{"id":"https://openalex.org/W3004287828","doi":"https://doi.org/10.1158/1535-7163.targ-19-b093","title":"Abstract B093: 50 gene breast cancer (BC) RNA subtype classifier and colorectal cancer (CRC) CMS subtype classifier applied to 90 prostate cancer (PC) patients reveals distinct subtype differences","display_name":"Abstract B093: 50 gene breast cancer (BC) RNA subtype classifier and colorectal cancer (CRC) CMS subtype classifier applied to 90 prostate cancer (PC) patients reveals distinct subtype differences","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W3004287828","doi":"https://doi.org/10.1158/1535-7163.targ-19-b093","mag":"3004287828"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-19-b093","doi":"https://doi.org/10.1158/1535-7163.targ-19-b093","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-19-b093","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062107881","display_name":"Jacob J. Adashek","orcid":"https://orcid.org/0000-0003-4272-312X","observed_orcids":["https://orcid.org/0000-0003-4272-312X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob J Adashek","raw_affiliation_strings":["1University of South Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of South Florida, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL;","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041033274","display_name":"Sumanta Kumar Pal","orcid":"https://orcid.org/0000-0002-1712-0848","observed_orcids":["https://orcid.org/0000-0002-1712-0848"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumanta K Pal","raw_affiliation_strings":["2City of Hope Comprehensive Cancer Center, Duarte, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2City of Hope Comprehensive Cancer Center, Duarte, CA;","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033331007","display_name":"Saihitha Veerapaneni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saihitha Veerapaneni","raw_affiliation_strings":["3ImmunityBio, Santa Cruz, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3ImmunityBio, Santa Cruz, CA;","institution_ids":["https://openalex.org/I4210144466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055303411","display_name":"Elias I. Obeid","orcid":"https://orcid.org/0000-0001-5120-9435","observed_orcids":["https://orcid.org/0000-0001-5120-9435"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Obeid","raw_affiliation_strings":["4Fox Chase Cancer Center, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Fox Chase Cancer Center, Philadelphia, PA;","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091310696","display_name":"Christopher W. Szeto","orcid":"https://orcid.org/0000-0002-2344-7716","observed_orcids":["https://orcid.org/0000-0002-2344-7716"]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W Szeto","raw_affiliation_strings":["3ImmunityBio, Santa Cruz, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3ImmunityBio, Santa Cruz, CA;","institution_ids":["https://openalex.org/I4210144466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077908907","display_name":"Sandeep K. Reddy","orcid":"https://orcid.org/0000-0002-1458-6853","observed_orcids":["https://orcid.org/0000-0002-1458-6853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandeep K Reddy","raw_affiliation_strings":["5NantHealth, Culver City, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5NantHealth, Culver City, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055269586","display_name":"Roberto Henrique Nussenzveig","orcid":"https://orcid.org/0000-0003-2612-1348","observed_orcids":["https://orcid.org/0000-0003-2612-1348"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Nussenzveig","raw_affiliation_strings":["6Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100763587","display_name":"Neeraj Agarwal","orcid":"https://orcid.org/0000-0003-1076-0428","observed_orcids":["https://orcid.org/0000-0003-1076-0428","https://orcid.org/0000-0001-6574-8499"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neeraj Agarwal","raw_affiliation_strings":["6Huntsman Cancer Institute, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Huntsman Cancer Institute, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"12_Supplement","first_page":"B093","last_page":"B093"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/breast-cancer-intrinsic-subtypes","display_name":"breast cancer intrinsic subtypes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/consensus-molecular-subtypes","display_name":"consensus molecular subtypes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/luminal-a-subtype","display_name":"luminal A","score":0.7229999899864197},{"id":"https://openalex.org/keywords/luminal-b","display_name":"luminal B","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tmprss2-erg-fusion","display_name":"TMPRSS2-ERG fusion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/spop-mutations","display_name":"SPOP mutations","score":0.5289999842643738},{"id":"https://openalex.org/keywords/foxa1-mutations","display_name":"FOXA1 mutations","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4359999895095825},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.7194998264312744},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6771048307418823},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5158364176750183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5081427097320557},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48906001448631287},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4876950681209564},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.48537981510162354},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4598781168460846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4173855781555176},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41343575716018677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36352288722991943},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.22064551711082458},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20271602272987366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-19-b093","doi":"https://doi.org/10.1158/1535-7163.targ-19-b093","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-19-b093","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3004897521","https://openalex.org/W2981410747","https://openalex.org/W3127172910","https://openalex.org/W4248182031","https://openalex.org/W2156397926","https://openalex.org/W7096869446","https://openalex.org/W2947669958","https://openalex.org/W2590277577","https://openalex.org/W4280587240","https://openalex.org/W2028296678"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"BC":[2,139,156,172,313],"and":[3,29,65,88,97,107,121,124,142,158,169,186,202,216,256,271,280,359,388],"CRC":[4,38,315],"are":[5,212,218],"heterogeneous":[6],"diseases":[7],"with":[8,302],"several":[9],"distinct":[10,374],"disease":[11],"subtypes.":[12],"A":[13],"50-gene":[14,108,255],"qPCR":[15],"assay":[16,148],"(PAM50)":[17],"identifies":[18,40],"5":[19,155],"intrinsic":[20],"biological":[21],"subtypes:":[22,42],"luminal":[23,25],"A,":[24,178],"B,":[26,181],"HER2-enriched,":[27,183],"basal-like,":[28],"normal-like":[30],"in":[31,37,100,227,287,297,306,326],"breast":[32,109,353],"cancer.":[33],"Consensus":[34],"molecular":[35,82,101],"subtype":[36,173,193,262,357,364,375],"(CMS)":[39],"4":[41],"CMS1-4.":[43],"PC":[44,75,102,153,163,251],"can":[45],"be":[46],"classified":[47,188],"by":[48,268],"specific":[49,60],"genomic":[50,87],"rearrangements,":[51],"such":[52,62],"as":[53,63,189,263,277],"the":[54,93,105,264,381],"TMPRSS2-ERG":[55],"fusion":[56],"occur":[57],"or":[58,67,314],"whether":[59],"mutations":[61,99,226],"SPOP":[64],"FOXA1":[66],"germline":[68,98,123,224,295,324],"BRCA":[69],"is":[70,300,317],"present,":[71],"yet":[72],"25%":[73],"of":[74,95,223,292,321,380],"remains":[76],"difficult":[77],"to":[78,91,151,230,367],"classify":[79,152],"based":[80,145],"on":[81,115,146,385],"drivers.":[83],"We":[84],"used":[85,150],"comprehensive":[86],"transcriptomic":[89,128],"data":[90,134],"determine":[92],"association":[94],"somatic":[96,304,309],"subtypes":[103,157],"using":[104,167,254],"CMS":[106,143,159,192,257,363],"cancer":[110,354,361,370],"classifiers.":[111],"Methods:":[112],"Retrospective":[113],"analysis":[114],"Whole":[116],"exome":[117],"(WES)":[118],"DNA":[119],"tumor":[120],"paired":[122],"matched":[125],"deep":[126],"whole":[127],"sequencing":[129],"(RNA-Seq)":[130],"(\u223c200x106reads":[131],"per":[132],"tumor)":[133],"from":[135],"NantHealth":[136],"was":[137,149,175,195,275],"performed.":[138],"Intrinsic":[140],"Subtypes":[141],"sorting":[144],"RNAseq":[147,168],"into":[154],"1-4.":[160],"Results:":[161],"90":[162,368],"patients":[164,372],"were":[165],"classifiable":[166],"WES":[170],"DNA.":[171],"distribution":[174,194],"64.4%":[176],"Luminal":[177,180],"31.1%":[179],"2.2%":[182,184],"normal-like,":[185],"0":[187,203],"Basal-like.":[190],"The":[191,290],"83.3%":[196],"CMS4,":[197],"15.6%":[198],"CM1,":[199],"1.1%":[200],"CMS3,":[201],"CMS2.":[204],"Overlap":[205],"comparison":[206],"revealed":[207],"that":[208],"almost":[209],"all":[210],"LumA":[211,231,240,261],"CMS4":[213],"(56/58,":[214],"96.6%)":[215],"CMS1":[217,282],"LumB":[219,228,233,274],"(11/14,":[220],"78.6%).":[221],"Analysis":[222],"DDR":[225,237,298,327],"compared":[229],"showed":[232],"has":[234],"significantly":[235],"more":[236],"mutants":[238],"than":[239,323],"(OR":[241],"2.68,":[242],"p":[243],"=":[244],"0.035":[245],"one-sided":[246],"Fishers":[247],"exact":[248],"test).":[249],"Conclusions:":[250],"molecularly":[252],"profiled":[253],"classification":[258],"we":[259],"found":[260],"predominant":[265],"subgroup":[266],"characterized":[267,276],"low":[269],"TMB":[270,279,322],"high":[272],"CMS4.":[273],"higher":[278],"greater":[281],"suggesting":[283],"potential":[284],"immunotherapy":[285],"eligibility":[286],"this":[288],"subtype.":[289],"presence":[291],"potentially":[293],"pathogenic":[294],"variants":[296],"genes":[299],"associated":[301],"subsequent":[303],"increase":[305],"TMB,":[307],"however,":[308],"expression":[310],"subtyping":[311],"(by":[312],"types)":[316],"a":[318],"stronger":[319],"indicator":[320],"pPV":[325],"genes.":[328],"Citation":[329],"Format:":[330],"Jacob":[331],"J":[332],"Adashek,":[333],"Sumanta":[334],"K":[335,345],"Pal,":[336],"Saihitha":[337],"Veerapaneni,":[338],"Elias":[339],"Obeid,":[340],"Christopher":[341],"W":[342],"Szeto,":[343],"Sandeep":[344],"Reddy,":[346],"Roberto":[347],"Nussenzveig,":[348],"Neeraj":[349],"Agarwal.":[350],"50":[351],"gene":[352],"(BC)":[355],"RNA":[356],"classifier":[358,365],"colorectal":[360],"(CRC)":[362],"applied":[366],"prostate":[369],"(PC)":[371],"reveals":[373],"differences":[376],"[abstract].":[377],"In:":[378],"Proceedings":[379],"AACR-NCI-EORTC":[382],"International":[383],"Conference":[384],"Molecular":[386],"Targets":[387],"Cancer":[389,400],"Therapeutics;":[390],"2019":[391],"Oct":[392],"26-30;":[393],"Boston,":[394],"MA.":[395],"Philadelphia":[396],"(PA):":[397],"AACR;":[398],"Mol":[399],"Ther":[401],"2019;18(12":[402],"Suppl):Abstract":[403],"nr":[404],"B093.":[405],"doi:10.1158/1535-7163.TARG-19-B093":[406]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2020-02-07T00:00:00"}