{"id":"https://openalex.org/W3000796393","doi":"https://doi.org/10.1021/jacs.9b10538","title":"Selection of Aptamers with Large Hydrophobic 2\u2032-Substituents","display_name":"Selection of Aptamers with Large Hydrophobic 2\u2032-Substituents","publication_year":2020,"publication_date":"2020-01-21","ids":{"openalex":"https://openalex.org/W3000796393","doi":"https://doi.org/10.1021/jacs.9b10538","mag":"3000796393","pmid":"https://pubmed.ncbi.nlm.nih.gov/31961667"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.9b10538","doi":"https://doi.org/10.1021/jacs.9b10538","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.9b10538","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101992911","display_name":"Qian Shao","orcid":"https://orcid.org/0000-0003-1909-4177","observed_orcids":["https://orcid.org/0000-0003-1909-4177"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Shao","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":"https://orcid.org/0000-0003-1909-4177","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061738560","display_name":"Tingjian Chen","orcid":"https://orcid.org/0000-0002-4458-4269","observed_orcids":["https://orcid.org/0000-0002-4458-4269"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingjian Chen","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087360871","display_name":"Kai Sheng","orcid":"https://orcid.org/0000-0001-9394-2256","observed_orcids":["https://orcid.org/0000-0001-9394-2256"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Sheng","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035543428","display_name":"Zhixia Liu","orcid":"https://orcid.org/0000-0001-5605-9747","observed_orcids":["https://orcid.org/0000-0001-5605-9747"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhixia Liu","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013366944","display_name":"Zhuochen Zhang","orcid":"https://orcid.org/0009-0007-9067-5894","observed_orcids":["https://orcid.org/0009-0007-9067-5894"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhuochen Zhang","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025948470","display_name":"Floyd E. Romesberg","orcid":"https://orcid.org/0000-0001-6317-1315","observed_orcids":["https://orcid.org/0000-0001-6317-1315"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Floyd E. Romesberg","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States"],"raw_orcid":"https://orcid.org/0000-0001-6317-1315","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025948470"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.3578,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.79266891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"142","issue":"5","first_page":"2125","last_page":"2128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer-selection","display_name":"aptamer selection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.7799999713897705},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.6800000071525574},{"id":"https://openalex.org/keywords/factor-ixa","display_name":"factor IXa","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hydrophobic-core","display_name":"hydrophobic core","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9224941730499268},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.8487789630889893},{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.6328544616699219},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6101130247116089},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.5100591778755188},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.49491018056869507},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.48991817235946655},{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.43564921617507935},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3866021931171417},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34356236457824707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.288398802280426},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.20048397779464722},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.1421632468700409},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jacs.9b10538","doi":"https://doi.org/10.1021/jacs.9b10538","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.9b10538","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:31961667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31961667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1777917025","display_name":null,"funder_award_id":"N66001-14-2-4052","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"}],"funders":[{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1907335761","https://openalex.org/W1938598663","https://openalex.org/W1964692210","https://openalex.org/W1964858690","https://openalex.org/W1974045722","https://openalex.org/W2008819279","https://openalex.org/W2023373190","https://openalex.org/W2027937758","https://openalex.org/W2036332544","https://openalex.org/W2056285082","https://openalex.org/W2059346730","https://openalex.org/W2066074720","https://openalex.org/W2066356596","https://openalex.org/W2122992861","https://openalex.org/W2131159842","https://openalex.org/W2139188291","https://openalex.org/W2340611904","https://openalex.org/W2514433423","https://openalex.org/W2563971010","https://openalex.org/W2589899704","https://openalex.org/W2734959488","https://openalex.org/W2740994733","https://openalex.org/W2883421066","https://openalex.org/W4231299834"],"related_works":["https://openalex.org/W2589899704","https://openalex.org/W7015265354","https://openalex.org/W2414651231","https://openalex.org/W4230708835","https://openalex.org/W2029760928","https://openalex.org/W4407191328","https://openalex.org/W6989766694","https://openalex.org/W7149298088","https://openalex.org/W2765843125","https://openalex.org/W4362665245"],"abstract_inverted_index":{"-methyl,":[0],"or":[1,69],"azido":[2,16],"substituent.":[3],"Here":[4],"we":[5,12,53],"use":[6,14,54],"SFM4-3":[7,30,55,80],"to":[8,18,56,103],"synthesize":[9],"2'-azido-modified":[10],"DNA;":[11],"then":[13],"the":[15,32,47,70,83],"group":[17],"attach":[19],"different,":[20],"large":[21,60],"hydrophobic":[22,61,96],"groups":[23],"via":[24],"click":[25],"chemistry.":[26],"We":[27],"show":[28],"that":[29,64,79,87,98],"recognizes":[31],"modified":[33],"templates":[34],"under":[35],"standard":[36],"conditions,":[37],"producing":[38],"natural":[39],"DNA":[40],"and":[41,90],"thereby":[42],"allowing":[43],"amplification.":[44],"To":[45],"demonstrate":[46],"utility":[48],"of":[49,85],"this":[50],"remarkable":[51],"property,":[52],"select":[57],"aptamers":[58,86],"with":[59,95],"2'":[62],"substituents":[63],"bind":[65],"human":[66],"neutrophil":[67],"elastase":[68],"blood":[71],"coagulation":[72],"protein":[73],"factor":[74],"IXa.":[75],"The":[76],"results":[77],"indicate":[78],"should":[81],"facilitate":[82],"discovery":[84],"adopt":[88],"novel":[89,105],"perhaps":[91],"more":[92],"protein-like":[93],"folds":[94],"cores":[97],"in":[99],"turn":[100],"allow":[101],"them":[102],"access":[104],"activities.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-30T00:00:00"}
