{"id":"https://openalex.org/W3000693080","doi":"https://doi.org/10.1136/jnnp-2019-abn-2.152","title":"171 Alemtuzumab induced neutropaenia: women at risk","display_name":"171 Alemtuzumab induced neutropaenia: women at risk","publication_year":2019,"publication_date":"2019-11-14","ids":{"openalex":"https://openalex.org/W3000693080","doi":"https://doi.org/10.1136/jnnp-2019-abn-2.152","mag":"3000693080"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2019-abn-2.152","doi":"https://doi.org/10.1136/jnnp-2019-abn-2.152","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2019-abn-2.152","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057006002","display_name":"Riffat Tanveer","orcid":"https://orcid.org/0009-0000-4264-6828","observed_orcids":["https://orcid.org/0009-0000-4264-6828","https://orcid.org/0009-0005-8736-0133"]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Riffat Tanveer","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103130708","display_name":"Adrian Pace","orcid":"https://orcid.org/0000-0002-9488-1077","observed_orcids":["https://orcid.org/0000-0002-9488-1077"]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adrian Pace","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039683609","display_name":"David J. Rog","orcid":"https://orcid.org/0000-0002-7262-4248","observed_orcids":["https://orcid.org/0000-0002-7262-4248"]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Rog","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sharaf Nazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sharaf Nazar","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751586","display_name":"Paul R. Talbot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Talbot","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044282181","display_name":"Fran Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fran Jackson","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067747010","display_name":"Tatiana Mihalova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801120809","display_name":"Salford Royal NHS Foundation Trust","ror":"https://ror.org/019j78370","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801120809","https://openalex.org/I4405259061"]},{"id":"https://openalex.org/I4210111611","display_name":"Salford Royal Hospital","ror":"https://ror.org/027rkpb34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111611","https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tatiana Mihalova","raw_affiliation_strings":["Salford Royal Hopsital NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salford Royal Hopsital NHS Foundation Trust","institution_ids":["https://openalex.org/I2801120809","https://openalex.org/I4210111611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"90","issue":"12","first_page":"e45.3","last_page":"e45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alemtuzumab","display_name":"alemtuzumab","score":1.0},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cd52","display_name":"CD52","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7179999947547913},{"id":"https://openalex.org/keywords/neutropenic-infection","display_name":"neutropenic infection","score":0.5569999814033508},{"id":"https://openalex.org/keywords/neutrophil-depletion","display_name":"neutrophil depletion","score":0.6439999938011169},{"id":"https://openalex.org/keywords/blood-monitoring","display_name":"blood monitoring","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.7810238599777222},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45879265666007996},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3290014863014221},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3282730281352997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2893262207508087},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jnnp-2019-abn-2.152","doi":"https://doi.org/10.1136/jnnp-2019-abn-2.152","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2019-abn-2.152","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:jnnp:90/12/e45-c","doi":null,"is_oa":false,"landing_page_url":"http://jnnp.bmj.com/cgi/content/short/90/12/e45-c","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2757801096","https://openalex.org/W2563726675","https://openalex.org/W2898841693","https://openalex.org/W2899140676","https://openalex.org/W2802596299","https://openalex.org/W3176077646","https://openalex.org/W2734796066","https://openalex.org/W2883299023","https://openalex.org/W6902451591","https://openalex.org/W2809611711"],"abstract_inverted_index":{"Background":[0],"Alemtuzumab,":[1],"a":[2],"CD52":[3,26],"-":[4],"specific":[5,194],"monoclonal":[6],"antibody":[7],"depletes":[8],"T":[9],"and":[10,27,97,162,193],"B":[11],"cell":[12],"population":[13,59],"to":[14,134,146],"reduce":[15],"relapse":[16],"in":[17,39,48,142],"multiple":[18],"sclerosis.":[19],"Neutrophils":[20],"also":[21,70],"express":[22],"low":[23],"levels":[24],"of":[25,37,66,75,88,92,180],"can":[28],"be":[29],"depleted":[30],"transiently":[31],"by":[32],"alemtuzumab,":[33],"increasing":[34],"the":[35,40,49,85,103],"risk":[36,58,179],"infection":[38,167],"post-alemtuzumab":[41],"treatment":[42,81],"period.":[43],"Aim":[44],"In":[45,171],"this":[46],"study":[47,74],"Greater":[50],"Manchester":[51],"Neuroscience":[52],"Centre":[53],"(GMNC)":[54],"we":[55],"investigated":[56],"at":[57,84,176],"for":[60,190],"alemtuzumab":[61,83,112,181],"induced":[62,182],"neutropaenia.":[63,183],"The":[64],"outcome":[65],"these":[67],"patients":[68,76,155,192],"is":[69,188],"discussed.":[71],"Method":[72],"Retrospective":[73],"who":[77],"developed":[78,121,159],"neutropaenia":[79,122,138,148],"following":[80],"with":[82,111],"GMNC.":[86],"Data":[87],"patient":[89,105,119],"demographics,":[90],"grade":[91],"neutropeania,":[93],"symptoms":[94],"while":[95],"neutropaenic":[96,153],"management":[98],"were":[99,156],"evaluated.":[100],"Results":[101],"Of":[102],"131":[104],"(86":[106],"F:":[107,114],"45":[108],"M)":[109],"treated":[110],"(1.9":[113],"1":[115,126,158,163],"M":[116],"ratio),":[117],"18":[118],"(13.7%)":[120],"(17":[123],"F":[124,129],"Vs":[125,130],"M,":[127],"19.8%":[128],"2.2%":[131],"M).":[132],"Moderate":[133],"severe":[135],"(grade":[136],"2\u20134)":[137],"was":[139,149],"only":[140],"observed":[141],"females.":[143],"Average":[144],"duration":[145],"develop":[147],"41":[150],"days.":[151],"While":[152],"16":[154],"asymptomatic,":[157],"flu-like":[160],"illness":[161],"had":[164],"recurrent":[165],"chest":[166],"requiring":[168],"antibiotic.":[169],"Conclusion":[170],"our":[172],"experience,":[173],"women":[174],"are":[175],"significantly":[177],"higher":[178],"Monthly":[184],"serial":[185],"blood":[186],"monitoring":[187],"adequate":[189],"most":[191],"intervention":[195],"rarely":[196],"required.":[197]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}
