{"id":"https://openalex.org/W3003357230","doi":"https://doi.org/10.11594/jtls.10.01.03","title":"Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling","display_name":"Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling","publication_year":2020,"publication_date":"2020-01-30","ids":{"openalex":"https://openalex.org/W3003357230","doi":"https://doi.org/10.11594/jtls.10.01.03","mag":"3003357230"},"language":"en","primary_location":{"id":"doi:10.11594/jtls.10.01.03","doi":"https://doi.org/10.11594/jtls.10.01.03","is_oa":true,"landing_page_url":"https://doi.org/10.11594/jtls.10.01.03","pdf_url":"https://jtrolis.ub.ac.id/index.php/jtrolis/article/download/1151/pdf","source":{"id":"https://openalex.org/S2764860916","display_name":"Journal of Tropical Life Science","issn_l":"2087-5517","issn":["2087-5517","2527-4376"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tropical Life Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jtrolis.ub.ac.id/index.php/jtrolis/article/download/1151/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038368922","display_name":"Dewi Ratih Tirto Sari","orcid":"https://orcid.org/0000-0002-3937-841X","observed_orcids":["https://orcid.org/0000-0002-3937-841X"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Dewi Ratih Tirto Sari","raw_affiliation_strings":["Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Indonesia \r\nBiology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Indonesia \r\nBiology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013803625","display_name":"Anna Safitri","orcid":"https://orcid.org/0000-0003-4262-8640","observed_orcids":["https://orcid.org/0000-0003-4262-8640"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Anna Safitri","raw_affiliation_strings":["Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Indonesia \r\nDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Indonesia \r\nDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061095593","display_name":"James R. Ketudat Cairns","orcid":"https://orcid.org/0000-0003-3042-1626","observed_orcids":["https://orcid.org/0000-0003-3042-1626"]},"institutions":[{"id":"https://openalex.org/I82475049","display_name":"Suranaree University of Technology","ror":"https://ror.org/05sgb8g78","country_code":"TH","type":"education","lineage":["https://openalex.org/I82475049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"James Robert Ketudat Cairns","raw_affiliation_strings":["School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand","institution_ids":["https://openalex.org/I82475049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087968529","display_name":"Fatchiyah Fatchiyah","orcid":"https://orcid.org/0000-0001-6241-9665","observed_orcids":["https://orcid.org/0000-0001-6241-9665"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Fatchiyah Fatchiyah","raw_affiliation_strings":["Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Indonesia \r\nBiology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Smart Molecule of Natural Genetics Resources, Brawijaya University, Indonesia \r\nBiology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000000,"currency":"IDR","value_usd":196},"apc_paid":{"value":3000000,"currency":"IDR","value_usd":196},"fwci":1.705,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.84110677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4846000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4846000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.2312999963760376,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthocyanins","display_name":"anthocyanins","score":1.0},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9399999976158142},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.9240000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.44999998807907104},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cyanidin-3-o-glucoside","display_name":"cyanidin-3-glucoside","score":0.9509999752044678},{"id":"https://openalex.org/keywords/delphinidin-3-o-glucoside","display_name":"delphinidin-3-glucoside","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pelargonidin-3-o-glucoside","display_name":"pelargonidin-3-glucoside","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peonidin-3-o-glucoside","display_name":"peonidin-3-glucoside","score":0.9980000257492065},{"id":"https://openalex.org/keywords/petunidin-3-o-glucoside","display_name":"petunidin-3-O-glucoside","score":0.9990000128746033},{"id":"https://openalex.org/keywords/malvidin-3-o-glucoside","display_name":"malvidin-3-glucoside","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bir-domain","display_name":"BIR domain","score":0.7940000295639038},{"id":"https://openalex.org/keywords/allosteric-site","display_name":"allosteric site","score":0.7870000004768372},{"id":"https://openalex.org/keywords/natural-product-inhibitors","display_name":"natural product inhibitors","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2778612514","wikidata":"https://www.wikidata.org/wiki/Q3137150","display_name":"Petunidin","level":5,"score":0.7817506790161133},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5815203189849854},{"id":"https://openalex.org/C2781021748","wikidata":"https://www.wikidata.org/wiki/Q367258","display_name":"Delphinidin","level":4,"score":0.5735697150230408},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5672072768211365},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.509491503238678},{"id":"https://openalex.org/C91096171","wikidata":"https://www.wikidata.org/wiki/Q17855901","display_name":"Caspase 7","level":5,"score":0.48110049962997437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4480043053627014},{"id":"https://openalex.org/C158180186","wikidata":"https://www.wikidata.org/wiki/Q278487","display_name":"PubChem","level":2,"score":0.4399494230747223},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.42232874035835266},{"id":"https://openalex.org/C2778945092","wikidata":"https://www.wikidata.org/wiki/Q262547","display_name":"Anthocyanin","level":2,"score":0.4120328724384308},{"id":"https://openalex.org/C2777667348","wikidata":"https://www.wikidata.org/wiki/Q417606","display_name":"Cyanidin","level":3,"score":0.33583781123161316},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3326050341129303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32031697034835815},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.09159877896308899},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0828033983707428},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.11594/jtls.10.01.03","doi":"https://doi.org/10.11594/jtls.10.01.03","is_oa":true,"landing_page_url":"https://doi.org/10.11594/jtls.10.01.03","pdf_url":"https://jtrolis.ub.ac.id/index.php/jtrolis/article/download/1151/pdf","source":{"id":"https://openalex.org/S2764860916","display_name":"Journal of Tropical Life Science","issn_l":"2087-5517","issn":["2087-5517","2527-4376"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tropical Life Science","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ff170ce56c914ba5866b5e1b31db48ce","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ff170ce56c914ba5866b5e1b31db48ce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Tropical Life Science, Vol 10, Iss 1, Pp 15-25 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.11594/jtls.10.01.03","doi":"https://doi.org/10.11594/jtls.10.01.03","is_oa":true,"landing_page_url":"https://doi.org/10.11594/jtls.10.01.03","pdf_url":"https://jtrolis.ub.ac.id/index.php/jtrolis/article/download/1151/pdf","source":{"id":"https://openalex.org/S2764860916","display_name":"Journal of Tropical Life Science","issn_l":"2087-5517","issn":["2087-5517","2527-4376"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314997","host_organization_name":"Brawijaya University","host_organization_lineage":["https://openalex.org/P4310314997"],"host_organization_lineage_names":["Brawijaya University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tropical Life Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3003357230.pdf","grobid_xml":"https://content.openalex.org/works/W3003357230.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1574721287","https://openalex.org/W1580445881","https://openalex.org/W1765735955","https://openalex.org/W1887624773","https://openalex.org/W1988491494","https://openalex.org/W1996888275","https://openalex.org/W2000137515","https://openalex.org/W2075729429","https://openalex.org/W2085848065","https://openalex.org/W2099818615","https://openalex.org/W2114543843","https://openalex.org/W2141918040","https://openalex.org/W2142451896","https://openalex.org/W2162362258","https://openalex.org/W2169546849","https://openalex.org/W2269962830","https://openalex.org/W2274001604","https://openalex.org/W2282612468","https://openalex.org/W2307778533","https://openalex.org/W2341834065","https://openalex.org/W2414667422","https://openalex.org/W2526910962","https://openalex.org/W2536620887","https://openalex.org/W2542011357","https://openalex.org/W2559390490","https://openalex.org/W2560004578","https://openalex.org/W2625658222","https://openalex.org/W2733424582","https://openalex.org/W2747068608","https://openalex.org/W2748053146","https://openalex.org/W2769840974","https://openalex.org/W2787011902","https://openalex.org/W2790466644","https://openalex.org/W2791166185","https://openalex.org/W2799843766","https://openalex.org/W2932571709"],"related_works":["https://openalex.org/W6992872982","https://openalex.org/W4389848957","https://openalex.org/W4200325329","https://openalex.org/W2955598095","https://openalex.org/W2897600589","https://openalex.org/W2016731108","https://openalex.org/W4285342956","https://openalex.org/W2103160776","https://openalex.org/W3130851857","https://openalex.org/W4387064812"],"abstract_inverted_index":{"Caspase-3":[0],"is":[1],"a":[2,100],"biochemical":[3],"marker":[4],"for":[5,103],"cell":[6],"apoptosis.":[7],"Several":[8],"studies":[9,164],"focused":[10],"on":[11,83],"exploring":[12],"caspase":[13],"inhibitor":[14,150],"potential":[15,28,148,157],"in":[16,20,112],"natural":[17],"compounds.":[18],"Hence,":[19],"this":[21,169],"study":[22,142],"investigated":[23],"the":[24],"anthocyanins":[25,146],"as":[26,149,158],"anti-apoptotic":[27],"activity":[29],"through":[30],"caspase-3":[31,45,55,84,111,152],"using":[32,59,65],"molecular":[33],"docking.":[34],"Six":[35],"types":[36],"of":[37,87,96,151],"anthocyanin":[38],"were":[39,57],"retrieved":[40],"from":[41,49],"PubChem":[42],"database":[43],"and":[44,54,63,77,93,115,125,132,154,162],"protein":[46,56,153],"was":[47],"downloaded":[48],"Protein":[50],"Data":[51],"Bank.":[52],"Anthocyanins":[53],"docked":[58],"HEX":[60],"8.0":[61],"program":[62],"visualized":[64],"Discovery":[66],"Studio":[67],"4.1":[68],"software.":[69],"The":[70],"interaction":[71],"among":[72],"cyanidin-3-O-glucoside,":[73],"delphinidin-3-O-glucoside,":[74],"pelargonidin-3-O-glucoside,":[75],"peonidin-3-O-glucoside":[76],"petunidin-3-O-glucoside":[78],"showed":[79,122],"similar":[80],"binding":[81],"pattern":[82],"protein.":[85],"All":[86],"them":[88],"bind":[89],"to":[90,167],"BIR2":[91,114],"region":[92],"allosteric":[94],"site":[95,102],"caspase-3,":[97],"which":[98,137],"are":[99,165],"crucial":[101],"apoptosis":[104],"regulation.":[105],"Interestingly,":[106],"malvidin-3-O-glucoside":[107],"also":[108],"interacted":[109],"with":[110],"BIR1,":[113],"BIR3":[116],"regions.":[117],"In":[118],"addition,":[119],"anthocyanins-caspase-3":[120],"complex":[121],"low":[123],"energy":[124],"demonstrated":[126],"several":[127],"hydrogen":[128],"bonds,":[129],"hydrophobic":[130],"interactions":[131],"van":[133],"der":[134],"Waals":[135],"interactions,":[136],"indicated":[138],"stable":[139],"interaction.":[140],"This":[141],"implies":[143],"that":[144],"all":[145],"have":[147,156],"might":[155],"anti-apoptosis.":[159],"Further":[160],"in-vitro":[161],"in-vivo":[163],"need":[166],"confirm":[168],"experimental.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2020-02-07T00:00:00"}