459","https://openalex.org/W2089190692","https://openalex.org/W2101197781","https://openalex.org/W2105332557","https://openalex.org/W2122532908","https://openalex.org/W2124339110","https://openalex.org/W2125987139","https://openalex.org/W2129484410","https://openalex.org/W2130423950","https://openalex.org/W2137798134","https://openalex.org/W2142323794","https://openalex.org/W2143971829","https://openalex.org/W2163483214","https://openalex.org/W2166163084","https://openalex.org/W2437128875","https://openalex.org/W2592210340","https://openalex.org/W2737532180","https://openalex.org/W2761472101"],"related_works":["https://openalex.org/W2419617622","https://openalex.org/W2416645461","https://openalex.org/W2023341576","https://openalex.org/W2271577402","https://openalex.org/W2076608010","https://openalex.org/W4390652782","https://openalex.org/W2070957499","https://openalex.org/W2902991773","https://openalex.org/W2003322533","https://openalex.org/W2074585853"],"abstract_inverted_index":{"Maintaining":[0],"the":[1,31,77,134,162,177,194],"pluripotency":[2,34,157,178],"of":[3,19,33,63,81,120,137,164,179,184,197],"either":[4],"embryonic":[5,127],"stem":[6,12,20,180],"(ES)":[7],"cells":[8,14,42,139,149,181],"or":[9],"induced":[10],"pluripotent":[11],"(iPS)":[13],"is":[15],"a":[16,112],"fundamental":[17],"part":[18],"cell":[21],"research.":[22],"In":[23],"this":[24],"study,":[25],"we":[26,172],"reported":[27],"that":[28,147,174],"cordycepin":[29,45,74,104,131,143,152,175],"promoted":[30],"expression":[32,61,79,118],"markers":[35],"in":[36,125],"ES":[37,41],"and":[38,53,68,95,188,192],"iPS":[39,138,148],"cells.":[40,169],"treated":[43],"with":[44,111],"demonstrated":[46,173],"their":[47],"potential":[48],"for":[49],"generating":[50],"embryoid":[51],"bodies":[52],"differentiating":[54,165],"into":[55,166],"all":[56],"three":[57],"germ":[58],"layers.":[59],"The":[60,116],"levels":[62,80,119],"phospho-Jak2,":[64],"phospho-Stat3,":[65],"integrin":[66,69],"\u03b1V,":[67],"\u03b25":[70],"were":[71,100,107,123,140],"increased":[72],"after":[73,103,109,130,142,151],"treatment.":[75,132,144],"Furthermore,":[76],"protein":[78],"IL-6":[82],"family":[83],"proteins":[84],"(IL-6,":[85],"IL-11,":[86],"LIF,":[87],"oncostatin":[88],"M":[89],"(OSM),":[90],"ciliary":[91],"neurotrophic":[92],"factor":[93,98],"(CNTF)),":[94],"epidermal":[96],"growth":[97],"(EGF)":[99],"also":[101,160],"upregulated":[102,124],"treatment,":[105,153],"but":[106,159],"restored":[108],"co-treatment":[110],"Jak2":[113],"inhibitor":[114],"(AG490).":[115],"gene":[117],"Yamanaka":[121],"factors":[122],"mouse":[126],"fibroblasts":[128],"(MEFs)":[129],"Moreover,":[133],"generation":[135,195],"efficiencies":[136],"elevated":[141],"We":[145],"found":[146],"generated":[150],"not":[154],"only":[155],"expressed":[156],"markers,":[158],"showed":[161],"ability":[163],"neuron":[167],"stem/progenitor":[168],"Taken":[170],"together,":[171],"maintained":[176],"via":[182],"regulation":[183],"extracellular":[185],"matrix":[186],"(ECM)":[187],"Jak2/Stat3":[189],"signaling":[190],"pathway":[191],"improved":[193],"efficiency":[196],"iPSCs.":[198]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}