{"id":"https://openalex.org/W3000629489","doi":"https://doi.org/10.1080/2162402x.2019.1710052","title":"Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds","display_name":"Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compounds","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000629489","doi":"https://doi.org/10.1080/2162402x.2019.1710052","mag":"3000629489","pmid":"https://pubmed.ncbi.nlm.nih.gov/32002305","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6959453"},"language":"en","primary_location":{"id":"doi:10.1080/2162402x.2019.1710052","doi":"https://doi.org/10.1080/2162402x.2019.1710052","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2019.1710052","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2019.1710052?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2019.1710052?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021572863","display_name":"Denis L. Fontes Jardim","orcid":"https://orcid.org/0000-0003-4663-1521","observed_orcids":["https://orcid.org/0000-0003-4663-1521"]},"institutions":[{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Denis L. Jardim","raw_affiliation_strings":["Centro de Oncologia Hospital S\u00edrio Liban\u00eas","Department of Medical Oncology, Centro de Oncologia Hospital S\u00edrio Liban\u00eas, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Hospital S\u00edrio Liban\u00eas","institution_ids":["https://openalex.org/I4210149843"]},{"raw_affiliation_string":"Department of Medical Oncology, Centro de Oncologia Hospital S\u00edrio Liban\u00eas, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210149843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064252296","display_name":"D\u00e9bora De Melo Gagliato","orcid":"https://orcid.org/0000-0001-7480-0674","observed_orcids":["https://orcid.org/0000-0001-7480-0674"]},"institutions":[{"id":"https://openalex.org/I4210114248","display_name":"Benefic\u00eancia Portuguesa de S\u00e3o Paulo","ror":"https://ror.org/02d7mxj93","country_code":"BR","type":"nonprofit","lineage":["https://openalex.org/I4210114248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D\u00e9bora De Melo Gagliato","raw_affiliation_strings":["Hospital Benefic\u00eancia Portuguesa","Department of Medical Oncology, Hospital Benefic\u00eancia Portuguesa, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Benefic\u00eancia Portuguesa","institution_ids":["https://openalex.org/I4210114248"]},{"raw_affiliation_string":"Department of Medical Oncology, Hospital Benefic\u00eancia Portuguesa, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210114248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035123356","display_name":"Mina Nikanjam","orcid":"https://orcid.org/0000-0001-7052-6348","observed_orcids":["https://orcid.org/0000-0001-7052-6348"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mina Nikanjam","raw_affiliation_strings":["University of California","Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California","institution_ids":["https://openalex.org/I2803209242"]},{"raw_affiliation_string":"Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027865998","display_name":"Donald A. Barkauskas","orcid":"https://orcid.org/0000-0002-2339-719X","observed_orcids":["https://orcid.org/0000-0002-2339-719X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald A. Barkauskas","raw_affiliation_strings":["Keck School of Medicine of the University of Southern California","Biostatistics Division, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of the University of Southern California","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Biostatistics Division, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["University of California","Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California, San Diego, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4110-1214","affiliations":[{"raw_affiliation_string":"University of California","institution_ids":["https://openalex.org/I2803209242"]},{"raw_affiliation_string":"Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021572863"],"corresponding_institution_ids":["https://openalex.org/I4210149843"],"apc_list":{"value":2375,"currency":"GBP","value_usd":2913},"apc_paid":{"value":2375,"currency":"GBP","value_usd":2913},"fwci":0.4563,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.49020967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"1710052","last_page":"1710052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-combination","display_name":"anticancer drug combination","score":0.9520000219345093},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.7839999794960022},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.5899999737739563},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6399289965629578},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5868754982948303},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48410189151763916},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4658689498901367},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.44013458490371704},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.417934387922287},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4167424142360687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35320615768432617},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3449455499649048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23158469796180725}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1080/2162402x.2019.1710052","doi":"https://doi.org/10.1080/2162402x.2019.1710052","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2019.1710052","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2019.1710052?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6959453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6959453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Text"},{"id":"pmid:32002305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32002305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8fk9k3kc","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8fk9k3kc","pdf_url":"https://escholarship.org/content/qt8fk9k3kc/qt8fk9k3kc.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoImmunology, vol 9, iss 1","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:68c8fc18a4be4f07990edc45b5242cd0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/68c8fc18a4be4f07990edc45b5242cd0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoImmunology, Vol 9, Iss 1 (2020)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8fk9k3kc","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8fk9k3kc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncoimmunology, vol 9, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/2162402x.2019.1710052","doi":"https://doi.org/10.1080/2162402x.2019.1710052","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2019.1710052","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2019.1710052?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[{"id":"https://openalex.org/G3360784914","display_name":null,"funder_award_id":"CA023100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7810585149","display_name":"Specialized Cancer Center Support Grant","funder_award_id":"P30CA023100","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000629489.pdf","grobid_xml":"https://content.openalex.org/works/W3000629489.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1621260533","https://openalex.org/W1987407561","https://openalex.org/W1990488900","https://openalex.org/W1995439679","https://openalex.org/W2012932483","https://openalex.org/W2016351173","https://openalex.org/W2036756589","https://openalex.org/W2037716205","https://openalex.org/W2045265095","https://openalex.org/W2079315541","https://openalex.org/W2103724490","https://openalex.org/W2112762770","https://openalex.org/W2115731038","https://openalex.org/W2121280521","https://openalex.org/W2127068904","https://openalex.org/W2130066229","https://openalex.org/W2131730234","https://openalex.org/W2139168999","https://openalex.org/W2143163879","https://openalex.org/W2165921162","https://openalex.org/W2200963198","https://openalex.org/W2282398516","https://openalex.org/W2301695049","https://openalex.org/W2460293505","https://openalex.org/W2462290874","https://openalex.org/W2482216880","https://openalex.org/W2552099557","https://openalex.org/W2554618897","https://openalex.org/W2594345796","https://openalex.org/W2600452401","https://openalex.org/W2601621622","https://openalex.org/W2606058235","https://openalex.org/W2606533981","https://openalex.org/W2733692754","https://openalex.org/W2735117693","https://openalex.org/W2736815193","https://openalex.org/W2738696434","https://openalex.org/W2763875663","https://openalex.org/W2771905132","https://openalex.org/W2774112395","https://openalex.org/W2774967383","https://openalex.org/W2802776309","https://openalex.org/W2808822836","https://openalex.org/W2808999070","https://openalex.org/W3022903699","https://openalex.org/W4213172209","https://openalex.org/W4229654507","https://openalex.org/W4235878939"],"related_works":["https://openalex.org/W2940404962","https://openalex.org/W2396596997","https://openalex.org/W4402558665","https://openalex.org/W2606533981","https://openalex.org/W2087915641","https://openalex.org/W3130175388","https://openalex.org/W2093044087","https://openalex.org/W2114539312","https://openalex.org/W2054100499","https://openalex.org/W2733692754"],"abstract_inverted_index":{"Hundreds":[0],"of":[1,9,25,171,214,235],"trials":[2,52,223],"are":[3],"being":[4],"conducted":[5],"to":[6,20,36,122,208],"evaluate":[7],"combination":[8,26,65,94,236],"newer":[10],"targeted":[11,117],"drugs":[12,216],"as":[13,15],"well":[14],"immunotherapy.":[16],"Our":[17],"aim":[18],"was":[19,154],"compare":[21],"efficacy":[22],"and":[23,42,71,115,163,181,185],"safety":[24,72],"versus":[27,63,204,217],"single":[28,56,123,209],"non-cytotoxic":[29,57,68,95,124,128,215],"anticancer":[30],"agents.":[31,210],"We":[32],"searched":[33],"PubMed":[34],"(01/01/2001":[35],"03/06/2018)":[37],"(and,":[38],"for":[39,49,157,179],"immunotherapy,":[40],"ASCO":[41],"ESMO":[43],"abstracts":[44],"(2016":[45],"through":[46],"March":[47],"2018))":[48],"randomized":[50,90,220],"clinical":[51,222],"that":[53],"compared":[54,207],"a":[55,64,77,80,112,116],"agent":[58,114],"(targeted,":[59],"hormonal,":[60],"or":[61],"immunotherapy)":[62],"with":[66,229],"another":[67,127],"partner.":[69],"Efficacy":[70],"endpoints":[73],"were":[74],"evaluated":[75],"in":[76,219,233,242],"meta-analysis":[78],"using":[79],"linear":[81],"mixed-effects":[82],"model":[83],"(guidelines":[84],"per":[85],"PRISMA":[86],"Report).We":[87],"included":[88,111],"95":[89],"comparisons":[91],"(single":[92,202],"vs.":[93],"therapies)":[96],"(59.4%,":[97],"phase":[98,101],"II;":[99],"41.6%,":[100],"III":[102],"trials)":[103],"(29,175":[104],"patients":[105],"(solid":[106],"tumors)).":[107],"Combinations":[108,166],"most":[109,155],"frequently":[110],"hormonal":[113],"small":[118,182],"molecule":[119,183],"(23%).":[120],"Compared":[121],"agents,":[125],"adding":[126],"drug":[129],"increased":[130,227],"response":[131],"rate":[132],"(odds":[133],"ratio":[134,142],"[OR]=1.61,":[135],"95%CI":[136,144,149,175,194],"1.40-1.84)and":[137],"prolonged":[138],"progression-free":[139],"survival":[140,147],"(hazard":[141],"[HR]=0.75,":[143],"0.69-0.81)and":[145],"overall":[146],"(HR=0.87,":[148],"0.81-0.94)":[150],"(all":[151],"p<0.001),":[152],"which":[153],"pronounced":[156],"the":[158,169,230,240],"association":[159],"between":[160],"immunotherapy":[161,180],"combinations":[162,213],"longer":[164],"survival.":[165,243],"also":[167],"significantlyincreased":[168],"risk":[170],"high-grade":[172],"toxicities":[173],"(OR=2.42,":[174],"1.98-2.97)":[176],"(most":[177],"notably":[178],"inhibitors)":[184],"mortality":[186,199],"at":[187],"least":[188],"possibly":[189],"therapy":[190],"related":[191],"(OR:":[192],"1.33,":[193],"1.15-1.53)":[195],"(both":[196],"p<0.001)":[197],"(absolute":[198],"=":[200],"0.90%":[201],"agent)":[203],"1.31%":[205],"(combinations))":[206],"In":[211],"conclusion,":[212],"monotherapy":[218],"cancer":[221],"attenuated":[224],"safety,":[225],"but":[226],"efficacy,":[228],"balance":[231],"tilting":[232],"favor":[234],"therapy,":[237],"based":[238],"on":[239],"prolongation":[241]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-23T00:00:00"}
