{"id":"https://openalex.org/W3002986355","doi":"https://doi.org/10.1098/rsif.2019.0712","title":"Evaluation of burst release and sustained release of pioglitazone-loaded fibrous mats on diabetic wound healing: an in vitro and in vivo comparison study","display_name":"Evaluation of burst release and sustained release of pioglitazone-loaded fibrous mats on diabetic wound healing: an in vitro and in vivo comparison study","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3002986355","doi":"https://doi.org/10.1098/rsif.2019.0712","mag":"3002986355","pmid":"https://pubmed.ncbi.nlm.nih.gov/31964272"},"language":"en","primary_location":{"id":"doi:10.1098/rsif.2019.0712","doi":"https://doi.org/10.1098/rsif.2019.0712","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2019.0712","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2019.0712","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2019.0712","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024622504","display_name":"Muhammet Emin \u00c7am","orcid":"https://orcid.org/0000-0001-5398-6801","observed_orcids":["https://orcid.org/0000-0001-5398-6801","https://orcid.org/0000-0002-9346-1724"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["GB","TR"],"is_corresponding":true,"raw_author_name":"Muhammet Emin Cam","raw_affiliation_strings":["Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul 34722, Turkey","Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK","Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul 34722, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110844549","display_name":"Sila Yildiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sila Yildiz","raw_affiliation_strings":["Centre for Discovery Brain Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Discovery Brain Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074674076","display_name":"Hussain Alenezi","orcid":"https://orcid.org/0000-0003-4563-7868","observed_orcids":["https://orcid.org/0000-0003-4563-7868"]},"institutions":[{"id":"https://openalex.org/I143601524","display_name":"Public Authority for Applied Education and Training","ror":"https://ror.org/024242h31","country_code":"KW","type":"education","lineage":["https://openalex.org/I143601524"]},{"id":"https://openalex.org/I4400573285","display_name":"College of Technological Studies","ror":"https://ror.org/00hwfn059","country_code":null,"type":"education","lineage":["https://openalex.org/I4400573285"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","KW"],"is_corresponding":false,"raw_author_name":"Hussain Alenezi","raw_affiliation_strings":["Department of Manufacturing Engineering, College of Technological Studies, PAAET, 13092 Kuwait City, Kuwait","Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Manufacturing Engineering, College of Technological Studies, PAAET, 13092 Kuwait City, Kuwait","institution_ids":["https://openalex.org/I143601524","https://openalex.org/I4400573285"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063163712","display_name":"S\u00fcmeyye Cesur","orcid":"https://orcid.org/0000-0001-5050-1303","observed_orcids":["https://orcid.org/0000-0001-5050-1303"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sumeyye Cesur","raw_affiliation_strings":["Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul 34722, Turkey","Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul 34722, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000274144","display_name":"Gul Sinemcan Ozcan","orcid":"https://orcid.org/0000-0003-2168-1629","observed_orcids":["https://orcid.org/0000-0003-2168-1629"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gul Sinemcan Ozcan","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Marmara University, Istanbul 34854, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Marmara University, Istanbul 34854, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078065573","display_name":"G\u00f6k\u00e7e Erdemir","orcid":"https://orcid.org/0000-0002-6476-2421","observed_orcids":["https://orcid.org/0000-0002-6476-2421"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gokce Erdemir","raw_affiliation_strings":["Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul 34093, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul 34093, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075666334","display_name":"Ursula Edirisinghe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799786270","display_name":"Hillingdon Hospitals NHS Foundation Trust","ror":"https://ror.org/04v0as660","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270"]},{"id":"https://openalex.org/I2802900303","display_name":"Hillingdon Hospital","ror":"https://ror.org/00jpae132","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2802900303"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ursula Edirisinghe","raw_affiliation_strings":["Accident and Emergency Department, Hillingdon Hospital, NHS Foundation Trust, Pield Heath Road, Uxbridge UB8 3NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accident and Emergency Department, Hillingdon Hospital, NHS Foundation Trust, Pield Heath Road, Uxbridge UB8 3NN, UK","institution_ids":["https://openalex.org/I2799786270","https://openalex.org/I2802900303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068971149","display_name":"Dilek Akak\u0131n","orcid":"https://orcid.org/0000-0002-1781-3708","observed_orcids":["https://orcid.org/0000-0002-1781-3708"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Dilek Akakin","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Marmara University, Istanbul 34854, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Marmara University, Istanbul 34854, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063722746","display_name":"Serap Erdem Kuruca","orcid":"https://orcid.org/0000-0001-7878-9994","observed_orcids":["https://orcid.org/0000-0001-7878-9994"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Durdane Serap Kuruca","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008398811","display_name":"Levent Kabasakal","orcid":"https://orcid.org/0000-0002-4050-1972","observed_orcids":["https://orcid.org/0000-0002-4050-1972","https://orcid.org/0000-0002-5474-6436"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Levent Kabasakal","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024660604","display_name":"O\u011fuzhan G\u00fcnd\u00fcz","orcid":"https://orcid.org/0000-0002-9427-7574","observed_orcids":["https://orcid.org/0000-0002-9427-7574","https://orcid.org/0000-0002-4926-6489"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Oguzhan Gunduz","raw_affiliation_strings":["Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul 34722, Turkey","Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nanotechnology and Biomaterials Research, Marmara University, Istanbul 34722, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050054155","display_name":"Mohan J. Edirisinghe","orcid":"https://orcid.org/0000-0001-8258-7914","observed_orcids":["https://orcid.org/0000-0001-8258-7914"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mohan Edirisinghe","raw_affiliation_strings":["Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK"],"raw_orcid":"https://orcid.org/0000-0001-8258-7914","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5024622504","https://openalex.org/A5050054155"],"corresponding_institution_ids":["https://openalex.org/I45129253","https://openalex.org/I74897591"],"apc_list":null,"apc_paid":null,"fwci":7.0999,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.97657866,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"17","issue":"162","first_page":"20190712","last_page":"20190712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9789999723434448},{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6650000214576721},{"id":"https://openalex.org/keywords/burst-release","display_name":"burst release","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fibrous-mats","display_name":"fibrous mats","score":0.9369999766349792},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.8820000290870667},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.8830000162124634},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.656000018119812},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/epidermal-regeneration","display_name":"epidermal regeneration","score":0.75},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.382999986410141},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.6629999876022339},{"id":"https://openalex.org/keywords/hair-follicle-formation","display_name":"hair follicle formation","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7764347791671753},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7268499135971069},{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.7119380831718445},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6083346009254456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5538491010665894},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.48466306924819946},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4799404740333557},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42517536878585815},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.39015132188796997},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3811856210231781},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25463294982910156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24357318878173828},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.23374783992767334},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16383308172225952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15353676676750183},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12766358256340027},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.11784902215003967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11437344551086426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10008102655410767},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1098/rsif.2019.0712","doi":"https://doi.org/10.1098/rsif.2019.0712","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2019.0712","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2019.0712","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},{"id":"pmid:31964272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31964272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Royal Society, Interface","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6685017","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7014808","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7014808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7014808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J R Soc Interface","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10091849","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10091849/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Royal Society Interface , 17 (162) , Article 20190712. (2020)","raw_type":"Article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/105038","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/105038","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/243083","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11424/243083","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1098/rsif.2019.0712","doi":"https://doi.org/10.1098/rsif.2019.0712","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2019.0712","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2019.0712","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3002986355.pdf","grobid_xml":"https://content.openalex.org/works/W3002986355.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W157961183","https://openalex.org/W1596824448","https://openalex.org/W1853201500","https://openalex.org/W1949832432","https://openalex.org/W1977872296","https://openalex.org/W1989838345","https://openalex.org/W2002569622","https://openalex.org/W2002625362","https://openalex.org/W2006476586","https://openalex.org/W2009660839","https://openalex.org/W2010619374","https://openalex.org/W2016594044","https://openalex.org/W2045623236","https://openalex.org/W2060306388","https://openalex.org/W2061071136","https://openalex.org/W2064336822","https://openalex.org/W2077300098","https://openalex.org/W2100868758","https://openalex.org/W2110231257","https://openalex.org/W2117887561","https://openalex.org/W2123950558","https://openalex.org/W2126445603","https://openalex.org/W2128211963","https://openalex.org/W2138607187","https://openalex.org/W2154476890","https://openalex.org/W2209058269","https://openalex.org/W2391302443","https://openalex.org/W2409628455","https://openalex.org/W2511224436","https://openalex.org/W2536983686","https://openalex.org/W2574904481","https://openalex.org/W2588662276","https://openalex.org/W2592518764","https://openalex.org/W2789892769","https://openalex.org/W2790563514","https://openalex.org/W2791311200","https://openalex.org/W2810239386","https://openalex.org/W2860835396","https://openalex.org/W2888070427","https://openalex.org/W2898325236","https://openalex.org/W2898821186","https://openalex.org/W2902494598","https://openalex.org/W2903665166","https://openalex.org/W2917967280","https://openalex.org/W2929722587","https://openalex.org/W2973048772","https://openalex.org/W2981123279","https://openalex.org/W4242639613"],"related_works":["https://openalex.org/W3142910047","https://openalex.org/W2471768190","https://openalex.org/W2965513749","https://openalex.org/W1967713685","https://openalex.org/W2581931459","https://openalex.org/W3111611808","https://openalex.org/W4323029873","https://openalex.org/W1542662550","https://openalex.org/W2028385841","https://openalex.org/W413045676"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,19],"provide":[3],"more":[4],"effective":[5],"treatment":[6,173],"strategies":[7],"for":[8,171],"the":[9,141,154,172],"rapid":[10],"healing":[11,59,85,112,183],"of":[12,25,114,143,161,174,182],"diabetic":[13,83,88,175],"wounds,":[14],"novel":[15],"therapeutic":[16,23],"approaches":[17],"need":[18],"be":[20],"developed.":[21],"The":[22,75,110],"potential":[24,57,170],"peroxisome":[26],"proliferator-activated":[27],"receptor-\u03b3":[28],"(PPAR-\u03b3)":[29],"agonist":[30,163],"pioglitazone":[31],"hydrochloride":[32],"(PHR)":[33],"in":[34,50,53,86,153,164,177],"two":[35],"different":[36,105],"release":[37,41,106,156,166],"kinetic":[38],"scenarios,":[39],"burst":[40],"and":[42,47,52,69,90,108,121,131,133,137,146,179,187],"sustained":[43,155,165],"release,":[44],"was":[45],"investigated":[46],"compared":[48],"with":[49,104,119,184],"vitro":[51],"vivo":[54],"tests":[55],"as":[56],"wound":[58,84,111],"dressings.":[60],"PHR-loaded":[61,79,124],"fibrous":[62,80,115,125],"mats":[63,81,116,126],"were":[64,150],"successfully":[65],"fabricated":[66],"using":[67],"polyvinyl-pyrrolidone":[68],"polycaprolactone":[70],"by":[71],"scalable":[72],"pressurized":[73],"gyration.":[74],"results":[76],"indicated":[77],"that":[78],"expedited":[82],"type-1":[87],"rats":[89],"did":[91],"not":[92],"show":[93],"any":[94],"cytotoxic":[95],"effect":[96],"on":[97],"NIH/3T3":[98],"(mouse":[99],"embryo":[100],"fibroblast)":[101],"cells,":[102],"albeit":[103],"kinetics":[107],"efficacies.":[109],"effects":[113],"are":[117],"presented":[118],"histological":[120],"biochemical":[122],"evaluations.":[123],"improved":[127,148],"neutrophil":[128],"infiltration,":[129],"oedema,":[130],"inflammation":[132],"increased":[134],"epidermal":[135],"regeneration":[136],"fibroblast":[138],"proliferation,":[139],"but":[140],"formation":[142],"hair":[144],"follicles":[145],"completely":[147],"oedema":[149],"observed":[151],"only":[152],"form.":[157],"Thus,":[158],"topical":[159],"administration":[160],"PPAR-\u03b3":[162],"form":[167],"has":[168],"high":[169,185],"wounds":[176],"inflammatory":[178],"proliferative":[180],"phases":[181],"bioavailability":[186],"fewer":[188],"systemic":[189],"side":[190],"effects.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}