{"id":"https://openalex.org/W3002712840","doi":null,"title":"Developing an in vitro model of haemorrhagic shock to investigate the molecular mechanism of valproic acid in the treatment of massive blood loss","display_name":"Developing an in vitro model of haemorrhagic shock to investigate the molecular mechanism of valproic acid in the treatment of massive blood loss","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W3002712840","mag":"3002712840"},"language":"en","primary_location":{"id":"mag:3002712840","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792364","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058136099","display_name":"Alexandra M.E. Zuckermann","orcid":"https://orcid.org/0000-0002-0242-8815","observed_orcids":["https://orcid.org/0000-0002-0242-8815"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexandra M.E. Zuckermann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0242-8815","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058136099"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.9890000224113464},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/massive-blood-loss","display_name":"massive blood loss","score":0.9300000071525574},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.9700000286102295},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.9210000038146973},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.7686980962753296},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6369220614433289},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5971745848655701},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5930392742156982},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4522058963775635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39867597818374634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39042750000953674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23227527737617493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17722353339195251},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16181126236915588},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.14223313331604004},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.1297605037689209},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.09855496883392334}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3002712840","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.792364","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":287,"referenced_works":["https://openalex.org/W65155625","https://openalex.org/W80953942","https://openalex.org/W90443912","https://openalex.org/W133779903","https://openalex.org/W164556504","https://openalex.org/W182140896","https://openalex.org/W202813042","https://openalex.org/W308130168","https://openalex.org/W1487848458","https://openalex.org/W1503343720","https://openalex.org/W1519487278","https://openalex.org/W1565324087","https://openalex.org/W1568605582","https://openalex.org/W1574784740","https://openalex.org/W1579231583","https://openalex.org/W1595963262","https://openalex.org/W1642857149","https://openalex.org/W1726025741","https://openalex.org/W1902399643","https://openalex.org/W1907575477","https://openalex.org/W1908612571","https://openalex.org/W1911808475","https://openalex.org/W1939083266","https://openalex.org/W1956140656","https://openalex.org/W1963664287","https://openalex.org/W1963720608","https://openalex.org/W1964951942","https://openalex.org/W1965301923","https://openalex.org/W1965327012","https://openalex.org/W1966561450","https://openalex.org/W1966864702","https://openalex.org/W1967931372","https://openalex.org/W1968305447","https://openalex.org/W1968317137","https://openalex.org/W1968410036","https://openalex.org/W1969397460","https://openalex.org/W1969699638","https://openalex.org/W1971239186","https://openalex.org/W1971784189","https://openalex.org/W1973021910","https://openalex.org/W1973239192","https://openalex.org/W1973350716","https://openalex.org/W1975454216","https://openalex.org/W1976238769","https://openalex.org/W1976584956","https://openalex.org/W1976844018","https://openalex.org/W1977209833","https://openalex.org/W1977227142","https://openalex.org/W1978893041","https://openalex.org/W1980467489","https://openalex.org/W1981201938","https://openalex.org/W1982164070","https://openalex.org/W1983334409","https://openalex.org/W1983819128","https://openalex.org/W1983845790","https://openalex.org/W1984025642","https://openalex.org/W1984621921","https://openalex.org/W1985454477","https://openalex.org/W1986876732","https://openalex.org/W1986933738","https://openalex.org/W1987555043","https://openalex.org/W1987685674","https://openalex.org/W1988409390","https://openalex.org/W1988769784","https://openalex.org/W1989186104","https://openalex.org/W1990414934","https://openalex.org/W1990540492","https://openalex.org/W1991086588","https://openalex.org/W1991269972","https://openalex.org/W1991275220","https://openalex.org/W1993457255","https://openalex.org/W1994524362","https://openalex.org/W1995201952","https://openalex.org/W1995773014","https://openalex.org/W1997267372","https://openalex.org/W1997590082","https://openalex.org/W1997755216","https://openalex.org/W1998038367","https://openalex.org/W1998203489","https://openalex.org/W2000683036","https://openalex.org/W2000829157","https://openalex.org/W2000988854","https://openalex.org/W2001404673","https://openalex.org/W2003763099","https://openalex.org/W2005558505","https://openalex.org/W2006677458","https://openalex.org/W2007434627","https://openalex.org/W2008404887","https://openalex.org/W2008412332","https://openalex.org/W2008494261","https://openalex.org/W2008693544","https://openalex.org/W2009933732","https://openalex.org/W2009938323","https://openalex.org/W2010286320","https://openalex.org/W2010847506","https://openalex.org/W2010972371","https://openalex.org/W2011257176","https://openalex.org/W2011484579","https://openalex.org/W2012112428","https://openalex.org/W2012225322","https://openalex.org/W2013027490","https://openalex.org/W2015416439","https://openalex.org/W2015538824","https://openalex.org/W2016233862","https://openalex.org/W2016323460","https://openalex.org/W2016777209","https://openalex.org/W2018017628","https://openalex.org/W2018298304","https://openalex.org/W2018328223","https://openalex.org/W2019304821","https://openalex.org/W2019812235","https://openalex.org/W2019845642","https://openalex.org/W2020187563","https://openalex.org/W2021341917","https://openalex.org/W2023349347","https://openalex.org/W2025571425","https://openalex.org/W2026311526","https://openalex.org/W2027271469","https://openalex.org/W2027329984","https://openalex.org/W2027363457","https://openalex.org/W2028276857","https://openalex.org/W2028494426","https://openalex.org/W2028775513","https://openalex.org/W2029747432","https://openalex.org/W2030397096","https://openalex.org/W2032346637","https://openalex.org/W2032863945","https://openalex.org/W2034035188","https://openalex.org/W2034614265","https://openalex.org/W2034753731","https://openalex.org/W2035252744","https://openalex.org/W2035711389","https://openalex.org/W2036390801","https://openalex.org/W2036864436","https://openalex.org/W2037828169","https://openalex.org/W2037992248","https://openalex.org/W2038531680","https://openalex.org/W2039307777","https://openalex.org/W2040101760","https://openalex.org/W2042129729","https://openalex.org/W2042449627","https://openalex.org/W2044984495","https://openalex.org/W2045737085","https://openalex.org/W2046395086","https://openalex.org/W2047352825","https://openalex.org/W2047446828","https://openalex.org/W2047591801","https://openalex.org/W2047732548","https://openalex.org/W2047780283","https://openalex.org/W2051023783","https://openalex.org/W2051026651","https://openalex.org/W2051152566","https://openalex.org/W2052931002","https://openalex.org/W2053767668","https://openalex.org/W2055007585","https://openalex.org/W2055303877","https://openalex.org/W2056833504","https://openalex.org/W2056907950","https://openalex.org/W2057679261","https://openalex.org/W2058138221","https://openalex.org/W2059030268","https://openalex.org/W2059134795","https://openalex.org/W2059351132","https://openalex.org/W2061530054","https://openalex.org/W2062289724","https://openalex.org/W2063488708","https://openalex.org/W2064345264","https://openalex.org/W2064911233","https://openalex.org/W2065094127","https://openalex.org/W2067796079","https://openalex.org/W2069078859","https://openalex.org/W2070643074","https://openalex.org/W2071060833","https://openalex.org/W2071934663","https://openalex.org/W2072366969","https://openalex.org/W2072866076","https://openalex.org/W2073109135","https://openalex.org/W2075211183","https://openalex.org/W2075449020","https://openalex.org/W2076243878","https://openalex.org/W2076403167","https://openalex.org/W2076891180","https://openalex.org/W2076892771","https://openalex.org/W2078364998","https://openalex.org/W2078461915","https://openalex.org/W2079202692","https://openalex.org/W2080478082","https://openalex.org/W2080658126","https://openalex.org/W2081442315","https://openalex.org/W2082629538","https://openalex.org/W2083393429","https://openalex.org/W2083695545","https://openalex.org/W2084253055","https://openalex.org/W2084254278","https://openalex.org/W2084702956","https://openalex.org/W2084846482","https://openalex.org/W2085557430","https://openalex.org/W2086031243","https://openalex.org/W2086759170","https://openalex.org/W2087155042","https://openalex.org/W2087986742","https://openalex.org/W2088077925","https://openalex.org/W2090692462","https://openalex.org/W2091707342","https://openalex.org/W2092528215","https://openalex.org/W2092531246","https://openalex.org/W2092915190","https://openalex.org/W2094043001","https://openalex.org/W2094063881","https://openalex.org/W2094089029","https://openalex.org/W2094253796","https://openalex.org/W2094424802","https://openalex.org/W2094916309","https://openalex.org/W2094999596","https://openalex.org/W2095247701","https://openalex.org/W2095522181","https://openalex.org/W2095797772","https://openalex.org/W2098036842","https://openalex.org/W2098145833","https://openalex.org/W2098249941","https://openalex.org/W2099245182","https://openalex.org/W2099803844","https://openalex.org/W2100587126","https://openalex.org/W2102516488","https://openalex.org/W2102650381","https://openalex.org/W2103797621","https://openalex.org/W2105795952","https://openalex.org/W2107237644","https://openalex.org/W2107277218","https://openalex.org/W2107733280","https://openalex.org/W2108003465","https://openalex.org/W2108743126","https://openalex.org/W2109027708","https://openalex.org/W2111430444","https://openalex.org/W2112310203","https://openalex.org/W2114264201","https://openalex.org/W2114287704","https://openalex.org/W2114360185","https://openalex.org/W2115769793","https://openalex.org/W2116513829","https://openalex.org/W2117039119","https://openalex.org/W2117691193","https://openalex.org/W2118719170","https://openalex.org/W2121294856","https://openalex.org/W2121683669","https://openalex.org/W2121714067","https://openalex.org/W2123619341","https://openalex.org/W2124243768","https://openalex.org/W2124371647","https://openalex.org/W2125904354","https://openalex.org/W2129546321","https://openalex.org/W2133674420","https://openalex.org/W2134773980","https://openalex.org/W2135085078","https://openalex.org/W2142493853","https://openalex.org/W2142522741","https://openalex.org/W2143027433","https://openalex.org/W2143370650","https://openalex.org/W2145447273","https://openalex.org/W2148104091","https://openalex.org/W2152207188","https://openalex.org/W2152695471","https://openalex.org/W2153943744","https://openalex.org/W2154256241","https://openalex.org/W2156371985","https://openalex.org/W2158937675","https://openalex.org/W2159732007","https://openalex.org/W2159970180","https://openalex.org/W2162159944","https://openalex.org/W2165367624","https://openalex.org/W2165455805","https://openalex.org/W2166245070","https://openalex.org/W2167118090","https://openalex.org/W2168547139","https://openalex.org/W2168589849","https://openalex.org/W2168710949","https://openalex.org/W2170694278","https://openalex.org/W2171520502","https://openalex.org/W2241599947","https://openalex.org/W2322211964","https://openalex.org/W2324514343","https://openalex.org/W2335878131","https://openalex.org/W2395842133","https://openalex.org/W2407165303","https://openalex.org/W2415932287","https://openalex.org/W2435188188","https://openalex.org/W2920807090"],"related_works":["https://openalex.org/W6959717134","https://openalex.org/W2167599650","https://openalex.org/W2765195294","https://openalex.org/W2115769793","https://openalex.org/W1769244282","https://openalex.org/W6958756843","https://openalex.org/W3150002346","https://openalex.org/W2408900570","https://openalex.org/W2010384121","https://openalex.org/W4291222008"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-30T00:00:00"}
