{"id":"https://openalex.org/W3000679737","doi":"https://doi.org/10.1002/jcb.29651","title":"Development of a novel liposomal nanoparticle formulation of cisplatin to breast cancer therapy","display_name":"Development of a novel liposomal nanoparticle formulation of cisplatin to breast cancer therapy","publication_year":2020,"publication_date":"2020-01-07","ids":{"openalex":"https://openalex.org/W3000679737","doi":"https://doi.org/10.1002/jcb.29651","mag":"3000679737","pmid":"https://pubmed.ncbi.nlm.nih.gov/31907989"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.29651","doi":"https://doi.org/10.1002/jcb.29651","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.29651","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087919672","display_name":"Mehrnaz Ghafari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223669574","display_name":"Shahid Sadoughi University of Medical Sciences and Health Services","ror":"https://ror.org/01zby9g91","country_code":"IR","type":"education","lineage":["https://openalex.org/I223669574"]},{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrnaz Ghafari","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran","Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran","institution_ids":["https://openalex.org/I235686326"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046763777","display_name":"Fateme Haghiralsadat","orcid":"https://orcid.org/0000-0002-8655-2118","observed_orcids":["https://orcid.org/0000-0002-8655-2118","https://orcid.org/0000-0002-7576-4617"]},"institutions":[{"id":"https://openalex.org/I223669574","display_name":"Shahid Sadoughi University of Medical Sciences and Health Services","ror":"https://ror.org/01zby9g91","country_code":"IR","type":"education","lineage":["https://openalex.org/I223669574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fateme Haghiralsadat","raw_affiliation_strings":["Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute Shahid Sadoughi University of Medical Sciences Yazd Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]},{"raw_affiliation_string":"Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute Shahid Sadoughi University of Medical Sciences Yazd Iran","institution_ids":["https://openalex.org/I223669574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047814927","display_name":"Soudeh Khanamani Falahati\u2010pour","orcid":"https://orcid.org/0000-0002-3539-8982","observed_orcids":["https://orcid.org/0000-0002-3539-8982"]},"institutions":[{"id":"https://openalex.org/I86959772","display_name":"Rafsanjan University of Medical Sciences","ror":"https://ror.org/01v8x0f60","country_code":"IR","type":"education","lineage":["https://openalex.org/I86959772"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Soudeh Khanamani Falahati\u2010pour","raw_affiliation_strings":["Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran"],"raw_orcid":"https://orcid.org/0000-0002-3539-8982","affiliations":[{"raw_affiliation_string":"Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran","institution_ids":["https://openalex.org/I86959772"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060406367","display_name":"Javad Zavar Reza","orcid":"https://orcid.org/0000-0003-4065-0772","observed_orcids":["https://orcid.org/0000-0003-4065-0772"]},"institutions":[{"id":"https://openalex.org/I223669574","display_name":"Shahid Sadoughi University of Medical Sciences and Health Services","ror":"https://ror.org/01zby9g91","country_code":"IR","type":"education","lineage":["https://openalex.org/I223669574"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Javad Zavar Reza","raw_affiliation_strings":["Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"],"raw_orcid":"https://orcid.org/0000-0003-4065-0772","affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran","institution_ids":["https://openalex.org/I223669574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047814927","https://openalex.org/A5060406367"],"corresponding_institution_ids":["https://openalex.org/I223669574","https://openalex.org/I86959772"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.4528,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.78043134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"121","issue":"7","first_page":"3584","last_page":"3592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liposomal-nanoparticles","display_name":"liposomal nanoparticles","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pegylated-liposomes","display_name":"PEGylated liposomes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/breast-cancer-chemotherapy","display_name":"breast cancer chemotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9570000171661377},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.656000018119812},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nanoparticle-formulation-optimization","display_name":"nanoparticle formulation optimization","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.866055965423584},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.8323606252670288},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6866157054901123},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6099176406860352},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6066746115684509},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.5627956390380859},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.4875154197216034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4537714421749115},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3884936273097992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30524858832359314},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.25263550877571106},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23755642771720886},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.20753249526023865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16473793983459473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10860514640808105},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.09768134355545044},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/jcb.29651","doi":"https://doi.org/10.1002/jcb.29651","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.29651","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:31907989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31907989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.kmu.ac.ir:32926","doi":null,"is_oa":false,"landing_page_url":"http://eprints.kmu.ac.ir/32926/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400818","display_name":"Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I33103891","host_organization_name":"Ardabil University of Medical Sciences","host_organization_lineage":["https://openalex.org/I33103891"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.kmu.ac.ir:37355","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077888757&doi=10.1002%2fjcb.29651&partnerID=40&md5=5c0708330b7f0338c32a792447e394cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400818","display_name":"Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I33103891","host_organization_name":"Ardabil University of Medical Sciences","host_organization_lineage":["https://openalex.org/I33103891"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1630018437","https://openalex.org/W1975970944","https://openalex.org/W1987659508","https://openalex.org/W2034175020","https://openalex.org/W2077985528","https://openalex.org/W2102449174","https://openalex.org/W2104174252","https://openalex.org/W2107946534","https://openalex.org/W2123318149","https://openalex.org/W2288421652","https://openalex.org/W2521615731","https://openalex.org/W2544890774","https://openalex.org/W2597530034","https://openalex.org/W2605212866","https://openalex.org/W2606706893","https://openalex.org/W2903196883","https://openalex.org/W2939319152","https://openalex.org/W2982371398"],"related_works":["https://openalex.org/W4385484108","https://openalex.org/W2378494387","https://openalex.org/W2087024653","https://openalex.org/W2999553432","https://openalex.org/W2081385498","https://openalex.org/W4400517953","https://openalex.org/W2022241033","https://openalex.org/W2340565213","https://openalex.org/W4410351348","https://openalex.org/W3019414432"],"abstract_inverted_index":{"Cisplatin":[0],"is":[1,35],"one":[2],"of":[3,28,39,57,60,80,107,115,123,141,156,176],"the":[4,19,24,29,55,58,142,148,154,174],"conventional":[5],"drugs":[6],"used":[7],"in":[8,169],"chemotherapy":[9],"which":[10],"has":[11],"a":[12,89,104,112,166],"potent":[13],"antitumor":[14],"function.":[15],"However,":[16],"due":[17],"to":[18,26,43,86,91],"dangerous":[20],"side":[21],"effects,":[22],"including":[23],"damage":[25],"DNA":[27],"normal":[30],"cells,":[31],"its":[32],"clinical":[33],"use":[34],"limited.":[36],"The":[37,127,138],"aim":[38],"this":[40],"study":[41,160],"was":[42,145],"prepare":[44],"and":[45,66,84,120,134,173],"characterize":[46],"nanoliposome":[47],"containing":[48,74],"cisplatin.":[49],"We":[50],"optimized":[51],"liposome":[52],"formulations":[53,73,129],"through":[54],"modification":[56],"proportion":[59],"SPC80":[61],"(soybeanphospholipids":[62],"with":[63],"75%":[64],"phosphatidylcholine)":[65],"cholesterol":[67],"content.":[68],"Then,":[69],"novel":[70],"PEGylated":[71,101],"liposomal":[72,143],"SPC80:":[75],"cholesterol:":[76],"DSPE-mPEG":[77],"(at":[78],"ratios":[79],"85:10:5)":[81],"were":[82],"designed":[83],"developed":[85],"serve":[87],"as":[88],"therapy":[90],"achieve":[92],"more":[93],"improved":[94],"pharmaceutical":[95],"efficiency.":[96],"Zeta":[97],"Sizer":[98],"showed":[99],"that":[100,152,162],"nanoliposomes":[102],"had":[103],"mean":[105],"diameter":[106],"119.7":[108],"\u00b1":[109,117,125],"2.1":[110],"nm,":[111],"zeta":[113],"potential":[114],"-26.03":[116],"1.34":[118],"mV,":[119],"entrapment":[121],"efficiency":[122,155],"96.65":[124],"3%.":[126],"optimum":[128],"represented":[130],"sustained,":[131],"thermo-sensitive":[132],"release,":[133],"augmented":[135],"cellular":[136,157],"uptake.":[137,158],"cytotoxic":[139],"effect":[140],"drug":[144,151,171],"higher":[146],"than":[147],"free":[149],"medication":[150],"confirmed":[153],"This":[159],"suggests":[161],"nanoliposome-loaded":[163],"cisplatin":[164],"plays":[165],"vital":[167],"role":[168],"improving":[170],"efficacy":[172],"reduction":[175],"dosage.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}
