{"id":"https://openalex.org/W3000984240","doi":"https://doi.org/10.1007/s11523-020-00695-0","title":"Genetic Profiling of Advanced Melanoma: Candidate Mutations for Predicting Sensitivity and Resistance to Targeted Therapy","display_name":"Genetic Profiling of Advanced Melanoma: Candidate Mutations for Predicting Sensitivity and Resistance to Targeted Therapy","publication_year":2020,"publication_date":"2020-01-25","ids":{"openalex":"https://openalex.org/W3000984240","doi":"https://doi.org/10.1007/s11523-020-00695-0","mag":"3000984240","pmid":"https://pubmed.ncbi.nlm.nih.gov/31980996","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7028806"},"language":"en","primary_location":{"id":"doi:10.1007/s11523-020-00695-0","doi":"https://doi.org/10.1007/s11523-020-00695-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11523-020-00695-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-020-00695-0.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11523-020-00695-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077075027","display_name":"Magdalena Olbryt","orcid":"https://orcid.org/0000-0001-9961-6427","observed_orcids":["https://orcid.org/0000-0001-9961-6427"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Magdalena Olbryt","raw_affiliation_strings":["Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland. Magdalena.Olbryt@io.gliwice.pl","Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland"],"raw_orcid":"https://orcid.org/0000-0001-9961-6427","affiliations":[{"raw_affiliation_string":"Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland. Magdalena.Olbryt@io.gliwice.pl","institution_ids":["https://openalex.org/I4210150880"]},{"raw_affiliation_string":"Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030121602","display_name":"Wojciech Pig\u0142owski","orcid":"https://orcid.org/0000-0002-9727-7318","observed_orcids":["https://orcid.org/0000-0002-9727-7318"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech Pig\u0142owski","raw_affiliation_strings":["Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland","Tumor Pathology Department, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Gliwice, Poland"],"raw_orcid":"https://orcid.org/0000-0002-9727-7318","affiliations":[{"raw_affiliation_string":"Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland","institution_ids":["https://openalex.org/I4210150880"]},{"raw_affiliation_string":"Tumor Pathology Department, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Gliwice, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083788062","display_name":"Marcin Rajczykowski","orcid":"https://orcid.org/0000-0002-3975-1309","observed_orcids":["https://orcid.org/0000-0002-3975-1309"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Rajczykowski","raw_affiliation_strings":["II Clinic of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Gliwice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"II Clinic of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Gliwice, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062078840","display_name":"Aleksandra Pfeifer","orcid":"https://orcid.org/0000-0002-0189-9711","observed_orcids":["https://orcid.org/0000-0002-0189-9711"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Pfeifer","raw_affiliation_strings":["Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Gliwice, Poland"],"raw_orcid":"https://orcid.org/0000-0002-0189-9711","affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Gliwice, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039511986","display_name":"Sebastian Student","orcid":"https://orcid.org/0000-0003-1812-5496","observed_orcids":["https://orcid.org/0000-0003-1812-5496"]},"institutions":[{"id":"https://openalex.org/I119004910","display_name":"Silesian University of Technology","ror":"https://ror.org/02dyjk442","country_code":"PL","type":"education","lineage":["https://openalex.org/I119004910"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Sebastian Student","raw_affiliation_strings":["Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, Gliwice, Poland","Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 16, Gliwice, Poland"],"raw_orcid":"https://orcid.org/0000-0003-1812-5496","affiliations":[{"raw_affiliation_string":"Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]},{"raw_affiliation_string":"Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 16, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002741707","display_name":"Anna Fiszer-Kierzkowska","orcid":"https://orcid.org/0000-0001-6734-2089","observed_orcids":["https://orcid.org/0000-0001-6734-2089"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Fiszer-Kierzkowska","raw_affiliation_strings":["Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Institute, Oncology Center Gliwice Branch, Wybrzeze Armii Krajowej 15, Gliwice, Poland","institution_ids":["https://openalex.org/I4210150880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077075027"],"corresponding_institution_ids":["https://openalex.org/I4210150880"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":1.4293,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.80548108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"101","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/braf-mek-inhibitors","display_name":"BRAF/MEK inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/intrinsic-resistance","display_name":"intrinsic resistance","score":0.7720000147819519},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8799999952316284},{"id":"https://openalex.org/keywords/genetic-profiling","display_name":"genetic profiling","score":0.47999998927116394},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ctnnb1","display_name":"CTNNB1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/kit","display_name":"KIT","score":0.699999988079071},{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.6830000281333923},{"id":"https://openalex.org/keywords/map2k2","display_name":"MAP2K2","score":0.972000002861023},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.703000009059906},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5370000004768372},{"id":"https://openalex.org/keywords/variants-of-uncertain-significance","display_name":"variants of uncertain significance","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.8733965158462524},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.8371667861938477},{"id":"https://openalex.org/C1167327","wikidata":"https://www.wikidata.org/wiki/Q14884140","display_name":"HRAS","level":5,"score":0.812410831451416},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.6583154201507568},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6334930658340454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.62759929895401},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6094129085540771},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5881761908531189},{"id":"https://openalex.org/C2778830669","wikidata":"https://www.wikidata.org/wiki/Q3011604","display_name":"Dabrafenib","level":5,"score":0.562965989112854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5171836614608765},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.49533596634864807},{"id":"https://openalex.org/C2778472372","wikidata":"https://www.wikidata.org/wiki/Q7833138","display_name":"Trametinib","level":4,"score":0.4270172715187073},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3581535518169403},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.3396821618080139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2450227439403534},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2314530313014984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22467198967933655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22248908877372742},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17599540948867798},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.14287498593330383},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.08064448833465576},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.07704299688339233},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076610","descriptor_name":"Genetic Profile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11523-020-00695-0","doi":"https://doi.org/10.1007/s11523-020-00695-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11523-020-00695-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-020-00695-0.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7028806","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7028806","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Target Oncol","raw_type":"Text"},{"id":"pmid:31980996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31980996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11523-020-00695-0","doi":"https://doi.org/10.1007/s11523-020-00695-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11523-020-00695-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-020-00695-0.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6401455694","display_name":null,"funder_award_id":"2018/02/X/NZ7/00606","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000984240.pdf","grobid_xml":"https://content.openalex.org/works/W3000984240.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1498931318","https://openalex.org/W1950829641","https://openalex.org/W1968797216","https://openalex.org/W1982330331","https://openalex.org/W2003402062","https://openalex.org/W2009642188","https://openalex.org/W2011582941","https://openalex.org/W2019564564","https://openalex.org/W2035000040","https://openalex.org/W2051807533","https://openalex.org/W2052005627","https://openalex.org/W2062088207","https://openalex.org/W2094780514","https://openalex.org/W2096860625","https://openalex.org/W2110764732","https://openalex.org/W2111404068","https://openalex.org/W2112934459","https://openalex.org/W2126361538","https://openalex.org/W2131040858","https://openalex.org/W2134471382","https://openalex.org/W2134490812","https://openalex.org/W2141674733","https://openalex.org/W2158416296","https://openalex.org/W2160766792","https://openalex.org/W2167059308","https://openalex.org/W2167278603","https://openalex.org/W2168420784","https://openalex.org/W2171367970","https://openalex.org/W2176310149","https://openalex.org/W2253928581","https://openalex.org/W2469418432","https://openalex.org/W2491982852","https://openalex.org/W2526607882","https://openalex.org/W2539418106","https://openalex.org/W2565941502","https://openalex.org/W2590342477","https://openalex.org/W2611270905","https://openalex.org/W2619288770","https://openalex.org/W2746208952","https://openalex.org/W2765367195","https://openalex.org/W2767133684","https://openalex.org/W2769057657","https://openalex.org/W2891635302","https://openalex.org/W2945593576","https://openalex.org/W2949857618","https://openalex.org/W2964674548","https://openalex.org/W2968171383"],"related_works":["https://openalex.org/W2588555070","https://openalex.org/W4281567257","https://openalex.org/W1968797216","https://openalex.org/W2336228219","https://openalex.org/W2746208952","https://openalex.org/W2978561675","https://openalex.org/W2704415527","https://openalex.org/W2891828091","https://openalex.org/W2090301551","https://openalex.org/W4376630878"],"abstract_inverted_index":{"BACKGROUND:":[0],"Molecularly":[1],"targeted":[2,94],"therapy":[3,95],"has":[4],"revolutionized":[5],"the":[6,50,61,103,217,234],"treatment":[7,26,72,227],"of":[8,18,25,28,53,64,90,117,168,206,219,236],"advanced":[9,68,87],"melanoma.":[10],"However,":[11],"despite":[12],"its":[13],"high":[14],"efficiency,":[15],"a":[16],"majority":[17],"patients":[19,34,70,91],"experience":[20],"relapse":[21],"within":[22],"1":[23],"year":[24],"because":[27],"acquired":[29],"resistance,":[30],"and":[31,143,152,192,203,222],"approximately":[32],"10-25%":[33],"gain":[35],"no":[36],"benefit":[37],"from":[38,82],"these":[39],"agents":[40],"owing":[41],"to":[42,59,224,238],"intrinsic":[43],"resistance.":[44],"This":[45],"is":[46],"mainly":[47],"caused":[48],"by":[49],"genetic":[51,163],"heterogeneity":[52],"melanoma":[54,69,88,119],"cells.":[55],"OBJECTIVE:":[56],"We":[57],"aimed":[58],"validate":[60],"predictive":[62],"significance":[63,208],"selected":[65],"genes":[66],"in":[67,165,176,233],"before":[71],"with":[73,93,228],"BRAF/MEK":[74,239],"inhibitors.":[75],"PATIENTS":[76],"AND":[77],"METHODS:":[78],"Archival":[79],"DNA":[80],"derived":[81],"37":[83,169],"formalin-fixed":[84],"paraffin-embedded":[85],"pre-treatment":[86],"samples":[89,170],"treated":[92],"was":[96],"used":[97],"for":[98,149],"next-generation":[99],"sequencing":[100],"analysis":[101,160,212],"using":[102,155],"Ion":[104],"Torrent":[105],"platform.":[106],"The":[107,145],"AmpliSeq":[108],"Custom":[109],"Panel":[110],"comprised":[111],"coding":[112],"sequences":[113,146],"or":[114,201],"hot":[115],"spots":[116],"23":[118],"genes:":[120],"ATM,":[121],"BRAF,":[122],"CDK4,":[123,178],"CDKN2A,":[124,179],"CTNNB1,":[125,180],"EGFR,":[126,181],"HOXD8,":[127,182],"HRAS,":[128,183],"IDH1,":[129],"KIT,":[130,184],"KRAS,":[131],"MAP3K8,":[132],"MAP2K1,":[133,185],"MAP2K2,":[134,186],"MITF,":[135,187],"MYC,":[136,188],"NF1,":[137,189],"NRAS,":[138],"PAX5,":[139,190],"PIK3R1,":[140],"PTEN,":[141,177],"RAC1,":[142,191],"RB1.":[144,193],"were":[147,174,209],"evaluated":[148],"genomic":[150],"alterations":[151,164],"further":[153,243],"validated":[154],"Sanger":[156],"sequencing.":[157],"RESULTS:":[158],"Our":[159],"revealed":[161,213],"non-BRAF":[162],"28":[166],"out":[167],"(75.7%).":[171],"Genetic":[172],"changes":[173],"identified":[175],"Fifteen":[194],"known":[195],"pathogenic":[196,220],"mutations":[197,221],"(single":[198],"nucleotide":[199],"variants":[200,205],"indels)":[202],"11":[204],"unknown":[207],"detected.":[210],"Statistical":[211],"an":[214],"association":[215],"between":[216],"presence":[218],"time":[223],"progression":[225],"during":[226],"combination":[229],"therapy.":[230],"CONCLUSIONS:":[231],")":[232],"generation":[235],"resistance":[237],"inhibitors":[240],"should":[241],"be":[242],"investigated.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-30T00:00:00"}
