{"id":"https://openalex.org/W3000998517","doi":null,"title":"Pleiotropic role of macrophage migration inhibitory factor in cancer.","display_name":"Pleiotropic role of macrophage migration inhibitory factor in cancer.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3000998517","mag":"3000998517","pmid":"https://pubmed.ncbi.nlm.nih.gov/31911860","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943360"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6943360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046250123","display_name":"Maheedhara Reddy Guda","orcid":"https://orcid.org/0000-0003-1791-5875","observed_orcids":["https://orcid.org/0000-0003-1791-5875"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maheedhara R Guda","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084636266","display_name":"Matthew A Rashid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A Rashid","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012539225","display_name":"Swapna Asuthkar","orcid":"https://orcid.org/0000-0002-0659-3068","observed_orcids":["https://orcid.org/0000-0002-0659-3068"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swapna Asuthkar","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019496219","display_name":"Anvesh Jalasutram","orcid":"https://orcid.org/0000-0002-9183-0688","observed_orcids":["https://orcid.org/0000-0002-9183-0688"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anvesh Jalasutram","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003446814","display_name":"John L. Caniglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L Caniglia","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045764669","display_name":"Andrew J. Tsung","orcid":"https://orcid.org/0000-0003-1202-5902","observed_orcids":["https://orcid.org/0000-0003-1202-5902"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J Tsung","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","Department of Neurosurgery, University of Illinois College of Medicine at Peoria Peoria, IL, USA","Illinois Neurological Institute Peoria, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]},{"raw_affiliation_string":"Illinois Neurological Institute Peoria, IL, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074078829","display_name":"Kiran Kumar Velpula","orcid":"https://orcid.org/0000-0001-8947-5958","observed_orcids":["https://orcid.org/0000-0001-8947-5958"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]},{"id":"https://openalex.org/I83073037","display_name":"Yogi Vemana University","ror":"https://ror.org/0137gef36","country_code":"IN","type":"education","lineage":["https://openalex.org/I83073037"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Kiran K Velpula","raw_affiliation_strings":["Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","Department of Neurosurgery, University of Illinois College of Medicine at Peoria Peoria, IL, USA","Department of Pediatrics, University of Illinois College of Medicine at Peoria Peoria, IL, USA","Department of Microbiology, Yogi Vemana University Kadapa, AP, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]},{"raw_affiliation_string":"Department of Pediatrics, University of Illinois College of Medicine at Peoria Peoria, IL, USA","institution_ids":["https://openalex.org/I4210130227"]},{"raw_affiliation_string":"Department of Microbiology, Yogi Vemana University Kadapa, AP, India","institution_ids":["https://openalex.org/I83073037"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2518,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.88591841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"12","first_page":"2760","last_page":"2773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6439999938011169},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":1.0},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cell-cycle-dysregulation","display_name":"cell cycle dysregulation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.9692239761352539},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.642353355884552},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6333920955657959},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6319164037704468},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5569331049919128},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.49427103996276855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49059024453163147},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4746207296848297},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4650716781616211},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4406777620315552},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4379894733428955},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4297895133495331},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39066970348358154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3554556369781494},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2338787317276001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21504747867584229}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6943360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:31911860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31911860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:3000998517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31911860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6943360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6943360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W109149868","https://openalex.org/W221215209","https://openalex.org/W1271572098","https://openalex.org/W1584642143","https://openalex.org/W1775915307","https://openalex.org/W1965060537","https://openalex.org/W1974433996","https://openalex.org/W1974757283","https://openalex.org/W1975009528","https://openalex.org/W1979259404","https://openalex.org/W1984372257","https://openalex.org/W1989832114","https://openalex.org/W1992499848","https://openalex.org/W2001737701","https://openalex.org/W2007784745","https://openalex.org/W2010426445","https://openalex.org/W2024397767","https://openalex.org/W2026192283","https://openalex.org/W2029174607","https://openalex.org/W2029665800","https://openalex.org/W2040336985","https://openalex.org/W2047297009","https://openalex.org/W2047308155","https://openalex.org/W2050313949","https://openalex.org/W2076583198","https://openalex.org/W2082163938","https://openalex.org/W2083995543","https://openalex.org/W2089009101","https://openalex.org/W2091063540","https://openalex.org/W2102204623","https://openalex.org/W2108951258","https://openalex.org/W2109017823","https://openalex.org/W2112280924","https://openalex.org/W2114072861","https://openalex.org/W2115984648","https://openalex.org/W2131678991","https://openalex.org/W2138916360","https://openalex.org/W2142394051","https://openalex.org/W2146088970","https://openalex.org/W2146133435","https://openalex.org/W2152205015","https://openalex.org/W2153213901","https://openalex.org/W2165359467","https://openalex.org/W2181078066","https://openalex.org/W2283975315","https://openalex.org/W2399085547","https://openalex.org/W2415737428","https://openalex.org/W2417400244","https://openalex.org/W2521208759","https://openalex.org/W2531373072","https://openalex.org/W2538555622","https://openalex.org/W2551526386","https://openalex.org/W2607244245","https://openalex.org/W2729828302","https://openalex.org/W2735151069","https://openalex.org/W2757408762","https://openalex.org/W2770871597","https://openalex.org/W2791390184","https://openalex.org/W2809200263","https://openalex.org/W2838549027","https://openalex.org/W2910236793","https://openalex.org/W2912466573","https://openalex.org/W2934620676","https://openalex.org/W2938965256","https://openalex.org/W2947212897","https://openalex.org/W2955236845"],"related_works":["https://openalex.org/W2517270366","https://openalex.org/W2387351862","https://openalex.org/W7135629324","https://openalex.org/W2537739770","https://openalex.org/W2370960218","https://openalex.org/W2078001534","https://openalex.org/W3032812412","https://openalex.org/W2369216063","https://openalex.org/W2142587601","https://openalex.org/W2112280924"],"abstract_inverted_index":{"Macrophage":[0],"migration":[1],"inhibitory":[2],"factor":[3],"(MIF)":[4],"is":[5,19,25,67,81],"an":[6],"inflammatory":[7],"cytokine":[8],"that":[9,79,103,124],"serves":[10],"many":[11],"roles":[12],"in":[13,22,40,72,83,86,106],"inflammation":[14],"and":[15,31,37,57,59,88,98,115,129],"immunity;":[16],"however,":[17],"it":[18],"also":[20],"involved":[21],"carcinogenesis.":[23],"This":[24],"a":[26],"review":[27,66],"of":[28,43,64,75,93,109],"the":[29,91,94],"clinical":[30],"experimental":[32],"data":[33],"published":[34],"on":[35],"MIF":[36,80,104],"its":[38],"role":[39,71],"various":[41,73],"types":[42,74,108],"cancers":[44],"such":[45],"as":[46],"glioblastomas,":[47],"lung":[48],"cancer,":[49,51,53,56],"breast":[50],"gastric":[52],"melanoma,":[54],"bladder":[55],"head":[58],"neck":[60],"cancers.":[61,76],"The":[62],"goal":[63],"this":[65],"to":[68,90],"show":[69,78,102],"MIFs":[70],"Data":[77],"overexpressed":[82],"these":[84,107],"malignancies":[85],"humans,":[87],"contributes":[89],"deregulation":[92],"cell":[95],"cycle,":[96],"angiogenesis,":[97],"metastasis.":[99],"Clinical":[100],"studies":[101],"overexpression":[105],"tumors":[110],"significantly":[111],"decreases":[112],"survival":[113],"rate,":[114],"increases":[116],"tumor":[117],"aggression.":[118],"There":[119],"are":[120,125],"multiple":[121],"anti-MIF":[122],"molecules":[123],"currently":[126],"being":[127],"explored":[128],"investigations":[130],"should":[131],"be":[132],"continued.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-30T00:00:00"}
