{"id":"https://openalex.org/W3002016602","doi":"https://doi.org/10.1038/s41598-020-57985-w","title":"Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells","display_name":"Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells","publication_year":2020,"publication_date":"2020-01-23","ids":{"openalex":"https://openalex.org/W3002016602","doi":"https://doi.org/10.1038/s41598-020-57985-w","mag":"3002016602","pmid":"https://pubmed.ncbi.nlm.nih.gov/31974518","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6978388"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-57985-w","doi":"https://doi.org/10.1038/s41598-020-57985-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-57985-w","pdf_url":"https://www.nature.com/articles/s41598-020-57985-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-57985-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060814129","display_name":"Silja Steinmann","orcid":"https://orcid.org/0000-0001-9177-1414","observed_orcids":["https://orcid.org/0000-0001-9177-1414"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silja Steinmann","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043105963","display_name":"M Schoedsack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marek Schoedsack","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042840348","display_name":"Fabian Heinrich","orcid":"https://orcid.org/0000-0002-2922-4863","observed_orcids":["https://orcid.org/0000-0002-2922-4863"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Heinrich","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114033998","display_name":"Philippe Christophe Breda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philippe C. Breda","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032170040","display_name":"Aaron Ochel","orcid":"https://orcid.org/0000-0001-6954-1997","observed_orcids":["https://orcid.org/0000-0001-6954-1997"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Aaron Ochel","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005787669","display_name":"Gisa Tiegs","orcid":"https://orcid.org/0000-0002-8011-0167","observed_orcids":["https://orcid.org/0000-0002-8011-0167"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gisa Tiegs","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. g.tiegs@uke.de","Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. g.tiegs@uke.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049581826","display_name":"Katrin Neumann","orcid":"https://orcid.org/0000-0002-3858-3171","observed_orcids":["https://orcid.org/0000-0002-3858-3171","https://orcid.org/0000-0002-3989-8095"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Katrin Neumann","raw_affiliation_strings":["Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. kat.neumann@uke.de","Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. kat.neumann@uke.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005787669","https://openalex.org/A5049581826"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":1.9684,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87362679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"1071","last_page":"1071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/group-2-innate-lymphoid-cells","display_name":"ILC2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ilc2-activation","display_name":"ILC2 activation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/immune-mediated-hepatitis","display_name":"immune-mediated hepatitis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cytokine-regulation","display_name":"cytokine regulation","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.86948561668396},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7917835116386414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49979686737060547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38342079520225525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34363722801208496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3322909474372864}],"mesh":[{"descriptor_ui":"D000067596","descriptor_name":"Interleukin-33","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000067596","descriptor_name":"Interleukin-33","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-020-57985-w","doi":"https://doi.org/10.1038/s41598-020-57985-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-57985-w","pdf_url":"https://www.nature.com/articles/s41598-020-57985-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6978388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6978388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31974518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31974518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4671803","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/lsh2200907.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:79abe358718540ea87d7147163871112","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/79abe358718540ea87d7147163871112","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-57985-w","doi":"https://doi.org/10.1038/s41598-020-57985-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-57985-w","pdf_url":"https://www.nature.com/articles/s41598-020-57985-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1623951614","display_name":null,"funder_award_id":"SPP193 7","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4998462225","display_name":null,"funder_award_id":"SFB 841 project B1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5345868840","display_name":null,"funder_award_id":"Project B1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G670423126","display_name":null,"funder_award_id":"SFB 841","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320335947","display_name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3002016602.pdf","grobid_xml":"https://content.openalex.org/works/W3002016602.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1829679176","https://openalex.org/W1855313929","https://openalex.org/W1953168141","https://openalex.org/W1967173904","https://openalex.org/W1967715707","https://openalex.org/W1977213133","https://openalex.org/W1990121282","https://openalex.org/W1995070836","https://openalex.org/W1997745506","https://openalex.org/W1997883939","https://openalex.org/W1998420703","https://openalex.org/W2002307060","https://openalex.org/W2008658190","https://openalex.org/W2009008191","https://openalex.org/W2010180179","https://openalex.org/W2015053270","https://openalex.org/W2019215354","https://openalex.org/W2023719946","https://openalex.org/W2047875752","https://openalex.org/W2047882259","https://openalex.org/W2050604953","https://openalex.org/W2057210516","https://openalex.org/W2058866971","https://openalex.org/W2073361650","https://openalex.org/W2089685608","https://openalex.org/W2097139406","https://openalex.org/W2102829493","https://openalex.org/W2106790228","https://openalex.org/W2116569673","https://openalex.org/W2121209580","https://openalex.org/W2124436787","https://openalex.org/W2131520834","https://openalex.org/W2140206763","https://openalex.org/W2148772311","https://openalex.org/W2151325231","https://openalex.org/W2158204425","https://openalex.org/W2162674326","https://openalex.org/W2182536415","https://openalex.org/W2300983099","https://openalex.org/W2344906887","https://openalex.org/W2557148924","https://openalex.org/W2609556606","https://openalex.org/W2614987262","https://openalex.org/W2774218093","https://openalex.org/W2778138625","https://openalex.org/W2800614989","https://openalex.org/W2804628361"],"related_works":["https://openalex.org/W2784412292","https://openalex.org/W2557148924","https://openalex.org/W2938524357","https://openalex.org/W4393025214","https://openalex.org/W2922220228","https://openalex.org/W3120421901","https://openalex.org/W6889004199","https://openalex.org/W2042667842","https://openalex.org/W2921328039","https://openalex.org/W2801650225"],"abstract_inverted_index":{"Abstract":[0],"In":[1,140],"immune-mediated":[2,58,175],"hepatitis,":[3,59],"type":[4,77],"2":[5,78],"innate":[6],"lymphoid":[7],"cells":[8,16,143],"(ILC2)":[9],"as":[10,12,80,82],"well":[11,81],"effector":[13],"CD4+":[14,130],"T":[15,131],"have":[17],"been":[18],"shown":[19],"to":[20,117],"drive":[21],"disease":[22],"pathology.":[23],"However,":[24],"less":[25],"is":[26,156],"known":[27],"about":[28],"mechanisms":[29],"involved":[30],"in":[31,43,67,115,128,174],"the":[32,60],"regulation":[33],"of":[34,76,102,146,150],"ILC2":[35,46,86,105,123,147,154,169],"function":[36,155],"during":[37],"liver":[38,68,118],"inflammation.":[39],"We":[40],"showed":[41],"that":[42],"homeostasis,":[44],"hepatic":[45,85,104,122,153,168],"constituted":[47],"a":[48,53,125],"very":[49],"small":[50],"population":[51],"with":[52],"naive,":[54],"inactive":[55],"phenotype.":[56],"During":[57],"cytokines":[61,79],"IL-33":[62,70,164],"and":[63,74,161,165],"IFN\u03b3":[64,88],"were":[65,106],"expressed":[66],"tissue.":[69],"induced":[71,124],"strong":[72],"activation":[73],"expression":[75,137],"IL-6":[83],"by":[84,98,148,158,180],"while":[87],"suppressed":[89],"cytokine":[90,136],"production.":[91],"Interestingly,":[92],"this":[93],"inhibitory":[94],"effect":[95],"was":[96],"overcome":[97],"IL-33.":[99],"The":[100],"phenotype":[101,127],"activated":[103,129],"stable":[107],"since":[108],"they":[109],"did":[110],"not":[111],"show":[112],"functional":[113],"plasticity":[114],"response":[116],"inflammation-induced":[119],"cytokines.":[120],"Moreover,":[121],"Th2":[126],"cells,":[132],"which":[133],"increased":[134],"ILC2-derived":[135],"via":[138],"IL-2.":[139],"contrast,":[141],"Th1":[142,183],"inhibited":[144],"survival":[145],"production":[149],"IFN\u03b3.":[151,162],"Thus,":[152],"regulated":[157],"IL-33,":[159],"IL-2,":[160],"While":[163],"IL-2":[166],"support":[167],"activation,":[170],"their":[171],"inflammatory":[172],"activity":[173],"hepatitis":[176],"might":[177],"be":[178],"limited":[179],"infiltrating":[181],"IFN\u03b3-expressing":[182],"cells.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-30T00:00:00"}
