{"id":"https://openalex.org/W3003244346","doi":"https://doi.org/10.1152/ajprenal.00567.2019","title":"miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury","display_name":"miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury","publication_year":2020,"publication_date":"2020-01-31","ids":{"openalex":"https://openalex.org/W3003244346","doi":"https://doi.org/10.1152/ajprenal.00567.2019","mag":"3003244346","pmid":"https://pubmed.ncbi.nlm.nih.gov/32003595"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00567.2019","doi":"https://doi.org/10.1152/ajprenal.00567.2019","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00567.2019","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100708612","display_name":"Yan Yu","orcid":"https://orcid.org/0000-0001-9592-7623","observed_orcids":["https://orcid.org/0000-0001-9592-7623"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yu Yan","raw_affiliation_strings":["Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia","Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101140848","display_name":"Zhengwei Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengwei Ma","raw_affiliation_strings":["Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia","Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042277520","display_name":"Jiefu Zhu","orcid":"https://orcid.org/0000-0001-9105-022X","observed_orcids":["https://orcid.org/0000-0001-9105-022X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiefu Zhu","raw_affiliation_strings":["Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031086889","display_name":"Mengru Zeng","orcid":"https://orcid.org/0000-0002-9735-8417","observed_orcids":["https://orcid.org/0000-0002-9735-8417"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengru Zeng","raw_affiliation_strings":["Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410252","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0001-6040-5323","observed_orcids":["https://orcid.org/0000-0001-6040-5323"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050155862","display_name":"Zheng Dong","orcid":"https://orcid.org/0000-0003-3538-8095","observed_orcids":["https://orcid.org/0000-0003-3538-8095"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Zheng Dong","raw_affiliation_strings":["Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia","Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5050155862"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I25041050","https://openalex.org/I2799702486","https://openalex.org/I4210153856","https://openalex.org/I4210159865"],"apc_list":null,"apc_paid":null,"fwci":4.9637,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.96510695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"318","issue":"4","first_page":"F878","last_page":"F887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-214","display_name":"miR-214","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mfn2","display_name":"mitofusin 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ischemic-acute-kidney-injury","display_name":"ischemic acute kidney injury","score":0.9520000219345093},{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion","display_name":"renal ischemia-reperfusion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mitochondrial-fragmentation","display_name":"mitochondrial fragmentation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/renal-tubular-apoptosis","display_name":"renal tubular apoptosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.8815634846687317},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7186956405639648},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.6601171493530273},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6590008735656738},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.6413426995277405},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6319414973258972},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.48546674847602844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.469093918800354},{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.46370014548301697},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46110162138938904},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4440573453903198},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.43590784072875977},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4293050765991211},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.41755905747413635},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37653470039367676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3424813449382782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32473647594451904},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.2601349949836731},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.12479627132415771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06746816635131836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05277365446090698},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.00567.2019","doi":"https://doi.org/10.1152/ajprenal.00567.2019","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00567.2019","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:32003595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32003595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7191449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7191449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7191449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2073272583","display_name":null,"funder_award_id":"I01 BX000319","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2309475472","display_name":null,"funder_award_id":"DK087843","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3462512259","display_name":null,"funder_award_id":"IK6 BX005236","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4890845435","display_name":null,"funder_award_id":"DK058831","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7493276296","display_name":null,"funder_award_id":"R01 DK058831","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7903414325","display_name":null,"funder_award_id":"BX000319","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000870396","display_name":"Kidney Injury by Cisplatin and Renoprotective Strategies","funder_award_id":"R01DK087843","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1965518526","https://openalex.org/W1971799714","https://openalex.org/W1989026904","https://openalex.org/W2002321863","https://openalex.org/W2009572885","https://openalex.org/W2010369463","https://openalex.org/W2020871623","https://openalex.org/W2047459673","https://openalex.org/W2066517990","https://openalex.org/W2067463198","https://openalex.org/W2068362864","https://openalex.org/W2073625832","https://openalex.org/W2085367705","https://openalex.org/W2093229584","https://openalex.org/W2101800432","https://openalex.org/W2103313018","https://openalex.org/W2106391242","https://openalex.org/W2131213428","https://openalex.org/W2131415852","https://openalex.org/W2140835115","https://openalex.org/W2150572884","https://openalex.org/W2154258399","https://openalex.org/W2155978870","https://openalex.org/W2157334943","https://openalex.org/W2169378494","https://openalex.org/W2297008280","https://openalex.org/W2333220158","https://openalex.org/W2339490592","https://openalex.org/W2340407049","https://openalex.org/W2417089533","https://openalex.org/W2519391457","https://openalex.org/W2624526338","https://openalex.org/W2735368759","https://openalex.org/W2740802860","https://openalex.org/W2743743758","https://openalex.org/W2745222979","https://openalex.org/W2750514629","https://openalex.org/W2766858075","https://openalex.org/W2766902151","https://openalex.org/W2802100814","https://openalex.org/W2806455336","https://openalex.org/W2892185452","https://openalex.org/W2894906387","https://openalex.org/W2895895706","https://openalex.org/W2907750652","https://openalex.org/W2908860015","https://openalex.org/W2920607627","https://openalex.org/W2923237341","https://openalex.org/W2944265421","https://openalex.org/W2944370458","https://openalex.org/W2946404562","https://openalex.org/W2950261172","https://openalex.org/W2980963701"],"related_works":["https://openalex.org/W2093662055","https://openalex.org/W2016581978","https://openalex.org/W2120002758","https://openalex.org/W2058599282","https://openalex.org/W1986873096","https://openalex.org/W2140488719","https://openalex.org/W2379108742","https://openalex.org/W2089938118","https://openalex.org/W2766411031","https://openalex.org/W2590112481"],"abstract_inverted_index":{"Disruption":[0],"of":[1,28,82,88,109,174,189],"mitochondrial":[2,33,45,103,190],"dynamics":[3,191],"is":[4],"an":[5],"important":[6],"pathogenic":[7],"event":[8],"in":[9,39,65,95,113,119,161,166,176,196],"both":[10],"acute":[11,53],"and":[12,51,69,105,152,192],"chronic":[13],"kidney":[14,54,72,131],"diseases,":[15],"but":[16],"the":[17,26,181,187],"underlying":[18],"mechanism":[19],"remains":[20],"poorly":[21],"understood.":[22],"Here,":[23],"we":[24,121],"report":[25],"regulation":[27,118],"mitofusin-2":[29],"(Mfn2;":[30],"a":[31,123],"key":[32],"fusion":[34],"protein)":[35],"by":[36,171],"microRNA-214":[37],"(miR-214)":[38],"renal":[40,47,154],"ischemia-reperfusion":[41],"that":[42,184],"contributes":[43,185],"to":[44,186],"fragmentation,":[46],"tubular":[48,74,133,193],"cell":[49,194],"death,":[50],"ischemic":[52,67,157,162,197],"injury":[55],"(AKI).":[56],"miR-214":[57,83,89,110,127,159],"was":[58,63,164],"induced,":[59],"whereas":[60,107],"Mfn2":[61,93,175],"expression":[62],"decreased,":[64],"mouse":[66,124],"AKI":[68,163],"cultured":[70],"rat":[71],"proximal":[73,132],"cells":[75,134],"(RPTCs)":[76],"following":[77,97],"ATP":[78,98],"depletion":[79],"treatment.":[80],"Overexpression":[81],"decreased":[84],"Mfn2.":[85],"Conversely,":[86],"inhibition":[87],"with":[90,126,138],"anti-miR-214":[91],"prevented":[92],"downregulation":[94],"RPTCs":[96],"depletion.":[99],"Anti-miR-214":[100],"further":[101],"ameliorated":[102],"fragmentation":[104],"apoptosis,":[106,112],"overexpression":[108],"increased":[111],"ATP-depleted":[114],"RPTCs.":[115],"To":[116],"test":[117],"vivo,":[120],"established":[122],"model":[125],"specifically":[128],"deleted":[129],"from":[130],"(PT-":[135],"miR-214\u2212/\u2212).":[136],"Compared":[137],"wild-type":[139],"mice,":[140,169],"PT-":[141,167],"miR-214\u2212/\u2212":[142,168],"mice":[143],"had":[144],"less":[145],"severe":[146],"tissue":[147],"damage,":[148],"fewer":[149],"apoptotic":[150],"cells,":[151],"better":[153],"function":[155],"after":[156],"AKI.":[158],"induction":[160],"suppressed":[165],"accompanied":[170],"partial":[172],"preservation":[173],"kidneys.":[177],"These":[178],"results":[179],"unveil":[180],"miR-214/Mfn2":[182],"axis":[183],"disruption":[188],"death":[195],"AKI,":[198],"offering":[199],"new":[200],"therapeutic":[201],"targets.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}