{"id":"https://openalex.org/W300072942","doi":null,"title":"Ventilatory regulation in eucapnic morbid obesity.","display_name":"Ventilatory regulation in eucapnic morbid obesity.","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W300072942","mag":"300072942","pmid":"https://pubmed.ncbi.nlm.nih.gov/6424520"},"language":"en","primary_location":{"id":"pmid:6424520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6424520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109275980","display_name":"N. K. Burki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N K Burki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113763987","display_name":"Baker Rw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R W Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6927,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.58435852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"129","issue":"4","first_page":"538","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"morbid obesity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ventilatory-regulation","display_name":"ventilatory regulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/occlusion-pressure","display_name":"occlusion pressure","score":0.9020000100135803},{"id":"https://openalex.org/keywords/thoracic-compliance","display_name":"thoracic compliance","score":0.7590000033378601},{"id":"https://openalex.org/keywords/respiratory-rate","display_name":"respiratory rate","score":0.6470000147819519},{"id":"https://openalex.org/keywords/expiratory-time","display_name":"expiratory time","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hypoxic-ventilatory-response","display_name":"hypoxic ventilatory response","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hypercapnic-ventilatory-response","display_name":"hypercapnic ventilatory response","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.7829197645187378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7819646000862122},{"id":"https://openalex.org/C56283660","wikidata":"https://www.wikidata.org/wiki/Q1073808","display_name":"Functional residual capacity","level":4,"score":0.708916187286377},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.5845382213592529},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.5696871280670166},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5359583497047424},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5205503702163696},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5166923999786377},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.5102856159210205},{"id":"https://openalex.org/C79959777","wikidata":"https://www.wikidata.org/wiki/Q754333","display_name":"Respiratory minute volume","level":3,"score":0.4988722801208496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4087602198123932},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3735211491584778},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3082931637763977},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06229338049888611},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.05526763200759888},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013147","descriptor_name":"Spirometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6424520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6424520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},{"id":"mag:300072942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6424520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130271395","https://openalex.org/W32555490","https://openalex.org/W2069608178","https://openalex.org/W1989793378","https://openalex.org/W1796278849","https://openalex.org/W7096116517","https://openalex.org/W2035145184","https://openalex.org/W2049914155","https://openalex.org/W2512232353","https://openalex.org/W2506522623"],"abstract_inverted_index":{"In":[0],"morbid":[1,26],"obesity,":[2],"there":[3],"is":[4,227,231],"an":[5,104,138,170,198],"increased":[6,16,101,156,171,235],"hindrance":[7],"to":[8,114,129,174,181,210,237],"breathing":[9],"caused":[10],"by":[11,31,37,150,197,233],"the":[12,15,19,92,119,125,158,184,234],"effects":[13],"of":[14,63,103,127,217,223],"mass":[17],"on":[18],"chest":[20],"wall":[21],"and":[22,56,68,80,176],"abdomen;":[23],"subjects":[24,47,193,206],"with":[25,59],"obesity":[27],"can":[28],"maintain":[29,194],"eucapnia":[30,195],"increasing":[32],"inspiratory":[33,128,145],"neuromuscular":[34,146],"drive":[35,147],"and/or":[36],"altering":[38],"central":[39,141,201],"breath":[40,142,202],"timing.":[41,143,203],"We":[42],"studied":[43],"23":[44],"eucapnic,":[45],"obese":[46,93,159,185,192],"(greater":[48],"than":[49,88],"190%":[50],"predicted":[51],"ideal":[52],"weight),":[53],"7":[54],"males":[55],"16":[57],"females":[58],"a":[60,115],"mean":[61],"age":[62],"36.6":[64],"+/-":[65],"9.2":[66],"yr":[67],"18":[69],"healthy,":[70],"normal":[71],"male":[72],"subjects.":[73,94,186],"Total":[74],"lung":[75],"capacity,":[76,79],"functional":[77],"residual":[78],"total":[81],"thoracic":[82],"compliance":[83],"were":[84],"significantly":[85,100,135,155,166],"(p":[86],"less":[87],"0.05)":[89],"reduced":[90],"in":[91,106,110,118,140,157,183,200],"At":[95],"rest,":[96],"minute":[97],"ventilation":[98],"was":[99,112,133,154,164,169],"because":[102],"increase":[105],"respiratory":[107,219],"frequency,":[108],"which":[109],"turn":[111],"due":[113],"significant":[116],"decrease":[117],"expiratory":[120,130],"time":[121,131],"(TE)":[122],"per":[123],"breath;":[124],"ratio":[126],"(TI/TE)":[132],"thus":[134],"altered,":[136],"indicating":[137],"alteration":[139,199],"Resting":[144],"(as":[148],"represented":[149],"mouth":[151],"occlusion":[152],"pressure)":[153],"subjects,":[160],"but":[161],"tidal":[162],"volume":[163],"not":[165],"altered.":[167],"There":[168],"ventilatory":[172,179],"responsiveness":[173,180,209,236],"hypoxia":[175],"relatively":[177],"decreased":[178,208],"hypercapnia":[182],"These":[187],"results":[188],"indicate":[189],"that":[190,229],"morbidly":[191],"primarily":[196],"Although":[204],"these":[205],"have":[207],"CO2,":[211],"putting":[212],"them":[213],"at":[214],"some":[215],"risk":[216],"developing":[218],"failure":[220],"under":[221],"conditions":[222],"hypercapnic/hypoxic":[224],"stress,":[225],"it":[226],"possible":[228],"this":[230],"counteracted":[232],"hypoxia.":[238]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}