{"id":"https://openalex.org/W3004945402","doi":null,"title":"Prognostic impact of KRAS and BRAF mutations in patients who underwent simultaneous resection for initially resectable colorectal liver metastases.","display_name":"Prognostic impact of KRAS and BRAF mutations in patients who underwent simultaneous resection for initially resectable colorectal liver metastases.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3004945402","mag":"3004945402","pmid":"https://pubmed.ncbi.nlm.nih.gov/31949686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963078"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5916419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963078","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100326337","display_name":"Qi Lin","orcid":"https://orcid.org/0000-0001-5154-1366","observed_orcids":["https://orcid.org/0000-0001-5154-1366"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Lin","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088306943","display_name":"Mi Jian","orcid":"https://orcid.org/0000-0001-8851-0811","observed_orcids":["https://orcid.org/0000-0001-8851-0811"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mi Jian","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102151161","display_name":"Zhengchuan Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng-Chuan Niu","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108238251","display_name":"Pingping Xu","orcid":"https://orcid.org/0009-0009-7522-6585","observed_orcids":["https://orcid.org/0009-0009-7522-6585"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping-Ping Xu","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103267207","display_name":"Peng Zheng","orcid":"https://orcid.org/0000-0001-6595-7477","observed_orcids":["https://orcid.org/0000-0001-6595-7477"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zheng","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100622260","display_name":"Jianmin Xu","orcid":"https://orcid.org/0000-0002-5462-8421","observed_orcids":["https://orcid.org/0000-0002-5462-8421"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Min Xu","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1043,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.44923021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"11","issue":"12","first_page":"5981","last_page":"5991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.906000018119812},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":1.0},{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.9670000076293945},{"id":"https://openalex.org/keywords/synchronous-resection","display_name":"simultaneous resection","score":0.7419999837875366},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.800000011920929},{"id":"https://openalex.org/keywords/precision-surgery","display_name":"precision surgery","score":0.8700000047683716},{"id":"https://openalex.org/keywords/resectability","display_name":"resectability","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9404418468475342},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8418077230453491},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7566980123519897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7183243036270142},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5862672328948975},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.585541844367981},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.47634652256965637},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4379667043685913},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.432519793510437},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4315495491027832},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4298189580440521},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.381666898727417},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31224381923675537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10851317644119263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09390148520469666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5916419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31949686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6963078","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6963078/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3004945402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31949686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5916419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6963078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1520183139","https://openalex.org/W1527958696","https://openalex.org/W1535319703","https://openalex.org/W1553251238","https://openalex.org/W1586939666","https://openalex.org/W1597604324","https://openalex.org/W1970844261","https://openalex.org/W1976550982","https://openalex.org/W1980714336","https://openalex.org/W1983494252","https://openalex.org/W1984008327","https://openalex.org/W1984449916","https://openalex.org/W1985645498","https://openalex.org/W1987403189","https://openalex.org/W1990162237","https://openalex.org/W1994078883","https://openalex.org/W1998728654","https://openalex.org/W2013269714","https://openalex.org/W2015686545","https://openalex.org/W2029715965","https://openalex.org/W2038202392","https://openalex.org/W2049282019","https://openalex.org/W2063985381","https://openalex.org/W2067240437","https://openalex.org/W2070583523","https://openalex.org/W2085070000","https://openalex.org/W2097998307","https://openalex.org/W2100543432","https://openalex.org/W2111905790","https://openalex.org/W2125229905","https://openalex.org/W2126919363","https://openalex.org/W2131371081","https://openalex.org/W2131413118","https://openalex.org/W2135800465","https://openalex.org/W2138970634","https://openalex.org/W2139168548","https://openalex.org/W2145070131","https://openalex.org/W2153325649","https://openalex.org/W2155311724","https://openalex.org/W2155710441","https://openalex.org/W2165741055","https://openalex.org/W2169206875","https://openalex.org/W2223730291","https://openalex.org/W2225497209","https://openalex.org/W2234830428","https://openalex.org/W2235523093","https://openalex.org/W2301065828","https://openalex.org/W2309451803","https://openalex.org/W2461171250"],"related_works":["https://openalex.org/W2966412933","https://openalex.org/W1586939666","https://openalex.org/W3151362592","https://openalex.org/W2739014137","https://openalex.org/W2802291700","https://openalex.org/W2479947159","https://openalex.org/W7169813089","https://openalex.org/W2225497209","https://openalex.org/W4293029445","https://openalex.org/W2890872350"],"abstract_inverted_index":{"status":[0],"in":[1],"current":[2],"practice":[3],"as":[4],"an":[5],"important":[6],"determinant":[7],"for":[8,11],"precision":[9],"surgery":[10],"initially":[12],"resectable":[13],"SCRLMs.":[14]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-02-14T00:00:00"}