{"id":"https://openalex.org/W3005050600","doi":"https://doi.org/10.1002/ygh2.390","title":"Cost\u2010effectiveness of integrating gut microbiota analysis into hospitalisation prediction in cirrhosis","display_name":"Cost\u2010effectiveness of integrating gut microbiota analysis into hospitalisation prediction in cirrhosis","publication_year":2020,"publication_date":"2020-02-06","ids":{"openalex":"https://openalex.org/W3005050600","doi":"https://doi.org/10.1002/ygh2.390","mag":"3005050600","pmid":"https://pubmed.ncbi.nlm.nih.gov/33071650","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7567123"},"language":"en","primary_location":{"id":"doi:10.1002/ygh2.390","doi":"https://doi.org/10.1002/ygh2.390","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ygh2.390","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ygh2.390","source":{"id":"https://openalex.org/S4210214149","display_name":"GastroHep","issn_l":"1478-1239","issn":["1478-1239"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GastroHep","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ygh2.390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067770887","display_name":"Jasmohan Singh Bajaj","orcid":"https://orcid.org/0000-0003-4928-3681","observed_orcids":["https://orcid.org/0000-0003-4928-3681"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jasmohan S. Bajaj","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4928-3681","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033030105","display_name":"Chathur Acharya","orcid":"https://orcid.org/0000-0002-6512-4552","observed_orcids":["https://orcid.org/0000-0002-6512-4552"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chathur Acharya","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6512-4552","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083068675","display_name":"Masoumeh Sikaroodi","orcid":"https://orcid.org/0000-0002-8592-1145","observed_orcids":["https://orcid.org/0000-0002-8592-1145"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masoumeh Sikaroodi","raw_affiliation_strings":["Microbiome Analysis Center, George Mason University, Manassas, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analysis Center, George Mason University, Manassas, VA, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024426792","display_name":"Patrick Martin Gillevet","orcid":"https://orcid.org/0000-0001-7734-5566","observed_orcids":["https://orcid.org/0000-0001-7734-5566"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Gillevet","raw_affiliation_strings":["Microbiome Analysis Center, George Mason University, Manassas, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiome Analysis Center, George Mason University, Manassas, VA, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012827359","display_name":"Leroy R. Thacker","orcid":"https://orcid.org/0000-0001-9805-3909","observed_orcids":["https://orcid.org/0000-0001-9805-3909"]},"institutions":[{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leroy R. Thacker","raw_affiliation_strings":["Department of Biostatistics, Virginia Commonwealth University Medical Center, Richmond, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Virginia Commonwealth University Medical Center, Richmond, VA, USA","institution_ids":["https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067770887"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.4952,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.59849133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2","issue":"2","first_page":"79","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hospital-readmission-prediction","display_name":"hospital readmission prediction","score":0.7630000114440918},{"id":"https://openalex.org/keywords/16s-rrna-gene-sequencing","display_name":"16S rRNA gene sequencing","score":0.9079999923706055},{"id":"https://openalex.org/keywords/metagenomics","display_name":"metagenomics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.574999988079071},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.9290000200271606},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6252707242965698},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4764140844345093},{"id":"https://openalex.org/C2983335822","wikidata":"https://www.wikidata.org/wiki/Q942582","display_name":"Cost analysis","level":2,"score":0.4144798815250397},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3882424235343933},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3533892035484314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3514958322048187},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.329983115196228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27995535731315613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2499922215938568},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.2271859049797058},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19523301720619202},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15377700328826904}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/ygh2.390","doi":"https://doi.org/10.1002/ygh2.390","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ygh2.390","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ygh2.390","source":{"id":"https://openalex.org/S4210214149","display_name":"GastroHep","issn_l":"1478-1239","issn":["1478-1239"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GastroHep","raw_type":"journal-article"},{"id":"pmid:33071650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33071650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GastroHep","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7567123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7567123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"GastroHep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/ygh2.390","doi":"https://doi.org/10.1002/ygh2.390","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ygh2.390","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ygh2.390","source":{"id":"https://openalex.org/S4210214149","display_name":"GastroHep","issn_l":"1478-1239","issn":["1478-1239"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GastroHep","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G156308804","display_name":null,"funder_award_id":"R01HS025412","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G2892885354","display_name":null,"funder_award_id":"R21HS024004","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"},{"id":"https://openalex.org/G3479891709","display_name":null,"funder_award_id":"I01 CX001076","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G368076639","display_name":null,"funder_award_id":"2I0CX001076","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G7992464556","display_name":"Modulation of Gut-Brain Axis Using Fecal Microbiome Transplant Capsules in Cirrhosis","funder_award_id":"R21TR002024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3005050600.pdf","grobid_xml":"https://content.openalex.org/works/W3005050600.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1518286619","https://openalex.org/W2048457974","https://openalex.org/W2078799829","https://openalex.org/W2091059988","https://openalex.org/W2123148741","https://openalex.org/W2127497497","https://openalex.org/W2142200501","https://openalex.org/W2153975492","https://openalex.org/W2159845343","https://openalex.org/W2162742658","https://openalex.org/W2170325206","https://openalex.org/W2202114114","https://openalex.org/W2301201889","https://openalex.org/W2330298674","https://openalex.org/W2332285453","https://openalex.org/W2337704259","https://openalex.org/W2404566241","https://openalex.org/W2492106461","https://openalex.org/W2527420458","https://openalex.org/W2573649779","https://openalex.org/W2620821479","https://openalex.org/W2636014882","https://openalex.org/W2791082239","https://openalex.org/W2791636223","https://openalex.org/W2793640830","https://openalex.org/W2794227528","https://openalex.org/W2800122300","https://openalex.org/W2807338956","https://openalex.org/W2883272774","https://openalex.org/W2884990061","https://openalex.org/W2885504931","https://openalex.org/W2890526629","https://openalex.org/W2890906710","https://openalex.org/W2898712323","https://openalex.org/W2912285354","https://openalex.org/W2913987398","https://openalex.org/W2937433371","https://openalex.org/W2938740358","https://openalex.org/W2943140621","https://openalex.org/W2945296904"],"related_works":["https://openalex.org/W2412667562","https://openalex.org/W2793640830","https://openalex.org/W7213864700","https://openalex.org/W4288748591","https://openalex.org/W4399585046","https://openalex.org/W2404566241","https://openalex.org/W2113270082","https://openalex.org/W1985561538","https://openalex.org/W2789583779","https://openalex.org/W4410174153"],"abstract_inverted_index":{"BACKGROUND:":[0],"Admissions":[1,14],"in":[2,45,52,221],"cirrhosis":[3,61,222],"are":[4],"expensive":[5],"and":[6,47,75,91,102,111,123,135,145,154,163,185,216],"often":[7],"unpredictable":[8],"based":[9],"on":[10],"purely":[11],"clinical":[12,43],"variables.":[13],"could":[15],"be":[16],"related":[17],"to":[18,42,80],"complications":[19],"associated":[20],"with":[21,156],"gut":[22,39],"microbial":[23],"changes,":[24],"which":[25],"can":[26],"improve":[27],"prognostication.":[28],"However,":[29],"the":[30,108,197,238],"cost-effectiveness":[31,36,104],"is":[32,212],"unclear.":[33],"AIMS:":[34],"Determine":[35],"of":[37,50,59,85,93,98,133,160,226],"adding":[38],"microbiota":[40,68,138,210],"analysis":[41,139,211],"parameters":[44],"prediction":[46],"subsequent":[48],"reduction":[49,175],"admissions":[51,86,148,164,220],"cirrhosis.":[53],"METHODS:":[54],"Using":[55,130],"a":[56],"Markov":[57],"model":[58],"1000":[60],"patients":[62],"over":[63,223],"90":[64],"days,":[65],"we":[66],"modeled":[67],"testing":[69],"using":[70,87],"16srRNA":[71],"($250/sample),":[72],"low-depth":[73],"($350/sample)":[74],"high-depth":[76],"($650/sample)":[77],"metagenomics":[78],"added":[79],"standard-of-care":[81],"(SOC)":[82],"for":[83,107,118,178,183,189,203,214],"prevention":[84],"standard":[88,225],"outcome":[89,136],"costs":[90,117,132,159],"rates":[92,125],"development.":[94],"We":[95],"generated":[96],"quality":[97],"life":[99],"years":[100],"(QALY)":[101],"Incremental":[103],"ratios":[105],"(ICER)":[106],"base":[109],"scenarios":[110],"performed":[112],"sensitivity":[113,234],"analyses":[114,235],"by":[115,151],"varying":[116],"outcomes":[119,134],"(transplant,":[120],"death,":[121],"admission)":[122],"admission":[124,199,240],"(40%,":[126],"range":[127],"25%-60%).":[128],"RESULTS:":[129],"fixed":[131],"rates,":[137],"was":[140,173,201],"cost-saving":[141,229],"($47K-$97K)":[142],"at":[143],"$250":[144],"$350/sample":[146,184],"if":[147],"were":[149,165],"reduced":[150],"5%over":[152],"SOC":[153],">10%":[155],"$650/sample.":[157,190],"When":[158],"LT,":[161],"death":[162],"varied,":[166],"these":[167],"cost-savings":[168,192],"remained":[169,193,230],"robust":[170,194,231],"provided":[171],"there":[172],">2.1%":[174],"(range":[176,181,187],"1.3%-3.2%)":[177],"$250/sample,":[179],">2.9%":[180],"1.8%-4.4%)":[182],">5.4%":[186],"3.3%-8.2%)":[188],"These":[191],"even":[195,232],"when":[196],"assumed":[198],"rate":[200],"varied":[202,237],"all":[204],"sample":[205],"cost":[206],"values.":[207],"CONCLUSIONS:":[208],"Gut":[209],"cost-effective":[213],"predicting":[215],"potentially":[217],"preventing":[218],"90-day":[219],"current":[224],"care.":[227],"This":[228],"after":[233],"that":[236],"background":[239],"rates.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-02-14T00:00:00"}
