{"id":"https://openalex.org/W3000896338","doi":null,"title":"Antiepileptic Drugs and Suicidality in Veterans with Seizures.","display_name":"Antiepileptic Drugs and Suicidality in Veterans with Seizures.","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W3000896338","mag":"3000896338","pmid":"https://pubmed.ncbi.nlm.nih.gov/31886473"},"language":"en","primary_location":{"id":"pmid:31886473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31886473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology (E-Cronicon)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033940986","display_name":"Shawniqua Williams Roberson","orcid":"https://orcid.org/0000-0003-1331-380X","observed_orcids":["https://orcid.org/0000-0003-1331-380X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawniqua Williams Roberson","raw_affiliation_strings":["Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA","Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007933445","display_name":"Rizwana Rehman","orcid":"https://orcid.org/0000-0003-3988-458X","observed_orcids":["https://orcid.org/0000-0003-3988-458X"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rizwana Rehman","raw_affiliation_strings":["Southeast Epilepsy Center of Excellence, Durham VA Medical Center, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southeast Epilepsy Center of Excellence, Durham VA Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014565041","display_name":"Gabriel Bucurescu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Bucurescu","raw_affiliation_strings":["Department of Neurology, Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210133394"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8165,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77858188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10376","display_name":"Suicide and Self-Harm Studies","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.17679999768733978,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.996999979019165},{"id":"https://openalex.org/keywords/suicidality","display_name":"suicidality","score":0.9879999756813049},{"id":"https://openalex.org/keywords/veterans","display_name":"veterans","score":0.6990000009536743},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.7919999957084656},{"id":"https://openalex.org/keywords/suicidal-ideation","display_name":"suicidal ideation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/substance-abuse","display_name":"substance abuse","score":0.7889999747276306},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9959999918937683},{"id":"https://openalex.org/keywords/age-as-risk-factor","display_name":"age as risk factor","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6794373393058777},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.6113903522491455},{"id":"https://openalex.org/C2776641880","wikidata":"https://www.wikidata.org/wiki/Q944142","display_name":"Suicidal ideation","level":4,"score":0.5746350884437561},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5576775670051575},{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.5372087955474854},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5120230317115784},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4925006330013275},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.4887983500957489},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4369465112686157},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4200349450111389},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.3609684705734253},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32992130517959595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18157550692558289},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.14119869470596313},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:31886473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31886473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology (E-Cronicon)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5883592","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6934105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934105","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology (ECronicon)","raw_type":"Text"},{"id":"mag:3000896338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31886473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6934105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934105","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology (ECronicon)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1622861445","https://openalex.org/W1969486849","https://openalex.org/W1991762756","https://openalex.org/W1993080065","https://openalex.org/W1999279264","https://openalex.org/W2000871849","https://openalex.org/W2007339452","https://openalex.org/W2016455461","https://openalex.org/W2020552436","https://openalex.org/W2029519386","https://openalex.org/W2041010897","https://openalex.org/W2043007630","https://openalex.org/W2044452957","https://openalex.org/W2048011411","https://openalex.org/W2059560616","https://openalex.org/W2086056052","https://openalex.org/W2087539512","https://openalex.org/W2100602245","https://openalex.org/W2105252107","https://openalex.org/W2122841131","https://openalex.org/W2129089721","https://openalex.org/W2130148728","https://openalex.org/W2134342251","https://openalex.org/W2135557901","https://openalex.org/W2137500003","https://openalex.org/W2151169255","https://openalex.org/W2164373058","https://openalex.org/W2195022665","https://openalex.org/W2472917974","https://openalex.org/W2474631331","https://openalex.org/W2556423603"],"related_works":["https://openalex.org/W2034194594","https://openalex.org/W2035277224","https://openalex.org/W2618612696","https://openalex.org/W2115371687","https://openalex.org/W2137422566","https://openalex.org/W1983444163","https://openalex.org/W2889084562","https://openalex.org/W2728356670","https://openalex.org/W2594582114","https://openalex.org/W2129543824"],"abstract_inverted_index":{"Objectives:":[0],"Veterans":[1],"and":[2,36,76,104,161,198,219],"patients":[3,60,207,234],"with":[4,50,67,80,88,119,139,176,186,208,235],"epilepsy":[5,37],"are":[6,202,210],"at":[7,61],"higher":[8],"risk":[9,26,93,178,189,236],"of":[10,27,31,48,59,70,97,113,166,179,216,241],"suicide":[11],"than":[12],"the":[13,25,32,62,91,214],"general":[14],"population.":[15],"Some":[16],"studies":[17,205],"suggest":[18],"that":[19],"antiepileptic":[20],"drugs":[21,218],"(AEDs)":[22],"further":[23],"increase":[24],"suicide.":[28],"The":[29,191],"nature":[30],"relationship":[33,44,158],"between":[34,73,159],"suicidality":[35,160],"treatment":[38],"needs":[39],"clarification.":[40],"We":[41,53],"examined":[42],"this":[43],"in":[45,206],"a":[46,55,68,187],"cohort":[47],"veterans":[49],"seizures.":[51],"Methods:":[52],"performed":[54],"retrospective":[56],"chart":[57],"analysis":[58],"Philadelphia":[63],"VA":[64],"Medical":[65],"Center":[66],"diagnosis":[69],"seizure":[71],"disorder":[72],"January":[74],"2000":[75],"April":[77],"2007.":[78],"Patients":[79,118],"suicidal":[81,84,127],"ideation":[82,128],"and/or":[83],"behaviors":[85],"were":[86,110,122,173],"analyzed":[87],"respect":[89],"to":[90,125,212,228],"following":[92],"factors:":[94],"age,":[95],"history":[96,165,240],"traumatic":[98],"brain":[99],"injury":[100],"(TBI),":[101],"substance":[102,120,182,196,242],"abuse":[103,121,183,197,243],"AED":[105,162,249],"prescription.":[106],"Results:":[107],"526":[108],"charts":[109],"reviewed,":[111],"385":[112],"which":[114],"met":[115],"inclusion":[116],"criteria.":[117],"more":[123],"likely":[124],"have":[126],"(adjusted":[129,141],"odds":[130,142],"ratio":[131,143],"3.37,":[132],"95%":[133,145],"CI":[134,146],"1.84":[135],"-6.18).":[136],"Risk":[137],"decreased":[138],"age":[140],"0.94,":[144],"0.92":[147],"-":[148],"0.97":[149],"for":[150],"each":[151],"year).":[152],"There":[153],"was":[154,184],"no":[155],"statistically":[156],"significant":[157],"use":[163],"or":[164,251],"TBI.":[167],"Conclusion:":[168],"In":[169],"our":[170],"population,":[171],"AEDs":[172],"not":[174,227],"associated":[175,185],"increased":[177],"suicidality,":[180,195],"whereas":[181],"substantial":[188],"increase.":[190],"interactions":[192],"among":[193],"seizures,":[194],"other":[199,220],"neuropsychiatric":[200],"diseases":[201],"complex.":[203],"Large-scale":[204],"seizures":[209],"needed":[211],"understand":[213],"impact":[215],"individual":[217],"contributing":[221],"factors.":[222],"Providers":[223],"should":[224,244],"be":[225,245],"cautious":[226],"withhold":[229],"potentially":[230],"beneficial":[231],"treatment,":[232],"however":[233],"factors":[237],"such":[238],"as":[239],"followed":[246],"closely":[247],"after":[248],"initiation":[250],"adjustment.":[252]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
