{"id":"https://openalex.org/W3002807490","doi":null,"title":"MiR-100-5p, miR-199a-3p and miR-199b-5p induce autophagic death of endometrial carcinoma cell through targeting mTOR.","display_name":"MiR-100-5p, miR-199a-3p and miR-199b-5p induce autophagic death of endometrial carcinoma cell through targeting mTOR.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W3002807490","mag":"3002807490","pmid":"https://pubmed.ncbi.nlm.nih.gov/31966798","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6965939"},"language":"en","primary_location":{"id":"pmid:31966798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31966798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6965939/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008253097","display_name":"Junhong Cai","orcid":"https://orcid.org/0000-0002-8159-4140","observed_orcids":["https://orcid.org/0000-0002-8159-4140"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhong Cai","raw_affiliation_strings":["Central Laboratory, Hainan General Hospital Haikou, Hainan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Hainan General Hospital Haikou, Hainan, China","institution_ids":["https://openalex.org/I4210128478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386129","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0002-4448-2051","observed_orcids":["https://orcid.org/0000-0002-4448-2051"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Hainan General Hospital Haikou, Hainan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Hainan General Hospital Haikou, Hainan, China","institution_ids":["https://openalex.org/I4210128478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074807528","display_name":"Sizhe Huang","orcid":"https://orcid.org/0009-0003-8923-8946","observed_orcids":["https://orcid.org/0009-0003-8923-8946"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sizhe Huang","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Hainan General Hospital Haikou, Hainan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Hainan General Hospital Haikou, Hainan, China","institution_ids":["https://openalex.org/I4210128478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035968724","display_name":"Mengdan Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengdan Yan","raw_affiliation_strings":["Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Northwest University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Northwest University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jingjie Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjie Li","raw_affiliation_strings":["Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Northwest University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Northwest University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100602798","display_name":"Tianbo Jin","orcid":"https://orcid.org/0000-0002-7491-3991","observed_orcids":["https://orcid.org/0000-0002-7491-3991"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianbo Jin","raw_affiliation_strings":["Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Northwest University Xi'an, Shaanxi, China","School of Life Sciences, Northwest University Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Northwest University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"School of Life Sciences, Northwest University Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100754367","display_name":"Shan Bao","orcid":"https://orcid.org/0000-0001-5548-1436","observed_orcids":["https://orcid.org/0000-0001-5548-1436"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Bao","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Hainan General Hospital Haikou, Hainan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Hainan General Hospital Haikou, Hainan, China","institution_ids":["https://openalex.org/I4210128478"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3697,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.51564283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"10","issue":"9","first_page":"9262","last_page":"9272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-100-5p","display_name":"miR-100-5p","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mir-199a-3p","display_name":"miR-199a-3p","score":1.0},{"id":"https://openalex.org/keywords/mir-199b-5p","display_name":"miR-199b-5p","score":1.0},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/autophagic-cell-death","display_name":"autophagic cell death","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9539999961853027},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7049999833106995},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ishikawa-cells","display_name":"Ishikawa cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/kle-cells","display_name":"KLE cells","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.8198318481445312},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.7365632653236389},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7318588495254517},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7180148959159851},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7019690871238708},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5909180045127869},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5437135100364685},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5355970859527588},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4760960340499878},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4655298590660095},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44933363795280457},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42812204360961914},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.414014995098114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37597382068634033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25380825996398926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18218666315078735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0724790096282959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05205738544464111}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:31966798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31966798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6965939","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6965939/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3002807490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31966798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6965939","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6965939/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W595388308","https://openalex.org/W1970760326","https://openalex.org/W1977767269","https://openalex.org/W1982446575","https://openalex.org/W1986241711","https://openalex.org/W1993925306","https://openalex.org/W1996114270","https://openalex.org/W2010231082","https://openalex.org/W2020218669","https://openalex.org/W2024978537","https://openalex.org/W2037320436","https://openalex.org/W2052746044","https://openalex.org/W2056120940","https://openalex.org/W2060157525","https://openalex.org/W2060556766","https://openalex.org/W2081022172","https://openalex.org/W2088394201","https://openalex.org/W2105493915","https://openalex.org/W2124022855","https://openalex.org/W2126410483","https://openalex.org/W2145432294","https://openalex.org/W2145720555","https://openalex.org/W2155391095","https://openalex.org/W2171047126","https://openalex.org/W2396220511","https://openalex.org/W2593816418","https://openalex.org/W2743254891"],"related_works":["https://openalex.org/W2802551298","https://openalex.org/W2157702264","https://openalex.org/W2956865895","https://openalex.org/W2088394201","https://openalex.org/W1955837289","https://openalex.org/W1966590334","https://openalex.org/W4200636027","https://openalex.org/W2593997208","https://openalex.org/W2051642326","https://openalex.org/W2909828943"],"abstract_inverted_index":{"OBJECTIVE:":[0],"in":[1,18,23,84],"Ishikawa":[2],"and":[3,16,25,32,35,47,65,76,99,119],"KLE":[4,24],"cells":[5,20,27,85],"were":[6,21,51,78],"detected.":[7],"METHODS:":[8],"The":[9],"effects":[10,56],"of":[11,57,106,126],"three":[12,58],"miRNAs":[13,59],"on":[14,60],"proliferation":[15],"apoptosis":[17],"EEC":[19,107,127],"analyzed":[22],"ISK":[26],"transfected":[28,86],"with":[29,87,91],"miR-100-5p,":[30,74,97,117],"miR-199a-3p":[31,75,98,118],"miR-199b-5p":[33,77,100,120],"mimics":[34,89],"inhibitors.":[36],"Quantitative":[37],"real-time":[38],"polymerase":[39],"chain":[40],"reaction":[41],"(qRT-PCR),":[42],"CCK-8":[43],"method,":[44],"flow":[45],"cytometry":[46],"luciferase":[48,70,82],"reporter":[49,71],"assay":[50],"used":[52],"to":[53],"assess":[54],"the":[55,81,103,123],"cell":[61,108,128],"viability,":[62],"proliferation,":[63],"apoptosis,":[64],"autophagy.":[66],"RESULTS:":[67],"<0.05).":[68],"Finally,":[69],"results":[72,94,114],"showed":[73],"all":[79],"down-regulated":[80],"activity":[83],"miRNA":[88],"compared":[90],"mock.":[92],"All":[93],"suggested":[95,115],"that":[96,116],"may":[101,121],"induce":[102,122],"autophagic":[104,124],"death":[105,125],"through":[109,129],"targeting":[110,130],"mTOR.":[111,131],"CONCLUSIONS:":[112],"Our":[113]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-30T00:00:00"}