{"id":"https://openalex.org/W3003235367","doi":"https://doi.org/10.1165/rcmb.2019-0296oc","title":"Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis","display_name":"Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis","publication_year":2020,"publication_date":"2020-01-16","ids":{"openalex":"https://openalex.org/W3003235367","doi":"https://doi.org/10.1165/rcmb.2019-0296oc","mag":"3003235367","pmid":"https://pubmed.ncbi.nlm.nih.gov/31944822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7110981"},"language":"en","primary_location":{"id":"doi:10.1165/rcmb.2019-0296oc","doi":"https://doi.org/10.1165/rcmb.2019-0296oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2019-0296oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7110981","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011568674","display_name":"Daniela Maria dos Santos","orcid":"https://orcid.org/0000-0002-3740-1305","observed_orcids":["https://orcid.org/0000-0002-3740-1305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela M. Santos","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":"https://orcid.org/0000-0002-3740-1305","affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071993155","display_name":"Lorena Pantano","orcid":"https://orcid.org/0000-0002-3859-3249","observed_orcids":["https://orcid.org/0000-0002-3859-3249"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorena Pantano","raw_affiliation_strings":["Harvard T. H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard T. H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080770078","display_name":"Gina Pronzati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gina Pronzati","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020357564","display_name":"Paula E. Grasberger","orcid":"https://orcid.org/0000-0003-4241-081X","observed_orcids":["https://orcid.org/0000-0003-4241-081X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Grasberger","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016619960","display_name":"Clemens K. Probst","orcid":"https://orcid.org/0000-0002-5546-9143","observed_orcids":["https://orcid.org/0000-0002-5546-9143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clemens K. Probst","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019912344","display_name":"Katharine E. Black","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katharine E. Black","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005070112","display_name":"Jillian J. Spinney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jillian J. Spinney","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025991868","display_name":"Lida P. Hariri","orcid":"https://orcid.org/0000-0002-6190-624X","observed_orcids":["https://orcid.org/0000-0002-6190-624X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lida P. Hariri","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049005985","display_name":"Royale Nichols","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Royale Nichols","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101914612","display_name":"Yufei Lin","orcid":"https://orcid.org/0000-0001-7257-3068","observed_orcids":["https://orcid.org/0000-0001-7257-3068"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufei Lin","raw_affiliation_strings":["Harvard T. H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard T. H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017618321","display_name":"Michael Bieler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Bieler","raw_affiliation_strings":["Computational Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091182975","display_name":"Peter Seither","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Seither","raw_affiliation_strings":["Business Development and Licensing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Business Development and Licensing","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010285060","display_name":"Paul L. Nicklin","orcid":"https://orcid.org/0000-0002-7790-0117","observed_orcids":["https://orcid.org/0000-0002-7790-0117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Nicklin","raw_affiliation_strings":["Research Beyond Borders, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Beyond Borders, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110106820","display_name":"David Wyatt","orcid":"https://orcid.org/0000-0001-5859-7389","observed_orcids":["https://orcid.org/0000-0001-5859-7389"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Wyatt","raw_affiliation_strings":["Biotherapeutics Discovery, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ri\u00df, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapeutics Discovery, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Ri\u00df, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018732153","display_name":"Andrew Martin Tager","orcid":"https://orcid.org/0000-0002-5826-918X","observed_orcids":["https://orcid.org/0000-0002-5826-918X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew M. Tager","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008009598","display_name":"Benjamin D. Medoff","orcid":"https://orcid.org/0000-0002-2558-0449","observed_orcids":["https://orcid.org/0000-0002-2558-0449"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benjamin D. Medoff","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, and"],"raw_orcid":"https://orcid.org/0000-0002-2558-0449","affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008009598"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6166,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.96255617,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"62","issue":"4","first_page":"479","last_page":"492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9010000228881836},{"id":"https://openalex.org/keywords/yap-inhibitor","display_name":"YAP inhibitor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9200000166893005},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.6669999957084656},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.8679999709129333},{"id":"https://openalex.org/keywords/yap-phosphorylation","display_name":"YAP phosphorylation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antifibrotic-agents","display_name":"antifibrotic agents","score":0.7250000238418579},{"id":"https://openalex.org/keywords/bleomycin-induced-fibrosis","display_name":"bleomycin-induced fibrosis","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.7017791271209717},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6285910606384277},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.628069281578064},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.6240066885948181},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.5692456960678101},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.5160834193229675},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.500852108001709},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4624175727367401},{"id":"https://openalex.org/C2779982574","wikidata":"https://www.wikidata.org/wiki/Q14913010","display_name":"Mevalonate pathway","level":4,"score":0.4195353388786316},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3760579526424408},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3445588946342468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33729904890060425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3323482871055603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3150142729282379},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21255236864089966},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.20871630311012268},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19337177276611328},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14085325598716736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14018628001213074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10355052351951599},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06704339385032654}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1165/rcmb.2019-0296oc","doi":"https://doi.org/10.1165/rcmb.2019-0296oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2019-0296oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7110981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7110981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},{"id":"pmid:31944822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31944822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7110981","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7110981","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2280138942","display_name":"Targeting Cell-specific Functions of the Rho Kinase Pathway in Pulmonary Fibrosis","funder_award_id":"R01HL133153","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3984656054","display_name":"Epithelial cell activation of fibroblasts in pulmonary fibrosis","funder_award_id":"K08HL133603","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W834352309","https://openalex.org/W1588127651","https://openalex.org/W1594157448","https://openalex.org/W1904552307","https://openalex.org/W1914659192","https://openalex.org/W1977291335","https://openalex.org/W1991001144","https://openalex.org/W1995160678","https://openalex.org/W1998143312","https://openalex.org/W1999439792","https://openalex.org/W2003519013","https://openalex.org/W2003969287","https://openalex.org/W2015703244","https://openalex.org/W2017871510","https://openalex.org/W2018809578","https://openalex.org/W2019431738","https://openalex.org/W2025315052","https://openalex.org/W2033073960","https://openalex.org/W2033887346","https://openalex.org/W2039944972","https://openalex.org/W2050303077","https://openalex.org/W2061058076","https://openalex.org/W2062461864","https://openalex.org/W2065977597","https://openalex.org/W2080319552","https://openalex.org/W2087917437","https://openalex.org/W2099709490","https://openalex.org/W2100641053","https://openalex.org/W2107841008","https://openalex.org/W2126500397","https://openalex.org/W2128288763","https://openalex.org/W2131115981","https://openalex.org/W2134164289","https://openalex.org/W2134215992","https://openalex.org/W2134937820","https://openalex.org/W2135994596","https://openalex.org/W2138871107","https://openalex.org/W2143568978","https://openalex.org/W2146337514","https://openalex.org/W2154530183","https://openalex.org/W2155635222","https://openalex.org/W2159038842","https://openalex.org/W2165828459","https://openalex.org/W2167978765","https://openalex.org/W2168072233","https://openalex.org/W2168666423","https://openalex.org/W2172772811","https://openalex.org/W2223413920","https://openalex.org/W2295717665","https://openalex.org/W2347012456","https://openalex.org/W2409976397","https://openalex.org/W2434775463","https://openalex.org/W2464261159","https://openalex.org/W2484875770","https://openalex.org/W2528648757","https://openalex.org/W2529086141","https://openalex.org/W2535020783","https://openalex.org/W2610199736","https://openalex.org/W2736102792","https://openalex.org/W2741303755","https://openalex.org/W2751699489","https://openalex.org/W2782697025","https://openalex.org/W2783271194","https://openalex.org/W2790696411","https://openalex.org/W2794734792","https://openalex.org/W2797290792","https://openalex.org/W2884435515","https://openalex.org/W2889074463","https://openalex.org/W2900996054","https://openalex.org/W2903654157","https://openalex.org/W2920807317","https://openalex.org/W2923415172","https://openalex.org/W2945457209","https://openalex.org/W2982291379","https://openalex.org/W3164588709","https://openalex.org/W4386692139"],"related_works":["https://openalex.org/W2970849908","https://openalex.org/W4225753356","https://openalex.org/W2903654157","https://openalex.org/W2149239692","https://openalex.org/W2126500397","https://openalex.org/W2080319552","https://openalex.org/W2168072233","https://openalex.org/W4388766211","https://openalex.org/W2991045302","https://openalex.org/W3159041271"],"abstract_inverted_index":{"Abstract":[0],"Idiopathic":[1],"pulmonary":[2,111,149],"fibrosis":[3,97],"is":[4,13,29],"a":[5,30,47,139],"lung":[6,21,57,102,124],"disease":[7],"with":[8,23],"limited":[9],"therapeutic":[10],"options":[11],"that":[12,33,85,93,116],"characterized":[14],"by":[15],"pathological":[16],"fibroblast":[17,40],"activation":[18],"and":[19,36,80,92,104,137],"aberrant":[20],"remodeling":[22],"scar":[24],"formation.":[25],"YAP":[26,52,70,76,90,119,135],"(Yes-associated":[27],"protein)":[28],"transcriptional":[31],"coactivator":[32],"mediates":[34],"mechanical":[35],"biochemical":[37],"signals":[38],"controlling":[39],"activation.":[41],"In":[42],"this":[43],"study,":[44],"we":[45,114],"developed":[46],"high-throughput":[48],"small-molecule":[49,132],"screen":[50],"for":[51,134,141],"inhibitors":[53,64,136],"in":[54,99,105,120,122,147],"primary":[55],"human":[56,101],"fibroblasts.":[58,125],"Multiple":[59],"HMG-CoA":[60],"(hydroxymethylglutaryl-coenzyme":[61],"A)":[62],"reductase":[63],"(statins)":[65],"were":[66],"found":[67],"to":[68],"inhibit":[69],"nuclear":[71],"localization":[72],"via":[73],"induction":[74],"of":[75,110,131,145],"phosphorylation,":[77],"cytoplasmic":[78],"retention,":[79],"degradation.":[81],"We":[82],"further":[83],"show":[84,115],"the":[86,106,129,142],"mevalonate":[87],"pathway":[88],"regulates":[89],"activation,":[91],"simvastatin":[94,117],"treatment":[95],"reduces":[96],"markers":[98],"activated":[100],"fibroblasts":[103],"bleomycin":[107],"mouse":[108,123],"model":[109],"fibrosis.":[112,150],"Finally,":[113],"modulates":[118],"vivo":[121],"Our":[126],"results":[127],"highlight":[128],"potential":[130],"screens":[133],"provide":[138],"mechanism":[140],"antifibrotic":[143],"activity":[144],"statins":[146],"idiopathic":[148]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-02-07T00:00:00"}