{"id":"https://openalex.org/W3000627720","doi":"https://doi.org/10.1016/j.neuroscience.2019.12.019","title":"Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge","display_name":"Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000627720","doi":"https://doi.org/10.1016/j.neuroscience.2019.12.019","mag":"3000627720","pmid":"https://pubmed.ncbi.nlm.nih.gov/31917350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10233449"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2019.12.019","doi":"https://doi.org/10.1016/j.neuroscience.2019.12.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2019.12.019","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/06/19/566570.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034683398","display_name":"Daria Tchessalova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daria Tchessalova","raw_affiliation_strings":["Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: dtchessa@umich.edu","Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: dtchessa@umich.edu","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075346690","display_name":"Natalie Celia Tronson","orcid":"https://orcid.org/0000-0001-5676-1579","observed_orcids":["https://orcid.org/0000-0001-5676-1579"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natalie C. Tronson","raw_affiliation_strings":["Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: ntronson@umich.edu","Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States"],"raw_orcid":"https://orcid.org/0000-0001-5676-1579","affiliations":[{"raw_affiliation_string":"Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: ntronson@umich.edu","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Psychology and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075346690"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":1.256,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77712264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"428","issue":null,"first_page":"76","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.07280000299215317,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampal-gene-expression","display_name":"hippocampal gene expression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuroimmune-activation","display_name":"neuroimmune activation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/transcriptional-dysregulation","display_name":"transcriptional dysregulation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.5590000152587891},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.4860000014305115},{"id":"https://openalex.org/keywords/rna-sequencing","display_name":"RNA sequencing","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7229421138763428},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.5713022947311401},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5536884069442749},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5138530731201172},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47720107436180115},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4606476128101349},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.42493534088134766},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42407935857772827},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39648181200027466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38011494278907776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3620874285697937},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35458192229270935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24180084466934204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18731147050857544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15899208188056946},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.14350321888923645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09686926007270813}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroscience.2019.12.019","doi":"https://doi.org/10.1016/j.neuroscience.2019.12.019","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2019.12.019","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"doi:10.1101/566570","doi":"https://doi.org/10.1101/566570","is_oa":true,"landing_page_url":"https://doi.org/10.1101/566570","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/06/19/566570.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:31917350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31917350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10233449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10233449","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10233449/pdf/nihms-1898098.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/566570","doi":"https://doi.org/10.1101/566570","is_oa":true,"landing_page_url":"https://doi.org/10.1101/566570","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/06/19/566570.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8577918812","display_name":"Cytokine Signaling as a Mediator of Fear and Anxiety After Myocardial Infarction","funder_award_id":"R00MH093459","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000627720.pdf","grobid_xml":"https://content.openalex.org/works/W3000627720.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W115939226","https://openalex.org/W1731695440","https://openalex.org/W1842802220","https://openalex.org/W1858871521","https://openalex.org/W1965291001","https://openalex.org/W1967968285","https://openalex.org/W1972886222","https://openalex.org/W1973922157","https://openalex.org/W1975924070","https://openalex.org/W1976070593","https://openalex.org/W1984301503","https://openalex.org/W1989369404","https://openalex.org/W1994707167","https://openalex.org/W1996024251","https://openalex.org/W1998782626","https://openalex.org/W2009301288","https://openalex.org/W2016575029","https://openalex.org/W2025373842","https://openalex.org/W2026944960","https://openalex.org/W2029582308","https://openalex.org/W2030748288","https://openalex.org/W2034137314","https://openalex.org/W2040655707","https://openalex.org/W2042041381","https://openalex.org/W2043299701","https://openalex.org/W2043353308","https://openalex.org/W2051005796","https://openalex.org/W2051504363","https://openalex.org/W2053536449","https://openalex.org/W2065596291","https://openalex.org/W2067692579","https://openalex.org/W2076947415","https://openalex.org/W2087987871","https://openalex.org/W2093623845","https://openalex.org/W2094289216","https://openalex.org/W2097740790","https://openalex.org/W2107781399","https://openalex.org/W2135220031","https://openalex.org/W2138629438","https://openalex.org/W2152287997","https://openalex.org/W2156264094","https://openalex.org/W2164012002","https://openalex.org/W2171314958","https://openalex.org/W2179419840","https://openalex.org/W2224527671","https://openalex.org/W2235731665","https://openalex.org/W2280404143","https://openalex.org/W2286968510","https://openalex.org/W2288344309","https://openalex.org/W2292907345","https://openalex.org/W2296061140","https://openalex.org/W2314624240","https://openalex.org/W2353111961","https://openalex.org/W2509048649","https://openalex.org/W2552171384","https://openalex.org/W2552558587","https://openalex.org/W2555063823","https://openalex.org/W2555625955","https://openalex.org/W2585942752","https://openalex.org/W2588883201","https://openalex.org/W2593719298","https://openalex.org/W2594224471","https://openalex.org/W2764204627","https://openalex.org/W2783651643","https://openalex.org/W2788593837","https://openalex.org/W2790925227","https://openalex.org/W2796983933","https://openalex.org/W2800148666","https://openalex.org/W2804411892","https://openalex.org/W2804560798","https://openalex.org/W2808196202","https://openalex.org/W2889114795","https://openalex.org/W2891243896","https://openalex.org/W2891578341","https://openalex.org/W2900569176","https://openalex.org/W2904293409","https://openalex.org/W2910111050","https://openalex.org/W2922508899","https://openalex.org/W2951497943","https://openalex.org/W2969692811","https://openalex.org/W2979590126","https://openalex.org/W4300534374","https://openalex.org/W6694862919"],"related_works":["https://openalex.org/W2766202435","https://openalex.org/W2951497943","https://openalex.org/W2980342283","https://openalex.org/W4313244832","https://openalex.org/W2904825052","https://openalex.org/W2577936182","https://openalex.org/W1786209848","https://openalex.org/W3134243639","https://openalex.org/W2766484017","https://openalex.org/W7154742442"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-23T00:00:00"}