{"id":"https://openalex.org/W3003769080","doi":"https://doi.org/10.1097/aln.0000000000003158","title":"One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery","display_name":"One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery","publication_year":2020,"publication_date":"2020-02-06","ids":{"openalex":"https://openalex.org/W3003769080","doi":"https://doi.org/10.1097/aln.0000000000003158","mag":"3003769080","pmid":"https://pubmed.ncbi.nlm.nih.gov/32022771"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000003158","doi":"https://doi.org/10.1097/aln.0000000000003158","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000003158","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. 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Population Health Research Institute (D.I.S., D.C., S.Y., Y.L.M., A.L., K.B., S.P., P.J.D.) Department of Medicine (D.C., S.Y., G.G., P.J.D.) Department of Health Research Methods, Evidence, and Impact (D.C., S.Y., G.G., Y.L.M., A.L., P.J.D.) Faculty of Health Sciences, Department of Anesthesia (Y.L.M.) Department of Surgery (R.W., A.L.), McMaster University, Hamilton, Ontario, Canada Department of Anaesthesia and Pain Management, Royal Melbourne Hospital and Centre for Integrated Critical Care, University of Melbourne, Melbourne, Australia (K.L.) Public Health and Clinical Epidemiology-Iberoamerican Cochrane Centre, Barcelona, Spain (E.P.) University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada (M.G.) Department of Research, Foundation for Pediatric Cardiology, Institute of Cardiology and Faculty of Health Sciences (Departamento de","Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. 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Department of Surgery (R.W., A.L.), McMaster University, Hamilton, Ontario, Canada Department of Anaesthesia and Pain Management, Royal Melbourne Hospital and Centre for Integrated Critical Care, University of Melbourne, Melbourne, Australia (K.L.) Public Health and Clinical Epidemiology-Iberoamerican Cochrane Centre, Barcelona, Spain (E.P.) University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada (M.G.) Department of Research, Foundation for Pediatric Cardiology, Institute of Cardiology and Faculty of Health Sciences (Departamento de","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I154425047","https://openalex.org/I98251732"]},{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. 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Published online first on February 3, 2020","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","institution_ids":[]},{"raw_affiliation_string":"This article has a visual abstract available in the online version","institution_ids":[]},{"raw_affiliation_string":"This article is featured in \"This Month in Anesthesiology,\" page 1A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018419311","display_name":"Salim Yusuf","orcid":"https://orcid.org/0000-0003-4776-5601","observed_orcids":["https://orcid.org/0000-0003-4776-5601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salim Yusuf","raw_affiliation_strings":["Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. Links to the digital files are provided in the HTML text of this article on the Journal's Web site ()","This article has a visual abstract available in the online version","This article is featured in \"This Month in Anesthesiology,\" page 1A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Submitted for publication January 23, 2019. Accepted for publication December 20, 2019. Published online first on February 3, 2020","institution_ids":[]},{"raw_affiliation_string":"Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are available in both the HTML and PDF versions of this article. 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