{"id":"https://openalex.org/W3005135841","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.746","title":"CEACAM6 as a candidate biomarker for pelareorep sensitivity in pancreatic adenocarcinoma (PDAC).","display_name":"CEACAM6 as a candidate biomarker for pelareorep sensitivity in pancreatic adenocarcinoma (PDAC).","publication_year":2020,"publication_date":"2020-02-01","ids":{"openalex":"https://openalex.org/W3005135841","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.746","mag":"3005135841"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2020.38.4_suppl.746","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.746","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2020.38.4_suppl.746","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009849305","display_name":"Anne M. Noonan","orcid":"https://orcid.org/0000-0001-8083-8492","observed_orcids":["https://orcid.org/0000-0001-8083-8492"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Noonan","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042366783","display_name":"Jacob S. Yount","orcid":"https://orcid.org/0000-0002-6128-4575","observed_orcids":["https://orcid.org/0000-0002-6128-4575"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Yount","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000564338","display_name":"Jason J. David","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason David","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001650011","display_name":"Mindy Hoang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mindy Hoang","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112841074","display_name":"Colin W. Stets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin W. Stets","raw_affiliation_strings":["The Ohio State Comprehensive Cancer Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State Comprehensive Cancer Center, Columbus, OH;","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074891676","display_name":"Tanios Bekaii\u2010Saab","orcid":"https://orcid.org/0000-0001-7721-1699","observed_orcids":["https://orcid.org/0000-0001-7721-1699","https://orcid.org/0000-0003-4653-4537"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanios S. Bekaii-Saab","raw_affiliation_strings":["Mayo Clinic, Phoenix, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Phoenix, AZ;","institution_ids":["https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082021894","display_name":"Ying Huang","orcid":"https://orcid.org/0000-0001-9910-1212","observed_orcids":["https://orcid.org/0000-0001-9910-1212","https://orcid.org/0009-0002-6227-4755"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Huang","raw_affiliation_strings":["The Ohio State University, Division of Hematology, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Division of Hematology, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061124226","display_name":"Wendy L. Frankel","orcid":"https://orcid.org/0000-0003-1658-1009","observed_orcids":["https://orcid.org/0000-0003-1658-1009"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy L. Frankel","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Columbus, OH;","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031622926","display_name":"Cynthia Dawn Timmers","orcid":"https://orcid.org/0000-0002-0509-0805","observed_orcids":["https://orcid.org/0000-0002-0509-0805"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Dawn Timmers","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003245399","display_name":"John L. Hays","orcid":"https://orcid.org/0000-0003-3140-8677","observed_orcids":["https://orcid.org/0000-0003-3140-8677"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Hays","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012787117","display_name":"James Lin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Lin Chen","raw_affiliation_strings":["The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"4_suppl","first_page":"746","last_page":"746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceacam6","display_name":"CEACAM6","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cd66c","display_name":"CD66c","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pelareorep","display_name":"pelareorep","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.8510000109672546},{"id":"https://openalex.org/keywords/reovirus","display_name":"reovirus","score":0.6420000195503235},{"id":"https://openalex.org/keywords/viral-trafficking","display_name":"viral trafficking","score":0.4000000059604645},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.5090000033378601},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7940000295639038},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4970000088214874},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.75},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7164825201034546},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5072457194328308},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.49320024251937866},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4734729826450348},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4617498219013214},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4433186948299408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.437297523021698},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3827631175518036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19883573055267334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18264394998550415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1690366268157959},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2020.38.4_suppl.746","doi":"https://doi.org/10.1200/jco.2020.38.4_suppl.746","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2020.38.4_suppl.746","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391095476","https://openalex.org/W2946904359","https://openalex.org/W4410805512","https://openalex.org/W2095457805","https://openalex.org/W3170677659","https://openalex.org/W3030237798","https://openalex.org/W3030671769","https://openalex.org/W2954766326","https://openalex.org/W2993073257","https://openalex.org/W2803616070"],"abstract_inverted_index":{"746":[0],"Background:":[1],"Pelareorep":[2],"is":[3],"a":[4,83,253],"proprietary":[5],"formulation":[6],"of":[7,22,33,47,194,234,240,256,267],"live,":[8],"replication-competent,":[9],"naturally":[10],"occurring":[11],"Reovirus":[12],"Type":[13],"3":[14],"Dearing":[15],"strain.":[16],"A":[17],"randomized":[18],"phase":[19],"II":[20],"trial":[21,274],"pelareorep":[23,40,63,100,184,259],"in":[24,30,61,65,169,182,203,215,242,245,261,270],"combination":[25],"with":[26,118,189,200,230],"carboplatin":[27,52],"and":[28,53,133,143,147,163,244],"paclitaxel":[29,54],"first-line":[31],"treatment":[32],"metastatic":[34],"PDAC":[35],"(NCT01280058)":[36],"was":[37,121,128,137,156,212,227],"performed.":[38,176],"Although":[39],"did":[41],"not":[42,213,222],"improve":[43,264],"the":[44,62,74,148,183,223],"primary":[45],"endpoint":[46],"progression-free":[48],"survival":[49,164],"compared":[50],"to":[51,187,258],"alone,":[55],"impressive":[56],"durable":[57],"responses":[58],"were":[59,106,167,175,198],"seen":[60,214],"arm":[64,186],"some":[66],"patients":[67],"(pts).":[68],"Further,":[69],"prior":[70,108],"studies":[71],"have":[72],"noted":[73],"immunomodulatory":[75],"carcinoembryonic":[76],"antigen-related":[77],"cell":[78],"adhesion":[79],"molecule":[80],"(CEACAM6/CD66c)":[81],"as":[82],"receptor":[84],"for":[85,99,110,123,173],"specific":[86],"viral":[87,265],"subtypes.":[88],"We":[89],"thus":[90],"speculated":[91],"that":[92],"altered":[93],"CEACAM6":[94,153,195,241,250],"levels":[95,193,233],"may":[96,251],"be":[97,252],"predictive":[98],"sensitivity.":[101],"Methods:":[102],"Pre-treatment":[103],"tissue":[104,132],"biopsies":[105],"collected":[107],"enrolment":[109],"all":[111],"73":[112],"pts":[113,117,205],"on":[114],"study.":[115],"Evaluable":[116],"transcriptomic":[119],"data":[120],"available":[122],"only":[124],"31":[125],"pts.":[126,218],"RNA":[127],"purified":[129],"from":[130],"FFPE":[131,141],"gene":[134,161],"expression":[135,155,162,197,232],"analysis":[136,165],"performed":[138,168],"using":[139,166],"SensationPlus":[140],"Amplification":[142],"WT":[144],"labelling":[145],"kit":[146],"Human":[149],"Transcriptome":[150],"Array":[151],"2.0.":[152],"protein":[154],"determined":[157],"by":[158],"immunohistochemistry.":[159],"Differential":[160],"R/Bioconductor.":[170],"Appropriate":[171],"corrections":[172],"multiplicity":[174],"Results:":[177],"When":[178],"comparing":[179],"extraordinary":[180],"responders":[181],"treated":[185,217],"those":[188],"poor":[190],"outcomes,":[191],"low":[192],"mRNA":[196,231],"associated":[199],"prolonged":[201],"PFS":[202],"pelareorep-treated":[204],"(adjusted":[206],"p":[207,236],"=":[208,237],"0.05).":[209],"This":[210],"effect":[211],"non-pelareorep":[216],"The":[219],"luminal,":[220],"but":[221],"cytoplasmic":[224],"immunohistochemistry":[225],"score,":[226],"highly":[228],"correlated":[229],"CEACAM6,":[235],"0.001.":[238],"Modulation":[239],"vitro":[243],"vivo":[246],"are":[247],"underway.":[248],"Conclusions:":[249],"candidate":[254],"biomarker":[255],"sensitivity":[257],"and,":[260],"theory,":[262],"could":[263],"trafficking":[266],"this":[268],"compound":[269],"tumor":[271],"cells.":[272],"Clinical":[273],"information:":[275],"NCT01280058":[276],".":[277],"[Table:":[278],"see":[279],"text]":[280]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-02-14T00:00:00"}
