{"id":"https://openalex.org/W3001237207","doi":"https://doi.org/10.14260/jemds/2019/821","title":"Expression of E-Cadherin and Its Implication in Laryngeal Squamous Cell Carcinoma","display_name":"Expression of E-Cadherin and Its Implication in Laryngeal Squamous Cell Carcinoma","publication_year":2019,"publication_date":"2019-12-16","ids":{"openalex":"https://openalex.org/W3001237207","doi":"https://doi.org/10.14260/jemds/2019/821","mag":"3001237207"},"language":"en","primary_location":{"id":"doi:10.14260/jemds/2019/821","doi":"https://doi.org/10.14260/jemds/2019/821","is_oa":true,"landing_page_url":"https://doi.org/10.14260/jemds/2019/821","pdf_url":"https://doi.org/10.14260/jemds/2019/821","source":{"id":"https://openalex.org/S4210170031","display_name":"Journal of Evolution of Medical and Dental Sciences","issn_l":"2278-4748","issn":["2278-4748","2278-4802"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4322614713","host_organization_name":"Akshantala Enterprises Private Limited","host_organization_lineage":["https://openalex.org/P4322614713"],"host_organization_lineage_names":["Akshantala Enterprises Private Limited"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evolution of Medical and Dental Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.14260/jemds/2019/821","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ujjwal Ghosh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ujjwal Ghosh","raw_affiliation_strings":["Department of Pathology, Gopiballavpur Super-Speciality Hospital, Jhargram, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Gopiballavpur Super-Speciality Hospital, Jhargram, West Bengal, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030277742","display_name":"Suman Ghosh","orcid":"https://orcid.org/0000-0001-5755-8521","observed_orcids":["https://orcid.org/0000-0001-5755-8521"]},"institutions":[{"id":"https://openalex.org/I158908536","display_name":"Nil Ratan Sircar Medical College and Hospital","ror":"https://ror.org/04zpy9a42","country_code":"IN","type":"education","lineage":["https://openalex.org/I158908536","https://openalex.org/I226431899"]},{"id":"https://openalex.org/I68428275","display_name":"Medical College and Hospital, Kolkata","ror":"https://ror.org/021nb2v44","country_code":"IN","type":"education","lineage":["https://openalex.org/I226431899","https://openalex.org/I68428275"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Suman Ghosh","raw_affiliation_strings":["Department of Pathology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India","institution_ids":["https://openalex.org/I158908536","https://openalex.org/I68428275"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077206543","display_name":"Anup Kumar Roy","orcid":"https://orcid.org/0000-0002-2264-0944","observed_orcids":["https://orcid.org/0000-0002-2264-0944"]},"institutions":[{"id":"https://openalex.org/I158908536","display_name":"Nil Ratan Sircar Medical College and Hospital","ror":"https://ror.org/04zpy9a42","country_code":"IN","type":"education","lineage":["https://openalex.org/I158908536","https://openalex.org/I226431899"]},{"id":"https://openalex.org/I68428275","display_name":"Medical College and Hospital, Kolkata","ror":"https://ror.org/021nb2v44","country_code":"IN","type":"education","lineage":["https://openalex.org/I226431899","https://openalex.org/I68428275"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anup Kumar Roy","raw_affiliation_strings":["Department of Pathology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India","institution_ids":["https://openalex.org/I158908536","https://openalex.org/I68428275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030277742"],"corresponding_institution_ids":["https://openalex.org/I158908536","https://openalex.org/I68428275"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"8","issue":"50","first_page":"3790","last_page":"3795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/occult-metastases","display_name":"occult metastasis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7480000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/elective-neck-dissection","display_name":"elective neck dissection","score":0.8309999704360962},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9458677768707275},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.879467248916626},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.6170433163642883},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.47469562292099},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4579116702079773},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44299086928367615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38694828748703003},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36963188648223877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33257073163986206},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28636372089385986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.031435251235961914},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14260/jemds/2019/821","doi":"https://doi.org/10.14260/jemds/2019/821","is_oa":true,"landing_page_url":"https://doi.org/10.14260/jemds/2019/821","pdf_url":"https://doi.org/10.14260/jemds/2019/821","source":{"id":"https://openalex.org/S4210170031","display_name":"Journal of Evolution of Medical and Dental Sciences","issn_l":"2278-4748","issn":["2278-4748","2278-4802"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4322614713","host_organization_name":"Akshantala Enterprises Private Limited","host_organization_lineage":["https://openalex.org/P4322614713"],"host_organization_lineage_names":["Akshantala Enterprises Private Limited"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evolution of Medical and Dental Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14260/jemds/2019/821","doi":"https://doi.org/10.14260/jemds/2019/821","is_oa":true,"landing_page_url":"https://doi.org/10.14260/jemds/2019/821","pdf_url":"https://doi.org/10.14260/jemds/2019/821","source":{"id":"https://openalex.org/S4210170031","display_name":"Journal of Evolution of Medical and Dental Sciences","issn_l":"2278-4748","issn":["2278-4748","2278-4802"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4322614713","host_organization_name":"Akshantala Enterprises Private Limited","host_organization_lineage":["https://openalex.org/P4322614713"],"host_organization_lineage_names":["Akshantala Enterprises Private Limited"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evolution of Medical and Dental Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3001237207.pdf","grobid_xml":"https://content.openalex.org/works/W3001237207.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W91088060","https://openalex.org/W1489118867","https://openalex.org/W1493317689","https://openalex.org/W1836261337","https://openalex.org/W1878247513","https://openalex.org/W1917075338","https://openalex.org/W1981752846","https://openalex.org/W2005982817","https://openalex.org/W2026262319","https://openalex.org/W2039298921","https://openalex.org/W2047351348","https://openalex.org/W2050656020","https://openalex.org/W2053802406","https://openalex.org/W2055158239","https://openalex.org/W2062100928","https://openalex.org/W2062194061","https://openalex.org/W2065647828","https://openalex.org/W2081554585","https://openalex.org/W2095576421","https://openalex.org/W2108423050","https://openalex.org/W2115124950","https://openalex.org/W2119173706","https://openalex.org/W2129918246","https://openalex.org/W2157133670","https://openalex.org/W2158861003","https://openalex.org/W2184438729","https://openalex.org/W2514082752"],"related_works":["https://openalex.org/W2386863080","https://openalex.org/W2379877197","https://openalex.org/W2184438729","https://openalex.org/W4407896554","https://openalex.org/W2078780683","https://openalex.org/W2906059448","https://openalex.org/W2088848173","https://openalex.org/W2462934326","https://openalex.org/W3003124971","https://openalex.org/W2062100928"],"abstract_inverted_index":{"BACKGROUND":[0],"E-cadherin":[1,56,119,284,310],"is":[2,24,338],"essential":[3],"for":[4,102,118],"cell":[5,7,34,66,86,194,269],"to":[6,79,149,216,223,235,238,296,359],"adhesion":[8],"and":[9,21,31,108,113,262,279,326,342,364,374],"its":[10],"reduced":[11],"expression":[12,57,120,259,282],"will":[13,349],"result":[14],"in":[15,29,61,99,141,209,371],"dissemination":[16],"of":[17,39,55,63,153,163,183,190,205,227,231,258,260,266,281,283,316,324,353,367],"cells,":[18],"cancer":[19],"metastasis":[20,278,320],"invasiveness.Lymph-node":[22],"metastases":[23],"an":[25,307],"independent":[26],"prognostic":[27],"factor":[28],"head":[30],"neck":[32,47,276,336],"squamous":[33,65,85,193,268],"carcinoma.Studies":[35],"indicate":[36],"that":[37,290],"4-40%":[38],"patients":[40,207,221,299,312],"with":[41,44,180,219,244],"laryngeal":[42,64,84,192,267],"carcinoma":[43,87,195],"clinically/radiologically":[45],"negative":[46],"lymph":[48,332],"nodes":[49],"indeed":[50],"have":[51,144,175,301,313],"occult":[52,319],"metastases.So,":[53],"study":[54,73,154,164,202,211,287],"would":[58],"be":[59,294,356],"noteworthy":[60],"case":[62],"carcinoma.":[67],"METHODSAn":[68],"institution":[69],"based":[70],"observational":[71],"cross-sectional":[72],"was":[74,272],"conducted":[75],"from":[76,106,213,330],"February":[77],"2017":[78],"July":[80],"2018.Patients":[81],"diagnosed":[82],"as":[83],"(DL":[88],"biopsy/laryngectomy":[89],"specimen)":[90],"who":[91,300],"did":[92],"not":[93,350],"receive":[94],"chemo/":[95],"radiotherapy":[96],"were":[97,104,116,127,197],"included":[98,208],"the":[100,151,157,161,181,200,206,224,239,245,322,361,368],"study.Evaluation":[101],"grades":[103,265],"done":[105],"haematoxylin":[107],"eosin":[109],"stained":[110],"sections.Formalin":[111],"fixed":[112],"paraffin-embedded":[114],"blocks":[115],"analysed":[117,128],"by":[121,129,305,335],"immunohistochemistry":[122],"using":[123],"a":[124,252,339,372],"scoring":[125],"system.Data":[126],"Mean":[130],"\u00b1":[131],"Standard":[132],"Deviation,":[133],"(Min-Max).The":[134],"results":[135],"on":[136,166,309],"categorical":[137,167],"measurements":[138],"are":[139],"expressed":[140],"Number":[142],"(%).We":[143],"used":[145,176],"Student":[146],"t":[147],"test":[148,179],"find":[150,160],"significance":[152,162],"parameters":[155,165],"between":[156,169,256,275],"two":[158,170],"groups.To":[159],"scale":[168],"or":[171],"more":[172,302,314,357],"groups":[173],"we":[174,288],"Fisher":[177],"Exact":[178],"help":[182],"statistical":[184,254],"software":[185],"SPSS":[186],"18.0.":[187],"RESULTSA":[188],"total":[189],"50":[191,232],"cases":[196,233],"enrolled":[198],"during":[199],"entire":[201],"period.The":[203],"age":[204,225,240,247],"our":[210,286,291],"varied":[212],"37":[214],"years":[215,218,243],"77":[217],"most":[220],"belonging":[222],"group":[226,241],"61-70":[228,242],"yrs.18":[229],"out":[230],"contributing":[234],"36%":[236],"belonged":[237],"mean":[246],"being":[248],"57":[249],"years.We":[250],"found":[251,274],"definite":[253],"correlation":[255,271],"loss":[257,280],"Ecadherin":[261],"increasing":[263],"histological":[264],"carcinoma.Positive":[270],"also":[273],"node":[277,333],"CONCLUSIONSThrough":[285],"experienced":[289],"ability":[292],"can":[293,355],"increased":[295],"identify":[297],"those":[298],"aggressive":[303,365],"disease":[304],"keeping":[306],"eye":[308],"expression.These":[311],"chances":[315],"already":[317],"having":[318],"at":[321],"time":[323],"diagnosis":[325],"hence":[327],"may":[328],"benefit":[329],"elective":[331],"clearance":[334],"dissection.Metastasis":[337],"multi-step":[340],"process":[341],"involves":[343],"many":[344],"biomolecules.Therefore,":[345],"only":[346],"one":[347],"biomarker":[348],"suffice.A":[351],"panel":[352],"biomarkers":[354],"effective":[358],"predict":[360],"metastatic":[362],"potential":[363],"behaviour":[366],"primary":[369],"tumour":[370],"better":[373],"accurate":[375],"way.":[376]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-30T00:00:00"}
