{"id":"https://openalex.org/W3003198626","doi":null,"title":"Effect of autophagy on cardiomyocyte membrane Cx43 acute remodeling in rats with ischemia-reperfusion.","display_name":"Effect of autophagy on cardiomyocyte membrane Cx43 acute remodeling in rats with ischemia-reperfusion.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3003198626","mag":"3003198626","pmid":"https://pubmed.ncbi.nlm.nih.gov/31934092","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949570"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5911131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013428011","display_name":"Qing L\u00fc","orcid":"https://orcid.org/0000-0001-9255-7743","observed_orcids":["https://orcid.org/0000-0001-9255-7743"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Lu","raw_affiliation_strings":["Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wandong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wandong Li","raw_affiliation_strings":["Southern Medical University Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Medical University Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363825","display_name":"Zhigang Li","orcid":"https://orcid.org/0009-0009-4051-6312","observed_orcids":["https://orcid.org/0009-0009-4051-6312","https://orcid.org/0009-0007-2997-4182"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Li","raw_affiliation_strings":["Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027880821","display_name":"Zhi\u2010Nan Chen","orcid":"https://orcid.org/0000-0001-5512-4623","observed_orcids":["https://orcid.org/0000-0001-5512-4623"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhinan Chen","raw_affiliation_strings":["Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010153040","display_name":"Wenbo Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Fu","raw_affiliation_strings":["Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001248480","display_name":"Qijun Jiang","orcid":"https://orcid.org/0000-0002-9180-2396","observed_orcids":["https://orcid.org/0000-0002-9180-2396"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qijun Jiang","raw_affiliation_strings":["Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063425862","display_name":"Shifang Ding","orcid":"https://orcid.org/0009-0004-5542-6217","observed_orcids":["https://orcid.org/0009-0004-5542-6217"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shifang Ding","raw_affiliation_strings":["Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, General Hospital of Central Theater Command of PLA Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4401726912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5378,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68263587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"7","first_page":"2639","last_page":"2645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9890000224113464},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cx43-phosphorylation","display_name":"Cx43 phosphorylation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/myocardial-infarct-size","display_name":"myocardial infarct size","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cardiac-troponin-i","display_name":"cardiac troponin I","score":0.8610000014305115},{"id":"https://openalex.org/keywords/reperfusion-arrhythmias","display_name":"reperfusion arrhythmias","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ventricular-fibrillation-threshold","display_name":"ventricular fibrillation threshold","score":0.875}],"concepts":[{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.7467155456542969},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.7057569026947021},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6529946327209473},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6285096406936646},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.6184843182563782},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.598580539226532},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5928525924682617},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5845229625701904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5790498852729797},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.510506272315979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46335604786872864},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.45767495036125183},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4421869218349457},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.3467925190925598},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.339680016040802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28805404901504517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2704836130142212},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1643574833869934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09543848037719727},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.07961702346801758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07652974128723145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5911131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31934092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31934092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6949570","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6949570/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3003198626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31934092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5911131","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6949570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W642235081","https://openalex.org/W1987594610","https://openalex.org/W1992681494","https://openalex.org/W2001535302","https://openalex.org/W2038096650","https://openalex.org/W2051728143","https://openalex.org/W2075978348","https://openalex.org/W2093637056","https://openalex.org/W2100971797","https://openalex.org/W2109461620","https://openalex.org/W2110614144","https://openalex.org/W2111634870","https://openalex.org/W2132603512","https://openalex.org/W2143397461","https://openalex.org/W2162542267","https://openalex.org/W2170679758","https://openalex.org/W2175371769","https://openalex.org/W2276762215","https://openalex.org/W2321084382","https://openalex.org/W2735306595"],"related_works":["https://openalex.org/W2369012886","https://openalex.org/W2328473220","https://openalex.org/W2092017712","https://openalex.org/W3150722505","https://openalex.org/W2136703555","https://openalex.org/W7097336663","https://openalex.org/W2345138934","https://openalex.org/W2042500094","https://openalex.org/W4320883168","https://openalex.org/W2039023138"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"investigate":[2],"the":[3,60,133,136,171,189,208,223],"impact":[4],"of":[5,59,226],"autophagy":[6],"on":[7],"cardiomyocyte":[8],"membrane":[9,229],"connexin":[10],"43":[11],"(Cx43)":[12],"expression,":[13],"distribution,":[14],"and":[15,45,72,88,109,119,147,154,182,197,218],"phosphorylation":[16],"in":[17,122,148,161,188,201],"myocardial":[18,215,227],"ischemia-reperfusion":[19,216],"injury":[20,217],"(MI/RI).":[21],"METHODS:":[22],"Twenty-four":[23],"male":[24],"SD":[25],"rats":[26],"were":[27,113,125,158,185],"randomly":[28],"divided":[29],"into":[30],"a":[31,35,46],"sham":[32,39],"operation":[33,40],"group,":[34,41,44,135,173],"chloroquine":[36],"(CQ)":[37],"+":[38,48,163,203],"an":[42],"I/R":[43,49,134,164,190,204,209],"CQ":[47,162,202],"group.":[50,191,210],"The":[51,77],"MI/RI":[52],"model":[53],"was":[54,82,98,177],"established":[55],"by":[56,84,100,115,127,221],"reversible":[57],"ligation":[58],"left":[61,78,137],"anterior":[62],"descending":[63],"coronary":[64],"artery":[65],"to":[66],"induce":[67],"ischemia":[68],"for":[69,74],"30":[70],"min":[71],"reperfusion":[73,144],"2":[75],"h.":[76],"ventricular":[79,123,138,151],"infarct":[80,139],"size":[81],"measured":[83],"TTC":[85],"(2,3,5-triphenyltetrazolium":[86],"chloride)":[87],"Evans":[89],"blue":[90],"double":[91],"staining.":[92],"Cardiac":[93],"troponin":[94],"I":[95],"(cTnI)":[96],"content":[97],"detected":[99],"automatic":[101],"biochemical":[102],"analyzer.":[103],"Autophagy":[104,212],"related":[105],"gene":[106],"Beclin1,":[107],"Cx43,":[108],"p-Cx43":[110,120,183,198],"protein":[111,156,175,193],"expressions":[112],"tested":[114],"western":[116],"blot.":[117],"Cx43":[118,181,196],"distributions":[121],"myocardium":[124],"observed":[126],"immunofluorescence":[128],"analysis.":[129],"RESULTS:":[130],"Compared":[131,169],"with":[132,170,207],"size,":[140],"serum":[141],"cTnI":[142],"content,":[143],"arrhythmia":[145,220],"severity,":[146],"vivo":[149],"induced":[150],"fibrillation":[152],"threshold,":[153],"Beclin-1":[155,174,192],"expression":[157,176],"significantly":[159,178],"reduced":[160],"group":[165,205],"(P":[166],"<":[167],"0.05).":[168],"SH":[172],"enhanced,":[179],"while":[180],"levels":[184,199],"obviously":[186],"downregulated":[187],"declined,":[194],"whereas":[195],"enhanced":[200],"compared":[206],"CONCLUSION:":[211],"may":[213],"reduce":[214],"malignant":[219],"improving":[222],"acute":[224],"remodeling":[225],"cell":[228],"Cx43.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-02-07T00:00:00"}