{"id":"https://openalex.org/W3000679864","doi":"https://doi.org/10.1371/journal.pone.0218003","title":"PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses","display_name":"PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses","publication_year":2019,"publication_date":"2019-06-06","ids":{"openalex":"https://openalex.org/W3000679864","doi":"https://doi.org/10.1371/journal.pone.0218003","mag":"3000679864","pmid":"https://pubmed.ncbi.nlm.nih.gov/31170232","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6553779"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0218003","doi":"https://doi.org/10.1371/journal.pone.0218003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0218003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0218003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0218003&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017801434","display_name":"Marta Bueno","orcid":"https://orcid.org/0000-0001-7140-9899","observed_orcids":["https://orcid.org/0000-0001-7140-9899"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Bueno","raw_affiliation_strings":["Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7140-9899","affiliations":[{"raw_affiliation_string":"Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070293302","display_name":"Daniel C. Zank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Zank","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010318377","display_name":"Ivette Buend\u00eda-Rold\u00e1n","orcid":"https://orcid.org/0000-0002-8230-0749","observed_orcids":["https://orcid.org/0000-0002-8230-0749"]},"institutions":[{"id":"https://openalex.org/I4210102695","display_name":"Instituto Nacional de Enfermedades Respiratorias","ror":"https://ror.org/017fh2655","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210102695"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ivette Buendia-Rold\u00e1n","raw_affiliation_strings":["Instituto Nacional de Enfermedades Respiratorias \"Ismael Cosio Villegas\", Mexico City, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Enfermedades Respiratorias \"Ismael Cosio Villegas\", Mexico City, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I4210102695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064110649","display_name":"Kaitlin Fiedler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlin Fiedler","raw_affiliation_strings":["Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090978928","display_name":"Brenton G. Mays","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenton G. Mays","raw_affiliation_strings":["Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043158478","display_name":"Diana \u00c1lvarez","orcid":"https://orcid.org/0000-0001-6700-8101","observed_orcids":["https://orcid.org/0000-0001-6700-8101"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Alvarez","raw_affiliation_strings":["Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060836626","display_name":"John Sembrat","orcid":"https://orcid.org/0000-0003-4108-803X","observed_orcids":["https://orcid.org/0000-0003-4108-803X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Sembrat","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian Kimball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Kimball","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006488312","display_name":"Jordan Bullock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan K. Bullock","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023616683","display_name":"James L. Martin","orcid":"https://orcid.org/0000-0002-6758-7075","observed_orcids":["https://orcid.org/0000-0002-6758-7075"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Martin","raw_affiliation_strings":["Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061689322","display_name":"Mehdi syed Nouraie","orcid":"https://orcid.org/0000-0001-7465-0581","observed_orcids":["https://orcid.org/0000-0001-7465-0581"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehdi Nouraie","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072629352","display_name":"Brett A. Kaufman","orcid":"https://orcid.org/0000-0003-4767-4937","observed_orcids":["https://orcid.org/0000-0003-4767-4937"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett A. Kaufman","raw_affiliation_strings":["Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101688428","display_name":"Mauricio M. Rojas","orcid":"https://orcid.org/0000-0001-7340-4784","observed_orcids":["https://orcid.org/0000-0001-7340-4784"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210102695","display_name":"Instituto Nacional de Enfermedades Respiratorias","ror":"https://ror.org/017fh2655","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210102695"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Mauricio Rojas","raw_affiliation_strings":["Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Instituto Nacional de Enfermedades Respiratorias \"Ismael Cosio Villegas\", Mexico City, Distrito Federal, M\u00e9xico","McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Instituto Nacional de Enfermedades Respiratorias \"Ismael Cosio Villegas\", Mexico City, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I4210102695"]},{"raw_affiliation_string":"McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060963552","display_name":"Annie Pardo","orcid":"https://orcid.org/0000-0003-2168-9073","observed_orcids":["https://orcid.org/0000-0003-2168-9073"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Annie Pardo","raw_affiliation_strings":["Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027510239","display_name":"Mois\u00e9s Selman","orcid":"https://orcid.org/0000-0002-1022-4783","observed_orcids":["https://orcid.org/0000-0002-1022-4783"]},"institutions":[{"id":"https://openalex.org/I4210102695","display_name":"Instituto Nacional de Enfermedades Respiratorias","ror":"https://ror.org/017fh2655","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210102695"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mois\u00e9s Selman","raw_affiliation_strings":["Instituto Nacional de Enfermedades Respiratorias \"Ismael Cosio Villegas\", Mexico City, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Enfermedades Respiratorias \"Ismael Cosio Villegas\", Mexico City, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I4210102695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087409511","display_name":"Ana Lucia Mora","orcid":"https://orcid.org/0000-0003-1653-8318","observed_orcids":["https://orcid.org/0000-0003-1653-8318"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana L. Mora","raw_affiliation_strings":["Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087409511"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":1595,"currency":"USD","value_usd":1595},"apc_paid":{"value":1595,"currency":"USD","value_usd":1595},"fwci":7.7161,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.98258352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"14","issue":"6","first_page":"e0218003","last_page":"e0218003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-dna-release","display_name":"mitochondrial DNA release","score":0.7549999952316284},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9620000123977661},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mitochondrial-damage-associated-molecular-patterns","display_name":"mitochondrial damage-associated molecular patterns","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mitochondrial-dna-oxidation","display_name":"mitochondrial DNA oxidation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hypersensitivity-pneumonitis","display_name":"hypersensitivity pneumonitis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autoimmune-interstitial-lung-disease","display_name":"autoimmune interstitial lung disease","score":0.7820000052452087},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.9077010154724121},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.8391178846359253},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5487403273582458},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5233016610145569},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.5201368927955627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5175549387931824},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5104743242263794},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.47833749651908875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37103646993637085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3622359037399292},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.346762478351593},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.33973222970962524},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.31026116013526917},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.237917959690094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23773953318595886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21778720617294312},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15634626150131226},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0857478678226471},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099202","descriptor_name":"PTEN-Induced Putative Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056809","descriptor_name":"Alveolar Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0218003","doi":"https://doi.org/10.1371/journal.pone.0218003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0218003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0218003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6553779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6553779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:31170232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31170232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:68541fa065c84c808d41a0a0f14db3e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/68541fa065c84c808d41a0a0f14db3e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 14, Iss 6, p e0218003 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8239271","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/PINK1_attenuates_mtDNA_release_in_alveolar_epithelial_cells_and_TLR9_mediated_profibrotic_responses/8239271","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0218003","doi":"https://doi.org/10.1371/journal.pone.0218003","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0218003","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0218003&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1739728354","display_name":"Signaling mechanisms by which mitochondria regulates fibrosis in the lung","funder_award_id":"R01HL131789","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8975144258","display_name":"Aging of Mesenchymal Stem Cells Missing Link in IPF","funder_award_id":"R01HL123766","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000866542","display_name":"Translational Training Program in Pulmonary Biology and Medicine","funder_award_id":"T32HL007563","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000679864.pdf","grobid_xml":"https://content.openalex.org/works/W3000679864.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1557965441","https://openalex.org/W1961309807","https://openalex.org/W1981585201","https://openalex.org/W1982479111","https://openalex.org/W1983066584","https://openalex.org/W1992938929","https://openalex.org/W1996335775","https://openalex.org/W2018563185","https://openalex.org/W2035232303","https://openalex.org/W2038481472","https://openalex.org/W2044318535","https://openalex.org/W2049263710","https://openalex.org/W2051649262","https://openalex.org/W2054760729","https://openalex.org/W2064513969","https://openalex.org/W2065107255","https://openalex.org/W2083805398","https://openalex.org/W2086714780","https://openalex.org/W2092943609","https://openalex.org/W2104594319","https://openalex.org/W2107999586","https://openalex.org/W2113010696","https://openalex.org/W2114054457","https://openalex.org/W2117488044","https://openalex.org/W2125580847","https://openalex.org/W2137274600","https://openalex.org/W2138608324","https://openalex.org/W2138934076","https://openalex.org/W2150300479","https://openalex.org/W2153305565","https://openalex.org/W2162154761","https://openalex.org/W2162175607","https://openalex.org/W2165572246","https://openalex.org/W2475933914","https://openalex.org/W2528248212","https://openalex.org/W2581301471","https://openalex.org/W2583803798","https://openalex.org/W2745223933","https://openalex.org/W2752455162","https://openalex.org/W2762514850","https://openalex.org/W2791260322","https://openalex.org/W2803478805","https://openalex.org/W2887997888"],"related_works":["https://openalex.org/W2769428867","https://openalex.org/W2054760729","https://openalex.org/W2144353893","https://openalex.org/W2523598501","https://openalex.org/W7140042363","https://openalex.org/W7099984523","https://openalex.org/W3083233402","https://openalex.org/W814784632","https://openalex.org/W2791260322","https://openalex.org/W3013685395"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"shown":[3],"that":[4,70],"endoplasmic":[5],"reticulum":[6],"stress":[7,72,81],"(ER":[8],"stress)":[9],"represses":[10],"the":[11,29,47,52,117,191],"PTEN":[12],"inducible":[13],"kinase":[14],"1":[15],"(PINK1)":[16],"in":[17,43,51,76,99,134,141,150,165,190],"lung":[18,32,45,179],"type":[19],"II":[20],"alveolar":[21],"epithelial":[22],"cells":[23],"(AECII)":[24],"reducing":[25],"mitophagy":[26,50,189],"and":[27,58,73,85,89,113,130,136,152,176,201],"increasing":[28],"susceptibility":[30],"to":[31,79],"fibrosis.":[33],"Although":[34],"increased":[35],"circulating":[36,145],"mitochondrial":[37,55,80,194],"DNA":[38],"(mtDNA)":[39],"has":[40],"been":[41],"reported":[42],"chronic":[44],"diseases,":[46],"contribution":[48],"of":[49,54,60,87,111,116,144,171,193,203],"modulation":[53],"DAMP":[56],"release":[57,108,200],"activation":[59,110],"profibrotic":[61,118,206],"responses":[62],"is":[63],"unknown.":[64],"In":[65],"this":[66],"study,":[67],"we":[68],"show":[69],"ER":[71],"PINK1":[74,105,125,172,187],"deficiency":[75],"AECII":[77,100],"led":[78],"with":[82,158,168],"significant":[83],"oxidation":[84,129],"damage":[86,131,195],"mtDNA":[88,94,107,128,146,161],"subsequent":[90],"extracellular":[91],"release.":[92],"Extracellular":[93],"was":[95,122,162],"recognized":[96],"by":[97,101,124],"TLR9":[98,112],"an":[102],"endocytic-dependent":[103],"pathway.":[104],"deficiency-dependent":[106],"promoted":[109],"triggered":[114],"secretion":[115],"factor":[119],"TGF-\u03b2":[120,204],"which":[121],"rescued":[123],"overexpression.":[126],"Enhanced":[127],"were":[132,147],"found":[133,163],"aging":[135],"IPF":[137],"human":[138],"lungs":[139],"and,":[140],"concordance,":[142],"levels":[143],"significantly":[148],"elevated":[149,164],"plasma":[151],"bronchoalveolar":[153],"lavage":[154],"(BAL)":[155],"from":[156],"patients":[157],"IPF.":[159],"Free":[160],"other":[166],"ILDs":[167],"low":[169],"expression":[170],"including":[173],"hypersensitivity":[174],"pneumonitis":[175],"autoimmune":[177],"interstitial":[178],"diseases.":[180],"These":[181],"results":[182],"support":[183],"a":[184],"role":[185],"for":[186],"mediated":[188,205],"attenuation":[192],"associated":[196],"molecular":[197],"patterns":[198],"(DAMP)":[199],"control":[202],"responses.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-23T00:00:00"}
