{"id":"https://openalex.org/W3003248683","doi":"https://doi.org/10.4103/1673-5374.274330","title":"The role of cofilin in age-related neuroinflammation","display_name":"The role of cofilin in age-related neuroinflammation","publication_year":2020,"publication_date":"2020-01-28","ids":{"openalex":"https://openalex.org/W3003248683","doi":"https://doi.org/10.4103/1673-5374.274330","mag":"3003248683","pmid":"https://pubmed.ncbi.nlm.nih.gov/31997804","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7059588"},"language":"en","primary_location":{"id":"doi:10.4103/1673-5374.274330","doi":"https://doi.org/10.4103/1673-5374.274330","is_oa":true,"landing_page_url":"https://doi.org/10.4103/1673-5374.274330","pdf_url":null,"source":{"id":"https://openalex.org/S80372421","display_name":"Neural Regeneration Research","issn_l":"1673-5374","issn":["1673-5374","1876-7958"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regeneration Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/1673-5374.274330","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033644084","display_name":"Amsha S. Alsegiani","orcid":"https://orcid.org/0000-0003-2463-3606","observed_orcids":["https://orcid.org/0000-0003-2463-3606"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amsha S. Alsegiani","raw_affiliation_strings":["Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA","Author contributions:Both authors wrote the manuscript and approved the final manuscript","Zahoor A. Shah, "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Author contributions:Both authors wrote the manuscript and approved the final manuscript","institution_ids":[]},{"raw_affiliation_string":"Zahoor A. Shah, ","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102960676","display_name":"Zahoor Ahmad Shah","orcid":"https://orcid.org/0000-0001-8977-1618","observed_orcids":["https://orcid.org/0000-0001-8977-1618"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zahoor A. Shah","raw_affiliation_strings":["Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA","Author contributions:Both authors wrote the manuscript and approved the final manuscript"],"raw_orcid":"https://orcid.org/0000-0001-8977-1618","affiliations":[{"raw_affiliation_string":"Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA","institution_ids":["https://openalex.org/I90871651"]},{"raw_affiliation_string":"Author contributions:Both authors wrote the manuscript and approved the final manuscript","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102960676"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.6742,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.5755627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"15","issue":"8","first_page":"1451","last_page":"1459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cofilin-1","display_name":"cofilin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.9660000205039978},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aging-biomarkers","display_name":"aging biomarkers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9871986508369446},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.762043833732605},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6425108909606934},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5462120175361633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4747196435928345},{"id":"https://openalex.org/C2776601116","wikidata":"https://www.wikidata.org/wiki/Q24786722","display_name":"Cofilin","level":5,"score":0.4320266544818878},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27844858169555664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23924779891967773},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2301020622253418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1853485405445099},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.18003079295158386},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.12100517749786377},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.0},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/1673-5374.274330","doi":"https://doi.org/10.4103/1673-5374.274330","is_oa":true,"landing_page_url":"https://doi.org/10.4103/1673-5374.274330","pdf_url":null,"source":{"id":"https://openalex.org/S80372421","display_name":"Neural Regeneration Research","issn_l":"1673-5374","issn":["1673-5374","1876-7958"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regeneration Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7059588","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7059588/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7059588/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},{"id":"pmid:31997804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31997804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural regeneration research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:34f508b4607a4fe3bdfa411ddf13bd63","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/34f508b4607a4fe3bdfa411ddf13bd63","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neural Regeneration Research, Vol 15, Iss 8, Pp 1451-1459 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/1673-5374.274330","doi":"https://doi.org/10.4103/1673-5374.274330","is_oa":true,"landing_page_url":"https://doi.org/10.4103/1673-5374.274330","pdf_url":null,"source":{"id":"https://openalex.org/S80372421","display_name":"Neural Regeneration Research","issn_l":"1673-5374","issn":["1673-5374","1876-7958"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regeneration Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3003248683.pdf","grobid_xml":"https://content.openalex.org/works/W3003248683.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W90894251","https://openalex.org/W117797836","https://openalex.org/W336654075","https://openalex.org/W756826172","https://openalex.org/W1217233333","https://openalex.org/W1506474084","https://openalex.org/W1515023627","https://openalex.org/W1543577342","https://openalex.org/W1545082774","https://openalex.org/W1553210510","https://openalex.org/W1554454384","https://openalex.org/W1591312627","https://openalex.org/W1607135210","https://openalex.org/W1622777525","https://openalex.org/W1722071721","https://openalex.org/W1963892030","https://openalex.org/W1973963820","https://openalex.org/W1974851340","https://openalex.org/W1975396085","https://openalex.org/W1976493941","https://openalex.org/W1977085416","https://openalex.org/W1984559046","https://openalex.org/W1986635066","https://openalex.org/W1989478104","https://openalex.org/W1990131256","https://openalex.org/W1991725112","https://openalex.org/W1994674541","https://openalex.org/W1997122431","https://openalex.org/W1997375732","https://openalex.org/W2003529245","https://openalex.org/W2003736664","https://openalex.org/W2004399750","https://openalex.org/W2009277812","https://openalex.org/W2014089759","https://openalex.org/W2016486229","https://openalex.org/W2021460489","https://openalex.org/W2024370135","https://openalex.org/W2027953381","https://openalex.org/W2033966441","https://openalex.org/W2034337512","https://openalex.org/W2036091553","https://openalex.org/W2042991023","https://openalex.org/W2043826241","https://openalex.org/W2044732552","https://openalex.org/W2049717190","https://openalex.org/W2050048961","https://openalex.org/W2050320551","https://openalex.org/W2051096873","https://openalex.org/W2051665217","https://openalex.org/W2058669152","https://openalex.org/W2064487089","https://openalex.org/W2064894034","https://openalex.org/W2068011527","https://openalex.org/W2069245229","https://openalex.org/W2069270259","https://openalex.org/W2074661552","https://openalex.org/W2077511103","https://openalex.org/W2079756902","https://openalex.org/W2082402714","https://openalex.org/W2082780543","https://openalex.org/W2085151093","https://openalex.org/W2095547457","https://openalex.org/W2097049162","https://openalex.org/W2101898118","https://openalex.org/W2103407592","https://openalex.org/W2109060944","https://openalex.org/W2113690827","https://openalex.org/W2115784548","https://openalex.org/W2117073109","https://openalex.org/W2119459951","https://openalex.org/W2122000781","https://openalex.org/W2122037893","https://openalex.org/W2129622446","https://openalex.org/W2132485762","https://openalex.org/W2135276646","https://openalex.org/W2136493937","https://openalex.org/W2146060811","https://openalex.org/W2148361935","https://openalex.org/W2154349779","https://openalex.org/W2155152361","https://openalex.org/W2159822434","https://openalex.org/W2160910785","https://openalex.org/W2161685550","https://openalex.org/W2162500823","https://openalex.org/W2164510688","https://openalex.org/W2216677116","https://openalex.org/W2259248206","https://openalex.org/W2265153332","https://openalex.org/W2302223665","https://openalex.org/W2326950591","https://openalex.org/W2336750301","https://openalex.org/W2345604850","https://openalex.org/W2409842303","https://openalex.org/W2467479292","https://openalex.org/W2511531163","https://openalex.org/W2528944013","https://openalex.org/W2554361415","https://openalex.org/W2568020671","https://openalex.org/W2572710398","https://openalex.org/W2588440731","https://openalex.org/W2766196305","https://openalex.org/W2768371661","https://openalex.org/W2773573309","https://openalex.org/W2789329186","https://openalex.org/W2790139801","https://openalex.org/W2796418566","https://openalex.org/W2800497993","https://openalex.org/W2800766011","https://openalex.org/W2800932870","https://openalex.org/W2802894273","https://openalex.org/W2809474275","https://openalex.org/W2925056974","https://openalex.org/W4211216239"],"related_works":["https://openalex.org/W4402334464","https://openalex.org/W2130484652","https://openalex.org/W2027368264","https://openalex.org/W2529375487","https://openalex.org/W3200313493","https://openalex.org/W2805499947","https://openalex.org/W4311979165","https://openalex.org/W3088771928","https://openalex.org/W4399792979","https://openalex.org/W2091429622"],"abstract_inverted_index":{"Aging":[0],"brain":[1,70,131],"becomes":[2],"susceptible":[3],"to":[4,8,16,130],"neurodegenerative":[5,87],"diseases":[6,88],"due":[7],"the":[9,26,29,42,68,83,94,102,108,111,117],"shifting":[10],"of":[11,31,49,64,85,113,120],"microglia":[12],"and":[13,52,71,77,89,104,116,133],"astrocyte":[14],"phenotypes":[15],"an":[17],"active":[18],"\"pro-inflammatory\"":[19],"state,":[20],"causing":[21],"chronic":[22],"low-grade":[23],"neuroinflammation.":[24,123,134],"Despite":[25],"fact":[27],"that":[28],"role":[30,119],"neuroinflammation":[32,58],"during":[33,122],"aging":[34,69,109,132],"has":[35],"been":[36],"extensively":[37],"studied":[38],"in":[39,57,67,93,107],"recent":[40],"years,":[41],"underlying":[43],"causes":[44],"remain":[45],"unclear.":[46],"The":[47],"identification":[48],"relevant":[50],"proteins":[51],"understanding":[53],"their":[54,62],"potential":[55,63,118],"roles":[56],"can":[59],"help":[60],"explain":[61],"becoming":[65],"biomarkers":[66],"as":[72],"drug":[73],"targets":[74],"for":[75],"prevention":[76],"treatment.":[78],"This":[79],"will":[80],"eventually":[81],"reduce":[82],"chances":[84],"developing":[86],"promote":[90],"healthier":[91],"lives":[92],"elderly.":[95],"In":[96],"this":[97],"review,":[98],"we":[99],"have":[100],"summarized":[101],"morphological":[103],"cellular":[105],"changes":[106],"brain,":[110],"effects":[112],"age-related":[114],"neuroinflammation,":[115],"cofilin-1":[121],"We":[124],"also":[125],"discuss":[126],"other":[127],"factors":[128],"contributing":[129]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-02-07T00:00:00"}