{"id":"https://openalex.org/W3000903374","doi":"https://doi.org/10.1098/rsos.191171","title":"Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic \u03b1-cells","display_name":"Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic \u03b1-cells","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000903374","doi":"https://doi.org/10.1098/rsos.191171","mag":"3000903374","pmid":"https://pubmed.ncbi.nlm.nih.gov/32218947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7029933"},"language":"en","primary_location":{"id":"doi:10.1098/rsos.191171","doi":"https://doi.org/10.1098/rsos.191171","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsos.191171","pdf_url":null,"source":{"id":"https://openalex.org/S2737558550","display_name":"Royal Society Open Science","issn_l":"2054-5703","issn":["2054-5703"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society Open Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1098/rsos.191171","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046004500","display_name":"Vladimir Grubelnik","orcid":"https://orcid.org/0000-0002-4182-8520","observed_orcids":["https://orcid.org/0000-0002-4182-8520"]},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Vladimir Grubelnik","raw_affiliation_strings":["Faculty of Electrical Engineering and Computer Science, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Electrical Engineering and Computer Science, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070494468","display_name":"Rene Markovi\u010d","orcid":"https://orcid.org/0000-0001-9068-6373","observed_orcids":["https://orcid.org/0000-0001-9068-6373"]},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Rene Markovi\u010d","raw_affiliation_strings":["Faculty of Electrical Engineering and Computer Science, University of Maribor, 2000 Maribor, Slovenia","Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Electrical Engineering and Computer Science, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088730357","display_name":"Sa\u0161ka Lipov\u0161ek","orcid":"https://orcid.org/0000-0003-2898-7807","observed_orcids":["https://orcid.org/0000-0003-2898-7807"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]},{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["AT","SI"],"is_corresponding":false,"raw_author_name":"Sa\u0161ka Lipov\u0161ek","raw_affiliation_strings":["Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria","Faculty of Chemistry and Chemical Engineering, University of Maribor, 2000 Maribor, Slovenia","Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Faculty of Chemistry and Chemical Engineering, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085288007","display_name":"Gerd Leitinger","orcid":"https://orcid.org/0000-0002-5281-9830","observed_orcids":["https://orcid.org/0000-0002-5281-9830"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerd Leitinger","raw_affiliation_strings":["Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstrasse 6, 8010 Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071867549","display_name":"Marko Gosak","orcid":"https://orcid.org/0000-0001-9735-0485","observed_orcids":["https://orcid.org/0000-0001-9735-0485"]},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Marko Gosak","raw_affiliation_strings":["Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001461464","display_name":"Jurij Dolen\u0161ek","orcid":"https://orcid.org/0000-0003-3267-626X","observed_orcids":["https://orcid.org/0000-0003-3267-626X"]},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Jurij Dolen\u0161ek","raw_affiliation_strings":["Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073119824","display_name":"Ismael Valladolid\u2010Acebes","orcid":"https://orcid.org/0000-0002-7699-9207","observed_orcids":["https://orcid.org/0000-0002-7699-9207"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ismael Valladolid-Acebes","raw_affiliation_strings":["The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074543896","display_name":"Per\u2010Olof Berggren","orcid":"https://orcid.org/0000-0001-8991-413X","observed_orcids":["https://orcid.org/0000-0001-8991-413X"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per-Olof Berggren","raw_affiliation_strings":["The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital L1, 171 76 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073579013","display_name":"Andra\u017e Sto\u017eer","orcid":"https://orcid.org/0000-0003-2097-5502","observed_orcids":["https://orcid.org/0000-0003-2097-5502"]},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Andra\u017e Sto\u017eer","raw_affiliation_strings":["Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044431363","display_name":"Matja\u017e Perc","orcid":"https://orcid.org/0000-0002-3087-541X","observed_orcids":["https://orcid.org/0000-0002-3087-541X"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]},{"id":"https://openalex.org/I4210112164","display_name":"Complexity Science Hub","ror":"https://ror.org/023dz9m50","country_code":"AT","type":"nonprofit","lineage":["https://openalex.org/I4210112164"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["AT","SI","TW"],"is_corresponding":true,"raw_author_name":"Matja\u017e Perc","raw_affiliation_strings":["Complexity Science Hub Vienna, 1080 Vienna, Austria","Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan","Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complexity Science Hub Vienna, 1080 Vienna, Austria","institution_ids":["https://openalex.org/I4210112164"]},{"raw_affiliation_string":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044886935","display_name":"Marko Marhl","orcid":"https://orcid.org/0000-0003-0387-1162","observed_orcids":["https://orcid.org/0000-0003-0387-1162"]},"institutions":[{"id":"https://openalex.org/I37696226","display_name":"University of Maribor","ror":"https://ror.org/01d5jce07","country_code":"SI","type":"education","lineage":["https://openalex.org/I37696226"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Marko Marhl","raw_affiliation_strings":["Faculty of Education, University of Maribor, 2000 Maribor, Slovenia","Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Education, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]},{"raw_affiliation_string":"Faculty of Natural Sciences and Mathematics, University of Maribor, 2000 Maribor, Slovenia","institution_ids":["https://openalex.org/I37696226"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5044431363","https://openalex.org/A5044886935"],"corresponding_institution_ids":["https://openalex.org/I184693016","https://openalex.org/I37696226","https://openalex.org/I4210112164","https://openalex.org/I4210126829"],"apc_list":{"value":1200,"currency":"GBP","value_usd":1471},"apc_paid":{"value":1200,"currency":"GBP","value_usd":1471},"fwci":3.6313,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.93969648,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"191171","last_page":"191171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mitochondrial-ultrastructure","display_name":"mitochondrial ultrastructure","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthesis","display_name":"mitochondrial ATP production","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.7149999737739563},{"id":"https://openalex.org/keywords/computational-model","display_name":"computational model","score":0.6909999847412109},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7055712938308716},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6982860565185547},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6905725002288818},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.5937590599060059},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5914628505706787},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5904372334480286},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5742548704147339},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5286491513252258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.508319079875946},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.491219699382782},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4857657253742218},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.42767006158828735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38938236236572266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.260599821805954},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.24547553062438965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14162954688072205},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1098/rsos.191171","doi":"https://doi.org/10.1098/rsos.191171","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsos.191171","pdf_url":null,"source":{"id":"https://openalex.org/S2737558550","display_name":"Royal Society Open Science","issn_l":"2054-5703","issn":["2054-5703"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society Open Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7029933","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7029933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"R Soc Open Sci","raw_type":"Text"},{"id":"pmid:32218947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32218947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society open science","raw_type":"Journal Article"},{"id":"pmh:oai:dk.um.si:IzpisGradiva.php?id=90130","doi":null,"is_oa":true,"landing_page_url":"https://dk.um.si/IzpisGradiva.php?id=90130","pdf_url":null,"source":{"id":"https://openalex.org/S4377196302","display_name":"University of Maribor digital library (University of Maribor)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I37696226","host_organization_name":"University of Maribor","host_organization_lineage":["https://openalex.org/I37696226"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society open science, vol. 7, no. 1, pp. 1-17, 2020.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:454729f8eaaa4b82a6578669f44af8c2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/454729f8eaaa4b82a6578669f44af8c2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Royal Society Open Science, Vol 7, Iss 1 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1098/rsos.191171","doi":"https://doi.org/10.1098/rsos.191171","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsos.191171","pdf_url":null,"source":{"id":"https://openalex.org/S2737558550","display_name":"Royal Society Open Science","issn_l":"2054-5703","issn":["2054-5703"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society Open Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G781114115","display_name":null,"funder_award_id":"NNF18OC0033826","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1552235434","https://openalex.org/W1573089314","https://openalex.org/W1578136772","https://openalex.org/W1589179363","https://openalex.org/W1828476563","https://openalex.org/W1938258474","https://openalex.org/W1964063115","https://openalex.org/W1966764648","https://openalex.org/W1973842058","https://openalex.org/W1974939683","https://openalex.org/W1979899140","https://openalex.org/W1987417071","https://openalex.org/W1995919092","https://openalex.org/W2009127988","https://openalex.org/W2014243511","https://openalex.org/W2015752753","https://openalex.org/W2021920528","https://openalex.org/W2023149007","https://openalex.org/W2027670788","https://openalex.org/W2030386197","https://openalex.org/W2030845275","https://openalex.org/W2054484962","https://openalex.org/W2055791664","https://openalex.org/W2063349025","https://openalex.org/W2064908943","https://openalex.org/W2071824475","https://openalex.org/W2074847845","https://openalex.org/W2075735310","https://openalex.org/W2089125273","https://openalex.org/W2093664117","https://openalex.org/W2094657730","https://openalex.org/W2095268130","https://openalex.org/W2096514865","https://openalex.org/W2097575722","https://openalex.org/W2098957321","https://openalex.org/W2101814428","https://openalex.org/W2107405532","https://openalex.org/W2113278846","https://openalex.org/W2115002032","https://openalex.org/W2119437574","https://openalex.org/W2119901011","https://openalex.org/W2122905319","https://openalex.org/W2127262263","https://openalex.org/W2128326754","https://openalex.org/W2130777627","https://openalex.org/W2139512539","https://openalex.org/W2139896878","https://openalex.org/W2140255871","https://openalex.org/W2140488024","https://openalex.org/W2142485606","https://openalex.org/W2151570390","https://openalex.org/W2154785285","https://openalex.org/W2159570963","https://openalex.org/W2161741963","https://openalex.org/W2166243077","https://openalex.org/W2166954428","https://openalex.org/W2168500187","https://openalex.org/W2169254921","https://openalex.org/W2181446446","https://openalex.org/W2196326443","https://openalex.org/W2272838820","https://openalex.org/W2332381550","https://openalex.org/W2335870747","https://openalex.org/W2341611738","https://openalex.org/W2409963526","https://openalex.org/W2517397699","https://openalex.org/W2535658226","https://openalex.org/W2546480789","https://openalex.org/W2579298009","https://openalex.org/W2589213388","https://openalex.org/W2622785186","https://openalex.org/W2757711168","https://openalex.org/W2786903684","https://openalex.org/W2791899259","https://openalex.org/W2807927825","https://openalex.org/W2886098455","https://openalex.org/W2888657962","https://openalex.org/W2896240137","https://openalex.org/W2899548656","https://openalex.org/W2906355073","https://openalex.org/W2909991063","https://openalex.org/W2955219150","https://openalex.org/W2979060743","https://openalex.org/W6948666547"],"related_works":["https://openalex.org/W6992817532","https://openalex.org/W3111637597","https://openalex.org/W4220747142","https://openalex.org/W4416683117","https://openalex.org/W4404779248","https://openalex.org/W6894169774","https://openalex.org/W3197595987","https://openalex.org/W4224050839","https://openalex.org/W1889438230","https://openalex.org/W4414081257"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"mellitus":[3],"(T2DM)":[4],"has":[5],"been":[6],"associated":[7,122],"with":[8,123,154],"insulin":[9,21,32],"resistance":[10],"and":[11,18,34,89,114,133,158,185],"the":[12,23,50,118,126],"failure":[13],"of":[14,53,83,93,117,128,182],"\u03b2-cells":[15],"to":[16,49,111],"produce":[17],"secrete":[19],"enough":[20],"as":[22],"disease":[24],"progresses.":[25],"However,":[26],"clinical":[27,190],"treatments":[28],"based":[29],"solely":[30],"on":[31],"secretion":[33,52,130,175],"action":[35],"have":[36],"had":[37],"limited":[38],"success.":[39],"The":[40],"focus":[41],"is":[42],"therefore":[43],"shifting":[44],"towards":[45],"\u03b1-cells,":[46],"in":[47,64,68,97,104,131,168,176],"particular":[48],"dysregulated":[51,173],"glucagon.":[54],"Our":[55,161],"qualitative":[56],"electron-microscopy-based":[57],"observations":[58],"gave":[59],"an":[60],"indication":[61],"that":[62,150,164],"mitochondria":[63],"\u03b1-cells":[65,73,169],"are":[66],"altered":[67],"Western-diet-induced":[69],"T2DM.":[70],"In":[71],"particular,":[72],"extracted":[74],"from":[75],"mouse":[76],"pancreatic":[77],"tissue":[78],"showed":[79],"a":[80,85,90,101,146],"lower":[81,91],"density":[82],"mitochondria,":[84],"less":[86],"expressed":[87],"matrix":[88],"number":[92],"cristae.":[94],"These":[95],"deformities":[96],"mitochondrial":[98,105,166],"ultrastructure":[99],"imply":[100],"decreased":[102],"efficiency":[103],"ATP":[106],"production,":[107],"which":[108],"prompted":[109],"us":[110],"theoretically":[112],"explore":[113],"clarify":[115],"one":[116],"most":[119],"challenging":[120],"problems":[121],"T2DM,":[124,177],"namely":[125],"lack":[127],"glucagon":[129,159,174],"hypoglycaemia":[132],"its":[134],"oversecretion":[135],"at":[136],"high":[137],"blood":[138],"glucose":[139],"concentrations.":[140],"To":[141],"this":[142],"purpose,":[143],"we":[144],"constructed":[145],"novel":[147],"computational":[148],"model":[149],"links":[151],"\u03b1-cell":[152],"metabolism":[153,167],"their":[155],"electrical":[156],"activity":[157],"secretion.":[160],"results":[162],"show":[163],"defective":[165],"can":[170],"account":[171],"for":[172,188],"thus":[178],"improving":[179],"our":[180],"understanding":[181],"T2DM":[183],"pathophysiology":[184],"indicating":[186],"possibilities":[187],"new":[189],"treatments.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-30T00:00:00"}