{"id":"https://openalex.org/W3003438239","doi":"https://doi.org/10.1016/j.ultramic.2020.112950","title":"Reducing bias and variance for CTF estimation in single particle cryo-EM","display_name":"Reducing bias and variance for CTF estimation in single particle cryo-EM","publication_year":2020,"publication_date":"2020-01-28","ids":{"openalex":"https://openalex.org/W3003438239","doi":"https://doi.org/10.1016/j.ultramic.2020.112950","mag":"3003438239","pmid":"https://pubmed.ncbi.nlm.nih.gov/32151795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9930185"},"language":"en","primary_location":{"id":"doi:10.1016/j.ultramic.2020.112950","doi":"https://doi.org/10.1016/j.ultramic.2020.112950","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ultramic.2020.112950","pdf_url":null,"source":{"id":"https://openalex.org/S27731274","display_name":"Ultramicroscopy","issn_l":"0304-3991","issn":["0304-3991","1879-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultramicroscopy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9930185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034825543","display_name":"Ayelet Heimowitz","orcid":"https://orcid.org/0000-0002-3049-7746","observed_orcids":["https://orcid.org/0000-0002-3049-7746"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ayelet Heimowitz","raw_affiliation_strings":["The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States. Electronic address: aheimowitz@math.princeton.edu","The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States. Electronic address: aheimowitz@math.princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043290570","display_name":"Joakim And\u00e9n","orcid":"https://orcid.org/0000-0002-3377-813X","observed_orcids":["https://orcid.org/0000-0002-3377-813X"]},"institutions":[{"id":"https://openalex.org/I4387153999","display_name":"Flatiron Institute","ror":"https://ror.org/00sekdz59","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210107338","https://openalex.org/I4387153999"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joakim And\u00e9n","raw_affiliation_strings":["Center for Computational Mathematics, Flatiron Institute, New York, NY, United States. Electronic address: janden@flatironinstitute.org","Center for Computational Mathematics, Flatiron Institute, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Mathematics, Flatiron Institute, New York, NY, United States. Electronic address: janden@flatironinstitute.org","institution_ids":["https://openalex.org/I4387153999"]},{"raw_affiliation_string":"Center for Computational Mathematics, Flatiron Institute, New York, NY, United States","institution_ids":["https://openalex.org/I4387153999"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062844820","display_name":"Amit Singer","orcid":"https://orcid.org/0000-0002-6975-7955","observed_orcids":["https://orcid.org/0000-0002-6975-7955"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Singer","raw_affiliation_strings":["The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States; Department of Mathematics, Princeton University, Princeton, NJ, United States. Electronic address: amits@math.princeton.edu","Department of Mathematics, Princeton University, Princeton, NJ, United States","The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States; Department of Mathematics, Princeton University, Princeton, NJ, United States. Electronic address: amits@math.princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Mathematics, Princeton University, Princeton, NJ, United States","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"The Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, United States","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034825543"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":3050,"currency":"USD","value_usd":3050},"apc_paid":null,"fwci":0.8215,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72140957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"212","issue":null,"first_page":"112950","last_page":"112950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13552","display_name":"Advanced Materials Characterization Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-particle-cryo-em","display_name":"single-particle cryo-EM","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bias-mitigation","display_name":"bias mitigation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/variance-reduction","display_name":"variance reduction","score":0.972000002861023},{"id":"https://openalex.org/keywords/background-subtraction","display_name":"background subtraction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/spectral-estimation","display_name":"spectral estimation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/point-spread-function","display_name":"point spread function","score":0.8270000219345093},{"id":"https://openalex.org/keywords/high-resolution-reconstruction","display_name":"high-resolution reconstruction","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C164508769","wikidata":"https://www.wikidata.org/wiki/Q5165765","display_name":"Contrast transfer function","level":4,"score":0.7512357831001282},{"id":"https://openalex.org/C69179731","wikidata":"https://www.wikidata.org/wiki/Q510427","display_name":"Point spread function","level":2,"score":0.6259890794754028},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5871695876121521},{"id":"https://openalex.org/C168110828","wikidata":"https://www.wikidata.org/wiki/Q1331626","display_name":"Spectral density","level":2,"score":0.5247431397438049},{"id":"https://openalex.org/C57493831","wikidata":"https://www.wikidata.org/wiki/Q3134666","display_name":"Projection (relational algebra)","level":2,"score":0.49232614040374756},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.47635531425476074},{"id":"https://openalex.org/C102519508","wikidata":"https://www.wikidata.org/wiki/Q6520159","display_name":"Fourier transform","level":2,"score":0.4486801028251648},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.40838274359703064},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.31085944175720215},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24695292115211487},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24088916182518005},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.23125749826431274},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.21317362785339355},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.16515055298805237},{"id":"https://openalex.org/C70638346","wikidata":"https://www.wikidata.org/wiki/Q2913798","display_name":"Spherical aberration","level":3,"score":0.11195334792137146},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ultramic.2020.112950","doi":"https://doi.org/10.1016/j.ultramic.2020.112950","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ultramic.2020.112950","pdf_url":null,"source":{"id":"https://openalex.org/S27731274","display_name":"Ultramicroscopy","issn_l":"0304-3991","issn":["0304-3991","1879-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultramicroscopy","raw_type":"journal-article"},{"id":"pmid:32151795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32151795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultramicroscopy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9930185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9930185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ultramicroscopy","raw_type":"Text"},{"id":"pmh:oai:arXiv.org:1908.03454","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1908.03454","pdf_url":"https://arxiv.org/pdf/1908.03454","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.1908.03454","doi":"https://doi.org/10.48550/arxiv.1908.03454","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1908.03454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9930185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9930185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ultramicroscopy","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4499850717","display_name":"Reconstruction of heterogeneous and small macromolecules by cyro-EM","funder_award_id":"R01GM136780","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320306202","display_name":"Gordon and Betty Moore Foundation","ror":"https://ror.org/006wxqw41"},{"id":"https://openalex.org/F4320319356","display_name":"Flatiron Health","ror":"https://ror.org/0508h6p74"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3003438239.pdf","grobid_xml":"https://content.openalex.org/works/W3003438239.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W134625316","https://openalex.org/W173335161","https://openalex.org/W563711960","https://openalex.org/W1492556495","https://openalex.org/W1531098265","https://openalex.org/W1617956525","https://openalex.org/W1766888123","https://openalex.org/W1966389522","https://openalex.org/W1980885982","https://openalex.org/W1982295411","https://openalex.org/W1984074868","https://openalex.org/W2002896491","https://openalex.org/W2021429932","https://openalex.org/W2047327060","https://openalex.org/W2058552206","https://openalex.org/W2073949924","https://openalex.org/W2092709807","https://openalex.org/W2097638521","https://openalex.org/W2100455255","https://openalex.org/W2104234755","https://openalex.org/W2106822551","https://openalex.org/W2113804634","https://openalex.org/W2117948104","https://openalex.org/W2138390185","https://openalex.org/W2140818863","https://openalex.org/W2143712883","https://openalex.org/W2155722796","https://openalex.org/W2160559764","https://openalex.org/W2161648329","https://openalex.org/W2167208435","https://openalex.org/W2263224228","https://openalex.org/W2285319343","https://openalex.org/W2286539811","https://openalex.org/W2299689158","https://openalex.org/W2507897606","https://openalex.org/W2552577460","https://openalex.org/W2560172428","https://openalex.org/W2587625522","https://openalex.org/W2588224366","https://openalex.org/W2591444865","https://openalex.org/W2593511418","https://openalex.org/W2772063016","https://openalex.org/W2786417219","https://openalex.org/W2791354025","https://openalex.org/W2900691417","https://openalex.org/W2902148700","https://openalex.org/W2905218526","https://openalex.org/W2950967305","https://openalex.org/W2953320394","https://openalex.org/W4252839115"],"related_works":["https://openalex.org/W2967047871","https://openalex.org/W4410188841","https://openalex.org/W2131690894","https://openalex.org/W2148085578","https://openalex.org/W4399212208","https://openalex.org/W4406695416","https://openalex.org/W2065203671","https://openalex.org/W4403337319","https://openalex.org/W2147443197","https://openalex.org/W2047327060"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-02-07T00:00:00"}