{"id":"https://openalex.org/W3004615009","doi":"https://doi.org/10.1038/s41388-020-1191-x","title":"Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells","display_name":"Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells","publication_year":2020,"publication_date":"2020-02-06","ids":{"openalex":"https://openalex.org/W3004615009","doi":"https://doi.org/10.1038/s41388-020-1191-x","mag":"3004615009","pmid":"https://pubmed.ncbi.nlm.nih.gov/32029902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7118026"},"language":"en","primary_location":{"id":"doi:10.1038/s41388-020-1191-x","doi":"https://doi.org/10.1038/s41388-020-1191-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41388-020-1191-x","pdf_url":"https://www.nature.com/articles/s41388-020-1191-x.pdf","source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41388-020-1191-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058248605","display_name":"Hongge Wang","orcid":"https://orcid.org/0000-0002-7635-779X","observed_orcids":["https://orcid.org/0000-0002-7635-779X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongge Wang","raw_affiliation_strings":["Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066796807","display_name":"Zhang Shan","orcid":"https://orcid.org/0000-0002-7889-4169","observed_orcids":["https://orcid.org/0000-0002-7889-4169"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Zhang","raw_affiliation_strings":["Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021711468","display_name":"Liyan Song","orcid":"https://orcid.org/0000-0001-6545-4351","observed_orcids":["https://orcid.org/0000-0001-6545-4351"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyan Song","raw_affiliation_strings":["Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009024773","display_name":"Meng Qu","orcid":"https://orcid.org/0000-0002-1361-5392","observed_orcids":["https://orcid.org/0000-0002-1361-5392"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Qu","raw_affiliation_strings":["Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103269085","display_name":"Zhihua Zou","orcid":"https://orcid.org/0000-0001-9781-1034","observed_orcids":["https://orcid.org/0000-0001-9781-1034","https://orcid.org/0000-0003-4307-6788"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihua Zou","raw_affiliation_strings":["Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. zouzh@jlu.edu.cn","Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. zouzh@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Cell Biology and Biophysics, National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103269085"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":5.0525,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.96832411,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"39","issue":"14","first_page":"2905","last_page":"2920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alantolactone","display_name":"alantolactone","score":0.9800000190734863},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9869999885559082},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8519999980926514},{"id":"https://openalex.org/keywords/parp-trapping","display_name":"PARP trapping","score":0.7609999775886536},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.9580000042915344},{"id":"https://openalex.org/keywords/thioredoxin-reductase-inhibition","display_name":"thioredoxin reductase inhibition","score":0.9559999704360962},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ogg1","display_name":"OGG1","score":0.8360000252723694},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8659999966621399},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.6499999761581421},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8420000076293945},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.9327644109725952},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.8778039216995239},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.7874643802642822},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7152590751647949},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.6982179284095764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6750171184539795},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.6552011370658875},{"id":"https://openalex.org/C2781312401","wikidata":"https://www.wikidata.org/wiki/Q7919041","display_name":"Veliparib","level":5,"score":0.6108527183532715},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.5818799734115601},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5792493224143982},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5782163143157959},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.550009548664093},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42195650935173035},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4157112240791321},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3311058282852173},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3023476302623749},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2452549934387207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1600494086742401},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.15350443124771118},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11246371269226074},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09809380769729614}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078722","descriptor_name":"PC-3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045787","descriptor_name":"Sesquiterpenes, Eudesmane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41388-020-1191-x","doi":"https://doi.org/10.1038/s41388-020-1191-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41388-020-1191-x","pdf_url":"https://www.nature.com/articles/s41388-020-1191-x.pdf","source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:32029902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32029902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7118026","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7118026/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41388-020-1191-x","doi":"https://doi.org/10.1038/s41388-020-1191-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41388-020-1191-x","pdf_url":"https://www.nature.com/articles/s41388-020-1191-x.pdf","source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G119093077","display_name":null,"funder_award_id":"20180101237JC","funder_id":"https://openalex.org/F4320310121","funder_display_name":"Natural Science Foundation of Jilin Province"}],"funders":[{"id":"https://openalex.org/F4320310121","display_name":"Natural Science Foundation of Jilin Province","ror":null},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3004615009.pdf","grobid_xml":"https://content.openalex.org/works/W3004615009.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1564224574","https://openalex.org/W1848063234","https://openalex.org/W1946213204","https://openalex.org/W1969524738","https://openalex.org/W1973268287","https://openalex.org/W1978331091","https://openalex.org/W1984373702","https://openalex.org/W1993238109","https://openalex.org/W1996311090","https://openalex.org/W1998129814","https://openalex.org/W2009007206","https://openalex.org/W2026405645","https://openalex.org/W2026409525","https://openalex.org/W2031051286","https://openalex.org/W2034980302","https://openalex.org/W2045466228","https://openalex.org/W2056848326","https://openalex.org/W2060534647","https://openalex.org/W2074446011","https://openalex.org/W2077436902","https://openalex.org/W2094503136","https://openalex.org/W2098131661","https://openalex.org/W2098737737","https://openalex.org/W2103770333","https://openalex.org/W2139802796","https://openalex.org/W2142141154","https://openalex.org/W2147129352","https://openalex.org/W2153677655","https://openalex.org/W2154553542","https://openalex.org/W2157962151","https://openalex.org/W2168891239","https://openalex.org/W2179105349","https://openalex.org/W2191097576","https://openalex.org/W2255497797","https://openalex.org/W2295644844","https://openalex.org/W2337636620","https://openalex.org/W2514373129","https://openalex.org/W2539944286","https://openalex.org/W2553815939","https://openalex.org/W2562451460","https://openalex.org/W2562712448","https://openalex.org/W2597062310","https://openalex.org/W2614456022","https://openalex.org/W2621333085","https://openalex.org/W2732346161","https://openalex.org/W2752106298","https://openalex.org/W2756485536","https://openalex.org/W2772360514","https://openalex.org/W2787799922","https://openalex.org/W2790271688","https://openalex.org/W2794532094","https://openalex.org/W2795391593","https://openalex.org/W2800379950","https://openalex.org/W2801988573","https://openalex.org/W2810392784","https://openalex.org/W2893679332","https://openalex.org/W2898088739","https://openalex.org/W2907723942","https://openalex.org/W2911653212","https://openalex.org/W2912840928","https://openalex.org/W2913870207","https://openalex.org/W2925314634","https://openalex.org/W2938284866","https://openalex.org/W2941159973","https://openalex.org/W2946448900","https://openalex.org/W2950070812","https://openalex.org/W4211006558","https://openalex.org/W6675094597"],"related_works":["https://openalex.org/W4205313193","https://openalex.org/W3117375929","https://openalex.org/W2885866858","https://openalex.org/W4283658488","https://openalex.org/W3027186100","https://openalex.org/W3114384525","https://openalex.org/W2485675202","https://openalex.org/W2222392253","https://openalex.org/W2346452932","https://openalex.org/W4319299429"],"abstract_inverted_index":{"Abstract":[0],"PARP1":[1,143],"and":[2,11,23,75,118,149,174,182,192,226],"PARP2":[3],"play":[4],"critical":[5],"roles":[6],"in":[7,51,80,100,112],"regulating":[8],"DNA":[9,77,141,187],"repair":[10,137],"PARP":[12,32,49,95,216,235],"inhibitors":[13,50],"have":[14],"been":[15,29],"approved":[16],"for":[17],"the":[18,59,68,94,122,132,136,146,164,200,231],"treatment":[19],"of":[20,42,48,89,104,128,138,167,172,179,184,205,234],"BRCA1/2-mutated":[21],"ovarian":[22],"breast":[24],"cancers.":[25],"It":[26],"has":[27],"long":[28],"known":[30],"that":[31,86,131],"inhibition":[33],"sensitizes":[34],"cancer":[35,81,113],"cells":[36,117],"to":[37,71,98,190,229],"DNA-damaging":[38,54],"cytotoxic":[39],"agents":[40,222],"independent":[41],"BRCA":[43],"status,":[44],"however,":[45],"clinical":[46],"use":[47,171],"combination":[52,201],"with":[53,93,159,219],"chemotherapy":[55],"is":[56],"limited":[57],"by":[58,121,196],"more-than-additive":[60],"cytotoxicity.":[61,168],"The":[62],"natural":[63],"compound":[64],"alantolactone":[65],"(ATL)":[66],"inhibits":[67],"thioredoxin":[69],"reductase":[70],"induce":[72],"ROS":[73,123],"accumulation":[74],"oxidative":[76,140],"damage":[78],"selectively":[79],"cells.":[82],"Here,":[83],"we":[84],"showed":[85],"nontoxic":[87],"doses":[88],"ATL":[90,173],"markedly":[91],"synergized":[92],"inhibitor":[96,124],"olaparib":[97,150,175],"result":[99],"synthetic":[101],"lethality":[102,148],"irrespective":[103],"homologous":[105],"recombination":[106],"status.":[107],"Synergistic":[108],"cytotoxicity":[109,133],"was":[110,119,151],"seen":[111],"but":[114],"not":[115],"noncancerous":[116],"reduced":[120],"NAC":[125],"or":[126],"knockdown":[127,144],"OGG1,":[129],"demonstrating":[130],"resulted":[134],"from":[135],"ATL-induced":[139],"damage.":[142],"suppressed":[145],"synergistic":[147],"much":[152],"more":[153],"toxic":[154],"than":[155],"veliparib":[156],"when":[157],"combined":[158,170,218],"ATL,":[160],"suggesting":[161],"PARP-trapping":[162],"as":[163],"primary":[165],"inducer":[166],"Consistently,":[169],"caused":[176],"intense":[177],"signs":[178],"replication":[180],"stress":[181],"formation":[183],"double":[185],"strand":[186],"breaks,":[188],"leading":[189],"S":[191],"G2":[193],"arrest":[194],"followed":[195],"apoptosis.":[197],"In":[198],"vivo,":[199],"effectively":[202],"induced":[203],"regression":[204],"tumor":[206],"xenografts,":[207],"while":[208],"either":[209],"agent":[210],"alone":[211],"had":[212],"no":[213],"effect.":[214],"Hence,":[215],"trapping":[217],"specific":[220],"pro-oxidative":[221],"may":[223],"provide":[224],"safe":[225],"effective":[227],"ways":[228],"broaden":[230],"therapeutic":[232],"potential":[233],"inhibitors.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-02-14T00:00:00"}
