{"id":"https://openalex.org/W3001506311","doi":"https://doi.org/10.3389/fonc.2019.01478","title":"Simple Clinical Metrics Enhance AFP to Effectively Identify Cirrhotic Patients With Complicating Hepatocellular Carcinoma at Various AFP Levels","display_name":"Simple Clinical Metrics Enhance AFP to Effectively Identify Cirrhotic Patients With Complicating Hepatocellular Carcinoma at Various AFP Levels","publication_year":2020,"publication_date":"2020-01-24","ids":{"openalex":"https://openalex.org/W3001506311","doi":"https://doi.org/10.3389/fonc.2019.01478","mag":"3001506311","pmid":"https://pubmed.ncbi.nlm.nih.gov/32038998","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6993280"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2019.01478","doi":"https://doi.org/10.3389/fonc.2019.01478","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01478","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01478/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01478/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079289633","display_name":"Xi Zhang","orcid":"https://orcid.org/0000-0001-7402-6981","observed_orcids":["https://orcid.org/0000-0001-7402-6981"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhang","raw_affiliation_strings":["Center for Experimental Medicine Research, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Medicine Research, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427890","display_name":"Ting Wang","orcid":"https://orcid.org/0000-0001-6532-1110","observed_orcids":["https://orcid.org/0000-0001-6532-1110","https://orcid.org/0009-0008-8275-8929","https://orcid.org/0000-0002-8952-0840"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631773","display_name":"Kun-He Zhang","orcid":"https://orcid.org/0000-0003-3568-0600","observed_orcids":["https://orcid.org/0000-0003-3568-0600"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kun-He Zhang","raw_affiliation_strings":["Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030648709","display_name":"Sihai Chen","orcid":"https://orcid.org/0000-0002-0640-5936","observed_orcids":["https://orcid.org/0000-0002-0640-5936"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Hai Chen","raw_affiliation_strings":["Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011631723","display_name":"Yuting He","orcid":"https://orcid.org/0000-0001-6075-9922","observed_orcids":["https://orcid.org/0000-0001-6075-9922"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Ting He","raw_affiliation_strings":["Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100451687","display_name":"Yuqi Wang","orcid":"https://orcid.org/0000-0002-9793-6002","observed_orcids":["https://orcid.org/0000-0002-9793-6002","https://orcid.org/0009-0003-9580-6145","https://orcid.org/0009-0004-8224-4689","https://orcid.org/0009-0008-9122-6086","https://orcid.org/0009-0007-7862-2570"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Qi Wang","raw_affiliation_strings":["Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Jiangxi Institute of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210164024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101631773"],"corresponding_institution_ids":["https://openalex.org/I4210164024"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.3522,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.88809557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"1478","last_page":"1478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/afp-negative-hcc","display_name":"AFP-negative HCC","score":0.925000011920929},{"id":"https://openalex.org/keywords/hcc-diagnosis","display_name":"HCC diagnosis","score":0.5049999952316284},{"id":"https://openalex.org/keywords/clinical-risk-model","display_name":"clinical risk model","score":0.5989999771118164},{"id":"https://openalex.org/keywords/hepatitis-b-cirrhosis","display_name":"hepatitis B cirrhosis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/serum-electrolytes","display_name":"serum electrolytes","score":0.7260000109672546},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9919999837875366},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.7409999966621399},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.5960000157356262},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6620000004768372},{"id":"https://openalex.org/keywords/decision-curve-analysis","display_name":"decision curve analysis","score":0.5640000104904175},{"id":"https://openalex.org/keywords/calibration-curve","display_name":"calibration curve","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.9078859686851501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5830271244049072},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5197415351867676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47646594047546387},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.45376530289649963},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3864149749279022},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2019.01478","doi":"https://doi.org/10.3389/fonc.2019.01478","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01478","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01478/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5955840","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6993280","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6993280","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6993280","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:32038998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32038998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:33d1874280614355ba03edaaad18dcfb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33d1874280614355ba03edaaad18dcfb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 9 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2019.01478","doi":"https://doi.org/10.3389/fonc.2019.01478","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01478","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01478/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1428240784","display_name":null,"funder_award_id":"No. 20171BBG70083","funder_id":"https://openalex.org/F4320327780","funder_display_name":"Key Research and Development Program of Jiangxi Province"},{"id":"https://openalex.org/G3295798953","display_name":null,"funder_award_id":"No. 81702107","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6842374431","display_name":null,"funder_award_id":"81760536","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7005182406","display_name":null,"funder_award_id":"81702107","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8986812208","display_name":null,"funder_award_id":"No. 81760536","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327780","display_name":"Key Research and Development Program of Jiangxi Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3001506311.pdf","grobid_xml":"https://content.openalex.org/works/W3001506311.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W813464619","https://openalex.org/W1964404867","https://openalex.org/W1998618098","https://openalex.org/W2012685007","https://openalex.org/W2029202864","https://openalex.org/W2041487550","https://openalex.org/W2045030989","https://openalex.org/W2047146435","https://openalex.org/W2061538934","https://openalex.org/W2071476028","https://openalex.org/W2086454839","https://openalex.org/W2115606499","https://openalex.org/W2118391811","https://openalex.org/W2137052325","https://openalex.org/W2138893372","https://openalex.org/W2166339706","https://openalex.org/W2170740817","https://openalex.org/W2223605142","https://openalex.org/W2234453634","https://openalex.org/W2260062383","https://openalex.org/W2344882327","https://openalex.org/W2415889824","https://openalex.org/W2514079610","https://openalex.org/W2544387958","https://openalex.org/W2565602318","https://openalex.org/W2743977430","https://openalex.org/W2747236867","https://openalex.org/W2766870179","https://openalex.org/W2767349315","https://openalex.org/W2796067155","https://openalex.org/W2824088326","https://openalex.org/W2889646458","https://openalex.org/W2898585173","https://openalex.org/W2901233119","https://openalex.org/W2910957193","https://openalex.org/W2915809836"],"related_works":["https://openalex.org/W813464619","https://openalex.org/W7220500419","https://openalex.org/W4410180552","https://openalex.org/W1904256709","https://openalex.org/W2417161364","https://openalex.org/W2098637224","https://openalex.org/W2892524678","https://openalex.org/W2462690840","https://openalex.org/W2138893372","https://openalex.org/W2113642271"],"abstract_inverted_index":{"Background:":[0],"Hepatocellular":[1],"carcinoma":[2],"(HCC)":[3],"frequently":[4],"occurs":[5],"in":[6,25,174,250,317],"cirrhosis":[7,166,182,188],"and":[8,31,67,98,116,123,132,153,184,201,218,226,241,264,284,307],"closely":[9],"relates":[10],"to":[11,33,42,48,56,63,89,322],"poor":[12],"prognosis":[13],"of":[14,46,128,135,162,180,187,198,205,256,299,340],"cirrhotic":[15,72,288,341],"patients.":[16],"Alpha-fetoprotein":[17],"(AFP)":[18],"is":[19,335],"the":[20,44,93,136,144,147,206,224,294,323,338],"most":[21],"widely":[22],"used":[23],"biomarker":[24],"HCC":[26,35,50,76,87,109,190,344],"diagnosis":[27],"but":[28],"not":[29],"sensitive":[30],"specific":[32],"detect":[34,49],"at":[36,77],"low":[37],"AFP":[38,47,58,79,117,278,334,347],"levels.":[39,80,348],"In":[40],"order":[41],"enhance":[43],"ability":[45],"developed":[51,111,233],"on":[52],"cirrhosis,":[53],"we":[54],"attempted":[55],"combine":[57],"with":[59,74,84,112,165,189,194,234,253,291,333,345],"conventional":[60],"clinical":[61,100,114,133,208,318,331],"metrics":[62,115,209,332],"develop":[64],"a":[65,141,154],"simple":[66,181,330],"effective":[68],"method":[69],"for":[70,92,107,267,277,337],"identifying":[71],"patients":[73,83,164,289,342],"complicating":[75,343],"various":[78,346],"Methods:":[81],"Cirrhotic":[82],"or":[85],"without":[86],"hospitalized":[88],"receive":[90],"therapy":[91],"first":[94],"time":[95],"were":[96,102,138,172,271],"recruited":[97,173],"their":[99],"data":[101],"retrospectively":[103],"collected.":[104],"A":[105,160,229,310,326],"model":[106,137,230,295,328],"diagnosing":[108,251],"was":[110,231],"routine":[113],"by":[118,169],"binary":[119],"logistic":[120],"regression":[121],"analysis":[122],"internally":[124],"validated.":[125],"The":[126],"goodness":[127],"fit,":[129],"diagnostic":[130,327],"accuracy":[131,266],"usefulness":[134],"evaluated":[139],"using":[140],"calibration":[142],"curve,":[143],"area":[145],"under":[146],"receiver":[148],"operating":[149],"characteristic":[150],"curve":[151,156],"(AUROC)":[152],"decision":[155,319],"analysis,":[157],"respectively.":[158],"Results:":[159],"total":[161],"574":[163],"mainly":[167],"caused":[168],"hepatitis":[170],"B":[171],"this":[175],"study,":[176],"including":[177],"286":[178],"cases":[179,186],"(LC)":[183],"288":[185],"(LCC)":[191],"(124":[192],"AFP-negative),":[193],"an":[195,254,297],"average":[196],"age":[197],"53.2\u00b112.1":[199],"years":[200],"81.4%":[202],"males.":[203],"Twelve":[204],"19":[207],"(age,":[210],"gender,":[211],"AFP,":[212,236],"liver":[213],"function":[214],"tests,":[215],"serum":[216],"electrolytes":[217],"coagulation":[219],"tests)":[220],"significantly":[221],"differed":[222],"between":[223],"LC":[225],"LCC":[227],"groups.":[228],"successfully":[232],"age,":[235],"Na+,":[237],"Cl-,":[238],"alkaline":[239],"phosphatase,":[240],"activated":[242],"partial":[243],"thromboplastin":[244],"time,":[245],"which":[246,270],"exhibited":[247],"good":[248],"performance":[249],"LCC,":[252],"AUROC":[255,298],"0.918":[257],"(95%CI":[258,280,301],"0.895-0.940),":[259],"82.3%":[260],"sensitivity,":[261,304],"89.5%":[262],"specificity,":[263,306],"85.9%":[265],"all":[268],"patients,":[269],"much":[272],"higher":[273],"values":[274],"than":[275],"those":[276],"(0.846":[279],"0.815-0.878),":[281],"72.9%,":[282],"81.5%":[283],"77.2%,":[285],"respectively).":[286],"For":[287],"complicated":[290],"AFP-negative":[292],"HCC,":[293],"showed":[296],"0.854":[300],"0.812-0.896),":[302],"68.5%":[303],"86.6%":[305],"80.0%":[308],"accuracy.":[309],"high":[311],"net":[312],"benefit":[313],"could":[314],"be":[315],"obtained":[316],"making":[320],"according":[321],"model.":[324],"Conclusion:":[325],"combining":[329],"valuable":[336],"identification":[339]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-01-30T00:00:00"}
