{"id":"https://openalex.org/W3005099565","doi":"https://doi.org/10.1097/qad.0000000000002485","title":"Early antiretroviral therapy-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T-cell and B-cell memory","display_name":"Early antiretroviral therapy-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T-cell and B-cell memory","publication_year":2020,"publication_date":"2020-02-06","ids":{"openalex":"https://openalex.org/W3005099565","doi":"https://doi.org/10.1097/qad.0000000000002485","mag":"3005099565","pmid":"https://pubmed.ncbi.nlm.nih.gov/32167989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7531185"},"language":"en","primary_location":{"id":"doi:10.1097/qad.0000000000002485","doi":"https://doi.org/10.1097/qad.0000000000002485","is_oa":true,"landing_page_url":"https://doi.org/10.1097/qad.0000000000002485","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/qad.0000000000002485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086171339","display_name":"Nicola Cotugno","orcid":"https://orcid.org/0000-0002-7748-1581","observed_orcids":["https://orcid.org/0000-0002-7748-1581"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Nicola Cotugno","raw_affiliation_strings":["Department of Systems Medicine, Chair of Paediatrics, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, Chair of Paediatrics, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007092872","display_name":"Francesca Rocchi","orcid":"https://orcid.org/0000-0002-4255-0823","observed_orcids":["https://orcid.org/0000-0002-4255-0823","https://orcid.org/0000-0002-3243-9291"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Elena Morrocchi","raw_affiliation_strings":["Department of Systems Medicine, Chair of Paediatrics, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, Chair of Paediatrics, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003816502","display_name":"Stefano Rinaldi","orcid":"https://orcid.org/0000-0002-1499-4435","observed_orcids":["https://orcid.org/0000-0002-1499-4435"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Rinaldi","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami Miller School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063378391","display_name":"Salvatore Rocca","orcid":"https://orcid.org/0000-0002-2264-6158","observed_orcids":["https://orcid.org/0000-0002-2264-6158"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Rocca","raw_affiliation_strings":["Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028148787","display_name":"Ilaria Pepponi","orcid":"https://orcid.org/0000-0001-7610-738X","observed_orcids":["https://orcid.org/0000-0001-7610-738X"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Pepponi","raw_affiliation_strings":["Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039552244","display_name":"Silvia Di Cesare","orcid":"https://orcid.org/0000-0002-9912-7997","observed_orcids":["https://orcid.org/0000-0002-9912-7997"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia di Cesare","raw_affiliation_strings":["Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079172808","display_name":"Stefania Bernardi","orcid":"https://orcid.org/0000-0001-5672-0881","observed_orcids":["https://orcid.org/0000-0001-5672-0881"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Bernardi","raw_affiliation_strings":["Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074694529","display_name":"Paola Zangari","orcid":"https://orcid.org/0000-0003-0892-6222","observed_orcids":["https://orcid.org/0000-0003-0892-6222"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Zangari","raw_affiliation_strings":["Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024777848","display_name":"Suresh Pallikkuth","orcid":"https://orcid.org/0000-0003-4451-8859","observed_orcids":["https://orcid.org/0000-0003-4451-8859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh Pallikkuth","raw_affiliation_strings":["Department of Microbiology and Immunology, Miami Center for AIDS Research USA. Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Miami Center for AIDS Research USA. Miami","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010096706","display_name":"Lesley R. de Armas","orcid":"https://orcid.org/0000-0002-3720-8361","observed_orcids":["https://orcid.org/0000-0002-3720-8361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lesley de Armas","raw_affiliation_strings":["Department of Microbiology and Immunology, Miami Center for AIDS Research USA. Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Miami Center for AIDS Research USA. Miami","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068050214","display_name":"Ofer Levy","orcid":"https://orcid.org/0000-0002-5859-1945","observed_orcids":["https://orcid.org/0000-0002-5859-1945","https://orcid.org/0000-0003-1095-6156","https://orcid.org/0000-0003-2606-7484"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ofer Levy","raw_affiliation_strings":["Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA","Harvard Medical School, Boston","Precision Vaccines Program, Boston Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Precision Vaccines Program, Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068643623","display_name":"Paolo Rossi","orcid":"https://orcid.org/0000-0003-2620-7918","observed_orcids":["https://orcid.org/0000-0003-2620-7918"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Rossi","raw_affiliation_strings":["Department of Systems Medicine, Chair of Paediatrics, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, Chair of Paediatrics, University of Rome \u2018Tor Vergata\u2019, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002278563","display_name":"Savita G. Pahwa","orcid":"https://orcid.org/0000-0002-4470-4216","observed_orcids":["https://orcid.org/0000-0002-4470-4216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Savita Pahwa","raw_affiliation_strings":["Department of Microbiology and Immunology, Miami Center for AIDS Research USA. Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Miami Center for AIDS Research USA. Miami","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026539734","display_name":"Paolo Palma","orcid":"https://orcid.org/0000-0002-3066-4719","observed_orcids":["https://orcid.org/0000-0002-3066-4719"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Palma","raw_affiliation_strings":["Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit of Congenital and Perinatal Infections, Bambino Ges\u00f9 Childrens\u2019 Hospital, IRCCS","institution_ids":["https://openalex.org/I4210123352"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007092872","https://openalex.org/A5086171339"],"corresponding_institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4210123352"],"apc_list":null,"apc_paid":null,"fwci":1.7341,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83880309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"34","issue":"5","first_page":"669","last_page":"680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.9089999794960022},{"id":"https://openalex.org/keywords/early-antiretroviral-therapy","display_name":"early antiretroviral therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/il-21","display_name":"IL-21","score":0.8230000138282776},{"id":"https://openalex.org/keywords/b-cell-maturation","display_name":"B cell maturation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7210000157356262},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.5540000200271606},{"id":"https://openalex.org/keywords/t-cell-cytokine-production","display_name":"T cell cytokine production","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.776032567024231},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.5921136736869812},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5435601472854614},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5182873606681824},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4922102987766266},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4781673550605774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.468323290348053},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.4669528901576996},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.4502323865890503},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.42786264419555664},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.3893032371997833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35576486587524414},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3307546377182007},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018023","descriptor_name":"HIV Seronegativity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/qad.0000000000002485","doi":"https://doi.org/10.1097/qad.0000000000002485","is_oa":true,"landing_page_url":"https://doi.org/10.1097/qad.0000000000002485","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:32167989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32167989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7531185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7531185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AIDS","raw_type":"Text"},{"id":"pmh:oai:art.torvergata.it:2108/230759","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/230759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1097/qad.0000000000002485","doi":"https://doi.org/10.1097/qad.0000000000002485","is_oa":true,"landing_page_url":"https://doi.org/10.1097/qad.0000000000002485","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2893880928","display_name":"Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity","funder_award_id":"U19AI118608","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3283394321","display_name":"Antibody Responses in HIV and Aging","funder_award_id":"R01AI108472","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4825007437","display_name":"Immunity and HIV persistence in perinatal HIV infection","funder_award_id":"R01AI127347","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7568930575","display_name":"Targeting HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccines","funder_award_id":"U01AI135941","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000913280","display_name":"Miami Center for AIDS Research","funder_award_id":"P30AI073961","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1943288924","https://openalex.org/W1964885539","https://openalex.org/W1969256234","https://openalex.org/W1978693882","https://openalex.org/W1994826373","https://openalex.org/W2009900263","https://openalex.org/W2021114887","https://openalex.org/W2055421080","https://openalex.org/W2058669155","https://openalex.org/W2058744963","https://openalex.org/W2062362511","https://openalex.org/W2068243193","https://openalex.org/W2071330332","https://openalex.org/W2076274573","https://openalex.org/W2082685142","https://openalex.org/W2099069940","https://openalex.org/W2126156212","https://openalex.org/W2131640081","https://openalex.org/W2135390958","https://openalex.org/W2135669160","https://openalex.org/W2145863170","https://openalex.org/W2154931971","https://openalex.org/W2162453519","https://openalex.org/W2167835546","https://openalex.org/W2210832170","https://openalex.org/W2256205628","https://openalex.org/W2266921405","https://openalex.org/W2434557170","https://openalex.org/W2466872787","https://openalex.org/W2479292467","https://openalex.org/W2488623126","https://openalex.org/W2512784295","https://openalex.org/W2585630086","https://openalex.org/W2754619849","https://openalex.org/W2791204842","https://openalex.org/W2797581063","https://openalex.org/W2802888684","https://openalex.org/W2889432491","https://openalex.org/W2891608292","https://openalex.org/W2896466169","https://openalex.org/W2920132785","https://openalex.org/W2929204783","https://openalex.org/W7073902061"],"related_works":["https://openalex.org/W4313384038","https://openalex.org/W2090099177","https://openalex.org/W1495714471","https://openalex.org/W2998017941","https://openalex.org/W4410859685","https://openalex.org/W4408187596","https://openalex.org/W7056065468","https://openalex.org/W2401653437","https://openalex.org/W2936142236","https://openalex.org/W2045724785"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"long-term":[3],"persistence":[4],"of":[5,18,33,67,123,158,198,230,239],"HIV-specific":[6,202],"lymphocyte":[7],"immunity":[8],"in":[9,81,88,93,117,125,131,140,152,161,190,209],"perinatally":[10,22],"HIV-infected":[11,23],"children":[12,24],"treated":[13,211],"within":[14,29],"the":[15,30],"first":[16,31],"year":[17,32],"life.":[19],"DESIGN:":[20],"Twenty":[21],"who":[25],"received":[26],"ART":[27],"therapy":[28],"life":[34],"(early":[35],"treated)":[36],"and":[37,57,62,70,72,84,110,164,169,178,205,217,225],"with":[38,98,149],"stable":[39],"viral":[40],"control":[41],"(>5":[42],"years)":[43],"were":[44,76,184],"grouped":[45],"according":[46],"to":[47,51,95,174],"their":[48,213],"serological":[49,214],"response":[50,94],"HIV.":[52],"METHODS:":[53],"Western":[54],"blot":[55],"analysis":[56],"ELISA":[58],"defined":[59],"14":[60],"HIV-seropositive":[61],"six":[63],"seronegative":[64],"patients.":[65],"Frequencies":[66],"gp140-specific":[68,90,126,143,222,231],"T-cell":[69,73,223],"B-cell,":[71],"cytokine":[74],"production":[75,122,176],"quantified":[77],"by":[78,103,221,226],"flow":[79],"cytometry":[80],"both":[82,118],"seronegatives":[83,134,191],"seropositives.":[85],"Transcriptional":[86],"signatures":[87,229],"purified":[89],"B-cell":[91,170,199],"subsets,":[92],"in-vitro":[96,188,235],"stimulation":[97,148,181,189],"HIV":[99,150],"peptides":[100,151],"was":[101,129],"evaluated":[102],"multiplex":[104],"RT-PCR.":[105],"RESULTS:":[106],"Gp140-specific":[107],"T":[108,127,206],"cells":[109,112,128,146,207,233],"B":[111,145,204,232],"persist":[113,208],"at":[114],"similar":[115],"levels":[116],"groups.":[119],"A":[120],"higher":[121],"IL-21":[124],"found":[130],"seropositives":[132,193,218],"vs.":[133,192],"(P":[135],"=":[136],"0.003).":[137],"Gene":[138],"expression":[139,157],"switched":[141],"IgM-IgD-":[142],"memory":[144,203],"after":[147,166,187,234],"vitro":[153],"demonstrated":[154],"a":[155,195,240],"differential":[156],"genes":[159],"involved":[160],"signal":[162],"transduction":[163],"activation":[165],"BCR/TLR":[167],"triggering":[168],"activation.":[171],"Genes":[172],"relating":[173],"antibody":[175],"(PRDM1)":[177],"T-B":[179],"cognate":[180],"(CXCR4,":[182],"IL21R)":[183],"differentially":[185],"induced":[186],"suggesting":[194],"truncated":[196],"process":[197],"maturation.":[200],"CONCLUSION:":[201],"early":[210],"regardless":[212],"status.":[215],"Seronegatives":[216],"are":[219],"distinguished":[220],"function":[224],"distinct":[227],"transcriptional":[228],"stimulation,":[236],"presumably":[237],"because":[238],"different":[241],"antigen":[242],"exposure.":[243],"Such":[244],"qualitative":[245],"insights":[246],"may":[247],"inform":[248],"future":[249],"immunotherapeutic":[250],"interventions.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-02-14T00:00:00"}
