{"id":"https://openalex.org/W3003195605","doi":"https://doi.org/10.1093/rheumatology/kez651","title":"Alterations in activin A\u2013myostatin\u2013follistatin system associate with disease activity in inflammatory myopathies","display_name":"Alterations in activin A\u2013myostatin\u2013follistatin system associate with disease activity in inflammatory myopathies","publication_year":2019,"publication_date":"2019-12-06","ids":{"openalex":"https://openalex.org/W3003195605","doi":"https://doi.org/10.1093/rheumatology/kez651","mag":"3003195605","pmid":"https://pubmed.ncbi.nlm.nih.gov/31990347"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/kez651","doi":"https://doi.org/10.1093/rheumatology/kez651","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/kez651","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067016340","display_name":"Lucia Vernerov\u00e1","orcid":"https://orcid.org/0000-0001-6087-2175","observed_orcids":["https://orcid.org/0000-0001-6087-2175"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Lucia Vernerov\u00e1","raw_affiliation_strings":["Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052409966","display_name":"Veronika Horv\u00e1thov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Veronika Horv\u00e1thov\u00e1","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110569685","display_name":"Tereza Krop\u00e1\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-5496-4329","observed_orcids":["https://orcid.org/0000-0002-5496-4329"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Tereza Krop\u00e1\u010dkov\u00e1","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070476123","display_name":"Martina Vokurkov\u00e1","orcid":"https://orcid.org/0000-0002-7669-0648","observed_orcids":["https://orcid.org/0000-0002-7669-0648"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martina Vokurkov\u00e1","raw_affiliation_strings":["Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069449538","display_name":"Martin Klein","orcid":"https://orcid.org/0000-0002-1027-0923","observed_orcids":["https://orcid.org/0000-0002-1027-0923","https://orcid.org/0009-0001-7755-0735"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martin Klein","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059312680","display_name":"Michal Tom\u010d\u00edk","orcid":"https://orcid.org/0000-0002-8616-7850","observed_orcids":["https://orcid.org/0000-0002-8616-7850"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michal Tom\u010d\u00edk","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064499724","display_name":"Sab\u00edna Oresk\u00e1","orcid":"https://orcid.org/0000-0002-9912-725X","observed_orcids":["https://orcid.org/0000-0002-9912-725X"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Sab\u00edna Oresk\u00e1","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057948163","display_name":"Maja \u0160piritovi\u0107","orcid":"https://orcid.org/0000-0002-9114-2172","observed_orcids":["https://orcid.org/0000-0002-9114-2172"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Maja \u0160piritovi\u0107","raw_affiliation_strings":["Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019621028","display_name":"Hana \u0160tork\u00e1nov\u00e1","orcid":"https://orcid.org/0000-0002-6416-8385","observed_orcids":["https://orcid.org/0000-0002-6416-8385"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Hana \u0160tork\u00e1nov\u00e1","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062096932","display_name":"Barbora He\u0159m\u00e1nkov\u00e1","orcid":"https://orcid.org/0000-0002-1314-1123","observed_orcids":["https://orcid.org/0000-0002-1314-1123"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Barbora He\u0159m\u00e1nkov\u00e1","raw_affiliation_strings":["Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002726299","display_name":"Kate\u0159ina Kub\u00ednov\u00e1","orcid":"https://orcid.org/0000-0002-3175-1419","observed_orcids":["https://orcid.org/0000-0002-3175-1419"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Kate\u0159ina Kub\u00ednov\u00e1","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006308968","display_name":"Olga Kry\u0161t\u016ffkov\u00e1","orcid":"https://orcid.org/0000-0001-6059-6246","observed_orcids":["https://orcid.org/0000-0001-6059-6246"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Olga Kry\u0161t\u016ffkov\u00e1","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067401973","display_name":"Herman F. Mann","orcid":"https://orcid.org/0000-0002-4243-235X","observed_orcids":["https://orcid.org/0000-0002-4243-235X"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"He\u0159man Mann","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050698758","display_name":"Jozef Ukropec","orcid":"https://orcid.org/0000-0001-8401-6621","observed_orcids":["https://orcid.org/0000-0001-8401-6621"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210104728","display_name":"Institute of Experimental Endocrinology of the Slovak Academy of Sciences","ror":"https://ror.org/01a1nz002","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210104728","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jozef Ukropec","raw_affiliation_strings":["Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210104728","https://openalex.org/I4210123996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000575568","display_name":"Barbara Ukropcov\u00e1","orcid":"https://orcid.org/0000-0002-3309-7713","observed_orcids":["https://orcid.org/0000-0002-3309-7713"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210104728","display_name":"Institute of Experimental Endocrinology of the Slovak Academy of Sciences","ror":"https://ror.org/01a1nz002","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210104728","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Barbara Ukropcov\u00e1","raw_affiliation_strings":["Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava","Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210104728","https://openalex.org/I4210123996"]},{"raw_affiliation_string":"Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079921904","display_name":"Ji\u0159\u00ed Vencovsk\u00fd","orcid":"https://orcid.org/0000-0002-0851-0713","observed_orcids":["https://orcid.org/0000-0002-0851-0713"]},"institutions":[{"id":"https://openalex.org/I4210092695","display_name":"Institute of Rheumatology","ror":"https://ror.org/00jk0vn85","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210092695"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ji\u0159\u00ed Vencovsk\u00fd","raw_affiliation_strings":["Department of Rheumatology, First Faculty of Medicine","Division of Experimental Rheumatology, Institute of Rheumatology, Prague"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, First Faculty of Medicine","institution_ids":[]},{"raw_affiliation_string":"Division of Experimental Rheumatology, Institute of Rheumatology, Prague","institution_ids":["https://openalex.org/I4210092695"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5067016340"],"corresponding_institution_ids":["https://openalex.org/I4210092695"],"apc_list":{"value":3486,"currency":"GBP","value_usd":4597},"apc_paid":null,"fwci":2.1967,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.86604028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"9","first_page":"2491","last_page":"2501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-inflammatory-myopathies","display_name":"idiopathic inflammatory myopathies","score":0.9819999933242798},{"id":"https://openalex.org/keywords/inflammatory-myopathies","display_name":"myositis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/follistatin","display_name":"follistatin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/activin-a","display_name":"activin A","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9340000152587891},{"id":"https://openalex.org/keywords/myokines","display_name":"myokines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.796999990940094},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.847000002861023},{"id":"https://openalex.org/keywords/skeletal-muscle-gene-expression","display_name":"skeletal muscle gene expression","score":0.6840000152587891},{"id":"https://openalex.org/keywords/fstl3","display_name":"FSTL3","score":0.8600000143051147},{"id":"https://openalex.org/keywords/alk4","display_name":"ALK4","score":0.875},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":1.0},{"id":"https://openalex.org/keywords/atrogin-1","display_name":"atrogin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.6779999732971191},{"id":"https://openalex.org/keywords/muscle-biopsy","display_name":"muscle biopsy","score":0.5849999785423279},{"id":"https://openalex.org/keywords/manual-muscle-testing","display_name":"manual muscle testing","score":0.621999979019165},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778831791","wikidata":"https://www.wikidata.org/wiki/Q408122","display_name":"Follistatin","level":2,"score":0.9862114191055298},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.9130266904830933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8973615765571594},{"id":"https://openalex.org/C22517002","wikidata":"https://www.wikidata.org/wiki/Q14905179","display_name":"ACVR2B","level":4,"score":0.4521002769470215},{"id":"https://openalex.org/C38643226","wikidata":"https://www.wikidata.org/wiki/Q4677604","display_name":"Activin type 2 receptors","level":4,"score":0.43298962712287903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43121176958084106},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.41488659381866455},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3395174741744995},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.30590707063674927},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.10866039991378784}],"mesh":[{"descriptor_ui":"D000078331","descriptor_name":"Correlation of Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010808","descriptor_name":"Physical Examination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030201","descriptor_name":"Activin Receptors, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038681","descriptor_name":"Follistatin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D038702","descriptor_name":"Follistatin-Related Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044843","descriptor_name":"SKP Cullin F-Box Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/rheumatology/kez651","doi":"https://doi.org/10.1093/rheumatology/kez651","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/kez651","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},{"id":"pmid:31990347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31990347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2384220262","display_name":null,"funder_award_id":"16-33746\u2009A","funder_id":"https://openalex.org/F4320321798","funder_display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320321798","display_name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","ror":"https://ror.org/00y6khe77"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W39794179","https://openalex.org/W1522403604","https://openalex.org/W1543707496","https://openalex.org/W1580236405","https://openalex.org/W1586159393","https://openalex.org/W1687859954","https://openalex.org/W1967680994","https://openalex.org/W1972060594","https://openalex.org/W1996512453","https://openalex.org/W2006067401","https://openalex.org/W2029816532","https://openalex.org/W2031973282","https://openalex.org/W2035555824","https://openalex.org/W2047284298","https://openalex.org/W2049946444","https://openalex.org/W2054027756","https://openalex.org/W2060227777","https://openalex.org/W2064665289","https://openalex.org/W2072335655","https://openalex.org/W2074063262","https://openalex.org/W2077880750","https://openalex.org/W2077903365","https://openalex.org/W2084861994","https://openalex.org/W2087313135","https://openalex.org/W2099849009","https://openalex.org/W2105608476","https://openalex.org/W2115047630","https://openalex.org/W2119826306","https://openalex.org/W2141543467","https://openalex.org/W2149993139","https://openalex.org/W2151403954","https://openalex.org/W2159295364","https://openalex.org/W2159675211","https://openalex.org/W2167875128","https://openalex.org/W2169890434","https://openalex.org/W2314311014","https://openalex.org/W2406646548","https://openalex.org/W2418829285","https://openalex.org/W2466868774","https://openalex.org/W2569924285","https://openalex.org/W2594432891","https://openalex.org/W2601491516","https://openalex.org/W2627003412","https://openalex.org/W2770028464","https://openalex.org/W2889353926","https://openalex.org/W2900785865","https://openalex.org/W2965651703","https://openalex.org/W3082659271","https://openalex.org/W6601637982"],"related_works":["https://openalex.org/W7167054752","https://openalex.org/W4297458517","https://openalex.org/W4245436403","https://openalex.org/W3121851737","https://openalex.org/W3209692333","https://openalex.org/W3196902240","https://openalex.org/W2976574656","https://openalex.org/W3043944001","https://openalex.org/W2130384790","https://openalex.org/W7135632049"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,72],"aim":[2],"of":[3,15,31,36,61,74,98,171,217,261,269,277],"this":[4],"study":[5,248],"was":[6,88,144],"to":[7,147,167],"investigate":[8],"the":[9,81,181,278],"systemic":[10],"and":[11,25,40,51,66,76,109,165,204,214,232,252,258],"skeletal":[12,267],"muscle":[13,57,86,148,169,241,268,283],"levels":[14,97,127,255],"atrophy-associated":[16],"myokines":[17,75],"in":[18,80,85,119,131,239,256,266,282],"patients":[19,39,50,270],"with":[20,28,122,141,187,244,271],"idiopathic":[21],"inflammatory":[22],"myopathies":[23],"(IIM)":[24],"their":[26],"association":[27],"clinical":[29],"characteristics":[30],"myositis.":[32],"METHODS:":[33],"A":[34,65,126],"total":[35],"94":[37],"IIM":[38,49,120,132,240],"162":[41],"healthy":[42,53,123],"controls":[43,54],"were":[44,68,128],"recruited.":[45],"Of":[46],"those,":[47],"20":[48],"28":[52],"underwent":[55],"a":[56,273],"biopsy.":[58],"Circulating":[59],"concentrations":[60],"myostatin,":[62],"follistatin,":[63],"activin":[64,218,279],"TGF-\u03b21":[67],"assessed":[69,151],"by":[70,90,152],"ELISA.":[71],"expression":[73,196,216,260],"associated":[77],"genes":[78],"involved":[79],"myostatin":[82,100,205,251,262],"signalling":[83,264],"pathway":[84,263],"tissue":[87,242],"determined":[89],"real-time":[91],"PCR.":[92],"RESULTS:":[93],"We":[94],"report":[95],"decreased":[96],"circulating":[99],"(median":[101],"1817":[102],"vs":[103,113,134],"2659":[104],"pg/ml;":[105,115,136],"P":[106,116,137,162,177,192],"=":[107,117,138,160,163,175,178,190,193,202,212,224,230,237],"0.003)":[108,203],"increased":[110],"follistatin":[111,184,200,254],"(1319":[112],"1055":[114],"0.028)":[118],"compared":[121,140,243],"controls.":[124,142,245],"Activin":[125],"also":[129],"higher":[130,199,253],"(414":[133],"309":[135],"0.0005)":[139],"Myostatin":[143],"negatively":[145],"correlated":[146,185],"disease":[149],"activity":[150],"physician":[153],"on":[154],"visual":[155],"analogue":[156],"scale":[157],"(MDA)":[158],"(r":[159,174,189],"-0.289,":[161],"0.015)":[164],"positively":[166,186],"manual":[168],"testing":[170],"eight":[172],"muscles":[173],"0.366,":[176],"0.002).":[179],"On":[180],"other":[182],"hand,":[183],"MDA":[188],"0.235,":[191],"0.047).":[194],"Gene":[195],"analysis":[197],"showed":[198],"(P":[201,211,223,229,236],"inhibitor":[206],"follistatin-like":[207],"3":[208],"protein":[209],"(FSTL3)":[210],"0.008)":[213],"lower":[215,250],"receptor":[219],"type":[220],"1B":[221],"(ALK4)":[222],"0.034),":[225],"signal":[226],"transducer":[227],"SMAD3":[228],"0.023)":[231],"atrophy":[233],"marker":[234],"atrogin-1":[235],"0.0009)":[238],"CONCLUSION:":[246],"This":[247],"shows":[249],"circulation":[257],"attenuated":[259],"components":[265],"myositis,":[272],"newly":[274],"emerging":[275],"pattern":[276],"A-myostatin-follistatin":[280],"system":[281],"wasting":[284],"diseases.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-02-07T00:00:00"}