{"id":"https://openalex.org/W3003317145","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00025","title":"Enzyme-Instructed Self-Assembly for Cancer Therapy and Imaging","display_name":"Enzyme-Instructed Self-Assembly for Cancer Therapy and Imaging","publication_year":2020,"publication_date":"2020-01-29","ids":{"openalex":"https://openalex.org/W3003317145","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00025","mag":"3003317145","pmid":"https://pubmed.ncbi.nlm.nih.gov/31995365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082204"},"language":"en","primary_location":{"id":"doi:10.1021/acs.bioconjchem.0c00025","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00025","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.0c00025","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082204","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078286857","display_name":"Beom Jin Kim","orcid":"https://orcid.org/0000-0003-1526-6445","observed_orcids":["https://orcid.org/0000-0003-1526-6445"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beom Jin Kim","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100602838","display_name":"Bing Xu","orcid":"https://orcid.org/0000-0002-4639-387X","observed_orcids":["https://orcid.org/0000-0002-4639-387X","https://orcid.org/0000-0001-7138-8936","https://orcid.org/0000-0002-7385-9954","https://orcid.org/0000-0002-7242-6495"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bing Xu","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States"],"raw_orcid":"https://orcid.org/0000-0002-4639-387X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100602838"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9788,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.67997651,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"31","issue":"3","first_page":"492","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.45019999146461487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-instructed-self-assembly","display_name":"enzyme-instructed self-assembly","score":1.0},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.8330000042915344},{"id":"https://openalex.org/keywords/supramolecular-self-assembly","display_name":"supramolecular self-assembly","score":0.9430000185966492},{"id":"https://openalex.org/keywords/enzymatic-conversion","display_name":"enzymatic conversion","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hallmarks-of-cancer","display_name":"cancer hallmarks","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.7638068199157715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7261052131652832},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.7055789828300476},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5916992425918579},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5835862755775452},{"id":"https://openalex.org/C2994114330","wikidata":"https://www.wikidata.org/wiki/Q5031437","display_name":"Cancer imaging","level":3,"score":0.50714111328125},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4469189941883087},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.44581109285354614},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4404631555080414},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4373428225517273},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4274291694164276},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3333643972873688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20038920640945435},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1479870080947876},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.10484704375267029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09329614043235779},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08575376868247986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07554444670677185},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06335392594337463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05979350209236145},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.bioconjchem.0c00025","doi":"https://doi.org/10.1021/acs.bioconjchem.0c00025","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.0c00025","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:31995365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31995365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7082204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioconjug Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7082204","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7082204","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioconjug Chem","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000863427","display_name":"Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines","funder_award_id":"R01CA142746","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1048568792","https://openalex.org/W1974795477","https://openalex.org/W1976754679","https://openalex.org/W1979927327","https://openalex.org/W1994980982","https://openalex.org/W1996234823","https://openalex.org/W1996728254","https://openalex.org/W2006434892","https://openalex.org/W2013298034","https://openalex.org/W2015889028","https://openalex.org/W2024829972","https://openalex.org/W2028289489","https://openalex.org/W2030683115","https://openalex.org/W2044716544","https://openalex.org/W2047179731","https://openalex.org/W2063494783","https://openalex.org/W2067554667","https://openalex.org/W2068926508","https://openalex.org/W2072984130","https://openalex.org/W2073920604","https://openalex.org/W2074363870","https://openalex.org/W2076566034","https://openalex.org/W2076710572","https://openalex.org/W2085175869","https://openalex.org/W2086705938","https://openalex.org/W2096642770","https://openalex.org/W2103742020","https://openalex.org/W2106400946","https://openalex.org/W2111190523","https://openalex.org/W2119507443","https://openalex.org/W2124696897","https://openalex.org/W2135905231","https://openalex.org/W2139333712","https://openalex.org/W2161162374","https://openalex.org/W2161672948","https://openalex.org/W2163830997","https://openalex.org/W2168465208","https://openalex.org/W2175893746","https://openalex.org/W2213504946","https://openalex.org/W2255614276","https://openalex.org/W2294424925","https://openalex.org/W2314046004","https://openalex.org/W2317500537","https://openalex.org/W2321818080","https://openalex.org/W2325622903","https://openalex.org/W2330860594","https://openalex.org/W2487348170","https://openalex.org/W2517268210","https://openalex.org/W2549641338","https://openalex.org/W2560426735","https://openalex.org/W2577934459","https://openalex.org/W2588384666","https://openalex.org/W2588614136","https://openalex.org/W2589506535","https://openalex.org/W2592007767","https://openalex.org/W2594072584","https://openalex.org/W2598696960","https://openalex.org/W2600533839","https://openalex.org/W2614696572","https://openalex.org/W2673867070","https://openalex.org/W2764189746","https://openalex.org/W2773351978","https://openalex.org/W2773752080","https://openalex.org/W2781978875","https://openalex.org/W2782688529","https://openalex.org/W2783496111","https://openalex.org/W2786422304","https://openalex.org/W2789257593","https://openalex.org/W2790317037","https://openalex.org/W2803319613","https://openalex.org/W2808997364","https://openalex.org/W2810358116","https://openalex.org/W2823865577","https://openalex.org/W2899219379","https://openalex.org/W2902449173","https://openalex.org/W2905410102","https://openalex.org/W2949216521","https://openalex.org/W2955926857","https://openalex.org/W2964235985","https://openalex.org/W2980903185","https://openalex.org/W2982390503","https://openalex.org/W2983666708","https://openalex.org/W2986753177","https://openalex.org/W2988621271","https://openalex.org/W2991262652","https://openalex.org/W4244089250","https://openalex.org/W4250126132"],"related_works":["https://openalex.org/W2901725625","https://openalex.org/W2325622903","https://openalex.org/W2902847732","https://openalex.org/W4416201545","https://openalex.org/W2764189746","https://openalex.org/W4399440484","https://openalex.org/W2757942160","https://openalex.org/W3037964428","https://openalex.org/W4400307935","https://openalex.org/W4306968234"],"abstract_inverted_index":{"Enzymatic":[0],"reactions":[1],"and":[2,25,47,67],"self-assembly":[3,19],"are":[4],"two":[5],"fundamental":[6],"attributes":[7],"of":[8,22,32,41,71,82,92,102,114],"cells.":[9],"It":[10],"is":[11],"not":[12],"surprising":[13],"that":[14,109],"one":[15],"can":[16],"use":[17,91],"enzyme-instructed":[18],"(EISA)-the":[20],"integration":[21],"enzymatic":[23],"transformation":[24],"molecular":[26,95],"self-assembly-to":[27],"modulate":[28],"the":[29,54,68,80,90,100],"emergent":[30],"properties":[31],"supramolecular":[33,106],"assemblies":[34],"for":[35,43,94,104],"controlling":[36],"cell":[37],"behaviors.":[38],"The":[39],"exploration":[40],"EISA":[42,83,93,103],"developing":[44,85,105],"cancer":[45,86],"therapy":[46],"imaging":[48],"has":[49],"made":[50],"considerable":[51],"progress":[52,81],"over":[53],"last":[55],"five":[56],"years.":[57],"In":[58],"this":[59],"Topical":[60],"Review,":[61],"we":[62,88,98],"discuss":[63,89],"these":[64],"exciting":[65],"results":[66],"future":[69],"promise":[70],"EISA.":[72],"After":[73],"describing":[74],"several":[75],"key":[76],"studies":[77],"to":[78],"illustrate":[79],"in":[84],"therapy,":[87],"imaging.":[96],"Then,":[97],"give":[99],"outlook":[101],"anticancer":[107],"medicine":[108],"inhibits":[110],"multiple":[111],"hallmark":[112],"capabilities":[113],"cancer.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2020-02-07T00:00:00"}